Compounds in cluster

13 molecules are shown

Wt: 285.3 BDBM35011	Wt: 325.4 BDBM35012	Wt: 335.4 BDBM35016	Wt: 363.4 BDBM35017	Wt: 369.8 BDBM35019
Wt: 349.4 BDBM35022	Wt: 363.4 BDBM35023	Wt: 360.4 BDBM35024	Wt: 350.4 BDBM35026	Wt: 367.4 BDBM35050
Wt: 273.3 BDBM35007	Wt: 327.3 BDBM35008	Wt: 301.4 BDBM35010

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 35011,35012,35016,35017,35019,35022,35023,35024,35026,35050,35007,35008,35010
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35050 (benzothienopyrimidinone deriv., 20e) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	0.800	-12.4	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM35050 (benzothienopyrimidinone deriv., 20e) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	0.900	-12.3	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35012 (benzothienopyrimidinone deriv., 12b) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	1	-12.2	n/a	n/a	n/a	n/a	n/a	7.5	23
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM35026 (benzothienopyrimidinone deriv., 14k) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2	-11.9	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35026 (benzothienopyrimidinone deriv., 14k) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2	-11.9	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM35012 (benzothienopyrimidinone deriv., 12b) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	2	-11.9	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35019 (benzothienopyrimidinone deriv., 14d) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3	-11.6	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35016 (benzothienopyrimidinone deriv., 14a) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4	-11.4	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35024 (benzothienopyrimidinone deriv., 14i) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5	-11.3	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35023 (benzothienopyrimidinone deriv., 14h) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5	-11.3	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM35016 (benzothienopyrimidinone deriv., 14a) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	8	-11.0	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35011 (benzothienopyrimidinone deriv., 12a) Show SMILES CN(C)Cc1nc2c3cc(C=C)ccc3sc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	9	-10.9	n/a	n/a	n/a	n/a	n/a	7.5	23
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35008 (benzothienopyrimidinone deriv., 10b) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	11	-10.8	n/a	n/a	n/a	n/a	n/a	7.5	23
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM35023 (benzothienopyrimidinone deriv., 14h) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	12	-10.8	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM35019 (benzothienopyrimidinone deriv., 14d) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	13	-10.8	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35022 (benzothienopyrimidinone deriv., 14g) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	14	-10.7	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35010 (benzothienopyrimidinone deriv., 11b) Show SMILES CC(C)c1ccc2sc3c(nc(CN(C)C)[nH]c3=O)c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	20	-10.4	n/a	n/a	n/a	n/a	n/a	7.5	23
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM35024 (benzothienopyrimidinone deriv., 14i) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	21	-10.5	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM35010 (benzothienopyrimidinone deriv., 11b) Show SMILES CC(C)c1ccc2sc3c(nc(CN(C)C)[nH]c3=O)c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	21	-10.5	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35007 (benzothienopyrimidinone deriv., 10a) Show SMILES CN(C)Cc1nc2c3cc(C)ccc3sc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	32	-10.1	n/a	n/a	n/a	n/a	n/a	7.5	23
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM35022 (benzothienopyrimidinone deriv., 14g) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	32	-10.2	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM35011 (benzothienopyrimidinone deriv., 12a) Show SMILES CN(C)Cc1nc2c3cc(C=C)ccc3sc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	34	-10.2	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM35008 (benzothienopyrimidinone deriv., 10b) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	36	-10.1	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35017 (benzothienopyrimidinone deriv., 14b) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	65	-9.80	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM35017 (benzothienopyrimidinone deriv., 14b) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	109	-9.49	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM35007 (benzothienopyrimidinone deriv., 10a) Show SMILES CN(C)Cc1nc2c3cc(C)ccc3sc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	122	-9.43	n/a	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...				J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW
Abbott Laboratories					More data for this Ligand-Target Pair