Found 138 hits Enz. Inhib. hit(s) with Target = 'Potassium channel subfamily T member 1' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557676
(CHEMBL4763955)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C1CC1 |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557672
(CHEMBL4788669)Show SMILES COc1cc(ccn1)-c1noc(n1)[C@H](C)NC(=O)c1cc(nn1C)C(F)(F)F |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557680
(CHEMBL4741793)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C(F)(F)F |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.129013 BindingDB Entry DOI: 10.7270/Q2QV3RM2 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557680
(CHEMBL4741793)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C(F)(F)F |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557678
(CHEMBL4754084)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C(F)F |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557660
(CHEMBL4783741)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1cccc(F)c1 |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 136 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557666
(CHEMBL4786255)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(C)c1 |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 165 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557652
(CHEMBL4793291)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C1CC1)c1nc(no1)-c1cccc(C)c1 |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 167 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557679
(CHEMBL4793279)Show SMILES CNc1cc(ccn1)-c1noc(n1)[C@H](C)NC(=O)c1cc(nn1C)C(F)(F)F |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 195 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557677
(CHEMBL4750925)Show SMILES COCc1cc(ccn1)-c1noc(n1)[C@H](C)NC(=O)c1cc(nn1C)C(F)(F)F |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 322 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557656
(CHEMBL4783466)Show SMILES CCc1cc(C(=O)N[C@@H](C)c2nc(no2)-c2cccc(C)c2)n(C)n1 |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 335 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557674
(CHEMBL4795194)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)N(C)C |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 454 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557675
(CHEMBL4743249)Show SMILES COc1cc(cc(C)n1)-c1noc(n1)[C@H](C)NC(=O)c1cc(nn1C)C(F)(F)F |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 505 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Rattus norvegicus) | BDBM50557680
(CHEMBL4741793)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C(F)(F)F |r| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 545 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant rat KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557673
(CHEMBL4781553)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)N1CCCC1 |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 573 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Mus musculus) | BDBM50557680
(CHEMBL4741793)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C(F)(F)F |r| | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 622 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557682
(CHEMBL4745211)Show SMILES CO[C@@H](C)c1cc(ccn1)-c1noc(n1)[C@H](C)NC(=O)c1cc(nn1C)C(F)(F)F |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 744 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557683
(CHEMBL4758890)Show SMILES CO[C@H](C)c1cc(ccn1)-c1noc(n1)[C@H](C)NC(=O)c1cc(nn1C)C(F)(F)F |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 778 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557659
(CHEMBL4779088)Show SMILES CC(NC(=O)c1cc(nn1C)C(F)(F)F)c1noc(n1)-c1cccc(C)c1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 977 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617422
(US20230285377, Example 10)Show SMILES C[C@@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(ns1)-c1ccnc(c1)C(F)(F)F | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617419
(US20230285377, Example 7)Show SMILES C[C@@H](NC(=O)c1cccc(Cl)c1)c1nc(ns1)-c1ccnc(c1)C1CC1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617418
(US20230285377, Example 6)Show SMILES C[C@H](NC(=O)c1cccc(Cl)c1)c1nc(ns1)-c1ccnc(c1)C1CC1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617416
(US20230285377, Example 5)Show SMILES C[C@@H](NC(=O)c1ccccc1)c1nc(ns1)-c1ccnc(c1)C1CC1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617415
(US20230285377, Example 4)Show SMILES C[C@H](NC(=O)c1ccccc1)c1nc(ns1)-c1ccnc(c1)C1CC1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617413
