Found 251 hits of ic50 for UniProtKB: P53582 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50267199
(CHEMBL4079583)Show SMILES COc1ccc(cc1)N1CCN(CC1)c1nc(nc2ccccc12)-c1ccccn1 Show InChI InChI=1S/C24H23N5O/c1-30-19-11-9-18(10-12-19)28-14-16-29(17-15-28)24-20-6-2-3-7-21(20)26-23(27-24)22-8-4-5-13-25-22/h2-13H,14-17H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado Mesa University
Curated by ChEMBL
| Assay Description Inhibition of human MetAP1 |
J Nat Prod 80: 740-755 (2017)
Article DOI: 10.1021/acs.jnatprod.6b00970 BindingDB Entry DOI: 10.7270/Q2SN0CG4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435227
(CHEMBL2392772)Show SMILES Cc1nc(nc(NC2CCN(CC2)c2ncc(cc2Cl)C(F)(F)F)c1Cl)-c1ccccn1 Show InChI InChI=1S/C21H19Cl2F3N6/c1-12-17(23)19(31-18(29-12)16-4-2-3-7-27-16)30-14-5-8-32(9-6-14)20-15(22)10-13(11-28-20)21(24,25)26/h2-4,7,10-11,14H,5-6,8-9H2,1H3,(H,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM17589
((2S,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N-[(1S...)Show SMILES CCSCC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12 |r| Show InChI InChI=1S/C19H26N2O2S/c1-3-24-12-11-17(20)18(22)19(23)21-13(2)15-10-6-8-14-7-4-5-9-16(14)15/h4-10,13,17-18,22H,3,11-12,20H2,1-2H3,(H,21,23)/t13-,17+,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Abbott Laboratories
| Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L... |
Cancer Res 63: 7861-9 (2003)
BindingDB Entry DOI: 10.7270/Q2Z31WXK |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM17589
((2S,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N-[(1S...)Show SMILES CCSCC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12 |r| Show InChI InChI=1S/C19H26N2O2S/c1-3-24-12-11-17(20)18(22)19(23)21-13(2)15-10-6-8-14-7-4-5-9-16(14)15/h4-10,13,17-18,22H,3,11-12,20H2,1-2H3,(H,21,23)/t13-,17+,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against human methionine aminopeptidase-1 |
Bioorg Med Chem Lett 14: 865-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM17847
(CHEMBL327579 | pyridine-2-carboxylic acid inhibito...)Show InChI InChI=1S/C14H16N4O3S/c1-14(2,3)21-13(20)17-9-5-4-6-15-10(9)11(19)18-12-16-7-8-22-12/h4-8H,1-3H3,(H,17,20)(H,16,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado Mesa University
Curated by ChEMBL
| Assay Description Inhibition of human MetAP1 |
J Nat Prod 80: 740-755 (2017)
Article DOI: 10.1021/acs.jnatprod.6b00970 BindingDB Entry DOI: 10.7270/Q2SN0CG4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435217
(CHEMBL2392900)Show SMILES Cc1nc(nc(NC[C@H](NS(=O)(=O)CCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1 |r| Show InChI InChI=1S/C26H34ClN7O3S/c1-20-24(27)26(31-25(30-20)22-9-5-6-10-28-22)29-19-23(21-7-3-2-4-8-21)32-38(36,37)18-16-34-13-11-33(12-14-34)15-17-35/h2-10,23,32,35H,11-19H2,1H3,(H,29,30,31)/t23-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435224
(CHEMBL2392893)Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1 |r| Show InChI InChI=1S/C25H30ClN7O/c1-18-23(26)25(32-24(30-18)20-9-5-6-11-28-20)29-17-21(19-7-3-2-4-8-19)31-22(34)10-14-33-15-12-27-13-16-33/h2-9,11,21,27H,10,12-17H2,1H3,(H,31,34)(H,29,30,32)/t21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50433375
