Found 200 hits Enz. Inhib. hit(s) with Target = 'Transcriptional enhancer factor TEF-3' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM50547124
(CHEMBL242708 | NCI-0001009) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Reversible inhibition of CPM binding to nonacylated N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-Codon... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01275
BindingDB Entry DOI: 10.7270/Q2QN6BC1 |
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM50547126
(CHEMBL4763473) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| 1.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CPM binding to N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIPL cells p... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01275
BindingDB Entry DOI: 10.7270/Q2QN6BC1 |
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM50604885
(CHEMBL5177177)Show SMILES Fc1cccc(c1)-c1ccc2c(N3CCN(CC3)C(=O)C=C)n(Cc3ccccc3)nc2c1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114327
BindingDB Entry DOI: 10.7270/Q2NP28GR |
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM50535723
(CHEMBL4567546)Show SMILES NCCCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)C1(CC1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1c[nH]c2cc(Cl)ccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CC1CCC1)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C95H133ClN24O22/c96-57-30-31-60-56(49-106-67(60)46-57)45-70(112-78(127)61-26-12-38-103-61)84(133)109-65(28-14-40-105-94(101)102)87(136)118-95(34-35-95)92(142)117-64(27-13-39-104-93(99)100)81(130)107-63(25-7-9-37-98)80(129)115-72(43-53-18-10-19-53)90(139)120-50-58(122)47-75(120)88(137)114-71(48-77(125)126)85(134)116-73(51-121)86(135)111-68(42-52-16-2-1-3-17-52)82(131)113-69(44-55-22-11-21-54-20-4-5-23-59(54)55)83(132)108-62(24-6-8-36-97)79(128)110-66(32-33-76(123)124)89(138)119-41-15-29-74(119)91(140)141/h1-5,11,16-17,20-23,30-31,46,49,53,58,61-66,68-75,103,106,121-122H,6-10,12-15,18-19,24-29,32-45,47-48,50-51,97-98H2,(H,107,130)(H,108,132)(H,109,133)(H,110,128)(H,111,135)(H,112,127)(H,113,131)(H,114,137)(H,115,129)(H,116,134)(H,117,142)(H,118,136)(H,123,124)(H,125,126)(H,140,141)(H4,99,100,104)(H4,101,102,105)/t58-,61+,62+,63+,64+,65+,66+,68+,69+,70+,71+,72+,73+,74+,75+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21 (DE3) interaction with N-biotinylated YAP (60 to 100 residues) inc... |
Bioorg Med Chem Lett 29: 2316-2319 (2019)
Article DOI: 10.1016/j.bmcl.2019.06.022
BindingDB Entry DOI: 10.7270/Q2WH2TH8 |
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626350
(2-[[[4-cyano-7-(4-isopropyl-2- thienyl)-2,3-dihyd...)Show SMILES CC(C)c1csc(c1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100]
(Homo sapiens-Homo sapiens (Human)) | BDBM626350
(2-[[[4-cyano-7-(4-isopropyl-2- thienyl)-2,3-dihyd...)Show SMILES CC(C)c1csc(c1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626331
(US11787775, Compound 16-C)Show SMILES C[C@@H](c1ccc(cc1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2CCOc12)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM50535722
(CHEMBL4468725)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1c[nH]c2cc(Cl)ccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1CCC1)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C97H139ClN24O22/c1-53(2)42-70(114-84(132)67(30-16-40-107-97(103)104)112-89(137)73(116-81(129)63-28-14-38-105-63)46-58-50-108-69-47-59(98)32-33-62(58)69)86(134)111-66(29-15-39-106-96(101)102)82(130)109-65(27-9-11-37-100)85(133)119-75(44-55-20-12-21-55)94(142)122-51-60(124)48-78(122)92(140)118-74(49-80(127)128)90(138)120-76(52-123)91(139)115-71(43-54-18-4-3-5-19-54)87(135)117-72(45-57-24-13-23-56-22-6-7-25-61(56)57)88(136)110-64(26-8-10-36-99)83(131)113-68(34-35-79(125)126)93(141)121-41-17-31-77(121)95(143)144/h3-7,13,18-19,22-25,32-33,47,50,53,55,60,63-68,70-78,105,108,123-124H,8-12,14-17,20-21,26-31,34-46,48-49,51-52,99-100H2,1-2H3,(H,109,130)(H,110,136)(H,111,134)(H,112,137)(H,113,131)(H,114,132)(H,115,139)(H,116,129)(H,117,135)(H,118,140)(H,119,133)(H,120,138)(H,125,126)(H,127,128)(H,143,144)(H4,101,102,106)(H4,103,104,107)/t60-,63+,64+,65+,66+,67+,68+,70+,71+,72+,73+,74+,75+,76+,77+,78+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21 (DE3) interaction with N-biotinylated YAP (60 to 100 residues) inc... |
