Compile Data Set for Download or QSAR

Found 93 hits Enz. Inhib. hit(s) with Target = 'Eukaryotic initiation factor 4A-III'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description ATP competitive inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) ...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283464 (CHEMBL4162764) Show SMILES Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cn1)C(=O)c1c[nH]c(=O)c(c1)-c1cccc(c1)C#N |r| Show InChI InChI=1S/C29H21BrClN5O3/c30-22-6-9-25(33-16-22)29(39)36-11-10-35(17-26(36)19-4-7-23(31)8-5-19)28(38)21-13-24(27(37)34-15-21)20-3-1-2-18(12-20)14-32/h1-9,12-13,15-16,26H,10-11,17H2,(H,34,37)/t26-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283443 (CHEMBL4170030) Show SMILES Cn1cc(cc(-c2cccc(c2)C#N)c1=O)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cn1 |r| Show InChI InChI=1S/C30H23BrClN5O3/c1-35-17-22(14-25(29(35)39)21-4-2-3-19(13-21)15-33)28(38)36-11-12-37(30(40)26-10-7-23(31)16-34-26)27(18-36)20-5-8-24(32)9-6-20/h2-10,13-14,16-17,27H,11-12,18H2,1H3/t27-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM65493 (eIF4A3 inhibitor, 2) Show SMILES Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12 |r| Show InChI InChI=1S/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2/t23-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
BC Cancer Agency					Assay Description Inhibitory activity was assessed under the following conditions: 350 uM ATP/1.5 ug mL−1 RNA indicated by black; 35 uM ATP/1.5 ug mL−1 RNA...				ACS Chem Biol 12: 1760-1768 (2017) Article DOI: 10.1021/acschembio.7b00041 BindingDB Entry DOI: 10.7270/Q2T151TG
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM65493 (eIF4A3 inhibitor, 2) Show SMILES Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12 |r| Show InChI InChI=1S/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2/t23-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283445 (CHEMBL4175313) Show SMILES FC(F)(F)c1cccc(c1)-c1cc(cn(-c2ccccc2)c1=O)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cn1 |r| Show InChI InChI=1S/C35H25BrClF3N4O3/c36-26-11-14-30(41-19-26)34(47)43-16-15-42(21-31(43)22-9-12-27(37)13-10-22)32(45)24-18-29(23-5-4-6-25(17-23)35(38,39)40)33(46)44(20-24)28-7-2-1-3-8-28/h1-14,17-20,31H,15-16,21H2/t31-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283462 (CHEMBL4176393) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1c[nH]c(=O)c(c1)-c1cccc(c1)C#N Show InChI InChI=1S/C30H22Cl2N4O3/c31-24-8-4-20(5-9-24)27-18-35(12-13-36(27)30(39)21-6-10-25(32)11-7-21)29(38)23-15-26(28(37)34-17-23)22-3-1-2-19(14-22)16-33/h1-11,14-15,17,27H,12-13,18H2,(H,34,37)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM65493 (eIF4A3 inhibitor, 2) Show SMILES Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12 |r| Show InChI InChI=1S/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2/t23-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265561 (CHEMBL4073833) Show SMILES Cc1c(cnn1-c1cccc(c1)C#N)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cc1 |r| Show InChI InChI=1S/C29H23BrClN5O2/c1-19-26(17-33-36(19)25-4-2-3-20(15-25)16-32)29(38)34-13-14-35(28(37)22-5-9-23(30)10-6-22)27(18-34)21-7-11-24(31)12-8-21/h2-12,15,17,27H,13-14,18H2,1H3/t27-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283465 (CHEMBL4168783) Show SMILES Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cn1)C(=O)c1cnn2cc(Br)ccc12 |r| Show InChI InChI=1S/C24H18Br2ClN5O2/c25-16-3-7-20(28-11-16)24(34)31-10-9-30(14-22(31)15-1-5-18(27)6-2-15)23(33)19-12-29-32-13-17(26)4-8-21(19)32/h1-8,11-13,22H,9-10,14H2/t22-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283444 (CHEMBL4173010) Show SMILES Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1c[nH]c(=O)c2ccccc12 |r| Show InChI InChI=1S/C27H21BrClN3O3/c28-19-9-5-18(6-10-19)26(34)32-14-13-31(16-24(32)17-7-11-20(29)12-8-17)27(35)23-15-30-25(33)22-4-2-1-3-21(22)23/h1-12,15,24H,13-14,16H2,(H,30,33)/t24-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283442 (CHEMBL4172770) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1c[nH]c(=O)c(c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C29H22Cl3N3O3/c30-22-8-4-18(5-9-22)26-17-34(12-13-35(26)29(38)19-6-10-23(31)11-7-19)28(37)21-15-25(27(36)33-16-21)20-2-1-3-24(32)14-20/h1-11,14-16,26H,12-13,17H2,(H,33,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) using 1.5 ug/ml ...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265601 (CHEMBL4104965) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnc(o1)-c1cccc(c1)C#N Show InChI InChI=1S/C28H20BrClN4O3/c29-22-8-4-20(5-9-22)27(35)34-13-12-33(17-24(34)19-6-10-23(30)11-7-19)28(36)25-16-32-26(37-25)21-3-1-2-18(14-21)15-31/h1-11,14,16,24H,12-13,17H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265556 (CHEMBL4080736) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnc(o1)-c1cc(ccn1)C#N Show InChI InChI=1S/C27H19BrClN5O3/c28-20-5-1-19(2-6-20)26(35)34-12-11-33(16-23(34)18-3-7-21(29)8-4-18)27(36)24-15-32-25(37-24)22-13-17(14-30)9-10-31-22/h1-10,13,15,23H,11-12,16H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283446 (CHEMBL4169616) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1c[nH]c(=O)c(c1)-c1ccccc1 Show InChI InChI=1S/C29H23Cl2N3O3/c30-23-10-6-20(7-11-23)26-18-33(14-15-34(26)29(37)21-8-12-24(31)13-9-21)28(36)22-16-25(27(35)32-17-22)19-4-2-1-3-5-19/h1-13,16-17,26H,14-15,18H2,(H,32,35)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265592 (CHEMBL4061398) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12 Show InChI InChI=1S/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283461 (CHEMBL4164548) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1c[nH]c(=O)c(c1)-c1ccccc1Cl Show InChI InChI=1S/C29H22Cl3N3O3/c30-21-9-5-18(6-10-21)26-17-34(13-14-35(26)29(38)19-7-11-22(31)12-8-19)28(37)20-15-24(27(36)33-16-20)23-3-1-2-4-25(23)32/h1-12,15-16,26H,13-14,17H2,(H,33,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283463 (CHEMBL4176581) Show SMILES CS(=O)(=O)c1cccc(c1)-c1cc(c[nH]c1=O)C(=O)N1CCN(C(C1)c1ccc(Cl)cc1)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C30H25Cl2N3O5S/c1-41(39,40)25-4-2-3-21(15-25)26-16-22(17-33-28(26)36)29(37)34-13-14-35(30(38)20-7-11-24(32)12-8-20)27(18-34)19-5-9-23(31)10-6-19/h2-12,15-17,27H,13-14,18H2,1H3,(H,33,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265557 (CHEMBL4097260) Show SMILES Cc1c(cnn1-c1cccc(c1)C#N)C(=O)N1CCN(C(C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cc1 Show InChI InChI=1S/C29H23BrClN5O2/c1-19-26(17-33-36(19)25-4-2-3-20(15-25)16-32)29(38)34-13-14-35(28(37)22-5-9-23(30)10-6-22)27(18-34)21-7-11-24(31)12-8-21/h2-12,15,17,27H,13-14,18H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265602 (CHEMBL4087208) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnc(o1)-c1cccc(c1)C#N Show InChI InChI=1S/C28H20Cl2N4O3/c29-22-8-4-19(5-9-22)24-17-33(12-13-34(24)27(35)20-6-10-23(30)11-7-20)28(36)25-16-32-26(37-25)21-3-1-2-18(14-21)15-31/h1-11,14,16,24H,12-13,17H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265589 (CHEMBL4070582) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnc(o1)-c1ccccc1 Show InChI InChI=1S/C27H21BrClN3O3/c28-21-10-6-20(7-11-21)26(33)32-15-14-31(17-23(32)18-8-12-22(29)13-9-18)27(34)24-16-30-25(35-24)19-4-2-1-3-5-19/h1-13,16,23H,14-15,17H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283447 (CHEMBL4168400) Show SMILES FC(F)(F)c1cccc(c1)-c1cc(c[nH]c1=O)C(=O)N1CCN(C(C1)c1ccc(Cl)cc1)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C30H22Cl2F3N3O3/c31-23-8-4-18(5-9-23)26-17-37(12-13-38(26)29(41)19-6-10-24(32)11-7-19)28(40)21-15-25(27(39)36-16-21)20-2-1-3-22(14-20)30(33,34)35/h1-11,14-16,26H,12-13,17H2,(H,36,39)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265590 (CHEMBL4092418) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnn2cc(Br)ccc12 Show InChI InChI=1S/C25H19BrCl2N4O2/c26-18-5-10-22-21(13-29-32(22)14-18)25(34)30-11-12-31(24(33)17-3-8-20(28)9-4-17)23(15-30)16-1-6-19(27)7-2-16/h1-10,13-14,23H,11-12,15H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283459 (CHEMBL4159400) Show SMILES Cn1cc(cc(-c2cccc(c2)C(F)(F)F)c1=O)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cn1 |r| Show InChI InChI=1S/C30H23BrClF3N4O3/c1-37-16-20(14-24(28(37)41)19-3-2-4-21(13-19)30(33,34)35)27(40)38-11-12-39(29(42)25-10-7-22(31)15-36-25)26(17-38)18-5-8-23(32)9-6-18/h2-10,13-16,26H,11-12,17H2,1H3/t26-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265591 (CHEMBL4071622) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnn2ccc(Br)cc12 Show InChI InChI=1S/C25H19BrCl2N4O2/c26-18-9-10-32-22(13-18)21(14-29-32)25(34)30-11-12-31(24(33)17-3-7-20(28)8-4-17)23(15-30)16-1-5-19(27)6-2-16/h1-10,13-14,23H,11-12,15H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265593 (CHEMBL4088472) Show SMILES COc1ccc2c(cnn2c1)C(=O)N1CCN(C(C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cc1 Show InChI InChI=1S/C26H22BrClN4O3/c1-35-21-10-11-23-22(14-29-32(23)15-21)26(34)30-12-13-31(25(33)18-2-6-19(27)7-3-18)24(16-30)17-4-8-20(28)9-5-17/h2-11,14-15,24H,12-13,16H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283468 (CHEMBL4165785) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1c[nH]c(=O)c(c1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C29H22Cl3N3O3/c30-22-7-1-18(2-8-22)25-15-21(16-33-27(25)36)28(37)34-13-14-35(29(38)20-5-11-24(32)12-6-20)26(17-34)19-3-9-23(31)10-4-19/h1-12,15-16,26H,13-14,17H2,(H,33,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265568 (CHEMBL4080496) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnn2ccccc12 Show InChI InChI=1S/C25H20Cl2N4O2/c26-19-8-4-17(5-9-19)23-16-29(25(33)21-15-28-31-12-2-1-3-22(21)31)13-14-30(23)24(32)18-6-10-20(27)11-7-18/h1-12,15,23H,13-14,16H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283460 (CHEMBL4177474) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1c[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C27H21Cl2N3O3/c28-19-9-5-17(6-10-19)24-16-31(13-14-32(24)26(34)18-7-11-20(29)12-8-18)27(35)23-15-30-25(33)22-4-2-1-3-21(22)23/h1-12,15,24H,13-14,16H2,(H,30,33)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265571 (CHEMBL4091488) Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)N1CCN(C(C1)c1ccc(Cl)cc1)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C28H24Cl2N4O2/c1-19-25(17-31-34(19)24-5-3-2-4-6-24)28(36)32-15-16-33(27(35)21-9-13-23(30)14-10-21)26(18-32)20-7-11-22(29)12-8-20/h2-14,17,26H,15-16,18H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283467 (CHEMBL4162337) Show SMILES Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cncc2ccccc12 |r| Show InChI InChI=1S/C27H21BrClN3O2/c28-21-9-5-19(6-10-21)26(33)32-14-13-31(17-25(32)18-7-11-22(29)12-8-18)27(34)24-16-30-15-20-3-1-2-4-23(20)24/h1-12,15-16,25H,13-14,17H2/t25-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235741 (CHEMBL4099717) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1)C(O)=O Show InChI InChI=1S/C12H12ClNO2/c1-6(2)7-3-9(13)8-5-11(12(15)16)14-10(8)4-7/h3-6,14H,1-2H3,(H,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265599 (CHEMBL4097731) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnn2c(Br)cccc12 Show InChI InChI=1S/C25H19BrCl2N4O2/c26-23-3-1-2-21-20(14-29-32(21)23)25(34)30-12-13-31(24(33)17-6-10-19(28)11-7-17)22(15-30)16-4-8-18(27)9-5-16/h1-11,14,22H,12-13,15H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265559 (CHEMBL4083000) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnc(o1)-c1ccccc1C#N Show InChI InChI=1S/C28H20Cl2N4O3/c29-21-9-5-18(6-10-21)24-17-33(13-14-34(24)27(35)19-7-11-22(30)12-8-19)28(36)25-16-32-26(37-25)23-4-2-1-3-20(23)15-31/h1-12,16,24H,13-14,17H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM65492 (eIF4A3 inhibitor, 1) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnc(o1)-c1ccccc1 Show InChI InChI=1S/C27H21Cl2N3O3/c28-21-10-6-18(7-11-21)23-17-31(14-15-32(23)26(33)20-8-12-22(29)13-9-20)27(34)24-16-30-25(35-24)19-4-2-1-3-5-19/h1-13,16,23H,14-15,17H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
BC Cancer Agency					Assay Description Inhibitory activity was assessed under the following conditions: 350 uM ATP/1.5 ug mL−1 RNA indicated by black; 35 uM ATP/1.5 ug mL−1 RNA...				ACS Chem Biol 12: 1760-1768 (2017) Article DOI: 10.1021/acschembio.7b00041 BindingDB Entry DOI: 10.7270/Q2T151TG
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM65492 (eIF4A3 inhibitor, 1) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnc(o1)-c1ccccc1 Show InChI InChI=1S/C27H21Cl2N3O3/c28-21-10-6-18(7-11-21)23-17-31(14-15-32(23)26(33)20-8-12-22(29)13-9-20)27(34)24-16-30-25(35-24)19-4-2-1-3-5-19/h1-13,16,23H,14-15,17H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265562 (CHEMBL4085751) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1c[nH]c2ccccc12 Show InChI InChI=1S/C26H21Cl2N3O2/c27-19-9-5-17(6-10-19)24-16-30(26(33)22-15-29-23-4-2-1-3-21(22)23)13-14-31(24)25(32)18-7-11-20(28)12-8-18/h1-12,15,24,29H,13-14,16H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265603 (CHEMBL4089075) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnn(c1)-c1ccccc1 Show InChI