Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM205472 (PPiase inhibitor, 16) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Kentucky | Assay Description The compounds were first mixed with tetrasodium PPi (final concentration of 100 μM) at concentrations specified in the text in the reaction buff... | ACS Chem Biol 11: 3084-3092 (2016) Article DOI: 10.1021/acschembio.6b00510 BindingDB Entry DOI: 10.7270/Q2GF0SBF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM205471 (PPiase inhibitor, 15) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Kentucky | Assay Description The compounds were first mixed with tetrasodium PPi (final concentration of 100 μM) at concentrations specified in the text in the reaction buff... | ACS Chem Biol 11: 3084-3092 (2016) Article DOI: 10.1021/acschembio.6b00510 BindingDB Entry DOI: 10.7270/Q2GF0SBF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM50444854 (CHEMBL3099405) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.33E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis PPase using inorganic pyrophosphate as substrate preincubated for 2 mins followed by substrate addition meas... | Bioorg Med Chem 22: 406-18 (2013) Article DOI: 10.1016/j.bmc.2013.11.011 BindingDB Entry DOI: 10.7270/Q2K35W4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM205473 (PPiase inhibitor, 17) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Kentucky | Assay Description The compounds were first mixed with tetrasodium PPi (final concentration of 100 μM) at concentrations specified in the text in the reaction buff... | ACS Chem Biol 11: 3084-3092 (2016) Article DOI: 10.1021/acschembio.6b00510 BindingDB Entry DOI: 10.7270/Q2GF0SBF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM205469 (PPiase inhibitor, 13) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Kentucky | Assay Description The compounds were first mixed with tetrasodium PPi (final concentration of 100 μM) at concentrations specified in the text in the reaction buff... | ACS Chem Biol 11: 3084-3092 (2016) Article DOI: 10.1021/acschembio.6b00510 BindingDB Entry DOI: 10.7270/Q2GF0SBF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM50444850 (CHEMBL3099412) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.83E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis PPase using inorganic pyrophosphate as substrate preincubated for 2 mins followed by substrate addition meas... | Bioorg Med Chem 22: 406-18 (2013) Article DOI: 10.1016/j.bmc.2013.11.011 BindingDB Entry DOI: 10.7270/Q2K35W4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM205470 (PPiase inhibitor, 14) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.40E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Kentucky | Assay Description The compounds were first mixed with tetrasodium PPi (final concentration of 100 μM) at concentrations specified in the text in the reaction buff... | ACS Chem Biol 11: 3084-3092 (2016) Article DOI: 10.1021/acschembio.6b00510 BindingDB Entry DOI: 10.7270/Q2GF0SBF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM50444855 (CHEMBL3099425) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis PPase using inorganic pyrophosphate as substrate preincubated for 2 mins followed by substrate addition meas... | Bioorg Med Chem 22: 406-18 (2013) Article DOI: 10.1016/j.bmc.2013.11.011 BindingDB Entry DOI: 10.7270/Q2K35W4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM50444852 (CHEMBL3099409) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.74E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis PPase using inorganic pyrophosphate as substrate preincubated for 2 mins followed by substrate addition meas... | Bioorg Med Chem 22: 406-18 (2013) Article DOI: 10.1016/j.bmc.2013.11.011 BindingDB Entry DOI: 10.7270/Q2K35W4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM205474 (PPiase inhibitor, 18) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.80E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Kentucky | Assay Description The compounds were first mixed with tetrasodium PPi (final concentration of 100 μM) at concentrations specified in the text in the reaction buff... | ACS Chem Biol 11: 3084-3092 (2016) Article DOI: 10.1021/acschembio.6b00510 BindingDB Entry DOI: 10.7270/Q2GF0SBF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM50444858 (CHEMBL3099415) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis PPase using inorganic pyrophosphate as substrate preincubated for 2 mins followed by substrate addition meas... | Bioorg Med Chem 22: 406-18 (2013) Article DOI: 10.1016/j.bmc.2013.11.011 BindingDB Entry DOI: 10.7270/Q2K35W4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM205475 (PPiase inhibitor, 19) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.20E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Kentucky | Assay Description The compounds were first mixed with tetrasodium PPi (final concentration of 100 μM) at concentrations specified in the text in the reaction buff... | ACS Chem Biol 11: 3084-3092 (2016) Article DOI: 10.1021/acschembio.6b00510 BindingDB Entry DOI: 10.7270/Q2GF0SBF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM50444851 (CHEMBL3099410) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.81E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis PPase using inorganic pyrophosphate