Found 45 hits Enz. Inhib. hit(s) with Target = 'Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246344
(US9434693, 39)Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)[S@+]([O-])C(C)(C)C2)cc1-c1ccc(Cl)cc1 |r,wD:17.18,(2.27,6.3,;1.5,4.97,;-.04,4.97,;-.81,6.3,;-2.35,6.3,;-3.12,4.97,;-2.35,3.63,;-.81,3.63,;-.04,2.3,;-.95,1.05,;-.04,-.19,;-.44,-1.68,;-1.78,-2.45,;-1.78,-3.99,;-3.11,-4.76,;-3.11,-6.3,;-1.78,-5.53,;-4.44,-3.99,;-5.78,-4.76,;-4.44,-2.45,;-5.78,-1.68,;-5.21,-1.12,;-3.11,-1.68,;1.42,.28,;1.42,1.82,;2.51,2.91,;4,2.51,;5.09,3.6,;4.69,5.09,;5.78,6.18,;3.2,5.49,;2.11,4.4,)| Show InChI InChI=1S/C25H29ClN2O3S/c1-24(2)15-19(16-25(3,4)32(24)29)31-23-14-21(17-10-12-18(26)13-11-17)28(27-23)20-8-6-7-9-22(20)30-5/h6-14,19H,15-16H2,1-5H3/t19?,32- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246342
(US9434693, 37)Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)S(=O)(=O)C(C)(C)C2)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H29ClN2O4S/c1-24(2)15-19(16-25(3,4)33(24,29)30)32-23-14-21(17-10-12-18(26)13-11-17)28(27-23)20-8-6-7-9-22(20)31-5/h6-14,19H,15-16H2,1-5H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246350
(US9434693, 45)Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)S(=O)(=O)C(C)(C)C2)cc1-c1ccc(cc1)C#N Show InChI InChI=1S/C26H29N3O4S/c1-25(2)15-20(16-26(3,4)34(25,30)31)33-24-14-22(19-12-10-18(17-27)11-13-19)29(28-24)21-8-6-7-9-23(21)32-5/h6-14,20H,15-16H2,1-5H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246343
(US9434693, 38)Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)[S@+]([O-])C(C)(C)C2)cc1-c1ccc(Cl)cc1 |r,wU:17.18,(2.27,6.3,;1.5,4.97,;-.04,4.97,;-.81,6.3,;-2.35,6.3,;-3.12,4.97,;-2.35,3.63,;-.81,3.63,;-.04,2.3,;-.95,1.05,;-.04,-.19,;-.44,-1.68,;-1.78,-2.45,;-3.11,-1.68,;-4.44,-2.45,;-5.78,-1.68,;-5.21,-1.12,;-4.44,-3.99,;-5.78,-4.76,;-3.11,-4.76,;-3.11,-6.3,;-1.78,-5.53,;-1.78,-3.99,;1.42,.28,;1.42,1.82,;2.51,2.91,;4,2.51,;5.09,3.6,;4.69,5.09,;5.78,6.18,;3.2,5.49,;2.11,4.4,)| Show InChI InChI=1S/C25H29ClN2O3S/c1-24(2)15-19(16-25(3,4)32(24)29)31-23-14-21(17-10-12-18(26)13-11-17)28(27-23)20-8-6-7-9-22(20)30-5/h6-14,19H,15-16H2,1-5H3/t19?,32- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246338
(US9434693, 33)Show SMILES COc1ccc(cc1)-c1cc(OC2CC(C)(C)S(=O)(=O)C(C)(C)C2)nn1-c1ccccc1OC Show InChI InChI=1S/C26H32N2O5S/c1-25(2)16-20(17-26(3,4)34(25,29)30)33-24-15-22(18-11-13-19(31-5)14-12-18)28(27-24)21-9-7-8-10-23(21)32-6/h7-15,20H,16-17H2,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246345
(US9434693, 40)Show SMILES COc1ccccc1-n1nc(OCC2C(C)(C)OC2(C)C)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H27ClN2O3/c1-23(2)21(24(3,4)30-23)15-29-22-14-19(16-10-12-17(25)13-11-16)27(26-22)18-8-6-7-9-20(18)28-5/h6-14,21H,15H2,1-5H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246339
