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Compile Data Set for Download or QSAR

Found 41 hits Enz. Inhib. hit(s) with Target = 'Trehalase'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Trehalase


(Homo sapiens (Human))		BDBM50286541
PNG
(6-(4,5-Dihydroxy-6-hydroxymethyl-tetrahydro-pyran-...)
Show SMILES OCC1OCC(NC2C=C(CO)C(O)C(O)C2O)C(O)C1O |t:8|
Show InChI InChI=1S/C13H23NO8/c15-2-5-1-6(10(18)13(21)9(5)17)14-7-4-22-8(3-16)12(20)11(7)19/h1,6-21H,2-4H2
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 180n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Evaluated for the inhibition of trehalase from porcine kidneys

Bioorg Med Chem Lett 5: 487-490 (1995)


Article DOI: 10.1016/0960-894X(95)00055-X
BindingDB Entry DOI: 10.7270/Q2CR5TBX
More data for this
Ligand-Target Pair
Trehalase


(Bombyx mori)		BDBM50487995
PNG
(TREHAZOLIN)
Show SMILES OC[C@H]1O[C@H](NC2=N[C@@H]3[C@H](O2)[C@@H](O)[C@H](O)[C@]3(O)CO)[C@H](O)[C@@H](O)[C@@H]1O |r,t:6|
Show InChI InChI=1S/C13H22N2O10/c16-1-3-4(18)5(19)6(20)11(24-3)15-12-14-9-8(25-12)7(21)10(22)13(9,23)2-17/h3-11,16-23H,1-2H2,(H,14,15)/t3-,4-,5+,6-,7-,8-,9-,10+,11+,13+/m1/s1
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n/an/a 49n/an/an/an/an/an/a



Dalian University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Bombyx mori trehalase

J Agric Food Chem 49: 5279-84 (2001)


Article DOI: 10.1021/jf010632k
BindingDB Entry DOI: 10.7270/Q23R0WRR
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50407255
PNG
(CHEMBL2114189)
Show SMILES CC[C@H]1NC[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C6H13NO2/c1-2-4-6(9)5(8)3-7-4/h4-9H,2-3H2,1H3/t4-,5-,6-/m1/s1
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n/an/a 4.80E+3n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Concentration that causes 50% inhibition of mammalian trehalase was determined in porcine kidney

J Med Chem 37: 3701-6 (1994)


BindingDB Entry DOI: 10.7270/Q2ZC83H3
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM18355
PNG
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Show SMILES CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method

J Med Chem 38: 2349-56 (1995)


BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50016703
PNG
(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4-,5?/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method

J Med Chem 38: 2349-56 (1995)


BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50407255
PNG
(CHEMBL2114189)
Show SMILES CC[C@H]1NC[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C6H13NO2/c1-2-4-6(9)5(8)3-7-4/h4-9H,2-3H2,1H3/t4-,5-,6-/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Concentration that causes 50% inhibition of mammalian trehalase was determined in rat intestine

J Med Chem 37: 3701-6 (1994)


BindingDB Entry DOI: 10.7270/Q2ZC83H3
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM18353
PNG
((2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine...)
Show SMILES CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
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n/an/a 2.80E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method

J Med Chem 38: 2349-56 (1995)


BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50259956
PNG
(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...)
Show SMILES OC[C@H]1N[C@H](CO)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5-,6+,7+/m1/s1
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n/an/a 3.40E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibitory activity measured against trehalase of porcine kidney by colorimetric assay using the D-glucose oxidase-peroxidase method

J Med Chem 41: 2565-71 (1998)


Article DOI: 10.1021/jm970836l
BindingDB Entry DOI: 10.7270/Q25D8SHK
More data for this
Ligand-Target Pair
Trehalase


(Sus scrofa)		BDBM50487998
PNG
(CHEMBL2270665)
Show SMILES OCC1(CO)CO\C(N1)=N/c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C11H12ClFN2O3/c12-8-3-7(1-2-9(8)13)14-10-15-11(4-16,5-17)6-18-10/h1-3,16-17H,4-6H2,(H,14,15)
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n/an/a 3.55E+4n/an/an/an/an/an/a



Dalian University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sus scrofa (pig) trehalase using trehaloase as substrate incubated for 15 min prior to substrate addition measured after 1.5 hr by spec...

