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Compile Data Set for Download or QSAR

Found 105 hits of ic50 for UniProtKB: P14867   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50337263
PNG
(3-(2-chlorobenzyloxy)-2-(2-fluorophenyl)-2H-pyrazo...)
Show SMILES Fc1ccccc1-n1nc2c(cnc3ccccc23)c1OCc1ccccc1Cl
Show InChI InChI=1S/C23H15ClFN3O/c24-18-9-3-1-7-15(18)14-29-23-17-13-26-20-11-5-2-8-16(20)22(17)27-28(23)21-12-6-4-10-19(21)25/h1-13H,14H2
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n/an/a 1n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cells

Bioorg Med Chem Lett 21: 1523-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.107
BindingDB Entry DOI: 10.7270/Q289164V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM84957
PNG
(CGS 9896 | CHEMBL20042)
Show SMILES Clc1ccc(cc1)-n1[nH]c2c(cnc3ccccc23)c1=O
Show InChI InChI=1S/C16H10ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h1-9,19H
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n/an/a 1n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cells

Bioorg Med Chem Lett 21: 1523-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.107
BindingDB Entry DOI: 10.7270/Q289164V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50290077
PNG
(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)
Show SMILES CCCC(=O)N(C)Cc1c(nc2ccccn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN3O/c1-3-6-18(24)22(2)13-16-19(14-8-10-15(20)11-9-14)21-17-7-4-5-12-23(16)17/h4-5,7-12H,3,6,13H2,1-2H3
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n/an/a 1.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETB receptors)

Bioorg Med Chem Lett 7: 2277-2282 (1997)


Article DOI: 10.1016/S0960-894X(97)00404-6
BindingDB Entry DOI: 10.7270/Q2BK1CB0
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50290077
PNG
(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)
Show SMILES CCCC(=O)N(C)Cc1c(nc2ccccn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN3O/c1-3-6-18(24)22(2)13-16-19(14-8-10-15(20)11-9-14)21-17-7-4-5-12-23(16)17/h4-5,7-12H,3,6,13H2,1-2H3
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n/an/a 1.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)

Bioorg Med Chem Lett 7: 2277-2282 (1997)


Article DOI: 10.1016/S0960-894X(97)00404-6
BindingDB Entry DOI: 10.7270/Q2BK1CB0
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM98558
PNG
(US8492408, 7a)
Show SMILES COc1ncccc1-c1cc(ccn1)-n1cnc2cc(ccc12)C(C)(C)O
Show InChI InChI=1S/C21H20N4O2/c1-21(2,26)14-6-7-19-18(11-14)24-13-25(19)15-8-10-22-17(12-15)16-5-4-9-23-20(16)27-3/h4-13,26H,1-3H3
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n/an/a 1.20n/an/an/an/an/an/a



Aniona APS

US Patent


Assay Description
In vitro inhibition assay using GABA receptor.

US Patent US8492408 (2013)


BindingDB Entry DOI: 10.7270/Q28K77QX
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50608946
PNG
(CHEMBL2008708)
Show SMILES c1ccc2c(c1)[nH]c1cnc3c4cccnc4[nH]c3c21
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n/an/a 2n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50483961
PNG
(CHEMBL1795561)
Show SMILES Br.OC(=O)CCCn1nc(ccc1=N)-c1ccc(OCc2cccc(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C21H20N4O5/c22-20-11-10-19(23-24(20)12-2-5-21(26)27)16-6-8-18(9-7-16)30-14-15-3-1-4-17(13-15)25(28)29/h1,3-4,6-11,13,22H,2,5,12,14H2,(H,26,27)
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University College London

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABA A receptor alpha1beta2gamma2S expressed in HEK293 cells assessed as inhibition of GABA-induced current ...

Bioorg Med Chem Lett 21: 4252-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.067
BindingDB Entry DOI: 10.7270/Q2QR5101
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50608947
PNG
(CHEMBL5281056)
Show SMILES c1ccc2c(c1)[nH]c1cnc3c4ccncc4[nH]c3c21
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50483959
PNG
(CHEMBL1795560)
Show SMILES Br.COc1cccc(COc2ccc(cc2)-c2ccc(=N)n(CCCC(O)=O)n2)c1
Show InChI InChI=1S/C22H23N3O4/c1-28-19-5-2-4-16(14-19)15-29-18-9-7-17(8-10-18)20-11-12-21(23)25(24-20)13-3-6-22(26)27/h2,4-5,7-12,14,23H,3,6,13,15H2,1H3,(H,26,27)
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University College London

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABA A receptor alpha1beta2gamma2S expressed in HEK293 cells assessed as inhibition of GABA-induced current ...