InChI=1S/C27H22Cl2N4O2/c28-22-10-6-19(7-11-22)25-18-31(14-15-32(25)27(35)20-8-12-23(29)13-9-20)26(34)21-16-30-33(17-21)24-4-2-1-3-5-24/h1-13,16-17,25H,14-15,18H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50283466 (CHEMBL4176640) Show SMILES Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1ccnc2ccccc12 |r| Show InChI InChI=1S/C27H21BrClN3O2/c28-20-9-5-19(6-10-20)26(33)32-16-15-31(17-25(32)18-7-11-21(29)12-8-18)27(34)23-13-14-30-24-4-2-1-3-22(23)24/h1-14,25H,15-17H2/t25-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235795 (CHEMBL4089069) Show SMILES CC(C)c1cc(F)c2cc([nH]c2c1)C(O)=O Show InChI InChI=1S/C12H12FNO2/c1-6(2)7-3-9(13)8-5-11(12(15)16)14-10(8)4-7/h3-6,14H,1-2H3,(H,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235740 (CHEMBL4061441) Show SMILES CC(C)c1ccc2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H12FNO2/c1-6(2)8-4-3-7-5-9(12(15)16)14-11(7)10(8)13/h3-6,14H,1-2H3,(H,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonism of batrachotoxin-mediated sodium ion uptake into cultured neuroblastoma cells				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265560 (CHEMBL4079326) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnc(o1)-c1ccc(cc1)C#N Show InChI InChI=1S/C28H20Cl2N4O3/c29-22-9-5-19(6-10-22)24-17-33(13-14-34(24)27(35)21-7-11-23(30)12-8-21)28(36)25-16-32-26(37-25)20-3-1-18(15-31)2-4-20/h1-12,16,24H,13-14,17H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265600 (CHEMBL4089547) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnn2cccc(Br)c12 Show InChI InChI=1S/C25H19BrCl2N4O2/c26-21-2-1-11-32-23(21)20(14-29-32)25(34)30-12-13-31(24(33)17-5-9-19(28)10-6-17)22(15-30)16-3-7-18(27)8-4-16/h1-11,14,22H,12-13,15H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265594 (CHEMBL4099680) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(ccc12)C#N Show InChI InChI=1S/C26H19BrClN5O2/c27-20-6-2-19(3-7-20)25(34)32-12-11-31(16-24(32)18-4-8-21(28)9-5-18)26(35)22-14-30-33-15-17(13-29)1-10-23(22)33/h1-10,14-15,24H,11-12,16H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265588 (CHEMBL4090004) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccccc1)C(=O)c1cnc(o1)-c1ccccc1 Show InChI InChI=1S/C27H22ClN3O3/c28-22-13-11-19(12-14-22)23-18-30(15-16-31(23)26(32)21-9-5-2-6-10-21)27(33)24-17-29-25(34-24)20-7-3-1-4-8-20/h1-14,17,23H,15-16,18H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235794 (CHEMBL4067856) Show SMILES CC(C)c1ccc2c(F)c([nH]c2c1)C(O)=O Show InChI InChI=1S/C12H12FNO2/c1-6(2)7-3-4-8-9(5-7)14-11(10(8)13)12(15)16/h3-6,14H,1-2H3,(H,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Opioid receptor delta 1 in rat brain homogenates using [3H]naltrindole as radioligand				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235739 (CHEMBL4079731) Show SMILES CC(C)c1ccc2cc([nH]c2c1)C(O)=O Show InChI InChI=1S/C12H13NO2/c1-7(2)8-3-4-9-6-11(12(14)15)13-10(9)5-8/h3-7,13H,1-2H3,(H,14,15)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235796 (CHEMBL4081704) Show SMILES CC(C)c1cc2[nH]c(cc2cc1F)C(O)=O Show InChI InChI=1S/C12H12FNO2/c1-6(2)8-5-10-7(3-9(8)13)4-11(14-10)12(15)16/h3-6,14H,1-2H3,(H,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonism of batrachotoxin-mediated sodium ion uptake into cultured neuroblastoma cells				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair

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