J Agric Food Chem 49: 5279-84 (2001)


Article DOI: 10.1021/jf010632k
BindingDB Entry DOI: 10.7270/Q23R0WRR
More data for this
Ligand-Target Pair
Trehalase


(Sus scrofa)		BDBM18355
PNG
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Show SMILES CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
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n/an/a 3.60E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney trehalase

J Med Chem 55: 10347-62 (2012)


Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM18355
PNG
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Show SMILES CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
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n/an/a 3.80E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal trehalase

J Med Chem 55: 10347-62 (2012)


Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX
More data for this
Ligand-Target Pair
Trehalase


(Homo sapiens (Human))		BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Inhibitory activity against trehalase from porcine kidney

Bioorg Med Chem Lett 14: 5991-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.086
BindingDB Entry DOI: 10.7270/Q27P904W
More data for this
Ligand-Target Pair
Trehalase


(Sus scrofa)		BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 4.10E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney trehalase

J Med Chem 55: 10347-62 (2012)


Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 4.10E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Concentration that causes 50% inhibition of mammalian trehalase was determined in porcine kidney

J Med Chem 37: 3701-6 (1994)


BindingDB Entry DOI: 10.7270/Q2ZC83H3
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 4.20E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Concentration that causes 50% inhibition of mammalian trehalase was determined in rat intestine

J Med Chem 37: 3701-6 (1994)


BindingDB Entry DOI: 10.7270/Q2ZC83H3
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 4.20E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal trehalase

J Med Chem 55: 10347-62 (2012)


Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 4.20E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method

J Med Chem 38: 2349-56 (1995)


BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50031480
PNG
((2R,3R,4R)-2-Hydroxymethyl-1-methyl-pyrrolidine-3,...)
Show SMILES CN1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C6H13NO3/c1-7-2-5(9)6(10)4(7)3-8/h4-6,8-10H,2-3H2,1H3/t4-,5-,6-/m1/s1
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n/an/a<5.00E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method

J Med Chem 38: 2349-56 (1995)


BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50031482
PNG
((2R,3R,4R,5R)-1-Butyl-2,5-bis-hydroxymethyl-pyrrol...)
Show SMILES CCCCN1[C@H](CO)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-7(5-12)9(14)10(15)8(11)6-13/h7-10,12-15H,2-6H2,1H3/t7-,8-,9-,10-/m1/s1
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Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method

J Med Chem 38: 2349-56 (1995)


BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50031484
PNG
((2R,3R,4R)-1-Butyl-2-hydroxymethyl-pyrrolidine-3,4...)
Show SMILES CCCCN1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-10-5-8(12)9(13)7(10)6-11/h7-9,11-13H,2-6H2,1H3/t7-,8-,9-/m1/s1
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Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method

J Med Chem 38: 2349-56 (1995)


BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50031483
PNG
((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-1-methyl-pyrro...)
Show SMILES CN1[C@H](CO)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C7H15NO4/c1-8-4(2-9)6(11)7(12)5(8)3-10/h4-7,9-12H,2-3H2,1H3/t4-,5-,6-,7-/m1/s1
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Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method

J Med Chem 38: 2349-56 (1995)


BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50375511
PNG
(CHEMBL406973)
Show SMILES OC[C@@H]1NC[C@H](O)[C@H]1O
Show InChI InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4-,5-/m0/s1
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n/an/a 7.50E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal trehalase

J Med Chem 55: 10347-62 (2012)


Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX
More data for this
Ligand-Target Pair
Trehalase


(Sus scrofa)		BDBM50488002
PNG
(CHEMBL2270659)
Show SMILES OCC1(CO)CO\C(N1)=N/c1ccccc1F
Show InChI InChI=1S/C11H13FN2O3/c12-8-3-1-2-4-9(8)13-10-14-11(5-15,6-16)7-17-10/h1-4,15-16H,5-7H2,(H,13,14)
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n/an/a 7.58E+4n/an/an/an/an/an/a



Dalian University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sus scrofa (pig) trehalase using trehaloase as substrate incubated for 15 min prior to substrate addition measured after 1.5 hr by spec...