Bioorg Med Chem Lett 21: 4252-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.067
BindingDB Entry DOI: 10.7270/Q2QR5101
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM98560
PNG
(US8492408, 7c)
Show SMILES CC(C)(O)c1ccc2n(cnc2c1)-c1ccnc(c1)-c1ccncc1F
Show InChI InChI=1S/C20H17FN4O/c1-20(2,26)13-3-4-19-18(9-13)24-12-25(19)14-5-8-23-17(10-14)15-6-7-22-11-16(15)21/h3-12,26H,1-2H3
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n/an/a 7.5n/an/an/an/an/an/a



Aniona APS

US Patent


Assay Description
In vitro inhibition assay using GABA receptor.

US Patent US8492408 (2013)


BindingDB Entry DOI: 10.7270/Q28K77QX
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50537125
PNG
(CHEMBL1851667)
Show SMILES OC(=O)CCCn1nc(ccc1=N)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C21H21N3O3/c22-20-13-12-19(23-24(20)14-4-7-21(25)26)17-8-10-18(11-9-17)27-15-16-5-2-1-3-6-16/h1-3,5-6,8-13,22H,4,7,14-15H2,(H,25,26)
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n/an/a 11n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human alpha1beta2gamma2S GABA(A) receptor expressed in human tsA201 cells assessed as inhibition of GABA-induced membrane pote...

J Med Chem 62: 2798-2813 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00131
BindingDB Entry DOI: 10.7270/Q2D2225V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50483958
PNG
(CHEMBL1795348)
Show SMILES Br.OC(=O)CCCn1nc(ccc1=N)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C21H21N3O3/c22-20-13-12-19(23-24(20)14-4-7-21(25)26)17-8-10-18(11-9-17)27-15-16-5-2-1-3-6-16/h1-3,5-6,8-13,22H,4,7,14-15H2,(H,25,26)
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University College London

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABA A receptor alpha1beta2gamma2S expressed in HEK293 cells assessed as inhibition of GABA-induced current ...

Bioorg Med Chem Lett 21: 4252-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.067
BindingDB Entry DOI: 10.7270/Q2QR5101
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM26266
PNG
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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n/an/a 14n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Flumazenil binding to recombinant GABA-A receptor alpha-1 subunit in cerebellum

Bioorg Med Chem Lett 7: 2277-2282 (1997)


Article DOI: 10.1016/S0960-894X(97)00404-6
BindingDB Entry DOI: 10.7270/Q2BK1CB0
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50378769
PNG
(CHEMBL1204074)
Show SMILES On1ncc(C2CCNCC2)c1-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C20H21N3O/c24-23-20(19(14-22-23)16-9-11-21-12-10-16)18-8-4-7-17(13-18)15-5-2-1-3-6-15/h1-8,13-14,16,21,24H,9-12H2
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n/an/a 24n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human alpha1beta2gamma2S GABA(A) receptor expressed in human tsA201 cells assessed as inhibition of GABA-induced membrane pote...

J Med Chem 62: 2798-2813 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00131
BindingDB Entry DOI: 10.7270/Q2D2225V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50378769
PNG
(CHEMBL1204074)
Show SMILES On1ncc(C2CCNCC2)c1-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C20H21N3O/c24-23-20(19(14-22-23)16-9-11-21-12-10-16)18-8-4-7-17(13-18)15-5-2-1-3-6-15/h1-8,13-14,16,21,24H,9-12H2
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n/an/a 24n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells by FMP red assay

J Med Chem 53: 3417-21 (2010)


Article DOI: 10.1021/jm100106r
BindingDB Entry DOI: 10.7270/Q2GF0VFM
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM98561
PNG
(US8492408, 7d)
Show SMILES CC(C)(O)c1ccc2n(cnc2c1)-c1ccnc(c1)-c1ccncc1C#N
Show InChI InChI=1S/C21H17N5O/c1-21(2,27)15-3-4-20-19(9-15)25-13-26(20)16-5-8-24-18(10-16)17-6-7-23-12-14(17)11-22/h3-10,12-13,27H,1-2H3
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n/an/a 26n/an/an/an/an/an/a



Aniona APS

US Patent


Assay Description
In vitro inhibition assay using GABA receptor.

