BindingDB PrimarySearch

Found 15 hits Enz. Inhib. hit(s) with Target = 'Catechol O-methyltransferase' AND taxid = 9823
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Catechol O-methyltransferase (Sus scrofa)	BDBM50058814 (CHEMBL63052 \| N,N'-1,3-Propanediylbis(3,4-dihydrox...) Show SMILES Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Otago Curated by ChEMBL					Assay Description In vitro inhibitory activity against Catechol-O-methyltransferase from porcine liver; Competitive mode of inhibition				J Med Chem 40: 2035-9 (1997) Article DOI: 10.1021/jm9605187 BindingDB Entry DOI: 10.7270/Q27M072S
University of Otago Curated by ChEMBL					More data for this Ligand-Target Pair
Catechol O-methyltransferase (Sus scrofa)	BDBM50058813 (3,4,5-Trihydroxy-N-propyl-benzamide \| CHEMBL64275) Show SMILES CCCNC(=O)c1cc(O)c(O)c(O)c1 Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Otago Curated by ChEMBL					Assay Description In vitro inhibitory activity against Catechol-O-methyltransferase from porcine liver; Competitive mode of inhibition				J Med Chem 40: 2035-9 (1997) Article DOI: 10.1021/jm9605187 BindingDB Entry DOI: 10.7270/Q27M072S
University of Otago Curated by ChEMBL					More data for this Ligand-Target Pair
Catechol O-methyltransferase (Sus scrofa)	BDBM50058812 (CHEMBL302625 \| N,N'-1,3-Propanediylbis(3,4,5-trihy...) Show SMILES Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Otago Curated by ChEMBL					Assay Description In vitro inhibitory activity against Catechol-O-methyltransferase from porcine liver; Uncompetitive mode of inhibition				J Med Chem 40: 2035-9 (1997) Article DOI: 10.1021/jm9605187 BindingDB Entry DOI: 10.7270/Q27M072S
University of Otago Curated by ChEMBL					More data for this Ligand-Target Pair
Catechol O-methyltransferase (Sus scrofa)	BDBM50004044 (3-Hydroxy-4-methoxy-5-nitro-benzaldehyde \| CHEMBL8...) Show SMILES COc1c(O)cc(C=O)cc1[N+]([O-])=O Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	1.35E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Orgánica General (CSIC) Curated by ChEMBL					Assay Description Compound was evaluated for reversible inhibition of Catechol O-methyltransferase with variable AdoMet and saturating catechol as substrate (mixed inh...				J Med Chem 35: 4584-8 (1993) BindingDB Entry DOI: 10.7270/Q2X63KWW
					More data for this Ligand-Target Pair
Catechol O-methyltransferase (Sus scrofa)	BDBM50004044 (3-Hydroxy-4-methoxy-5-nitro-benzaldehyde \| CHEMBL8...) Show SMILES COc1c(O)cc(C=O)cc1[N+]([O-])=O Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	1.72E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Orgánica General (CSIC) Curated by ChEMBL					Assay Description Compound was evaluated for reversible inhibition of Catechol O-methyltransferase with saturating AdoMet and variable catechol as substrate (noncompet...				J Med Chem 35: 4584-8 (1993) BindingDB Entry DOI: 10.7270/Q2X63KWW
					More data for this Ligand-Target Pair
Catechol O-methyltransferase (Sus scrofa)	BDBM50058815 (CHEMBL264858 \| N,N'-1,5-Pentanediylbis(3,4,5-trihy...) Show SMILES Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.67E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Otago Curated by ChEMBL					Assay Description In vitro inhibitory activity against Catechol-O-methyltransferase from porcine liver; Uncompetitive mode of inhibition				J Med Chem 40: 2035-9 (1997) Article DOI: 10.1021/jm9605187 BindingDB Entry DOI: 10.7270/Q27M072S
University of Otago Curated by ChEMBL					More data for this Ligand-Target Pair
Catechol O-methyltransferase (Sus scrofa)	BDBM50058811 (CHEMBL60350 \| N,N'-1,6-Hexanediylbis(3,4,5-trihydr...) Show SMILES Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Otago Curated by ChEMBL					Assay Description In vitro inhibitory activity against Catechol-O-methyltransferase from porcine liver; Uncompetitive mode of inhibition				J Med Chem 40: 2035-9 (1997) Article DOI: 10.1021/jm9605187 BindingDB Entry DOI: 10.7270/Q27M072S
University of Otago Curated by ChEMBL					More data for this Ligand-Target Pair