(US9434693, 34)Show SMILES COc1ccc(cc1)-c1cc(OC2CC(C)(C)[S@+]([O-])C(C)(C)C2)nn1-c1ccccc1OC |r,wU:17.18,(-6.62,5.55,;-5.14,5.95,;-4.05,4.86,;-2.56,5.26,;-1.47,4.17,;-1.87,2.68,;-3.36,2.28,;-4.45,3.37,;-.78,1.59,;-.78,.05,;.68,-.42,;1.08,-1.91,;2.42,-2.68,;2.42,-4.22,;3.75,-4.99,;3.75,-6.53,;2.42,-5.76,;5.08,-4.22,;6.42,-4.99,;5.08,-2.68,;6.62,-2.68,;5.85,-1.35,;3.75,-1.91,;1.59,.82,;.68,2.07,;1.08,3.56,;-.01,4.64,;.39,6.13,;1.88,6.53,;2.97,5.44,;2.57,3.95,;3.66,2.87,;3.26,1.38,)| Show InChI InChI=1S/C26H32N2O4S/c1-25(2)16-20(17-26(3,4)33(25)29)32-24-15-22(18-11-13-19(30-5)14-12-18)28(27-24)21-9-7-8-10-23(21)31-6/h7-15,20H,16-17H2,1-6H3/t20?,33- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246341
(US9434693, 36)Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)SC(C)(C)C2)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H29ClN2O2S/c1-24(2)15-19(16-25(3,4)31-24)30-23-14-21(17-10-12-18(26)13-11-17)28(27-23)20-8-6-7-9-22(20)29-5/h6-14,19H,15-16H2,1-5H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246337
(US9434693, 32)Show SMILES COc1ccc(cc1)-c1cc(OC2CC(C)(C)SC(C)(C)C2)nn1-c1ccccc1OC Show InChI InChI=1S/C26H32N2O3S/c1-25(2)16-20(17-26(3,4)32-25)31-24-15-22(18-11-13-19(29-5)14-12-18)28(27-24)21-9-7-8-10-23(21)30-6/h7-15,20H,16-17H2,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246333
(US9434693, 28)Show SMILES CC(C)Oc1ccccc1-n1nc(OC2CCN(CC2)S(=O)(=O)C(C)C)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C26H32ClN3O4S/c1-18(2)33-25-8-6-5-7-23(25)30-24(20-9-11-21(27)12-10-20)17-26(28-30)34-22-13-15-29(16-14-22)35(31,32)19(3)4/h5-12,17-19,22H,13-16H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246348
(US9434693, 43)Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)OC(C)(C)C2)cc1-c1ccc(cc1)C#N Show InChI InChI=1S/C26H29N3O3/c1-25(2)15-20(16-26(3,4)32-25)31-24-14-22(19-12-10-18(17-27)11-13-19)29(28-24)21-8-6-7-9-23(21)30-5/h6-14,20H,15-16H2,1-5H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246329
(US9434693, 23)Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)OC(C)(C)C2)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H29ClN2O3/c1-24(2)15-19(16-25(3,4)31-24)30-23-14-21(17-10-12-18(26)13-11-17)28(27-23)20-8-6-7-9-22(20)29-5/h6-14,19H,15-16H2,1-5H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246340
(US9434693, 35)Show SMILES COc1ccc(cc1)-c1cc(OC2CC(C)(C)[S@+]([O-])C(C)(C)C2)nn1-c1ccccc1OC |r,wU:17.18,(-6.83,4.93,;-5.34,5.33,;-4.25,4.24,;-2.76,4.63,;-1.68,3.55,;-2.07,2.06,;-3.56,1.66,;-4.65,2.75,;-.99,.97,;-.99,-.57,;.48,-1.05,;.88,-2.53,;2.37,-2.93,;2.76,-4.42,;4.25,-4.82,;2.76,-5.22,;3.16,-5.91,;5.34,-3.73,;6.83,-3.33,;4.94,-2.24,;5.34,-.75,;6.43,-1.84,;3.45,-1.84,;1.38,.2,;.48,1.45,;.88,2.93,;-.21,4.02,;.19,5.51,;1.68,5.91,;2.76,4.82,;2.37,3.33,;3.45,2.24,;3.06,.75,)| Show InChI InChI=1S/C26H32N2O4S/c1-25(2)16-20(17-26(3,4)33(25)29)32-24-15-22(18-11-13-19(30-5)14-12-18)28(27-24)21-9-7-8-10-23(21)31-6/h7-15,20H,16-17H2,1-6H3/t20?,33- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246335
(US9434693, 30)Show SMILES COc1ccccc1-n1nc(OC2CN(C2)S(=O)(=O)c2c(C)noc2C)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H23ClN4O5S/c1-15-24(16(2)34-27-15)35(30,31)28-13-19(14-28)33-23-12-21(17-8-10-18(25)11-9-17)29(26-23)20-6-4-5-7-22(20)32-3/h4-12,19H,13-14H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246321