US Patent US8492408 (2013)


BindingDB Entry DOI: 10.7270/Q28K77QX
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50329649
PNG
(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Show SMILES CC(OC(=O)c1cc2c(cn1)[nH]c1ccccc21)c1ccccc1
Show InChI InChI=1S/C20H16N2O2/c1-13(14-7-3-2-4-8-14)24-20(23)18-11-16-15-9-5-6-10-17(15)22-19(16)12-21-18/h2-13,22H,1H3
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n/an/a 34n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM98559
PNG
(US8492408, 7b)
Show SMILES CC(C)(O)c1ccc2n(cnc2c1)-c1ccnc(c1)-c1cccnc1Cl
Show InChI InChI=1S/C20H17ClN4O/c1-20(2,26)13-5-6-18-17(10-13)24-12-25(18)14-7-9-22-16(11-14)15-4-3-8-23-19(15)21/h3-12,26H,1-2H3
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n/an/a 38n/an/an/an/an/an/a



Aniona APS

US Patent


Assay Description
In vitro inhibition assay using GABA receptor.

US Patent US8492408 (2013)


BindingDB Entry DOI: 10.7270/Q28K77QX
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50483960
PNG
(CHEMBL1795562)
Show SMILES Br.OC(=O)CCCn1nc(ccc1=N)-c1ccc(OCC#C)cc1
Show InChI InChI=1S/C17H17N3O3/c1-2-12-23-14-7-5-13(6-8-14)15-9-10-16(18)20(19-15)11-3-4-17(21)22/h1,5-10,18H,3-4,11-12H2,(H,21,22)
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University College London

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABA A receptor alpha1beta2gamma2S expressed in HEK293 cells assessed as inhibition of GABA-induced current ...

Bioorg Med Chem Lett 21: 4252-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.067
BindingDB Entry DOI: 10.7270/Q2QR5101
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM26266
PNG
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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n/an/a 46n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)

Bioorg Med Chem Lett 7: 2277-2282 (1997)


Article DOI: 10.1016/S0960-894X(97)00404-6
BindingDB Entry DOI: 10.7270/Q2BK1CB0
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50337265
PNG
(3-(2-chlorobenzyloxy)-2-(4-chlorophenyl)-6,7,8,9-t...)
Show SMILES Clc1ccc(cc1)-n1nc2c3CCCCc3ncc2c1OCc1ccccc1Cl
Show InChI InChI=1S/C23H19Cl2N3O/c24-16-9-11-17(12-10-16)28-23(29-14-15-5-1-3-7-20(15)25)19-13-26-21-8-4-2-6-18(21)22(19)27-28/h1,3,5,7,9-13H,2,4,6,8,14H2
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n/an/a 46n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cells

Bioorg Med Chem Lett 21: 1523-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.107
BindingDB Entry DOI: 10.7270/Q289164V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50337271
PNG
(2-(4-chlorophenyl)-3-(4-fluorobenzyloxy)-6,7,8,9-t...)
Show SMILES Fc1ccc(COc2n(nc3c4CCCCc4ncc23)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C23H19ClFN3O/c24-16-7-11-18(12-8-16)28-23(29-14-15-5-9-17(25)10-6-15)20-13-26-21-4-2-1-3-19(21)22(20)27-28/h5-13H,1-4,14H2
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n/an/a 50n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cells

Bioorg Med Chem Lett 21: 1523-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.107
BindingDB Entry DOI: 10.7270/Q289164V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50337264
PNG
(2-(benzo[d][1,3]dioxol-5-yl)-3-(2-chlorobenzyloxy)...)
Show SMILES Clc1ccccc1COc1n(nc2c1cnc1ccccc21)-c1ccc2OCOc2c1
Show InChI InChI=1S/C24H16ClN3O3/c25-19-7-3-1-5-15(19)13-29-24-18-12-26-20-8-4-2-6-17(20)23(18)27-28(24)16-9-10-21-22(11-16)31-14-30-21/h1-12H,13-14H2
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n/an/a 50n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cells

