Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50511915 (CHEMBL4517829) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated ... | J Med Chem 63: 5159-5184 (2020) Article DOI: 10.1021/acs.jmedchem.9b02094 BindingDB Entry DOI: 10.7270/Q2M048SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50511914 (CHEMBL4576925) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated ... | J Med Chem 63: 5159-5184 (2020) Article DOI: 10.1021/acs.jmedchem.9b02094 BindingDB Entry DOI: 10.7270/Q2M048SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517670 (NY0460 | US11124489, Compound 14) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50098793 (CHEMBL3593342) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Displacement of 8-NBD-cAMP from recombinant human EPAC1 by fluorescence assay | Bioorg Med Chem Lett 27: 1633-1639 (2017) Article DOI: 10.1016/j.bmcl.2017.02.065 BindingDB Entry DOI: 10.7270/Q2FF3VXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50241941 (CHEMBL4103080) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e... | Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50098719 (CHEMBL3593329) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity | J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50098793 (CHEMBL3593342) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity | J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50098719 (CHEMBL3593329) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Displacement of 8-NBD-cAMP from recombinant human EPAC1 by fluorescence assay | Bioorg Med Chem Lett 27: 1633-1639 (2017) Article DOI: 10.1016/j.bmcl.2017.02.065 BindingDB Entry DOI: 10.7270/Q2FF3VXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50098787 (CHEMBL3593468) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity | J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50098793 (CHEMBL3593342) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e... | Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50241952 (CHEMBL4099528) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description In vito concentration required to displace [3H]cyclofoxy (Kd = 0.8 nM and concentration is 1.3 nM) from mu and kappa2 receptor in rat brain membranes... | Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517689 (NY0562 | US11124489, Compound 33) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517688 (NY0561 | US11124489, Compound 32) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50241961 (CHEMBL4081514) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e... | Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50011360 (CHEMBL3260990) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Inhibition of EPAC1 (unknown origin) | Bioorg Med Chem Lett 27: 1633-1639 (2017) Article DOI: 10.1016/j.bmcl.2017.02.065 BindingDB Entry DOI: 10.7270/Q2FF3VXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50011360 (CHEMBL3260990) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Inhibition of EPAC1 (unknown origin) assessed as cAMP-mediated GEF activity | J Med Chem 57: 3651-65 (2014) Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50280395 (CHEMBL4171480) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Research in Cancer and Allied Diseases Curated by ChEMBL | Assay Description Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ... | ACS Med Chem Lett 8: 1183-1187 (2017) Article DOI: 10.1021/acsmedchemlett.7b00358 BindingDB Entry DOI: 10.7270/Q20C4Z83 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50452020 (CHEMBL4213611) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac... | Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50241957 (CHEMBL4100650) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description In vito concentration required to displace [3H]cyclofoxy (Kd = 0.8 nM and concentration is 1.3 nM) from mu and kappa2 receptor in rat brain membranes... | Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517717 (US11124489, Entry 32 | ZL0524) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517684 (NY0725 | US11124489, Compound 26) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50098797 (CHEMBL3593471) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity | J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50098796 (CHEMBL3593470) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity | J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517685 (NY0726 | US11124489, Compound 27) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50241954 (CHEMBL4082655) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e... | Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50280395 (CHEMBL4171480) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant human GST-fused EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta (DE3) assessed as inhibition of ... | Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50098794 (CHEMBL3593341) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity | J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517687 (NY0495 | US11124489, Compound 31) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50241953 (CHEMBL4091792) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e... | Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50511913 (CHEMBL4459738) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated ... | J Med Chem 63: 5159-5184 (2020) Article DOI: 10.1021/acs.jmedchem.9b02094 BindingDB Entry DOI: 10.7270/Q2M048SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50511918 (CHEMBL4450888) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated ... | J Med Chem 63: 5159-5184 (2020) Article DOI: 10.1021/acs.jmedchem.9b02094 BindingDB Entry DOI: 10.7270/Q2M048SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517675 (NY0541 | US11124489, Compound 17b) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517696 (US11124489, Entry 11 | ZL0475) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50452021 (CHEMBL4210825) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac... | Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517701 (US11124489, Entry 15 | ZL0479) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50280395 (CHEMBL4171480) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac... | Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50452009 (CHEMBL4205201) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac... | Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50241958 (CHEMBL4063555) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e... | Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517681 (NY0654 | US11124489, Compound 23) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50451965 (CHEMBL4217436) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac... | Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517704 (US11124489, Entry 17 | ZL0560) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517682 (NY0655 | US11124489, Compound 24) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50241966 (CHEMBL4092921) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e... | Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50098716 (CHEMBL3593332) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity | J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50098713 (CHEMBL3593335) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity | J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517702 (US11124489, Entry 16 | ZL0559) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50451966 (CHEMBL4205731) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac... | Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517698 (US11124489, Entry 13 | ZL0477) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM50452010 (CHEMBL4209582) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac... | Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human)) | BDBM517692 (NY0563 | US11124489, Compound 36) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ | |||||||||||
More data for this Ligand-Target Pair |
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