(US9434693, 15)Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)S(=O)(=O)C2CC2)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H26ClN3O4S/c1-31-23-5-3-2-4-21(23)28-22(17-6-8-18(25)9-7-17)16-24(26-28)32-19-12-14-27(15-13-19)33(29,30)20-10-11-20/h2-9,16,19-20H,10-15H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246336
(US9434693, 31)Show SMILES COc1ccc(cc1)-c1cc(OC2CC(C)(C)OC(C)(C)C2)nn1-c1ccccc1OC Show InChI InChI=1S/C26H32N2O4/c1-25(2)16-20(17-26(3,4)32-25)31-24-15-22(18-11-13-19(29-5)14-12-18)28(27-24)21-9-7-8-10-23(21)30-6/h7-15,20H,16-17H2,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246346
(US9434693, 41)Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)C(=O)C(C)(C)C2)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C26H29ClN2O3/c1-25(2)15-19(16-26(3,4)24(25)30)32-23-14-21(17-10-12-18(27)13-11-17)29(28-23)20-8-6-7-9-22(20)31-5/h6-14,19H,15-16H2,1-5H3 | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246319
(US9434693, 13)Show SMILES COc1ccccc1-n1nc(O[C@@H]2CC[C@@H](CC2)NC(=O)C(F)(F)F)cc1-c1ccc(Cl)cc1 |r,wU:12.12,15.19,(4.61,5.19,;3.84,3.85,;2.3,3.85,;1.53,5.19,;-.01,5.19,;-.78,3.85,;-.01,2.52,;1.53,2.52,;2.3,1.18,;1.39,-.06,;2.3,-1.31,;1.9,-2.79,;.41,-3.19,;-.68,-2.1,;-2.17,-2.5,;-2.56,-3.99,;-1.48,-5.08,;.01,-4.68,;-4.05,-4.39,;-5.14,-3.3,;-4.74,-1.81,;-6.63,-3.7,;-8.12,-4.1,;-7.03,-2.21,;-6.23,-5.19,;3.76,-.83,;3.76,.71,;4.85,1.8,;6.34,1.4,;7.43,2.49,;7.03,3.98,;8.12,5.06,;5.54,4.37,;4.45,3.29,)| Show InChI InChI=1S/C24H23ClF3N3O3/c1-33-21-5-3-2-4-19(21)31-20(15-6-8-16(25)9-7-15)14-22(30-31)34-18-12-10-17(11-13-18)29-23(32)24(26,27)28/h2-9,14,17-18H,10-13H2,1H3,(H,29,32)/t17-,18+ | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246349
(US9434693, 44)Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)SC(C)(C)C2)cc1-c1ccc(cc1)C#N Show InChI InChI=1S/C26H29N3O2S/c1-25(2)15-20(16-26(3,4)32-25)31-24-14-22(19-12-10-18(17-27)11-13-19)29(28-24)21-8-6-7-9-23(21)30-5/h6-14,20H,15-16H2,1-5H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246334
(US9434693, 29)Show SMILES CON(C)C(=O)N1CC(C1)Oc1cc(-c2ccc(Cl)cc2)n(n1)-c1ccccc1OC Show InChI InChI=1S/C22H23ClN4O4/c1-25(30-3)22(28)26-13-17(14-26)31-21-12-19(15-8-10-16(23)11-9-15)27(24-21)18-6-4-5-7-20(18)29-2/h4-12,17H,13-14H2,1-3H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246310
(US9434693, 4)Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)C(=O)N(C)C)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H27ClN4O3/c1-27(2)24(30)28-14-12-19(13-15-28)32-23-16-21(17-8-10-18(25)11-9-17)29(26-23)20-6-4-5-7-22(20)31-3/h4-11,16,19H,12-15H2,1-3H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246351
(US9434693, 46)Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)[S@+]([O-])C(C)(C)C2)cc1-c1ccc(cc1)C#N |r,wU:17.18,(3.06,1.12,;3.46,2.61,;2.37,3.7,;2.77,5.19,;1.68,6.28,;.19,5.88,;-.21,4.39,;.88,3.3,;.48,1.82,;1.39,.57,;.48,-.68,;.88,-2.16,;2.22,-2.93,;2.22,-4.47,;3.55,-5.24,;3.55,-6.78,;2.22,-6.01,;4.88,-4.47,;6.22,-5.24,;4.88,-2.93,;6.42,-2.93,;5.65,-1.6,;3.55,-2.16,;-.98,-.2,;-.98,1.34,;-2.07,2.43,;-1.67,3.92,;-2.76,5,;-4.29,4.65,;-4.65,3.12,;-3.56,2.03,;-5.37,5.73,;-6.46,6.82,)| Show InChI InChI=1S/C26H29N3O3S/c1-25(2)15-20(16-26(3,4)33(25)30)32-24-14-22(19-12-10-18(17-27)11-13-19)29(28-24)21-8-6-7-9-23(21)31-5/h6-14,20H,15-16H2,1-5H3/t20?,33- | PDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246312