Bioorg Med Chem Lett 21: 1523-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.107
BindingDB Entry DOI: 10.7270/Q289164V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50337274
PNG
(3-(2-chlorobenzyloxy)-2-(4-chlorophenyl)-2H-pyrazo...)
Show SMILES Clc1ccc(cc1)-n1nc2c(cnc3ccccc23)c1OCc1ccccc1Cl
Show InChI InChI=1S/C23H15Cl2N3O/c24-16-9-11-17(12-10-16)28-23(29-14-15-5-1-3-7-20(15)25)19-13-26-21-8-4-2-6-18(21)22(19)27-28/h1-13H,14H2
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n/an/a 64n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cells

Bioorg Med Chem Lett 21: 1523-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.107
BindingDB Entry DOI: 10.7270/Q289164V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50337270
PNG
(2-(4-chlorophenyl)-3-(2-fluorobenzyloxy)-6,7,8,9-t...)
Show SMILES Fc1ccccc1COc1n(nc2c3CCCCc3ncc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H19ClFN3O/c24-16-9-11-17(12-10-16)28-23(29-14-15-5-1-3-7-20(15)25)19-13-26-21-8-4-2-6-18(21)22(19)27-28/h1,3,5,7,9-13H,2,4,6,8,14H2
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n/an/a 64n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cells

Bioorg Med Chem Lett 21: 1523-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.107
BindingDB Entry DOI: 10.7270/Q289164V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50337268
PNG
(3-(2-chlorobenzyloxy)-2-(4-chlorophenyl)-8,8-dimet...)
Show SMILES CC1(C)CCc2ncc3c(OCc4ccccc4Cl)n(nc3c2C1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H23Cl2N3O/c1-25(2)12-11-22-19(13-25)23-20(14-28-22)24(31-15-16-5-3-4-6-21(16)27)30(29-23)18-9-7-17(26)8-10-18/h3-10,14H,11-13,15H2,1-2H3
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n/an/a 67n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cells

Bioorg Med Chem Lett 21: 1523-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.107
BindingDB Entry DOI: 10.7270/Q289164V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50337272
PNG
(2-(4-chlorophenyl)-3-(cyclopropylmethoxy)-2H-pyraz...)
Show SMILES Clc1ccc(cc1)-n1nc2c(cnc3ccccc23)c1OCC1CC1
Show InChI InChI=1S/C20H16ClN3O/c21-14-7-9-15(10-8-14)24-20(25-12-13-5-6-13)17-11-22-18-4-2-1-3-16(18)19(17)23-24/h1-4,7-11,13H,5-6,12H2
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n/an/a 74n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cells

Bioorg Med Chem Lett 21: 1523-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.107
BindingDB Entry DOI: 10.7270/Q289164V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50520683
PNG
(CHEMBL4476621)
Show SMILES Oc1ccccc1C(=O)NNC(=S)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H11Cl2N3O2S/c15-10-6-5-8(7-11(10)16)17-14(22)19-18-13(21)9-3-1-2-4-12(9)20/h1-7,20H,(H,18,21)(H2,17,19,22)
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n/an/a 75n/an/an/an/an/an/a



Universit£ Catholique de Louvain (UCLouvain)

Curated by ChEMBL


Assay Description
Displacement of [3H]muscimol from recombinant human GABAalpha1beta2gamma2 measured after 120 mins by scintillation counting method

Eur J Med Chem 159: 324-338 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.067
BindingDB Entry DOI: 10.7270/Q2VM4GND
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50208721
PNG
(4-(biphenyl-3-yl)-5-(piperidin-4-yl)isoxazol-3-ol ...)
Show SMILES O=c1[nH]oc(C2CCNCC2)c1-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C20H20N2O2/c23-20-18(19(24-22-20)15-9-11-21-12-10-15)17-8-4-7-16(13-17)14-5-2-1-3-6-14/h1-8,13,15,21H,9-12H2,(H,22,23)
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n/an/a 78n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells by FMP red assay

J Med Chem 53: 3417-21 (2010)


Article DOI: 10.1021/jm100106r
BindingDB Entry DOI: 10.7270/Q2GF0VFM
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50337275
PNG
(2-(4-chlorophenyl)-3-(cyclopropylmethoxy)-6,7,8,9-...)
Show SMILES Clc1ccc(cc1)-n1nc2c3CCCCc3ncc2c1OCC1CC1
Show InChI InChI=1S/C20H20ClN3O/c21-14-7-9-15(10-8-14)24-20(25-12-13-5-6-13)17-11-22-18-4-2-1-3-16(18)19(17)23-24/h7-11,13H,1-6,12H2
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n/an/a 94n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cells

Bioorg Med Chem Lett 21: 1523-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.107
BindingDB Entry DOI: 10.7270/Q289164V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM26266
PNG
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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n/an/a 130n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for in vitro functional inhibitory potency for prevention of sarafotoxin S6c induced constriction of rat tracheal rings (ETB r...