J Agric Food Chem 49: 5279-84 (2001)


Article DOI: 10.1021/jf010632k
BindingDB Entry DOI: 10.7270/Q23R0WRR
More data for this
Ligand-Target Pair
Trehalase


(Sus scrofa)		BDBM50487996
PNG
(CHEMBL2270890)
Show SMILES OCC1(CO)CO\C(N1)=N/c1ccc(F)c(F)c1F
Show InChI InChI=1S/C11H11F3N2O3/c12-6-1-2-7(9(14)8(6)13)15-10-16-11(3-17,4-18)5-19-10/h1-2,17-18H,3-5H2,(H,15,16)
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n/an/a 8.51E+4n/an/an/an/an/an/a



Dalian University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sus scrofa (pig) trehalase using trehaloase as substrate incubated for 15 min prior to substrate addition measured after 1.5 hr by spec...

J Agric Food Chem 49: 5279-84 (2001)


Article DOI: 10.1021/jf010632k
BindingDB Entry DOI: 10.7270/Q23R0WRR
More data for this
Ligand-Target Pair
Trehalase


(Sus scrofa)		BDBM50375511
PNG
(CHEMBL406973)
Show SMILES OC[C@@H]1NC[C@H](O)[C@H]1O
Show InChI InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4-,5-/m0/s1
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n/an/a 1.31E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney trehalase

J Med Chem 55: 10347-62 (2012)


Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50065255
PNG
((R)-2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol |...)
Show SMILES OCC1NC(CO)[C@@H](O)C(O)C1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3?,4?,5-,6?,7?/m1/s1
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n/an/a 1.40E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibitory activity measured against trehalase of porcine kidney by colorimetric assay using the D-glucose oxidase-peroxidase method

J Med Chem 41: 2565-71 (1998)


Article DOI: 10.1021/jm970836l
BindingDB Entry DOI: 10.7270/Q25D8SHK
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM18361
PNG
((2R,3S,4R,5R,6R)-2-butyl-6-(hydroxymethyl)piperidi...)
Show SMILES CCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-6-8(13)10(15)9(14)7(5-12)11-6/h6-15H,2-5H2,1H3/t6-,7-,8+,9-,10-/m1/s1
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n/an/a 1.67E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal trehalase

J Med Chem 55: 10347-62 (2012)


Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX
More data for this
Ligand-Target Pair
Trehalase


(Sus scrofa)		BDBM18361
PNG
((2R,3S,4R,5R,6R)-2-butyl-6-(hydroxymethyl)piperidi...)
Show SMILES CCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-6-8(13)10(15)9(14)7(5-12)11-6/h6-15H,2-5H2,1H3/t6-,7-,8+,9-,10-/m1/s1
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n/an/a 1.72E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney trehalase

J Med Chem 55: 10347-62 (2012)


Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50037814
PNG
(2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol | CHEMB...)
Show SMILES OCC1NC(CO)C(O)C1O
Show InChI InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2
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n/an/a 2.00E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Concentration that causes 50% inhibition of mammalian trehalase was determined in porcine kidney

J Med Chem 37: 3701-6 (1994)


BindingDB Entry DOI: 10.7270/Q2ZC83H3
More data for this
Ligand-Target Pair
Trehalase


(Sus scrofa)		BDBM50487997
PNG
(CHEMBL2270889)
Show SMILES OCC1(CO)CS\C(N1)=N/c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C11H12ClFN2O2S/c12-8-3-7(1-2-9(8)13)14-10-15-11(4-16,5-17)6-18-10/h1-3,16-17H,4-6H2,(H,14,15)
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n/an/a 2.40E+5n/an/an/an/an/an/a



Dalian University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sus scrofa (pig) trehalase using trehaloase as substrate incubated for 15 min prior to substrate addition measured after 1.5 hr by spec...