(CHEMBL472879 | GNF-Pf-359)Show InChI InChI=1S/C18H17ClN4/c1-13-16(19)18(21-12-10-14-7-3-2-4-8-14)23-17(22-13)15-9-5-6-11-20-15/h2-9,11H,10,12H2,1H3,(H,21,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01721 BindingDB Entry DOI: 10.7270/Q2BG2SZC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50295174
(Bengamide A | CHEMBL256279)Show SMILES CCCCCCCCCCCCCC(=O)O[C@H]1CC[C@H](NC(=O)[C@H](OC)[C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)C)C(=O)NC1 |r| Show InChI InChI=1S/C31H56N2O8/c1-5-6-7-8-9-10-11-12-13-14-15-16-26(35)41-23-18-19-24(30(38)32-21-23)33-31(39)29(40-4)28(37)27(36)25(34)20-17-22(2)3/h17,20,22-25,27-29,34,36-37H,5-16,18-19,21H2,1-4H3,(H,32,38)(H,33,39)/b20-17+/t23-,24-,25+,27-,28+,29+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado Mesa University
Curated by ChEMBL
| Assay Description Inhibition of human MetAP1 |
J Nat Prod 80: 740-755 (2017)
Article DOI: 10.1021/acs.jnatprod.6b00970 BindingDB Entry DOI: 10.7270/Q2SN0CG4 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50267193
(CHEMBL4078211)Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)(C)C)C(=O)N[C@H]1CC[C@H](CNC1=O)OC(=O)C1CCCCC1 |r| Show InChI InChI=1S/C25H42N2O8/c1-25(2,3)13-12-18(28)19(29)20(30)21(34-4)23(32)27-17-11-10-16(14-26-22(17)31)35-24(33)15-8-6-5-7-9-15/h12-13,15-21,28-30H,5-11,14H2,1-4H3,(H,26,31)(H,27,32)/b13-12+/t16-,17+,18-,19+,20-,21-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado Mesa University
Curated by ChEMBL
| Assay Description Inhibition of human MetAP1 |
J Nat Prod 80: 740-755 (2017)
Article DOI: 10.1021/acs.jnatprod.6b00970 BindingDB Entry DOI: 10.7270/Q2SN0CG4 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435219
(CHEMBL2392898)Show SMILES Cc1nc(nc(NC[C@H](NCCCCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1 |r| Show InChI InChI=1S/C28H38ClN7O/c1-22-26(29)28(34-27(33-22)24-11-5-6-12-30-24)32-21-25(23-9-3-2-4-10-23)31-13-7-8-14-35-15-17-36(18-16-35)19-20-37/h2-6,9-12,25,31,37H,7-8,13-21H2,1H3,(H,32,33,34)/t25-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435218
(CHEMBL2392899)Show SMILES Cc1nc(nc(NC[C@H](NS(=O)(=O)CCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1 |r| Show InChI InChI=1S/C24H30ClN7O2S/c1-18-22(25)24(30-23(29-18)20-9-5-6-10-27-20)28-17-21(19-7-3-2-4-8-19)31-35(33,34)16-15-32-13-11-26-12-14-32/h2-10,21,26,31H,11-17H2,1H3,(H,28,29,30)/t21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435226
(CHEMBL2392891)Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1 |r| Show InChI InChI=1S/C27H34ClN7O2/c1-20-25(28)27(33-26(31-20)22-9-5-6-11-29-22)30-19-23(21-7-3-2-4-8-21)32-24(37)10-12-34-13-15-35(16-14-34)17-18-36/h2-9,11,23,36H,10,12-19H2,1H3,(H,32,37)(H,30,31,33)/t23-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50433375
(CHEMBL472879 | GNF-Pf-359)Show InChI InChI=1S/C18H17ClN4/c1-13-16(19)18(21-12-10-14-7-3-2-4-8-14)23-17(22-13)15-9-5-6-11-20-15/h2-9,11H,10,12H2,1H3,(H,21,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 860 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50497538
(CHEMBL3337748)Show InChI InChI=1S/C10H7ClO/c1-6-4-7-5-8(11)2-3-9(7)10(6)12/h2-3,5H,1,4H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Heidelberg University
Curated by ChEMBL
| Assay Description Inhibition of N-terminal poly-His-tagged human MetAP-1 expressed in Escherichia coli BL21(DE3) incubated for 30 mins before MGMM substrate addition b... |