Bioorg Med Chem Lett 7: 2277-2282 (1997)


Article DOI: 10.1016/S0960-894X(97)00404-6
BindingDB Entry DOI: 10.7270/Q2BK1CB0
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50337277
PNG
(2-(4-chlorophenyl)-3-(cyclopropylmethoxy)-8-(1H-im...)
Show SMILES Clc1ccc(cc1)-n1nc2c(cnc3ccc(cc23)-n2ccnc2)c1OCC1CC1
Show InChI InChI=1S/C23H18ClN5O/c24-16-3-5-17(6-4-16)29-23(30-13-15-1-2-15)20-12-26-21-8-7-18(28-10-9-25-14-28)11-19(21)22(20)27-29/h3-12,14-15H,1-2,13H2
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n/an/a 134n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cells

Bioorg Med Chem Lett 21: 1523-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.107
BindingDB Entry DOI: 10.7270/Q289164V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50378770
PNG
(CHEMBL1202335)
Show SMILES On1ncc(C2CCNCC2)c1-c1ccccc1
Show InChI InChI=1S/C14H17N3O/c18-17-14(12-4-2-1-3-5-12)13(10-16-17)11-6-8-15-9-7-11/h1-5,10-11,15,18H,6-9H2
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n/an/a 150n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells by FMP red assay

J Med Chem 53: 3417-21 (2010)


Article DOI: 10.1021/jm100106r
BindingDB Entry DOI: 10.7270/Q2GF0VFM
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50097413
PNG
(CHEMBL3586473)
Show SMILES COc1cccc(F)c1C1=NCc2cnc(Nc3ccc(cc3)C(O)=O)nc2-c2ccc(Cl)cc12 |t:10|
Show InChI InChI=1S/C26H18ClFN4O3/c1-35-21-4-2-3-20(28)22(21)24-19-11-16(27)7-10-18(19)23-15(12-29-24)13-30-26(32-23)31-17-8-5-14(6-9-17)25(33)34/h2-11,13H,12H2,1H3,(H,33,34)(H,30,31,32)
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n/an/a 150n/an/an/an/an/an/a



Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL


Assay Description
Binding affinity to GABAA alpha-1 benzodiazepine binding site (unknown origin)

ACS Med Chem Lett 6: 630-4 (2015)


Article DOI: 10.1021/ml500409n
BindingDB Entry DOI: 10.7270/Q2WS8W1V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50337269
PNG
(3-(4-chlorobenzyloxy)-2-(4-chlorophenyl)-6,7,8,9-t...)
Show SMILES Clc1ccc(COc2n(nc3c4CCCCc4ncc23)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C23H19Cl2N3O/c24-16-7-5-15(6-8-16)14-29-23-20-13-26-21-4-2-1-3-19(21)22(20)27-28(23)18-11-9-17(25)10-12-18/h5-13H,1-4,14H2
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n/an/a 157n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cells

Bioorg Med Chem Lett 21: 1523-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.107
BindingDB Entry DOI: 10.7270/Q289164V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50378760
PNG
(CHEMBL1202340)
Show SMILES On1cc(C2CCNCC2)c(Cc2ccc3ccccc3c2)n1
Show InChI InChI=1S/C19H21N3O/c23-22-13-18(16-7-9-20-10-8-16)19(21-22)12-14-5-6-15-3-1-2-4-17(15)11-14/h1-6,11,13,16,20,23H,7-10,12H2
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n/an/a 170n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells by FMP red assay

J Med Chem 53: 3417-21 (2010)


Article DOI: 10.1021/jm100106r
BindingDB Entry DOI: 10.7270/Q2GF0VFM
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50378763
PNG
(CHEMBL1204077)
Show SMILES On1cc(C2CCNCC2)c(n1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C20H21N3O/c24-23-14-19(16-9-11-21-12-10-16)20(22-23)18-8-4-7-17(13-18)15-5-2-1-3-6-15/h1-8,13-14,16,21,24H,9-12H2
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n/an/a 210n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human alpha1beta2gamma2S GABA-A receptor expressed in tsA201 cells assessed as inhibition of GABA-induced effect after 30 mins...