(US9434693, 6)Show InChI InChI=1S/C21H21ClN2O3/c1-25-20-5-3-2-4-18(20)24-19(15-6-8-16(22)9-7-15)14-21(23-24)27-17-10-12-26-13-11-17/h2-9,14,17H,10-13H2,1H3 | PDB
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| US Patent
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246311
(US9434693, 5)Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)S(C)(=O)=O)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H24ClN3O4S/c1-29-21-6-4-3-5-19(21)26-20(16-7-9-17(23)10-8-16)15-22(24-26)30-18-11-13-25(14-12-18)31(2,27)28/h3-10,15,18H,11-14H2,1-2H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246326
(US9434693, 20)Show SMILES CC(C)Oc1ccccc1-n1nc(OC2CCN(CC2)S(C)(=O)=O)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H28ClN3O4S/c1-17(2)31-23-7-5-4-6-21(23)28-22(18-8-10-19(25)11-9-18)16-24(26-28)32-20-12-14-27(15-13-20)33(3,29)30/h4-11,16-17,20H,12-15H2,1-3H3 | PDB
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| n/a | n/a | 21.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246320
(US9434693, 14)Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)S(=O)(=O)C(F)(F)F)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H21ClF3N3O4S/c1-32-20-5-3-2-4-18(20)29-19(15-6-8-16(23)9-7-15)14-21(27-29)33-17-10-12-28(13-11-17)34(30,31)22(24,25)26/h2-9,14,17H,10-13H2,1H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246309
(US9434693, 3)Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)C(C)=O)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H24ClN3O3/c1-16(28)26-13-11-19(12-14-26)30-23-15-21(17-7-9-18(24)10-8-17)27(25-23)20-5-3-4-6-22(20)29-2/h3-10,15,19H,11-14H2,1-2H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246313
(US9434693, 7)Show InChI InChI=1S/C21H21ClN2O2S/c1-25-20-5-3-2-4-18(20)24-19(15-6-8-16(22)9-7-15)14-21(23-24)26-17-10-12-27-13-11-17/h2-9,14,17H,10-13H2,1H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246308
(US9434693, 2)Show SMILES COc1ccccc1-n1nc(OC2CCC(=O)CC2)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H21ClN2O3/c1-27-21-5-3-2-4-19(21)25-20(15-6-8-16(23)9-7-15)14-22(24-25)28-18-12-10-17(26)11-13-18/h2-9,14,18H,10-13H2,1H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246307
(US9434693, 1)Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)C(=O)OC(C)(C)C)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C26H30ClN3O4/c1-26(2,3)34-25(31)29-15-13-20(14-16-29)33-24-17-22(18-9-11-19(27)12-10-18)30(28-24)21-7-5-6-8-23(21)32-4/h5-12,17,20H,13-16H2,1-4H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246316
(US9434693, 10)Show SMILES COc1ccccc1-n1nc(OC2CCS(=O)(=O)CC2)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C21H21ClN2O4S/c1-27-20-5-3-2-4-18(20)24-19(15-6-8-16(22)9-7-15)14-21(23-24)28-17-10-12-29(25,26)13-11-17/h2-9,14,17H,10-13H2,1H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246314
(US9434693, 8)Show SMILES COc1ccccc1-n1nc(OC2CCN(CC(F)(F)F)CC2)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H23ClF3N3O2/c1-31-21-5-3-2-4-19(21)30-20(16-6-8-17(24)9-7-16)14-22(28-30)32-18-10-12-29(13-11-18)15-23(25,26)27/h2-9,14,18H,10-13,15H2,1H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246331