Bioorg Med Chem Lett 24: 5310-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.047 BindingDB Entry DOI: 10.7270/Q2057JW8 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435229
(CHEMBL2392771)Show SMILES Cc1nc(nc(NCCNc2cccc(n2)C(F)(F)F)c1Cl)-c1ccccn1 Show InChI InChI=1S/C18H16ClF3N6/c1-11-15(19)17(28-16(26-11)12-5-2-3-8-23-12)25-10-9-24-14-7-4-6-13(27-14)18(20,21)22/h2-8H,9-10H2,1H3,(H,24,27)(H,25,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435223
(CHEMBL2392894)Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1 |r| Show InChI InChI=1S/C26H32ClN7O/c1-19-24(27)26(33-25(31-19)21-10-5-6-12-29-21)30-18-22(20-8-3-2-4-9-20)32-23(35)11-7-15-34-16-13-28-14-17-34/h2-6,8-10,12,22,28H,7,11,13-18H2,1H3,(H,32,35)(H,30,31,33)/t22-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435225
(CHEMBL2392892)Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1 |r| Show InChI InChI=1S/C28H36ClN7O2/c1-21-26(29)28(34-27(32-21)23-10-5-6-12-30-23)31-20-24(22-8-3-2-4-9-22)33-25(38)11-7-13-35-14-16-36(17-15-35)18-19-37/h2-6,8-10,12,24,37H,7,11,13-20H2,1H3,(H,33,38)(H,31,32,34)/t24-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435228
(CHEMBL460432)Show InChI InChI=1S/C16H20ClN5O/c1-12-14(17)16(22-8-6-21(7-9-22)10-11-23)20-15(19-12)13-4-2-3-5-18-13/h2-5,23H,6-11H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50141738
((2S,3R)-3-Amino-5-ethylsulfanyl-2-hydroxy-pentanoi...)Show InChI InChI=1S/C13H20N2O3S/c1-2-19-9-8-11(14)12(16)13(17)15-18-10-6-4-3-5-7-10/h3-7,11-12,16H,2,8-9,14H2,1H3,(H,15,17)/t11-,12+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against human methionine aminopeptidase-1 |
Bioorg Med Chem Lett 14: 865-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435220
(CHEMBL2392897)Show SMILES Cc1nc(nc(NC[C@H](NCCCCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1 |r| Show InChI InChI=1S/C26H34ClN7/c1-20-24(27)26(33-25(32-20)22-11-5-6-12-29-22)31-19-23(21-9-3-2-4-10-21)30-13-7-8-16-34-17-14-28-15-18-34/h2-6,9-12,23,28,30H,7-8,13-19H2,1H3,(H,31,32,33)/t23-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50141691
((1S,2R)-3-Amino-5-ethylsulfanyl-2-hydroxy-pentanoi...)Show InChI InChI=1S/C14H23N3O2S/c1-3-20-9-8-12(15)13(18)14(19)17-16-11-6-4-10(2)5-7-11/h4-7,12-13,16,18H,3,8-9,15H2,1-2H3,(H,17,19)/t12-,13+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against human methionine aminopeptidase-1 |
Bioorg Med Chem Lett 14: 865-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435222
(CHEMBL2392895)Show SMILES Cc1nc(nc(NC[C@H](NCCCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1 |r| Show InChI InChI=1S/C25H32ClN7/c1-19-23(26)25(32-24(31-19)21-10-5-6-11-28-21)30-18-22(20-8-3-2-4-9-20)29-12-7-15-33-16-13-27-14-17-33/h2-6,8-11,22,27,29H,7,12-18H2,1H3,(H,30,31,32)/t22-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435231
(CHEMBL2392769)Show InChI InChI=1S/C18H17ClN4/c1-13-16(19)18(23(2)12-14-8-4-3-5-9-14)22-17(21-13)15-10-6-7-11-20-15/h3-11H,12H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM17847
(CHEMBL327579 | pyridine-2-carboxylic acid inhibito...)Show InChI InChI=1S/C14H16N4O3S/c1-14(2,3)21-13(20)17-9-5-4-6-15-10(9)11(19)18-12-16-7-8-22-12/h4-8H,1-3H3,(H,17,20)(H,16,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johns Hopkins University
| Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c... |
Proc Natl Acad Sci U S A 103: 18148-53 (2006)
Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50141693
((S)-3-Amino-2-hydroxy-4-isobutylsulfanyl-N-phenoxy...)Show InChI InChI=1S/C14H22N2O3S/c1-10(2)8-20-9-12(15)13(17)14(18)16-19-11-6-4-3-5-7-11/h3-7,10,12-13,17H,8-9,15H2,1-2H3,(H,16,18)/t12-,13+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against human methionine aminopeptidase-1 |
Bioorg Med Chem Lett 14: 865-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50141746
((S)-3-Amino-2-hydroxy-N-((S)-1-naphthalen-1-yl-eth...)Show SMILES CCCSC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12 Show InChI InChI=1S/C19H26N2O2S/c1-3-11-24-12-17(20)18(22)19(23)21-13(2)15-10-6-8-14-7-4-5-9-16(14)15/h4-10,13,17-18,22H,3,11-12,20H2,1-2H3,(H,21,23)/t13-,17+,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against human methionine aminopeptidase-1 |
Bioorg Med Chem Lett 14: 865-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50141713
((S)-3-Amino-2-hydroxy-N-phenoxy-4-propylsulfanyl-b...)Show InChI InChI=1S/C13H20N2O3S/c1-2-8-19-9-11(14)12(16)13(17)15-18-10-6-4-3-5-7-10/h3-7,11-12,16H,2,8-9,14H2,1H3,(H,15,17)/t11-,12+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against human methionine aminopeptidase-1 |
Bioorg Med Chem Lett 14: 865-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435221
(CHEMBL2392896)Show SMILES Cc1nc(nc(NC[C@H](NCCCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1 |r| Show InChI InChI=1S/C27H36ClN7O/c1-21-25(28)27(33-26(32-21)23-10-5-6-11-29-23)31-20-24(22-8-3-2-4-9-22)30-12-7-13-34-14-16-35(17-15-34)18-19-36/h2-6,8-11,24,30,36H,7,12-20H2,1H3,(H,31,32,33)/t24-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM68281
(Bengamide A)Show SMILES CCCCCCCCCCCCCOC(=O)C1CCC(NC(=O)[C@H](OC)[C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)C)C(=O)NC1 |r| Show InChI InChI=1S/C31H56N2O8/c1-5-6-7-8-9-10-11-12-13-14-15-20-41-31(39)23-17-18-24(29(37)32-21-23)33-30(38)28(40-4)27(36)26(35)25(34)19-16-22(2)3/h16,19,22-28,34-36H,5-15,17-18,20-21H2,1-4H3,(H,32,37)(H,33,38)/b19-16+/t23?,24?,25-,26+,27-,28-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Johns Hopkins University
| Assay Description The determined effects of seven bengamide analogs on the enzymatic activity of both recombinated human MetAP1 and MetAP2 in vitro. |
Chem Biol 14: 764-74 (2007)
Article DOI: 10.1016/j.chembiol.2007.05.010 BindingDB Entry DOI: 10.7270/Q2NC5ZN9 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50433377
(CHEMBL2375628)Show SMILES Cc1nc(nc(NCCNc2ccc(cn2)C(F)(F)F)c1Cl)-c1ccccn1 Show InChI InChI=1S/C18H16ClF3N6/c1-11-15(19)17(28-16(27-11)13-4-2-3-7-23-13)25-9-8-24-14-6-5-12(10-26-14)18(20,21)22/h2-7,10H,8-9H2,1H3,(H,24,26)(H,25,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50295174
(Bengamide A | CHEMBL256279)Show SMILES CCCCCCCCCCCCCC(=O)O[C@H]1CC[C@H](NC(=O)[C@H](OC)[C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)C)C(=O)NC1 |r| Show InChI InChI=1S/C31H56N2O8/c1-5-6-7-8-9-10-11-12-13-14-15-16-26(35)41-23-18-19-24(30(38)32-21-23)33-31(39)29(40-4)28(37)27(36)25(34)20-17-22(2)3/h17,20,22-25,27-29,34,36-37H,5-16,18-19,21H2,1-4H3,(H,32,38)(H,33,39)/b20-17+/t23-,24-,25+,27-,28+,29+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Santa Cruz
Curated by ChEMBL
| Assay Description Inhibition of methionine aminopeptidase 1 |
J Nat Prod 72: 588-603 (2010)