J Med Chem 56: 6536-40 (2013)


Article DOI: 10.1021/jm4006466
BindingDB Entry DOI: 10.7270/Q2K35XKM
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50378763
PNG
(CHEMBL1204077)
Show SMILES On1cc(C2CCNCC2)c(n1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C20H21N3O/c24-23-14-19(16-9-11-21-12-10-16)20(22-23)18-8-4-7-17(13-18)15-5-2-1-3-6-15/h1-8,13-14,16,21,24H,9-12H2
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n/an/a 210n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells by FMP red assay

J Med Chem 53: 3417-21 (2010)


Article DOI: 10.1021/jm100106r
BindingDB Entry DOI: 10.7270/Q2GF0VFM
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50493007
PNG
(CHEMBL2420450)
Show SMILES On1cc(C2CCNCC2)c(n1)-c1cn(Cc2ccccc2)c(n1)-c1ccccc1
Show InChI InChI=1S/C24H25N5O/c30-29-16-21(19-11-13-25-14-12-19)23(27-29)22-17-28(15-18-7-3-1-4-8-18)24(26-22)20-9-5-2-6-10-20/h1-10,16-17,19,25,30H,11-15H2
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n/an/a 210n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human alpha1beta2gamma2S GABA-A receptor expressed in tsA201 cells assessed as inhibition of GABA-induced effect after 30 mins...

J Med Chem 56: 6536-40 (2013)


Article DOI: 10.1021/jm4006466
BindingDB Entry DOI: 10.7270/Q2K35XKM
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50378763
PNG
(CHEMBL1204077)
Show SMILES On1cc(C2CCNCC2)c(n1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C20H21N3O/c24-23-14-19(16-9-11-21-12-10-16)20(22-23)18-8-4-7-17(13-18)15-5-2-1-3-6-15/h1-8,13-14,16,21,24H,9-12H2
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n/an/a 210n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human alpha1beta2gamma2S GABA(A) receptor expressed in human tsA201 cells assessed as inhibition of GABA-induced membrane pote...

J Med Chem 62: 2798-2813 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00131
BindingDB Entry DOI: 10.7270/Q2D2225V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50493007
PNG
(CHEMBL2420450)
Show SMILES On1cc(C2CCNCC2)c(n1)-c1cn(Cc2ccccc2)c(n1)-c1ccccc1
Show InChI InChI=1S/C24H25N5O/c30-29-16-21(19-11-13-25-14-12-19)23(27-29)22-17-28(15-18-7-3-1-4-8-18)24(26-22)20-9-5-2-6-10-20/h1-10,16-17,19,25,30H,11-15H2
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n/an/a 214n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human alpha1beta2gamma2S GABA-A receptor expressed in tsA201 cells assessed as inhibition of GABA-induced effect after 30 mins...

J Med Chem 56: 6536-40 (2013)


Article DOI: 10.1021/jm4006466
BindingDB Entry DOI: 10.7270/Q2K35XKM
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50001572
PNG
((gabazine)4-[6-Imino-3-(4-methoxy-phenyl)-6H-pyrid...)
Show SMILES COc1ccc(cc1)-c1ccc(=N)n(CCCC(O)=O)n1
Show InChI InChI=1S/C15H17N3O3/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20/h4-9,16H,2-3,10H2,1H3,(H,19,20)
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n/an/a 240n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human alpha1beta2gamma2S GABA(A) receptor expressed in human tsA201 cells assessed as inhibition of GABA-induced membrane pote...

J Med Chem 62: 2798-2813 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00131
BindingDB Entry DOI: 10.7270/Q2D2225V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50001572
PNG
((gabazine)4-[6-Imino-3-(4-methoxy-phenyl)-6H-pyrid...)
Show SMILES COc1ccc(cc1)-c1ccc(=N)n(CCCC(O)=O)n1
Show InChI InChI=1S/C15H17N3O3/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20/h4-9,16H,2-3,10H2,1H3,(H,19,20)
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n/an/a 240n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human alpha1beta2gamma2S GABA-A receptor expressed in tsA201 cells assessed as inhibition of GABA-induced effect after 30 mins...