Bioorg Med Chem Lett 29: 2316-2319 (2019)
Article DOI: 10.1016/j.bmcl.2019.06.022
BindingDB Entry DOI: 10.7270/Q2WH2TH8 |
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626323
(US11787775, Compound 8 | methyl 2-[[[4-cyano-7-(4-...)Show SMILES COC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(cc1)C(C)C | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626335
(2-[[[4-(4-isopropylphenyl)-6,7- dihydrofuro[3,2-d...)Show SMILES CC(C)c1ccc(cc1)-c1nc(NCC(=C)C(O)=O)nc2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626336
(2-[[[4-fluoro-7-(4-isopropylphenyl)- 2,3-dihydrob...)Show SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(O)=O)c(F)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626318
(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)Show SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626318
(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)Show SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626333
(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)Show SMILES OC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(OC(F)(F)F)cc1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626342
(2-[[[4-cyano-7-(2-fluoro-4- isopropyl-phenyl)-2,3...)Show SMILES CC(C)c1ccc(c(F)c1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100]
(Homo sapiens-Homo sapiens (Human)) | BDBM626318
(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)Show SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626317
(2-[[[7-(4-isopropylphenyl)-2,3- dihydrobenzofuran...)Show SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(N)=O)cc2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626332
(US11787775, Compound 16-D)Show SMILES C[C@H](c1ccc(cc1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2CCOc12)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626326
(7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-buty...)Show SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(C)=O)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626316
(2-[[[7-(4-isopropylphenyl)-2,3- dihydrobenzofuran...)Show SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(O)=O)cc2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626358
(2-[[[7-cyano-4-[4- (trifluoromethoxy)phenyl]-1,3-...)Show SMILES ONC(=O)C(=C)CNc1cc(-c2ccc(OC(F)(F)F)cc2)c2ncsc2c1C#N | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626324
(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)Show SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(=O)NO)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM50535724
(CHEMBL4467555)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1c[nH]c2cc(Cl)ccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1CCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C97H139ClN24O21/c1-54(2)45-70(114-84(131)67(31-16-42-107-97(103)104)112-89(136)73(116-81(128)63-29-14-40-105-63)49-59-52-108-69-50-60(98)34-35-62(59)69)86(133)111-66(30-15-41-106-96(101)102)82(129)109-65(28-9-11-39-100)85(132)119-75(47-56-21-12-22-56)94(141)121-43-17-32-77(121)92(139)118-74(51-80(126)127)90(137)120-76(53-123)91(138)115-71(46-55-19-4-3-5-20-55)87(134)117-72(48-58-25-13-24-57-23-6-7-26-61(57)58)88(135)110-64(27-8-10-38-99)83(130)113-68(36-37-79(124)125)93(140)122-44-18-33-78(122)95(142)143/h3-7,13,19-20,23-26,34-35,50,52,54,56,63-68,70-78,105,108,123H,8-12,14-18,21-22,27-33,36-49,51,53,99-100H2,1-2H3,(H,109,129)(H,110,135)(H,111,133)(H,112,136)(H,113,130)(H,114,131)(H,115,138)(H,116,128)(H,117,134)(H,118,139)(H,119,132)(H,120,137)(H,124,125)(H,126,127)(H,142,143)(H4,101,102,106)(H4,103,104,107)/t63-,64-,65-,66-,67-,68-,70-,71-,72-,73-,74-,75-,76-,77-,78-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21 (DE3) interaction with N-biotinylated YAP (60 to 100 residues) inc... |
Bioorg Med Chem Lett 29: 2316-2319 (2019)
Article DOI: 10.1016/j.bmcl.2019.06.022
BindingDB Entry DOI: 10.7270/Q2WH2TH8 |
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626354