J Agric Food Chem 49: 5279-84 (2001)


Article DOI: 10.1021/jf010632k
BindingDB Entry DOI: 10.7270/Q23R0WRR
More data for this
Ligand-Target Pair
Trehalase


(Sus scrofa)		BDBM50488003
PNG
(CHEMBL2270661)
Show SMILES OCC1(CO)CO\C(N1)=N/c1ccc(F)cc1
Show InChI InChI=1S/C11H13FN2O3/c12-8-1-3-9(4-2-8)13-10-14-11(5-15,6-16)7-17-10/h1-4,15-16H,5-7H2,(H,13,14)
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n/an/a 2.63E+5n/an/an/an/an/an/a



Dalian University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sus scrofa (pig) trehalase using trehaloase as substrate incubated for 15 min prior to substrate addition measured after 1.5 hr by spec...

J Agric Food Chem 49: 5279-84 (2001)


Article DOI: 10.1021/jf010632k
BindingDB Entry DOI: 10.7270/Q23R0WRR
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50408432
PNG
(CHEMBL2115215)
Show SMILES OC[C@H]1N[C@@H](CO)[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4+,5-,6-,7+/m1/s1
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n/an/a 3.60E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibitory activity measured against trehalase of porcine kidney by colorimetric assay using the D-glucose oxidase-peroxidase method

J Med Chem 41: 2565-71 (1998)


Article DOI: 10.1021/jm970836l
BindingDB Entry DOI: 10.7270/Q25D8SHK
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50031481
PNG
((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...)
Show SMILES OC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1
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n/an/a 3.60E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method

J Med Chem 38: 2349-56 (1995)


BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50037814
PNG
(2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol | CHEMB...)
Show SMILES OCC1NC(CO)C(O)C1O
Show InChI InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2
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n/an/a 3.60E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Concentration that causes 50% inhibition of mammalian trehalase was determined in rat intestine

J Med Chem 37: 3701-6 (1994)


BindingDB Entry DOI: 10.7270/Q2ZC83H3
More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)		BDBM50408431
PNG
(CHEMBL2114210)
Show SMILES OC[C@H]1N[C@H](CO)[C@@H](O)C(O)[C@@H]1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5-,6-/m1/s1
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n/an/a 4.60E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibitory activity measured against trehalase of porcine kidney by colorimetric assay using the D-glucose oxidase-peroxidase method

J Med Chem 41: 2565-71 (1998)


Article DOI: 10.1021/jm970836l
BindingDB Entry DOI: 10.7270/Q25D8SHK
More data for this
Ligand-Target Pair
Trehalase


(Sus scrofa)		BDBM50487993
PNG
(CHEMBL2270662)
Show SMILES OCC1(CO)CS\C(N1)=N/c1ccc(F)cc1
Show InChI InChI=1S/C11H13FN2O2S/c12-8-1-3-9(4-2-8)13-10-14-11(5-15,6-16)7-17-10/h1-4,15-16H,5-7H2,(H,13,14)
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n/an/a 5.75E+5n/an/an/an/an/an/a



Dalian University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sus scrofa (pig) trehalase using trehaloase as substrate incubated for 15 min prior to substrate addition measured after 1.5 hr by spec...