J Med Chem 56: 6536-40 (2013)


Article DOI: 10.1021/jm4006466
BindingDB Entry DOI: 10.7270/Q2K35XKM
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50337266
PNG
(3-(2-chlorobenzyloxy)-2-(4-chlorophenyl)-2,6,7,8,9...)
Show SMILES Clc1ccc(cc1)-n1nc2c3CCCCCc3ncc2c1OCc1ccccc1Cl
Show InChI InChI=1S/C24H21Cl2N3O/c25-17-10-12-18(13-11-17)29-24(30-15-16-6-4-5-8-21(16)26)20-14-27-22-9-3-1-2-7-19(22)23(20)28-29/h4-6,8,10-14H,1-3,7,9,15H2
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n/an/a 242n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cells

Bioorg Med Chem Lett 21: 1523-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.107
BindingDB Entry DOI: 10.7270/Q289164V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM31093
PNG
(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Show SMILES OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 |c:13|
Show InChI InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32)
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n/an/a 330n/an/an/an/an/an/a



Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL


Assay Description
Binding affinity to GABAA alpha-1 benzodiazepine binding site (unknown origin)

ACS Med Chem Lett 6: 630-4 (2015)


Article DOI: 10.1021/ml500409n
BindingDB Entry DOI: 10.7270/Q2WS8W1V
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50001572
PNG
((gabazine)4-[6-Imino-3-(4-methoxy-phenyl)-6H-pyrid...)
Show SMILES COc1ccc(cc1)-c1ccc(=N)n(CCCC(O)=O)n1
Show InChI InChI=1S/C15H17N3O3/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20/h4-9,16H,2-3,10H2,1H3,(H,19,20)
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n/an/a 349n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABA A receptor alpha1beta2gamma2S expressed in HEK293 cells assessed as inhibition of GABA-induced current ...

Bioorg Med Chem Lett 21: 4252-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.067
BindingDB Entry DOI: 10.7270/Q2QR5101
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50244157
PNG
(CHEMBL458317 | N-(4-chlorophenyl)-5-(2-(methylthio...)
Show SMILES CSc1nccc(n1)-c1ccc(s1)S(=O)(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C15H12ClN3O2S3/c1-22-15-17-9-8-12(18-15)13-6-7-14(23-13)24(20,21)19-11-4-2-10(16)3-5-11/h2-9,19H,1H3
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n/an/a 470n/an/an/an/an/an/a



Moltech Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro15-4513 from GABAA alpha-1-beta-2-gamma-2 receptor expressed in Sf9 baculovirus system

J Med Chem 51: 3788-803 (2008)


Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM126720
PNG
(US8778932, 31)
Show SMILES CC1=NN=C(c2cc3c(cccc3s2)C(F)(F)F)c2cc3oc(=O)[nH]c3cc2C1 |t:1,3|
Show InChI InChI=1S/C20H12F3N3O2S/c1-9-5-10-6-14-15(28-19(27)24-14)7-11(10)18(26-25-9)17-8-12-13(20(21,22)23)3-2-4-16(12)29-17/h2-4,6-8H,5H2,1H3,(H,24,27)
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n/an/a 479n/an/an/an/an/an/a



Jain University

Curated by ChEMBL


Assay Description
Antagonist activity at human GABA-A alpha1 receptor expressed in HEK293 cell membranes assessed as inhibition of GABA-induced response preincubated f...

Eur J Med Chem 138: 1002-1033 (2017)


Article DOI: 10.1016/j.ejmech.2017.07.038
BindingDB Entry DOI: 10.7270/Q2C24ZZC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50378771
PNG
(CHEMBL1204073)
Show SMILES On1ncc(C2CCNCC2)c1Cc1ccc2ccccc2c1Br
Show InChI InChI=1S/C19H20BrN3O/c20-19-15(6-5-13-3-1-2-4-16(13)19)11-18-17(12-22-23(18)24)14-7-9-21-10-8-14/h1-6,12,14,21,24H,7-11H2
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n/an/a 480n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells by FMP red assay

J Med Chem 53: 3417-21 (2010)


Article DOI: 10.1021/jm100106r
BindingDB Entry DOI: 10.7270/Q2GF0VFM
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Homo sapiens (Human))		BDBM50277545
PNG
(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Show SMILES COc1cc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2OC)ccc1C(O)=O |c:11|
Show InChI InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)
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n/an/a 490n/an/an/an/an/an/a



Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL


Assay Description
Binding affinity to GABAA alpha-1 benzodiazepine binding site (unknown origin)

ACS Med Chem Lett 6: 630-4 (2015)


Article DOI: 10.1021/ml500409n
BindingDB Entry DOI: 10.7270/Q2WS8W1V
More data for this
Ligand-Target Pair
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