Catechol O-methyltransferase (Sus scrofa)	BDBM50058816 (CHEMBL292067 \| N,N'-1,2-Ethanediylbis(3,4,5-trihyd...) Show SMILES Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.36E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Otago Curated by ChEMBL					Assay Description In vitro inhibitory activity against Catechol-O-methyltransferase from porcine liver; Uncompetitive mode of inhibition				J Med Chem 40: 2035-9 (1997) Article DOI: 10.1021/jm9605187 BindingDB Entry DOI: 10.7270/Q27M072S
University of Otago Curated by ChEMBL					More data for this Ligand-Target Pair
Catechol O-methyltransferase (Sus scrofa)	BDBM50004049 (3,4-Dihydroxy-2-nitro-benzaldehyde \| CHEMBL139882) Show SMILES Oc1ccc(C=O)c(c1O)[N+]([O-])=O Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Orgánica General (CSIC) Curated by ChEMBL					Assay Description In vitro inhibition of Catechol-O-methyltransferase (COMT) from isolated partially purified pig liver enzyme				J Med Chem 35: 4584-8 (1993) BindingDB Entry DOI: 10.7270/Q2X63KWW
					More data for this Ligand-Target Pair
Catechol O-methyltransferase (Sus scrofa)	BDBM50004045 (2,3-Dihydroxy-4-nitro-benzaldehyde \| CHEMBL357072) Show SMILES Oc1c(O)c(ccc1C=O)[N+]([O-])=O Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Orgánica General (CSIC) Curated by ChEMBL					Assay Description In vitro inhibition of Catechol-O-methyltransferase (COMT) from isolated partially purified pig liver enzyme				J Med Chem 35: 4584-8 (1993) BindingDB Entry DOI: 10.7270/Q2X63KWW
					More data for this Ligand-Target Pair
Catechol O-methyltransferase (Sus scrofa)	BDBM50004043 (3,4-Dihydroxy-5-Nitrobenzaldehyde (Rat) \| 3,4-Dihy...) Show SMILES Oc1cc(C=O)cc(c1O)[N+]([O-])=O Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Orgánica General (CSIC) Curated by ChEMBL					Assay Description In vitro inhibition of Catechol-O-methyltransferase (COMT) from isolated partially purified pig liver enzyme				J Med Chem 35: 4584-8 (1993) BindingDB Entry DOI: 10.7270/Q2X63KWW
					More data for this Ligand-Target Pair
Catechol O-methyltransferase (Sus scrofa)	BDBM50004047 (2,3-Dihydroxy-5-nitro-benzaldehyde \| CHEMBL141858) Show SMILES Oc1cc(cc(C=O)c1O)[N+]([O-])=O Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Orgánica General (CSIC) Curated by ChEMBL					Assay Description In vitro inhibition of Catechol-O-methyltransferase (COMT) from isolated partially purified pig liver enzyme				J Med Chem 35: 4584-8 (1993) BindingDB Entry DOI: 10.7270/Q2X63KWW
					More data for this Ligand-Target Pair
Catechol O-methyltransferase (Sus scrofa)	BDBM50004048 (4,5-Dihydroxy-2-nitro-benzaldehyde \| CHEMBL142876) Show SMILES Oc1cc(C=O)c(cc1O)[N+]([O-])=O Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Orgánica General (CSIC) Curated by ChEMBL					Assay Description In vitro inhibition of Catechol-O-methyltransferase (COMT) from isolated partially purified pig liver enzyme				J Med Chem 35: 4584-8 (1993) BindingDB Entry DOI: 10.7270/Q2X63KWW
					More data for this Ligand-Target Pair
Catechol O-methyltransferase (Sus scrofa)	BDBM50004046 (2,3-Dihydroxy-6-nitro-benzaldehyde \| CHEMBL334706) Show SMILES Oc1ccc(c(C=O)c1O)[N+]([O-])=O Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Orgánica General (CSIC) Curated by ChEMBL					Assay Description In vitro inhibition of Catechol-O-methyltransferase (COMT) from isolated partially purified pig liver enzyme				J Med Chem 35: 4584-8 (1993) BindingDB Entry DOI: 10.7270/Q2X63KWW
					More data for this Ligand-Target Pair
Catechol O-methyltransferase (Sus scrofa)	BDBM50004044 (3-Hydroxy-4-methoxy-5-nitro-benzaldehyde \| CHEMBL8...) Show SMILES COc1c(O)cc(C=O)cc1[N+]([O-])=O Show InChI	MMDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Orgánica General (CSIC) Curated by ChEMBL					Assay Description In vitro inhibition of Catechol-O-methyltransferase (COMT) from isolated partially purified pig liver enzyme				J Med Chem 35: 4584-8 (1993) BindingDB Entry DOI: 10.7270/Q2X63KWW
					More data for this Ligand-Target Pair