J Agric Food Chem 49: 5279-84 (2001)


Article DOI: 10.1021/jf010632k
BindingDB Entry DOI: 10.7270/Q23R0WRR
More data for this
Ligand-Target Pair
Trehalase


(Sus scrofa)		BDBM50487994
PNG
(CHEMBL2270891)
Show SMILES OCC1(CO)CS\C(N1)=N/c1ccc(F)c(F)c1F
Show InChI InChI=1S/C11H11F3N2O2S/c12-6-1-2-7(9(14)8(6)13)15-10-16-11(3-17,4-18)5-19-10/h1-2,17-18H,3-5H2,(H,15,16)
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n/an/a 7.08E+5n/an/an/an/an/an/a



Dalian University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sus scrofa (pig) trehalase using trehaloase as substrate incubated for 15 min prior to substrate addition measured after 1.5 hr by spec...

J Agric Food Chem 49: 5279-84 (2001)


Article DOI: 10.1021/jf010632k
BindingDB Entry DOI: 10.7270/Q23R0WRR
More data for this
Ligand-Target Pair
Trehalase


(Homo sapiens (Human))		BDBM50156355
PNG
(2-Butyl-6-hydroxymethyl-piperidine-3,4,5-triol | C...)
Show SMILES CCCCC1NC(CO)C(O)C(O)C1O
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-6-8(13)10(15)9(14)7(5-12)11-6/h6-15H,2-5H2,1H3
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n/an/a 7.80E+5n/an/an/an/an/an/a



Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Inhibitory activity against trehalase from porcine kidney

Bioorg Med Chem Lett 14: 5991-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.086
BindingDB Entry DOI: 10.7270/Q27P904W
More data for this
Ligand-Target Pair
Trehalase


(Sus scrofa)		BDBM50488000
PNG
(CHEMBL2270660)
Show SMILES OCC1(CO)CS\C(N1)=N/c1ccccc1F
Show InChI InChI=1S/C11H13FN2O2S/c12-8-3-1-2-4-9(8)13-10-14-11(5-15,6-16)7-17-10/h1-4,15-16H,5-7H2,(H,13,14)
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n/an/a 8.32E+5n/an/an/an/an/an/a



Dalian University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sus scrofa (pig) trehalase using trehaloase as substrate incubated for 15 min prior to substrate addition measured after 1.5 hr by spec...

J Agric Food Chem 49: 5279-84 (2001)


Article DOI: 10.1021/jf010632k
BindingDB Entry DOI: 10.7270/Q23R0WRR
More data for this
Ligand-Target Pair
Trehalase


(Sus scrofa)		BDBM50487999
PNG
(CHEMBL2270663)
Show SMILES OCC1(CO)CO\C(N1)=N/c1ccc(F)cc1F
Show InChI InChI=1S/C11H12F2N2O3/c12-7-1-2-9(8(13)3-7)14-10-15-11(4-16,5-17)6-18-10/h1-3,16-17H,4-6H2,(H,14,15)
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n/an/a 8.91E+5n/an/an/an/an/an/a



Dalian University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sus scrofa (pig) trehalase using trehaloase as substrate incubated for 15 min prior to substrate addition measured after 1.5 hr by spec...

J Agric Food Chem 49: 5279-84 (2001)


Article DOI: 10.1021/jf010632k
BindingDB Entry DOI: 10.7270/Q23R0WRR
More data for this
Ligand-Target Pair
Trehalase


(Sus scrofa)		BDBM50488001
PNG
(CHEMBL2270664)
Show SMILES OCC1(CO)CS\C(N1)=N/c1ccc(F)cc1F
Show InChI InChI=1S/C11H12F2N2O2S/c12-7-1-2-9(8(13)3-7)14-10-15-11(4-16,5-17)6-18-10/h1-3,16-17H,4-6H2,(H,14,15)
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n/an/a 6.17E+6n/an/an/an/an/an/a



Dalian University of Technology

Curated by ChEMBL


Assay Description
Inhibition of Sus scrofa (pig) trehalase using trehaloase as substrate incubated for 15 min prior to substrate addition measured after 1.5 hr by spec...

J Agric Food Chem 49: 5279-84 (2001)


Article DOI: 10.1021/jf010632k
BindingDB Entry DOI: 10.7270/Q23R0WRR
More data for this
Ligand-Target Pair