as substrate preincubated for 2 mins followed by substrate addition meas... | Bioorg Med Chem 22: 406-18 (2013) Article DOI: 10.1016/j.bmc.2013.11.011 BindingDB Entry DOI: 10.7270/Q2K35W4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM50444856 (CHEMBL3099424) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.02E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis PPase using inorganic pyrophosphate as substrate preincubated for 2 mins followed by substrate addition meas... | Bioorg Med Chem 22: 406-18 (2013) Article DOI: 10.1016/j.bmc.2013.11.011 BindingDB Entry DOI: 10.7270/Q2K35W4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM205467 (PPiase inhibitor, 11) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.10E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Kentucky | Assay Description The compounds were first mixed with tetrasodium PPi (final concentration of 100 μM) at concentrations specified in the text in the reaction buff... | ACS Chem Biol 11: 3084-3092 (2016) Article DOI: 10.1021/acschembio.6b00510 BindingDB Entry DOI: 10.7270/Q2GF0SBF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM205466 (PPiase inhibitor, 9) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.15E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Kentucky | Assay Description The compounds were first mixed with tetrasodium PPi (final concentration of 100 μM) at concentrations specified in the text in the reaction buff... | ACS Chem Biol 11: 3084-3092 (2016) Article DOI: 10.1021/acschembio.6b00510 BindingDB Entry DOI: 10.7270/Q2GF0SBF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM50444853 (CHEMBL3099407) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.18E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis PPase using inorganic pyrophosphate as substrate preincubated for 2 mins followed by substrate addition meas... | Bioorg Med Chem 22: 406-18 (2013) Article DOI: 10.1016/j.bmc.2013.11.011 BindingDB Entry DOI: 10.7270/Q2K35W4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM205464 (PPiase inhibitor, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.30E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Kentucky | Assay Description The compounds were first mixed with tetrasodium PPi (final concentration of 100 μM) at concentrations specified in the text in the reaction buff... | ACS Chem Biol 11: 3084-3092 (2016) Article DOI: 10.1021/acschembio.6b00510 BindingDB Entry DOI: 10.7270/Q2GF0SBF | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM50444859 (CHEMBL3099427) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.48E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis PPase using inorganic pyrophosphate as substrate preincubated for 2 mins followed by substrate addition meas... | Bioorg Med Chem 22: 406-18 (2013) Article DOI: 10.1016/j.bmc.2013.11.011 BindingDB Entry DOI: 10.7270/Q2K35W4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM205477 (PPiase inhibitor, 21) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.66E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Kentucky | Assay Description The compounds were first mixed with tetrasodium PPi (final concentration of 100 μM) at concentrations specified in the text in the reaction buff... | ACS Chem Biol 11: 3084-3092 (2016) Article DOI: 10.1021/acschembio.6b00510 BindingDB Entry DOI: 10.7270/Q2GF0SBF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM50444857 (CHEMBL3099418) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.55E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis PPase using inorganic pyrophosphate as substrate preincubated for 2 mins followed by substrate addition meas... | Bioorg Med Chem 22: 406-18 (2013) Article DOI: 10.1016/j.bmc.2013.11.011 BindingDB Entry DOI: 10.7270/Q2K35W4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM205465 (PPiase inhibitor, 6) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 5.40E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Kentucky | Assay Description The compounds were first mixed with tetrasodium PPi (final concentration of 100 μM) at concentrations specified in the text in the reaction buff... | ACS Chem Biol 11: 3084-3092 (2016) Article DOI: 10.1021/acschembio.6b00510 BindingDB Entry DOI: 10.7270/Q2GF0SBF | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM205468 (PPiase inhibitor, 12) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >6.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Kentucky | Assay Description The compounds were first mixed with tetrasodium PPi (final concentration of 100 μM) at concentrations specified in the text in the reaction buff... | ACS Chem Biol 11: 3084-3092 (2016) Article DOI: 10.1021/acschembio.6b00510 BindingDB Entry DOI: 10.7270/Q2GF0SBF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inorganic pyrophosphatase (Mycobacterium tuberculosis) | BDBM205476 (PPiase inhibitor, 20) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >6.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Kentucky | Assay Description The compounds were first mixed with tetrasodium PPi (final concentration of 100 μM) at concentrations specified in the text in the reaction buff... | ACS Chem Biol 11: 3084-3092 (2016) Article DOI: 10.1021/acschembio.6b00510 BindingDB Entry DOI: 10.7270/Q2GF0SBF | |||||||||||
More data for this Ligand-Target Pair |