(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)Show SMILES ONC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(OC(F)(F)F)cc1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626337
(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrofu...)Show SMILES CC(C)c1ccc(cc1)-c1nc(NCC(=C)C(O)=O)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM50535715
(CHEMBL4476332)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C200H320N52O57/c1-23-25-56-117(165(275)220-122(62-43-79-214-200(211)212)167(277)230-128(87-101(5)6)174(284)221-121(61-42-78-213-199(209)210)166(276)219-119(58-36-39-75-201)169(279)238-137(89-103(9)10)193(303)247-80-45-64-141(247)187(297)236-135(96-152(266)267)181(291)240-139(99-254)183(293)234-132(92-115-54-34-29-35-55-115)178(288)233-130(90-113-50-30-27-31-51-113)177(287)227-126(60-38-41-77-203)192(302)251-84-48-67-144(251)195(305)252-85-49-68-145(252)198(308)309)223-185(295)142-65-46-83-250(142)197(307)156(106(15)16)243-191(301)159(112(22)257)246-171(281)123(69-72-146(205)258)225-186(296)143-66-47-82-249(143)196(306)155(105(13)14)242-182(292)134(94-148(207)260)229-161(271)108(18)217-189(299)157(110(20)255)244-170(280)120(59-37-40-76-202)224-184(294)140-63-44-81-248(140)194(304)138(95-149(208)261)239-168(278)118(57-26-24-2)226-188(298)154(104(11)12)241-162(272)109(19)216-173(283)133(93-147(206)259)235-179(289)131(91-114-52-32-28-33-53-114)232-176(286)127(86-100(3)4)228-160(270)107(17)215-164(274)124(70-73-150(262)263)222-175(285)129(88-102(7)8)231-180(290)136(97-153(268)269)237-190(300)158(111(21)256)245-172(282)125(71-74-151(264)265)218-163(273)116(204)98-253/h27-35,50-55,100-112,116-145,154-159,253-257H,23-26,36-49,56-99,201-204H2,1-22H3,(H2,205,258)(H2,206,259)(H2,207,260)(H2,208,261)(H,215,274)(H,216,283)(H,217,299)(H,218,273)(H,219,276)(H,220,275)(H,221,284)(H,222,285)(H,223,295)(H,224,294)(H,225,296)(H,226,298)(H,227,287)(H,228,270)(H,229,271)(H,230,277)(H,231,290)(H,232,286)(H,233,288)(H,234,293)(H,235,289)(H,236,297)(H,237,300)(H,238,279)(H,239,278)(H,240,291)(H,241,272)(H,242,292)(H,243,301)(H,244,280)(H,245,282)(H,246,281)(H,262,263)(H,264,265)(H,266,267)(H,268,269)(H,308,309)(H4,209,210,213)(H4,211,212,214)/t107-,108-,109-,110+,111+,112+,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,154-,155-,156-,157-,158-,159-/m0/s1 | PDB
UniProtKB/SwissProt
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Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21 (DE3) interaction with N-biotinylated YAP (60 to 100 residues) inc... |
Bioorg Med Chem Lett 29: 2316-2319 (2019)
Article DOI: 10.1016/j.bmcl.2019.06.022
BindingDB Entry DOI: 10.7270/Q2WH2TH8 |
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626365
(2-[[[7-cyano-4-[4-(pentafluoro- lambda6-sulfanyl)...)Show SMILES ONC(=O)C(=C)CNc1cc(-c2ccc(cc2)S(F)(F)(F)(F)F)c2ncsc2c1C#N | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626362
(2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)ph...)Show SMILES OCc1c2CCOc2c(cc1NCC(=C)C(=O)NO)-c1ccc(OC(F)(F)F)cc1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626354
(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)Show SMILES ONC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(OC(F)(F)F)cc1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM50547124
(CHEMBL242708 | NCI-0001009) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to nonacylated N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIPL cell... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01275
BindingDB Entry DOI: 10.7270/Q2QN6BC1 |
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626361
(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)Show SMILES OC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(cc1)S(F)(F)(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626355
(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)Show SMILES ONC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(cc1)S(F)(F)(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100]
(Homo sapiens-Homo sapiens (Human)) | BDBM626358
(2-[[[7-cyano-4-[4- (trifluoromethoxy)phenyl]-1,3-...)Show SMILES ONC(=O)C(=C)CNc1cc(-c2ccc(OC(F)(F)F)cc2)c2ncsc2c1C#N | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626319