Article DOI: 10.1021/np800817y BindingDB Entry DOI: 10.7270/Q2765G84 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM17847
(CHEMBL327579 | pyridine-2-carboxylic acid inhibito...)Show InChI InChI=1S/C14H16N4O3S/c1-14(2,3)21-13(20)17-9-5-4-6-15-10(9)11(19)18-12-16-7-8-22-12/h4-8H,1-3H3,(H,17,20)(H,16,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Santa Cruz
Curated by ChEMBL
| Assay Description Inhibition of methionine aminopeptidase 1 |
J Nat Prod 72: 588-603 (2010)
Article DOI: 10.1021/np800817y BindingDB Entry DOI: 10.7270/Q2765G84 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM17590
((2S,3S)-3-amino-2-hydroxy-4-[(2-methylpropyl)sulfa...)Show SMILES CC(C)CSC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12 |r| Show InChI InChI=1S/C20H28N2O2S/c1-13(2)11-25-12-18(21)19(23)20(24)22-14(3)16-10-6-8-15-7-4-5-9-17(15)16/h4-10,13-14,18-19,23H,11-12,21H2,1-3H3,(H,22,24)/t14-,18+,19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Abbott Laboratories
| Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L... |
Cancer Res 63: 7861-9 (2003)
BindingDB Entry DOI: 10.7270/Q2Z31WXK |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM17590
((2S,3S)-3-amino-2-hydroxy-4-[(2-methylpropyl)sulfa...)Show SMILES CC(C)CSC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12 |r| Show InChI InChI=1S/C20H28N2O2S/c1-13(2)11-25-12-18(21)19(23)20(24)22-14(3)16-10-6-8-15-7-4-5-9-17(15)16/h4-10,13-14,18-19,23H,11-12,21H2,1-3H3,(H,22,24)/t14-,18+,19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against human methionine aminopeptidase-1 |
Bioorg Med Chem Lett 14: 865-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM68286
(Bengamide N | Bengamide O)Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)C)C(=O)NC1CCC(CN(C)C1=O)C(=O)OCCCCCCCCCCC(C)C |r| Show InChI InChI=1S/C32H58N2O8/c1-22(2)15-13-11-9-7-8-10-12-14-20-42-32(40)24-17-18-25(31(39)34(5)21-24)33-30(38)29(41-6)28(37)27(36)26(35)19-16-23(3)4/h16,19,22-29,35-37H,7-15,17-18,20-21H2,1-6H3,(H,33,38)/b19-16+/t24?,25?,26-,27+,28-,29-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Johns Hopkins University
| Assay Description The determined effects of seven bengamide analogs on the enzymatic activity of both recombinated human MetAP1 and MetAP2 in vitro. |
Chem Biol 14: 764-74 (2007)
Article DOI: 10.1016/j.chembiol.2007.05.010 BindingDB Entry DOI: 10.7270/Q2NC5ZN9 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM17849
(3-(2,2-dimethylpropanamido)-N-(1,3-thiazol-2-yl)py...)Show InChI InChI=1S/C14H16N4O2S/c1-14(2,3)12(20)17-9-5-4-6-15-10(9)11(19)18-13-16-7-8-21-13/h4-8H,1-3H3,(H,17,20)(H,16,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johns Hopkins University
| Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c... |
Proc Natl Acad Sci U S A 103: 18148-53 (2006)
Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50267195
(CHEMBL4061080)Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)C)C(=O)N[C@H]1CC[C@@H](CNC1=O)OC(=O)CCCCCCCCCCC(C)C |r| Show InChI InChI=1S/C31H56N2O8/c1-21(2)14-12-10-8-6-7-9-11-13-15-26(35)41-23-17-18-24(30(38)32-20-23)33-31(39)29(40-5)28(37)27(36)25(34)19-16-22(3)4/h16,19,21-25,27-29,34,36-37H,6-15,17-18,20H2,1-5H3,(H,32,38)(H,33,39)/b19-16+/t23-,24-,25+,27-,28+,29+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado Mesa University