(US20230285377, Example 2)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1cc(no1)-c1ccnc(c1)C(F)(F)F | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617412
(US20230285377, Example 1)Show SMILES CC(NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(ns1)-c1ccnc(c1)C(F)(F)F | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617423
(US20230285377, Example 11)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(ns1)-c1ccnc(c1)C(F)(F)F | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617424
(US20230285377, Example 12)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(ns1)-c1ccnc(c1)C1CC1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617425
(US20230285377, Example 13)Show SMILES C[C@@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(ns1)-c1ccnc(c1)C1CC1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617426
(US20230285377, Example 14)Show SMILES C[C@H](NC(=O)c1ccccc1)c1cc(no1)-c1ccnc(c1)C1CC1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617451
(US20230285377, Example 35)Show SMILES C[C@@H](NC(=O)N1CCCc2ccccc12)c1cc(no1)-c1ccnc(c1)C(F)(F)F | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617452
(US20230285377, Example 36)Show SMILES C[C@@H](NC(=O)c1ccnn1C1CCC1)c1cc(no1)-c1ccnc(c1)C(F)(F)F | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617455
(US20230285377, Example 39)Show SMILES C[C@@H](NC(=O)N1CCOc2ccccc12)c1cc(no1)-c1ccnc(c1)C(F)(F)F | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617460
(US20230285377, Example 44)Show SMILES COc1cc(ccn1)-c1nsc(CNCc2cc(nn2C)C(F)(F)F)n1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617461
(US20230285377, Example 45)Show SMILES COc1cc(ccn1)-c1nsc(n1)[C@@H](C)NC(=O)c1cc(nn1C)C(F)(F)F | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617428
(US20230285377, Example 16)Show SMILES C[C@@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1cc(no1)-c1ccnc(c1)C1CC1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617431
(US20230285377, Example 19)Show SMILES C[C@@H](NC(=O)c1cccc(Cl)c1)c1cc(no1)-c1ccnc(c1)C1CC1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617434
(US20230285377, Example 21)Show SMILES C[C@H](NC(=O)c1cccc(Cl)c1)c1cc(no1)-c1ccnc(c1)C(F)(F)F | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617439
(US20230285377, Example 25)Show SMILES CC(C)c1cc(C(=O)N[C@@H](C)c2cc(no2)-c2ccnc(c2)C(F)(F)F)n(C)n1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617447
(US20230285377, Example 31)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)F)c1cc(no1)-c1ccnc(c1)C(F)(F)F | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM617448
(US20230285377, Example 32)Show SMILES C[C@@H](NC(=O)c1cccc(c1)C(F)(F)F)c1cc(no1)-c1ccnc(c1)C(F)(F)F | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K078CS |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50607075
(CHEMBL5220335)Show SMILES COc1ccc(Cl)cc1NC(=O)CN1CCN(CC1)S(=O)(=O)N1CCN(CC1)S(=O)(=O)c1ccccc1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.129013 BindingDB Entry DOI: 10.7270/Q2QV3RM2 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Mus musculus) | BDBM50557676
(CHEMBL4763955)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C1CC1 |r| | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Mus musculus) | BDBM50557678
(CHEMBL4754084)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C(F)F |r| | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557664
(CHEMBL4750826)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1cncc(C)c1 |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50607067
(CHEMBL5218475)Show SMILES COc1ccc(Br)cc1NC(=O)CN1CCN(CC1)S(=O)(=O)N1CCC(C)CC1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.129013 BindingDB Entry DOI: 10.7270/Q2QV3RM2 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557670
(CHEMBL4744857)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1cc(C)ncn1 |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50557658
(CHEMBL4789512)Show SMILES CC(NC(=O)c1cc(nn1C)C(F)(F)F)c1cnn(c1)-c1cccc(C)c1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675 BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50607064
(CHEMBL1730394)Show SMILES COc1ccc(Cl)cc1NC(=O)CN1CCN(CC1)S(=O)(=O)N1CCC(C)CC1 | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.129013 BindingDB Entry DOI: 10.7270/Q2QV3RM2 |
More data for this Ligand-Target Pair | |
Potassium channel subfamily T member 1
(Homo sapiens) | BDBM50607085
(CHEMBL5221076)Show SMILES COc1ccc(Cl)cc1NC(=O)CN1CCN(C[C@H]1C)S(=O)(=O)N1CCC(C)CC1 |r| | PDB
NCI pathway Reactome pathway
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.129013 BindingDB Entry DOI: 10.7270/Q2QV3RM2 |
More data for this Ligand-Target Pair | |