(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)Show SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(N)=O)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626319
(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)Show SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(N)=O)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626364
(2-[[[4-cyano-7-(5-isopropylthiazol- 2-yl)-2,3-dih...)Show SMILES CC(C)c1cnc(s1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100]
(Homo sapiens-Homo sapiens (Human)) | BDBM626324
(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)Show SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(=O)NO)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM50547134
(CHEMBL4787565) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
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PC sid
UniChem
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FITC-labeled palmitate tracer binding to N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-Co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01275
BindingDB Entry DOI: 10.7270/Q2QN6BC1 |
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626334
(2-[[[4-cyano-7-[4-(1,1- difluoroethyl)phenyl]-2,3...)Show SMILES CC(F)(F)c1ccc(cc1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626330
(2-[[[4-cyano-7-[4- (trifluoromethyl)phenyl]-2,3- ...)Show SMILES OC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(cc1)C(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100]
(Homo sapiens-Homo sapiens (Human)) | BDBM626361
(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)Show SMILES OC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(cc1)S(F)(F)(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626324
(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)Show SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(=O)NO)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100]
(Homo sapiens-Homo sapiens (Human)) | BDBM626354
(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)Show SMILES ONC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(OC(F)(F)F)cc1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626339
(2-[[[6-methoxy-5-[(E)-2-[trans-4- (trifluoromethy...)Show SMILES COc1ncc(NCC(=C)C(O)=O)cc1\C=C\[C@H]1CC[C@@H](CC1)C(F)(F)F |r,wU:17.17,wD:20.24,(3.33,3.85,;2,4.62,;.67,3.85,;-.67,4.62,;-2,3.85,;-2,2.31,;-3.33,1.54,;-4.67,2.31,;-6,1.54,;-6,,;-7.34,2.31,;-8.67,1.54,;-7.34,3.85,;-.67,1.54,;.67,2.31,;2,1.54,;2,,;3.33,-.77,;4.67,,;6,-.77,;6,-2.31,;4.67,-3.08,;3.33,-2.31,;7.34,-3.08,;8.67,-2.31,;7.34,-4.62,;8.67,-3.85,)| | PDB
UniProtKB/SwissProt
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| PC cid
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| | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626360
(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)Show SMILES NC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(OC(F)(F)F)cc1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626322
(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)Show SMILES CC(C)c1ccc(cc1)-c1cc(N(C)CC(=C)C(O)=O)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100]
(Homo sapiens-Homo sapiens (Human)) | BDBM626355
(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)Show SMILES ONC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(cc1)S(F)(F)(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626347
(2-[[[4-cyano-7-(5-isopropylthiazol- 2-yl)-2,3-dih...)Show SMILES CC(C)c1cnc(s1)-c1cc(NCC(=C)C(=O)NO)c(C#N)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3
(Homo sapiens) | BDBM626328
(2-[[[4-(hydroxymethyl)-7-(4- isopropylphenyl)-2,3...)Show SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(N)=O)c(CO)c2CCOc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100]
(Homo sapiens-Homo sapiens (Human)) | BDBM626354
(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)Show SMILES ONC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(OC(F)(F)F)cc1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
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