Curated by ChEMBL
| Assay Description Inhibition of human MetAP1 |
J Nat Prod 80: 740-755 (2017)
Article DOI: 10.1021/acs.jnatprod.6b00970 BindingDB Entry DOI: 10.7270/Q2SN0CG4 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50295173
(Bengamide O | CHEMBL539894)Show SMILES CCC(C)CCCCCCCCCCC(=O)O[C@H]1CC[C@H](NC(=O)[C@H](OC)[C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)C)C(=O)N(C)C1 |r| Show InChI InChI=1S/C33H60N2O8/c1-7-24(4)16-14-12-10-8-9-11-13-15-17-28(37)43-25-19-20-26(33(41)35(5)22-25)34-32(40)31(42-6)30(39)29(38)27(36)21-18-23(2)3/h18,21,23-27,29-31,36,38-39H,7-17,19-20,22H2,1-6H3,(H,34,40)/b21-18+/t24?,25-,26-,27+,29-,30+,31+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Santa Cruz
Curated by ChEMBL
| Assay Description Inhibition of methionine aminopeptidase 1 |
J Nat Prod 72: 588-603 (2010)
Article DOI: 10.1021/np800817y BindingDB Entry DOI: 10.7270/Q2765G84 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM17850
(3-(3-phenylpropanamido)-N-(1,3-thiazol-2-yl)pyridi...)Show InChI InChI=1S/C18H16N4O2S/c23-15(9-8-13-5-2-1-3-6-13)21-14-7-4-10-19-16(14)17(24)22-18-20-11-12-25-18/h1-7,10-12H,8-9H2,(H,21,23)(H,20,22,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johns Hopkins University
| Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c... |
Proc Natl Acad Sci U S A 103: 18148-53 (2006)
Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50497521
(CHEMBL3337749)Show InChI InChI=1S/C10H7BrO/c1-6-4-7-5-8(11)2-3-9(7)10(6)12/h2-3,5H,1,4H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Heidelberg University
Curated by ChEMBL
| Assay Description Inhibition of N-terminal poly-His-tagged human MetAP-1 expressed in Escherichia coli BL21(DE3) incubated for 30 mins before MGMM substrate addition b... |
Bioorg Med Chem Lett 24: 5310-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.047 BindingDB Entry DOI: 10.7270/Q2057JW8 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50497528
(CHEMBL3337742)Show InChI InChI=1S/C12H14BrNO.ClH/c1-14(2)7-9-5-8-6-10(13)3-4-11(8)12(9)15;/h3-4,6,9H,5,7H2,1-2H3;1H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Heidelberg University
Curated by ChEMBL
| Assay Description Inhibition of N-terminal poly-His-tagged human MetAP-1 expressed in Escherichia coli BL21(DE3) incubated for 30 mins before MGMM substrate addition b... |
Bioorg Med Chem Lett 24: 5310-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.047 BindingDB Entry DOI: 10.7270/Q2057JW8 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50398199
(CHEMBL1738934)Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)(C)C)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C14H26N2O6/c1-14(2,3)6-5-8(17)10(19)11(20)12(22-4)13(21)16-7-9(15)18/h5-6,8,10-12,17,19-20H,7H2,1-4H3,(H2,15,18)(H,16,21)/b6-5+/t8-,10+,11-,12-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 3.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of Mn(II) form of human methionine aminopeptidase1 expressed in Escherichia coli at 100 mM |
J Med Chem 55: 8021-7 (2012)
Article DOI: 10.1021/jm3008695 BindingDB Entry DOI: 10.7270/Q2T43V72 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435237
(CHEMBL2392764)Show InChI InChI=1S/C18H17FN4/c1-13-16(19)18(21-12-10-14-7-3-2-4-8-14)23-17(22-13)15-9-5-6-11-20-15/h2-9,11H,10,12H2,1H3,(H,21,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50141708