(US9434693, 26)Show SMILES COc1ccccc1-n1nc(OC2CN(C2)S(C)(=O)=O)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C20H20ClN3O4S/c1-27-19-6-4-3-5-17(19)24-18(14-7-9-15(21)10-8-14)11-20(22-24)28-16-12-23(13-16)29(2,25)26/h3-11,16H,12-13H2,1-2H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246315
(US9434693, 9)Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)C(=O)C(F)(F)F)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H21ClF3N3O3/c1-32-20-5-3-2-4-18(20)30-19(15-6-8-16(24)9-7-15)14-21(28-30)33-17-10-12-29(13-11-17)22(31)23(25,26)27/h2-9,14,17H,10-13H2,1H3 | PDB
UniProtKB/SwissProt
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| n/a | n/a | 31.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246330
(US9434693, 25)Show SMILES COc1ccccc1-n1nc(OC2CN(C2)S(=O)(=O)C(C)C)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H24ClN3O4S/c1-15(2)31(27,28)25-13-18(14-25)30-22-12-20(16-8-10-17(23)11-9-16)26(24-22)19-6-4-5-7-21(19)29-3/h4-12,15,18H,13-14H2,1-3H3 | PDB
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| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246327
(US9434693, 21)Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)S(=O)(=O)C(C)C)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H28ClN3O4S/c1-17(2)33(29,30)27-14-12-20(13-15-27)32-24-16-22(18-8-10-19(25)11-9-18)28(26-24)21-6-4-5-7-23(21)31-3/h4-11,16-17,20H,12-15H2,1-3H3 | PDB
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UniChem
| US Patent
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246347
(US9434693, 42)Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)C(O)C(C)(C)C2)cc1-c1ccc(Cl)cc1 |(2.57,5.88,;1.8,4.54,;.26,4.54,;-.51,5.88,;-2.05,5.88,;-2.82,4.54,;-2.05,3.21,;-.51,3.21,;.26,1.88,;-.64,.63,;.26,-.62,;-.13,-2.1,;-1.62,-2.5,;-2.02,-3.99,;-3.51,-4.39,;-4.6,-5.48,;-3.11,-5.88,;-4.6,-3.3,;-6.08,-3.7,;-4.2,-1.81,;-5.69,-2.21,;-4.6,-.32,;-2.71,-1.41,;1.73,-.14,;1.73,1.4,;2.82,2.49,;4.31,2.09,;5.39,3.18,;5,4.67,;6.08,5.76,;3.51,5.06,;2.42,3.98,)| Show InChI InChI=1S/C26H31ClN2O3/c1-25(2)15-19(16-26(3,4)24(25)30)32-23-14-21(17-10-12-18(27)13-11-17)29(28-23)20-8-6-7-9-22(20)31-5/h6-14,19,24,30H,15-16H2,1-5H3 | PDB
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| US Patent
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246322
(US9434693, 16)Show SMILES COc1ccccc1-n1nc(OC2CCC(F)(F)CC2)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H21ClF2N2O2/c1-28-20-5-3-2-4-18(20)27-19(15-6-8-16(23)9-7-15)14-21(26-27)29-17-10-12-22(24,25)13-11-17/h2-9,14,17H,10-13H2,1H3 | PDB
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| US Patent
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246324
(US9434693, 18)Show SMILES CCc1ccccc1-n1nc(OC2CCN(CC2)C(=O)OC(C)(C)C)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C27H32ClN3O3/c1-5-19-8-6-7-9-23(19)31-24(20-10-12-21(28)13-11-20)18-25(29-31)33-22-14-16-30(17-15-22)26(32)34-27(2,3)4/h6-13,18,22H,5,14-17H2,1-4H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246317
(US9434693, 11)Show SMILES COc1ccccc1-n1nc(O[C@@H]2CC[C@@H](CC2)NC(=O)OC(C)(C)C)cc1-c1ccc(Cl)cc1 |r,wU:12.12,15.19,(4.95,5.13,;4.18,3.8,;2.64,3.8,;1.87,5.13,;.33,5.13,;-.44,3.8,;.33,2.47,;1.87,2.47,;2.64,1.13,;1.74,-.11,;2.64,-1.36,;2.24,-2.85,;.76,-3.25,;-.33,-2.16,;-1.82,-2.56,;-2.22,-4.04,;-1.13,-5.13,;.36,-4.73,;-3.71,-4.44,;-4.8,-3.35,;-4.4,-1.87,;-6.28,-3.75,;-7.37,-2.66,;-8.46,-1.57,;-6.28,-1.57,;-8.46,-3.75,;4.11,-.88,;4.11,.66,;5.19,1.74,;6.68,1.35,;7.77,2.43,;7.37,3.92,;8.46,5.01,;5.89,4.32,;4.8,3.23,)| Show InChI InChI=1S/C27H32ClN3O4/c1-27(2,3)35-26(32)29-20-13-15-21(16-14-20)34-25-17-23(18-9-11-19(28)12-10-18)31(30-25)22-7-5-6-8-24(22)33-4/h5-12,17,20-21H,13-16H2,1-4H3,(H,29,32)/t20-,21+ | PDB
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| US Patent
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246328
(US9434693, 22)Show SMILES COc1ccccc1-n1nc(OC2CN(C2)C(=O)OC(C)(C)C)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H26ClN3O4/c1-24(2,3)32-23(29)27-14-18(15-27)31-22-13-20(16-9-11-17(25)12-10-16)28(26-22)19-7-5-6-8-21(19)30-4/h5-13,18H,14-15H2,1-4H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246323
(US9434693, 17)Show SMILES CCc1ccccc1-n1nc(OC2CCC3(CC2)OCCO3)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H27ClN2O3/c1-2-18-5-3-4-6-22(18)28-23(19-7-9-20(26)10-8-19)17-24(27-28)31-21-11-13-25(14-12-21)29-15-16-30-25/h3-10,17,21H,2,11-16H2,1H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246332
(US9434693, 27)Show SMILES COc1ccccc1-n1nc(OC2CN(C2)C(=O)c2ccccc2)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C26H22ClN3O3/c1-32-24-10-6-5-9-22(24)30-23(18-11-13-20(27)14-12-18)15-25(28-30)33-21-16-29(17-21)26(31)19-7-3-2-4-8-19/h2-15,21H,16-17H2,1H3 | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246325
(US9434693, 19)Show SMILES CCc1ccccc1-n1nc(OC2CCN(CC2)S(C)(=O)=O)cc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H26ClN3O3S/c1-3-17-6-4-5-7-21(17)27-22(18-8-10-19(24)11-9-18)16-23(25-27)30-20-12-14-26(15-13-20)31(2,28)29/h4-11,16,20H,3,12-15H2,1-2H3 | PDB
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| US Patent
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Homo sapiens (Human)) | BDBM246318
(US9434693, 12)Show SMILES COc1ccccc1-n1nc(O[C@@H]2CC[C@H](N)CC2)cc1-c1ccc(Cl)cc1 |r,wU:12.12,15.16,(2.57,5.13,;1.8,3.8,;.26,3.8,;-.51,5.13,;-2.05,5.13,;-2.82,3.8,;-2.05,2.47,;-.51,2.47,;.26,1.13,;-.64,-.11,;.26,-1.36,;-.13,-2.85,;-1.62,-3.25,;-2.71,-2.16,;-4.2,-2.56,;-4.6,-4.04,;-6.08,-4.44,;-3.51,-5.13,;-2.02,-4.73,;1.73,-.88,;1.73,.66,;2.82,1.74,;4.31,1.35,;5.39,2.43,;5,3.92,;6.08,5.01,;3.51,4.32,;2.42,3.23,)| Show InChI InChI=1S/C22H24ClN3O2/c1-27-21-5-3-2-4-19(21)26-20(15-6-8-16(23)9-7-15)14-22(25-26)28-18-12-10-17(24)11-13-18/h2-9,14,17-18H,10-13,24H2,1H3/t17-,18+ | PDB
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Janssen Pharmaceutica NV
US Patent
| Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence... |
US Patent US9434693 (2016)
BindingDB Entry DOI: 10.7270/Q29S1PZJ |
More data for this
Ligand-Target Pair | |
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