Compile Data Set for Download or QSAR

Found 8 hits Enz. Inhib. hit(s) with Target = 'Poly(A)-specific ribonuclease PARN'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly(A)-specific ribonuclease PARN (Homo sapiens (Human))	BDBM92910 (Nucleoside, A6) Show SMILES OCC1OC(C(O)C(F)C1O)n1ccc(NC(=O)c2ccccc2)nc1=O Show InChI InChI=1S/C17H18FN3O6/c18-12-13(23)10(8-22)27-16(14(12)24)21-7-6-11(20-17(21)26)19-15(25)9-4-2-1-3-5-9/h1-7,10,12-14,16,22-24H,8H2,(H,19,20,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	2.10E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Thessaly					Assay Description The enzymatic activity was determined by the methylene blue assay.				Biochemistry 48: 6044-51 (2009) Article DOI: 10.1021/bi900236k BindingDB Entry DOI: 10.7270/Q21V5CJ5
					More data for this Ligand-Target Pair
Poly(A)-specific ribonuclease PARN (Homo sapiens (Human))	BDBM92909 (Nucleoside, A2) Show SMILES OC1OC(C(O)C(F)C1O)n1cnc2c(NC(=O)c3ccccc3)ncnc12 Show InChI InChI=1S/C17H16FN5O5/c18-9-11(24)16(28-17(27)12(9)25)23-7-21-10-13(19-6-20-14(10)23)22-15(26)8-4-2-1-3-5-8/h1-7,9,11-12,16-17,24-25,27H,(H,19,20,22,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5.10E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Thessaly					Assay Description The enzymatic activity was determined by the methylene blue assay.				Biochemistry 48: 6044-51 (2009) Article DOI: 10.1021/bi900236k BindingDB Entry DOI: 10.7270/Q21V5CJ5
					More data for this Ligand-Target Pair
Poly(A)-specific ribonuclease PARN (Homo sapiens (Human))	BDBM92911 (Nucleoside, C6) Show SMILES Nc1ccn(C2OC(CO)C(O)C(F)C2O)c(=O)n1 Show InChI InChI=1S/C10H14FN3O5/c11-6-7(16)4(3-15)19-9(8(6)17)14-2-1-5(12)13-10(14)18/h1-2,4,6-9,15-17H,3H2,(H2,12,13,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	6.45E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Thessaly					Assay Description The enzymatic activity was determined by the methylene blue assay.				Biochemistry 48: 6044-51 (2009) Article DOI: 10.1021/bi900236k BindingDB Entry DOI: 10.7270/Q21V5CJ5
					More data for this Ligand-Target Pair
Poly(A)-specific ribonuclease PARN (Homo sapiens (Human))	BDBM50119716 (CHEMBL3616525) Show SMILES CN(C)CCCn1c2ncn(CCc3ccccc3)c2c(=O)n(O)c1=O Show InChI InChI=1S/C18H23N5O3/c1-20(2)10-6-11-22-16-15(17(24)23(26)18(22)25)21(13-19-16)12-9-14-7-4-3-5-8-14/h3-5,7-8,13,26H,6,9-12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.39E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of PARN (unknown origin)				Bioorg Med Chem Lett 25: 4219-24 (2015) Article DOI: 10.1016/j.bmcl.2015.07.095 BindingDB Entry DOI: 10.7270/Q2BV7JFF
					More data for this Ligand-Target Pair
Poly(A)-specific ribonuclease PARN (Homo sapiens (Human))	BDBM50119651 (CHEMBL3616505) Show SMILES On1c(=O)[nH]c2ncn(Cc3ccccc3)c2c1=O Show InChI InChI=1S/C12H10N4O3/c17-11-9-10(14-12(18)16(11)19)13-7-15(9)6-8-4-2-1-3-5-8/h1-5,7,19H,6H2,(H,14,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of PARN (unknown origin)				Bioorg Med Chem Lett 25: 4219-24 (2015) Article DOI: 10.1016/j.bmcl.2015.07.095 BindingDB Entry DOI: 10.7270/Q2BV7JFF
					More data for this Ligand-Target Pair
Poly(A)-specific ribonuclease PARN (Homo sapiens (Human))	BDBM50119654 (CHEMBL3616507) Show SMILES On1c(=O)[nH]c2ncn(Cc3ccccn3)c2c1=O Show InChI InChI=1S/C11H9N5O3/c17-10-8-9(14-11(18)16(10)19)13-6-15(8)5-7-3-1-2-4-12-7/h1-4,6,19H,5H2,(H,14,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.19E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of PARN (unknown origin)				Bioorg Med Chem Lett 25: 4219-24 (2015) Article DOI: 10.1016/j.bmcl.2015.07.095 BindingDB Entry DOI: 10.7270/Q2BV7JFF
					More data for this Ligand-Target Pair
Poly(A)-specific ribonuclease PARN (Homo sapiens (Human))	BDBM50119655 (CHEMBL3616508) Show SMILES On1c(=O)[nH]c2ncn(Cc3cccnc3)c2c1=O Show InChI InChI=1S/C11H9N5O3/c17-10-8-9(14-11(18)16(10)19)13-6-15(8)5-7-2-1-3-12-4-7/h1-4,6,19H,5H2,(H,14,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of PARN (unknown origin)				Bioorg Med Chem Lett 25: 4219-24 (2015) Article DOI: 10.1016/j.bmcl.2015.07.095 BindingDB Entry DOI: 10.7270/Q2BV7JFF
					More data for this Ligand-Target Pair
Poly(A)-specific ribonuclease PARN (Homo sapiens (Human))	BDBM50119656 (CHEMBL3616509) Show SMILES On1c(=O)[nH]c2ncn(Cc3ccncc3)c2c1=O Show InChI InChI=1S/C11H9N5O3/c17-10-8-9(14-11(18)16(10)19)13-6-15(8)5-7-1-3-12-4-2-7/h1-4,6,19H,5H2,(H,14,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.45E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of PARN (unknown origin)				Bioorg Med Chem Lett 25: 4219-24 (2015) Article DOI: 10.1016/j.bmcl.2015.07.095 BindingDB Entry DOI: 10.7270/Q2BV7JFF
					More data for this Ligand-Target Pair