((R)-3-Amino-2-hydroxy-5-isopropylsulfanyl-pentanoi...)Show InChI InChI=1S/C14H22N2O3S/c1-10(2)20-9-8-12(15)13(17)14(18)16-19-11-6-4-3-5-7-11/h3-7,10,12-13,17H,8-9,15H2,1-2H3,(H,16,18)/t12-,13+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against human methionine aminopeptidase-1 |
Bioorg Med Chem Lett 14: 865-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50141697
(3-Amino-2-(S)-hydroxy-4-propylsulfanyl-butyric aci...)Show InChI InChI=1S/C14H23N3O2S/c1-3-8-20-9-12(15)13(18)14(19)17-16-11-6-4-10(2)5-7-11/h4-7,12-13,16,18H,3,8-9,15H2,1-2H3,(H,17,19)/t12-,13+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against human methionine aminopeptidase-1 |
Bioorg Med Chem Lett 14: 865-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50398196
(CHEMBL2181034)Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)(C)C)C(=O)NCCC(c1ccco1)c1ccccc1 |r| Show InChI InChI=1S/C25H35NO6/c1-25(2,3)14-12-19(27)21(28)22(29)23(31-4)24(30)26-15-13-18(20-11-8-16-32-20)17-9-6-5-7-10-17/h5-12,14,16,18-19,21-23,27-29H,13,15H2,1-4H3,(H,26,30)/b14-12+/t18?,19-,21+,22-,23-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of Mn(II) form of human methionine aminopeptidase1 expressed in Escherichia coli at 100 mM |
J Med Chem 55: 8021-7 (2012)
Article DOI: 10.1021/jm3008695 BindingDB Entry DOI: 10.7270/Q2T43V72 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50141699
((2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-N-(1-naphth...)Show SMILES CC(NC(=O)[C@@H](O)[C@H](N)CC1CCCCC1)c1ccc2ccccc2c1 Show InChI InChI=1S/C22H30N2O2/c1-15(18-12-11-17-9-5-6-10-19(17)14-18)24-22(26)21(25)20(23)13-16-7-3-2-4-8-16/h5-6,9-12,14-16,20-21,25H,2-4,7-8,13,23H2,1H3,(H,24,26)/t15?,20-,21+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against human methionine aminopeptidase-1 |
Bioorg Med Chem Lett 14: 865-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM68285
(Bengamide M)Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)C)C(=O)NC1CCC(CN(C)C1=O)C(=O)OCCCCCCCCCCCC(C)C |r| Show InChI InChI=1S/C33H60N2O8/c1-23(2)16-14-12-10-8-7-9-11-13-15-21-43-33(41)25-18-19-26(32(40)35(5)22-25)34-31(39)30(42-6)29(38)28(37)27(36)20-17-24(3)4/h17,20,23-30,36-38H,7-16,18-19,21-22H2,1-6H3,(H,34,39)/b20-17+/t25?,26?,27-,28+,29-,30-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Johns Hopkins University
| Assay Description The determined effects of seven bengamide analogs on the enzymatic activity of both recombinated human MetAP1 and MetAP2 in vitro. |
Chem Biol 14: 764-74 (2007)
Article DOI: 10.1016/j.chembiol.2007.05.010 BindingDB Entry DOI: 10.7270/Q2NC5ZN9 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50398197
(CHEMBL1738933)Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)(C)C)C(=O)NC1Cc2ccccc2C1 |r| Show InChI InChI=1S/C21H31NO5/c1-21(2,3)10-9-16(23)17(24)18(25)19(27-4)20(26)22-15-11-13-7-5-6-8-14(13)12-15/h5-10,15-19,23-25H,11-12H2,1-4H3,(H,22,26)/b10-9+/t16-,17+,18-,19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 5.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of Mn(II) form of human methionine aminopeptidase1 expressed in Escherichia coli at 100 mM |
J Med Chem 55: 8021-7 (2012)
Article DOI: 10.1021/jm3008695 BindingDB Entry DOI: 10.7270/Q2T43V72 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |