Compile Data Set for Download or QSAR

Found 1474 hits of ic50 for UniProtKB: P13866   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50242614 ((S)-1-((S)-2-((S)-2,5-diamino-5-oxopentanamido)-3-...) Show SMILES N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C13H22N4O6/c14-7(3-4-10(15)19)11(20)16-8(6-18)12(21)17-5-1-2-9(17)13(22)23/h7-9,18H,1-6,14H2,(H2,15,19)(H,16,20)(H,22,23)/t7-,8-,9-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
University Würzburg Curated by ChEMBL					Assay Description Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibition of methyl-alpha-D-[14C]glucopyranoside uptake after 1 hrs				J Biol Chem 282: 28501-13 (2007) Article DOI: 10.1074/jbc.M705416200 BindingDB Entry DOI: 10.7270/Q2SJ1KCM
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50242617 (CHEMBL521026 | QSPac) Show SMILES CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(O)=O |r| Show InChI InChI=1S/C15H24N4O7/c1-8(21)19-6-2-3-11(19)14(24)18-10(7-20)13(23)17-9(15(25)26)4-5-12(16)22/h9-11,20H,2-7H2,1H3,(H2,16,22)(H,17,23)(H,18,24)(H,25,26)/t9-,10-,11-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
University Würzburg Curated by ChEMBL					Assay Description Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibition of methyl-alpha-D-[14C]glucopyranoside uptake after 1 hrs				J Biol Chem 282: 28501-13 (2007) Article DOI: 10.1074/jbc.M705416200 BindingDB Entry DOI: 10.7270/Q2SJ1KCM
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50560402 (LIK-066 | Licogliflozin | Lik066 | USRE49080, Exam...) Show SMILES CCc1ccc(cc1Cc1ccc2OCCOc2c1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of SGLT1 (unknown origin)				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127387 BindingDB Entry DOI: 10.7270/Q2DZ0D1D
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM402285 (US10011627, 1) Show SMILES OC[C@@]12CO[C@@](O1)([C@H](O)[C@@H](O)[C@@H]2O)c1ccc(Cl)c(Cc2ccc3OCCOc3c2)c1 |TLB:10:9:3.4:6,THB:12:11:3.4:6,8:7:3.4:6| Show InChI InChI=1S/C22H23ClO8/c23-15-3-2-14(22-20(27)18(25)19(26)21(10-24,31-22)11-30-22)9-13(15)7-12-1-4-16-17(8-12)29-6-5-28-16/h1-4,8-9,18-20,24-27H,5-7,10-11H2/t18-,19-,20+,21-,22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a	n/a
Vernalis (R&D) Ltd					Assay Description The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...				Bioorg Med Chem 17: 6590-605 (2009) BindingDB Entry DOI: 10.7270/Q2C24ZS4
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132916 (US8846746, 194) Show SMILES C[C@@H]1[C@H](CNC1=O)C(=O)Nc1cc(-c2cccc(c2)C(C)(C)C)n(n1)-c1ccccc1Cl |r| Show InChI InChI=1S/C25H27ClN4O2/c1-15-18(14-27-23(15)31)24(32)28-22-13-21(16-8-7-9-17(12-16)25(2,3)4)30(29-22)20-11-6-5-10-19(20)26/h5-13,15,18H,14H2,1-4H3,(H,27,31)(H,28,29,32)/t15-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132862 (US8846746, 132) Show SMILES CC(C)(C)c1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)C2)nn1-c1ccccc1Cl |r| Show InChI InChI=1S/C24H25ClN4O2/c1-24(2,3)17-8-6-7-15(11-17)20-13-21(27-23(31)16-12-22(30)26-14-16)28-29(20)19-10-5-4-9-18(19)25/h4-11,13,16H,12,14H2,1-3H3,(H,26,30)(H,27,28,31)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM493926 (US10988462, Example 37) Show SMILES C[C@@H]1[C@H](CNC1=O)C(=O)Nc1cc(-c2cc(F)cc(OC(C)(C)C(F)(F)F)c2)n(n1)-c1cnc(nc1)N(C)C |r| Show InChI InChI=1S/C25H27F4N7O3/c1-13-18(12-30-21(13)37)22(38)33-20-9-19(36(34-20)16-10-31-23(32-11-16)35(4)5)14-6-15(26)8-17(7-14)39-24(2,3)25(27,28)29/h6-11,13,18H,12H2,1-5H3,(H,30,37)(H,33,34,38)/t13-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.980	n/a	n/a	n/a	n/a	n/a	n/a
Japan Tobacco Inc. US Patent					Assay Description Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...				US Patent US10988462 (2021) BindingDB Entry DOI: 10.7270/Q2TH8QV5
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM176693 (US9688710, 116 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-...) Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC3(CC3)C(=O)N3CCN(C)CC3)cc2)c1 |r| Show InChI InChI=1S/C33H45N3O6S/c1-21-7-12-24(30-28(39)27(38)29(40)31(42-30)43-3)20-25(21)19-23-10-8-22(9-11-23)5-4-6-26(37)34-33(13-14-33)32(41)36-17-15-35(2)16-18-36/h7-12,20,27-31,38-40H,4-6,13-19H2,1-3H3,(H,34,37)/t27-,28-,29+,30+,31-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Lexicon Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...				J Med Chem 60: 710-721 (2017) Article DOI: 10.1021/acs.jmedchem.6b01541 BindingDB Entry DOI: 10.7270/Q2C24ZQ7
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM133145 (US8846746, 463) Show SMILES CCOc1ccc(F)c(c1)-n1nc(NC(=O)[C@@H]2CNC(=O)C2)cc1-c1cccc(CO[C@H](C)C(F)(F)F)c1 |r| Show InChI InChI=1S/C26H26F4N4O4/c1-3-37-19-7-8-20(27)22(11-19)34-21(12-23(33-34)32-25(36)18-10-24(35)31-13-18)17-6-4-5-16(9-17)14-38-15(2)26(28,29)30/h4-9,11-12,15,18H,3,10,13-14H2,1-2H3,(H,31,35)(H,32,33,36)/t15-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132870 (US8846746, 140) Show SMILES CCC(F)(F)c1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)C2)nn1-c1ccccc1Cl |r| Show InChI InChI=1S/C23H21ClF2N4O2/c1-2-23(25,26)16-7-5-6-14(10-16)19-12-20(28-22(32)15-11-21(31)27-13-15)29-30(19)18-9-4-3-8-17(18)24/h3-10,12,15H,2,11,13H2,1H3,(H,27,31)(H,28,29,32)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132882 (US8846746, 154) Show SMILES CCC(F)(F)c1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)[C@@H]2C)nn1-c1ccccc1 |r| Show InChI InChI=1S/C24H24F2N4O2/c1-3-24(25,26)17-9-7-8-16(12-17)20-13-21(29-30(20)18-10-5-4-6-11-18)28-23(32)19-14-27-22(31)15(19)2/h4-13,15,19H,3,14H2,1-2H3,(H,27,31)(H,28,29,32)/t15-,19+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM493906 (US10988462, Example 21) Show SMILES C[C@@H]1[C@H](CNC1=O)C(=O)Nc1cc(-c2cc(F)cc(OC(C)(C)C(F)(F)F)c2)n(n1)-c1cncc(F)c1 |r| Show InChI InChI=1S/C24H22F5N5O3/c1-12-18(11-31-21(12)35)22(36)32-20-8-19(34(33-20)16-6-15(26)9-30-10-16)13-4-14(25)7-17(5-13)37-23(2,3)24(27,28)29/h4-10,12,18H,11H2,1-3H3,(H,31,35)(H,32,33,36)/t12-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Japan Tobacco Inc. US Patent					Assay Description Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...				US Patent US10988462 (2021) BindingDB Entry DOI: 10.7270/Q2TH8QV5
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132856 (US8846746, 126) Show SMILES CC(C)(C)c1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)C2)nn1-c1cccc(Cl)c1 |r| Show InChI InChI=1S/C24H25ClN4O2/c1-24(2,3)17-7-4-6-15(10-17)20-13-21(27-23(31)16-11-22(30)26-14-16)28-29(20)19-9-5-8-18(25)12-19/h4-10,12-13,16H,11,14H2,1-3H3,(H,26,30)(H,27,28,31)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM493905 (US10988462, Example 20) Show SMILES C[C@@H]1[C@H](CNC1=O)C(=O)Nc1cc(-c2cc(F)cc(OC(C)(C)C(F)(F)F)c2)n(n1)-c1ccc(nc1)C(F)(F)F |r| Show InChI InChI=1S/C25H22F7N5O3/c1-12-17(11-34-21(12)38)22(39)35-20-9-18(37(36-20)15-4-5-19(33-10-15)24(27,28)29)13-6-14(26)8-16(7-13)40-23(2,3)25(30,31)32/h4-10,12,17H,11H2,1-3H3,(H,34,38)(H,35,36,39)/t12-,17+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Japan Tobacco Inc. US Patent					Assay Description Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...				US Patent US10988462 (2021) BindingDB Entry DOI: 10.7270/Q2TH8QV5
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM493894 (US10988462, Example 10) Show SMILES C[C@@H]1[C@H](CNC1=O)C(=O)Nc1cc(-c2cc(F)cc(OC(C)(C)C(F)(F)F)c2)n(n1)-c1cncc(c1)C(F)(F)F |r| Show InChI InChI=1S/C25H22F7N5O3/c1-12-18(11-34-21(12)38)22(39)35-20-8-19(37(36-20)16-6-14(9-33-10-16)24(27,28)29)13-4-15(26)7-17(5-13)40-23(2,3)25(30,31)32/h4-10,12,18H,11H2,1-3H3,(H,34,38)(H,35,36,39)/t12-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Japan Tobacco Inc. US Patent					Assay Description Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...				US Patent US10988462 (2021) BindingDB Entry DOI: 10.7270/Q2TH8QV5
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132860 (US8846746, 130) Show SMILES FC(F)(F)Oc1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)C2)nn1-c1ccccc1Cl |r| Show InChI InChI=1S/C21H16ClF3N4O3/c22-15-6-1-2-7-16(15)29-17(12-4-3-5-14(8-12)32-21(23,24)25)10-18(28-29)27-20(31)13-9-19(30)26-11-13/h1-8,10,13H,9,11H2,(H,26,30)(H,27,28,31)/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132929 (US8846746, 208) Show SMILES CCC(F)(F)c1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)[C@@H]2C)nn1-c1ccccc1Cl |r| Show InChI InChI=1S/C24H23ClF2N4O2/c1-3-24(26,27)16-8-6-7-15(11-16)20-12-21(29-23(33)17-13-28-22(32)14(17)2)30-31(20)19-10-5-4-9-18(19)25/h4-12,14,17H,3,13H2,1-2H3,(H,28,32)(H,29,30,33)/t14-,17+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM493901 (US10988462, Example 17) Show SMILES C[C@@H]1[C@H](CNC1=O)C(=O)Nc1cc(-c2cc(F)cc(OC(C)(C)C(F)(F)F)c2)n(n1)-c1cncc(Cl)c1 |r| Show InChI InChI=1S/C24H22ClF4N5O3/c1-12-18(11-31-21(12)35)22(36)32-20-8-19(34(33-20)16-6-14(25)9-30-10-16)13-4-15(26)7-17(5-13)37-23(2,3)24(27,28)29/h4-10,12,18H,11H2,1-3H3,(H,31,35)(H,32,33,36)/t12-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Japan Tobacco Inc. US Patent					Assay Description Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...				US Patent US10988462 (2021) BindingDB Entry DOI: 10.7270/Q2TH8QV5
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132874 (US8846746, 144) Show SMILES CCC(F)(F)c1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)C2)nn1-c1ccccc1C |r| Show InChI InChI=1S/C24H24F2N4O2/c1-3-24(25,26)18-9-6-8-16(11-18)20-13-21(28-23(32)17-12-22(31)27-14-17)29-30(20)19-10-5-4-7-15(19)2/h4-11,13,17H,3,12,14H2,1-2H3,(H,27,31)(H,28,29,32)/t17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132915 (US8846746, 193) Show SMILES C[C@@H]1[C@H](CNC1=O)C(=O)Nc1cc(-c2cccc(OC(F)(F)F)c2)n(n1)-c1ccccc1Cl |r| Show InChI InChI=1S/C22H18ClF3N4O3/c1-12-15(11-27-20(12)31)21(32)28-19-10-18(30(29-19)17-8-3-2-7-16(17)23)13-5-4-6-14(9-13)33-22(24,25)26/h2-10,12,15H,11H2,1H3,(H,27,31)(H,28,29,32)/t12-,15+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132936 (US8846746, 215) Show SMILES C[C@@H]1[C@H](CNC1=O)C(=O)Nc1cc(-c2cccc(OCC(F)(F)F)c2)n(n1)-c1ccccc1Cl |r| Show InChI InChI=1S/C23H20ClF3N4O3/c1-13-16(11-28-21(13)32)22(33)29-20-10-19(31(30-20)18-8-3-2-7-17(18)24)14-5-4-6-15(9-14)34-12-23(25,26)27/h2-10,13,16H,11-12H2,1H3,(H,28,32)(H,29,30,33)/t13-,16+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132848 (US8846746, 117) Show SMILES CCCc1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)C2)nn1-c1ccccc1F |r| Show InChI InChI=1S/C23H23FN4O2/c1-2-6-15-7-5-8-16(11-15)20-13-21(26-23(30)17-12-22(29)25-14-17)27-28(20)19-10-4-3-9-18(19)24/h3-5,7-11,13,17H,2,6,12,14H2,1H3,(H,25,29)(H,26,27,30)/t17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132924 (US8846746, 203) Show SMILES C[C@@H]1[C@H](CNC1=O)C(=O)Nc1cc(-c2cccc(c2)C(F)(F)F)n(n1)-c1ccccc1Cl |r| Show InChI InChI=1S/C22H18ClF3N4O2/c1-12-15(11-27-20(12)31)21(32)28-19-10-18(13-5-4-6-14(9-13)22(24,25)26)30(29-19)17-8-3-2-7-16(17)23/h2-10,12,15H,11H2,1H3,(H,27,31)(H,28,29,32)/t12-,15+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132857 (US8846746, 127) Show SMILES Cc1cccc(c1)-n1nc(NC(=O)[C@H]2CNC(=O)C2)cc1-c1cccc(c1)C(C)(C)C |r| Show InChI InChI=1S/C25H28N4O2/c1-16-7-5-10-20(11-16)29-21(17-8-6-9-19(12-17)25(2,3)4)14-22(28-29)27-24(31)18-13-23(30)26-15-18/h5-12,14,18H,13,15H2,1-4H3,(H,26,30)(H,27,28,31)/t18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM133146 (US8846746, 464) Show SMILES CC(C)Oc1ccc(F)c(c1)-n1nc(NC(=O)[C@@H]2CNC(=O)C2)cc1-c1cccc(CO[C@H](C)C(F)(F)F)c1 |r| Show InChI InChI=1S/C27H28F4N4O4/c1-15(2)39-20-7-8-21(28)23(11-20)35-22(12-24(34-35)33-26(37)19-10-25(36)32-13-19)18-6-4-5-17(9-18)14-38-16(3)27(29,30)31/h4-9,11-12,15-16,19H,10,13-14H2,1-3H3,(H,32,36)(H,33,34,37)/t16-,19+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM133143 (US8846746, 461) Show SMILES CC(C)Oc1ccc(F)c(c1)-n1nc(NC(=O)[C@@H]2CNC(=O)C2)cc1-c1cccc(COCC(F)(F)F)c1 |r| Show InChI InChI=1S/C26H26F4N4O4/c1-15(2)38-19-6-7-20(27)22(10-19)34-21(11-23(33-34)32-25(36)18-9-24(35)31-12-18)17-5-3-4-16(8-17)13-37-14-26(28,29)30/h3-8,10-11,15,18H,9,12-14H2,1-2H3,(H,31,35)(H,32,33,36)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM402293 (US10011627, 9) Show SMILES CCc1ccc(cc1Cc1ccc2OCCOc2c1)[C@]12OC[C@](CO)(O1)[C@@H](O)[C@H](O)[C@H]2O |TLB:29:28:21.20:25,THB:27:26:21.20:25,31:30:21.20:25| Show InChI InChI=1S/C24H28O8/c1-2-15-4-5-17(24-22(28)20(26)21(27)23(12-25,32-24)13-31-24)11-16(15)9-14-3-6-18-19(10-14)30-8-7-29-18/h3-6,10-11,20-22,25-28H,2,7-9,12-13H2,1H3/t20-,21-,22+,23-,24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.49	n/a	n/a	n/a	n/a	n/a	n/a
Vernalis (R&D) Ltd					Assay Description The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...				Bioorg Med Chem 17: 6590-605 (2009) BindingDB Entry DOI: 10.7270/Q2C24ZS4
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM133004 (US8846746, 302) Show SMILES CCCc1cccc(c1)-c1cc(NC(=O)C2CCS(=O)(=O)CC2)nn1-c1ccccc1 Show InChI InChI=1S/C24H27N3O3S/c1-2-7-18-8-6-9-20(16-18)22-17-23(26-27(22)21-10-4-3-5-11-21)25-24(28)19-12-14-31(29,30)15-13-19/h3-6,8-11,16-17,19H,2,7,12-15H2,1H3,(H,25,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM133055 (US8846746, 360) Show SMILES CCCc1cccc(c1)-c1cc(NC(=O)C2CNC(=O)C22CC2)nn1-c1ccccc1 Show InChI InChI=1S/C25H26N4O2/c1-2-7-17-8-6-9-18(14-17)21-15-22(28-29(21)19-10-4-3-5-11-19)27-23(30)20-16-26-24(31)25(20)12-13-25/h3-6,8-11,14-15,20H,2,7,12-13,16H2,1H3,(H,26,31)(H,27,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132868 (US8846746, 138) Show SMILES CC(C)C(F)(F)c1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)C2)nn1-c1ccccc1 |r| Show InChI InChI=1S/C24H24F2N4O2/c1-15(2)24(25,26)18-8-6-7-16(11-18)20-13-21(28-23(32)17-12-22(31)27-14-17)29-30(20)19-9-4-3-5-10-19/h3-11,13,15,17H,12,14H2,1-2H3,(H,27,31)(H,28,29,32)/t17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM176697 (US9688710, 120 N-(2-methyl-1-(4-methylpiperidin-1-...) Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N3CCC(C)CC3)cc2)c1 |r| Show InChI InChI=1S/C34H48N2O6S/c1-21-15-17-36(18-16-21)33(41)34(3,4)35-27(37)8-6-7-23-10-12-24(13-11-23)19-26-20-25(14-9-22(26)2)31-29(39)28(38)30(40)32(42-31)43-5/h9-14,20-21,28-32,38-40H,6-8,15-19H2,1-5H3,(H,35,37)/t28-,29-,30+,31+,32-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Lexicon Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...				J Med Chem 60: 710-721 (2017) Article DOI: 10.1021/acs.jmedchem.6b01541 BindingDB Entry DOI: 10.7270/Q2C24ZQ7
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132803 (US8846746, 70) Show SMILES CC(C)Cc1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)C2)nn1-c1ccccc1 |r| Show InChI InChI=1S/C24H26N4O2/c1-16(2)11-17-7-6-8-18(12-17)21-14-22(26-24(30)19-13-23(29)25-15-19)27-28(21)20-9-4-3-5-10-20/h3-10,12,14,16,19H,11,13,15H2,1-2H3,(H,25,29)(H,26,27,30)/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM133135 (US8846746, 453) Show SMILES CCCOc1cccc(c1)-n1nc(NC(=O)[C@@H]2CNC(=O)C2)cc1-c1cccc(CO[C@H](C)C(F)(F)F)c1 |r| Show InChI InChI=1S/C27H29F3N4O4/c1-3-10-37-22-9-5-8-21(13-22)34-23(14-24(33-34)32-26(36)20-12-25(35)31-15-20)19-7-4-6-18(11-19)16-38-17(2)27(28,29)30/h4-9,11,13-14,17,20H,3,10,12,15-16H2,1-2H3,(H,31,35)(H,32,33,36)/t17-,20+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM133134 (US8846746, 452) Show SMILES CCOc1cccc(c1)-n1nc(NC(=O)[C@@H]2CNC(=O)C2)cc1-c1cccc(CO[C@H](C)C(F)(F)F)c1 |r| Show InChI InChI=1S/C26H27F3N4O4/c1-3-36-21-9-5-8-20(12-21)33-22(13-23(32-33)31-25(35)19-11-24(34)30-14-19)18-7-4-6-17(10-18)15-37-16(2)26(27,28)29/h4-10,12-13,16,19H,3,11,14-15H2,1-2H3,(H,30,34)(H,31,32,35)/t16-,19+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM176709 (US9688710, 132 N-(1-((2-(dimethylamino)ethyl)(meth...) Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N(C)CCN(C)C)cc2)c1 |r| Show InChI InChI=1S/C33H49N3O6S/c1-21-11-16-24(30-28(39)27(38)29(40)31(42-30)43-7)20-25(21)19-23-14-12-22(13-15-23)9-8-10-26(37)34-33(2,3)32(41)36(6)18-17-35(4)5/h11-16,20,27-31,38-40H,8-10,17-19H2,1-7H3,(H,34,37)/t27-,28-,29+,30+,31-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Lexicon Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...				J Med Chem 60: 710-721 (2017) Article DOI: 10.1021/acs.jmedchem.6b01541 BindingDB Entry DOI: 10.7270/Q2C24ZQ7
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM133147 (US8846746, 465) Show SMILES COCCOc1ccc(F)c(c1)-n1nc(NC(=O)[C@@H]2CNC(=O)C2)cc1-c1cccc(CO[C@H](C)C(F)(F)F)c1 |r| Show InChI InChI=1S/C27H28F4N4O5/c1-16(27(29,30)31)40-15-17-4-3-5-18(10-17)22-13-24(33-26(37)19-11-25(36)32-14-19)34-35(22)23-12-20(6-7-21(23)28)39-9-8-38-2/h3-7,10,12-13,16,19H,8-9,11,14-15H2,1-2H3,(H,32,36)(H,33,34,37)/t16-,19+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132809 (US8846746, 76) Show SMILES CCCc1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)C2)nn1-c1cccc(C)c1 |r| Show InChI InChI=1S/C24H26N4O2/c1-3-6-17-8-5-9-18(12-17)21-14-22(26-24(30)19-13-23(29)25-15-19)27-28(21)20-10-4-7-16(2)11-20/h4-5,7-12,14,19H,3,6,13,15H2,1-2H3,(H,25,29)(H,26,27,30)/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132869 (US8846746, 139) Show SMILES CCC(F)(F)c1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)C2)nn1-c1cccc(Cl)c1 |r| Show InChI InChI=1S/C23H21ClF2N4O2/c1-2-23(25,26)16-6-3-5-14(9-16)19-12-20(28-22(32)15-10-21(31)27-13-15)29-30(19)18-8-4-7-17(24)11-18/h3-9,11-12,15H,2,10,13H2,1H3,(H,27,31)(H,28,29,32)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132823 (US8846746, 91) Show SMILES CCCc1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)[C@@H]2C)nn1-c1ccccc1 |r| Show InChI InChI=1S/C24H26N4O2/c1-3-8-17-9-7-10-18(13-17)21-14-22(27-28(21)19-11-5-4-6-12-19)26-24(30)20-15-25-23(29)16(20)2/h4-7,9-14,16,20H,3,8,15H2,1-2H3,(H,25,29)(H,26,27,30)/t16-,20+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM133209 (US8846746, 534) Show SMILES CCOc1cc(F)cc(c1)-n1nc(NC(=O)[C@@H]2CNC(=O)C2)cc1-c1cccc(CO[C@H](C)C(F)(F)F)c1 |r| Show InChI InChI=1S/C26H26F4N4O4/c1-3-37-21-10-19(27)9-20(11-21)34-22(12-23(33-34)32-25(36)18-8-24(35)31-13-18)17-6-4-5-16(7-17)14-38-15(2)26(28,29)30/h4-7,9-12,15,18H,3,8,13-14H2,1-2H3,(H,31,35)(H,32,33,36)/t15-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM176414 (US9688710, 113 N-(2-methyl-1-(4-methylpiperazin-1-...) Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1 |r| Show InChI InChI=1S/C33H47N3O6S/c1-21-9-14-24(30-28(39)27(38)29(40)31(42-30)43-5)20-25(21)19-23-12-10-22(11-13-23)7-6-8-26(37)34-33(2,3)32(41)36-17-15-35(4)16-18-36/h9-14,20,27-31,38-40H,6-8,15-19H2,1-5H3,(H,34,37)/t27-,28-,29+,30+,31-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Lexicon Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...				J Med Chem 60: 710-721 (2017) Article DOI: 10.1021/acs.jmedchem.6b01541 BindingDB Entry DOI: 10.7270/Q2C24ZQ7
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50349240 (CHEMBL1807551) Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(cc2)C2CC2)c1 |r| Show InChI InChI=1S/C22H25ClO5/c23-17-8-7-15(22-21(27)20(26)19(25)18(11-24)28-22)10-16(17)9-12-1-3-13(4-2-12)14-5-6-14/h1-4,7-8,10,14,18-22,24-27H,5-6,9,11H2/t18-,19-,20+,21-,22+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human SGLT2 expressed in african green monkey COS7 cells assessed as inhibition of [14C]-methyl-alpha-D-glucopyranoside uptake after 2 ...				Bioorg Med Chem Lett 21: 4465-70 (2011) Article DOI: 10.1016/j.bmcl.2011.06.032 BindingDB Entry DOI: 10.7270/Q29W0FVZ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132759 (US8846746, 25) Show SMILES CC(C)(C)c1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)C2)nn1-c1ccccc1 |r| Show InChI InChI=1S/C24H26N4O2/c1-24(2,3)18-9-7-8-16(12-18)20-14-21(26-23(30)17-13-22(29)25-15-17)27-28(20)19-10-5-4-6-11-19/h4-12,14,17H,13,15H2,1-3H3,(H,25,29)(H,26,27,30)/t17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM402291 (US10011627, 7) Show SMILES CCCc1ccc(cc1Cc1ccc2OCCOc2c1)[C@]12OC[C@](CO)(O1)[C@@H](O)[C@H](O)[C@H]2O |TLB:30:29:22.21:26,THB:32:31:22.21:26,28:27:22.21:26| Show InChI InChI=1S/C25H30O8/c1-2-3-16-5-6-18(25-23(29)21(27)22(28)24(13-26,33-25)14-32-25)12-17(16)10-15-4-7-19-20(11-15)31-9-8-30-19/h4-7,11-12,21-23,26-29H,2-3,8-10,13-14H2,1H3/t21-,22-,23+,24-,25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.82	n/a	n/a	n/a	n/a	n/a	n/a
Vernalis (R&D) Ltd					Assay Description The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...				Bioorg Med Chem 17: 6590-605 (2009) BindingDB Entry DOI: 10.7270/Q2C24ZS4
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132832 (US8846746, 100) Show SMILES CCCc1cccc(c1)-c1cc(NC(=O)[C@H]2CNC(=O)C2)nn1-c1ccccc1Cl |r| Show InChI InChI=1S/C23H23ClN4O2/c1-2-6-15-7-5-8-16(11-15)20-13-21(26-23(30)17-12-22(29)25-14-17)27-28(20)19-10-4-3-9-18(19)24/h3-5,7-11,13,17H,2,6,12,14H2,1H3,(H,25,29)(H,26,27,30)/t17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM493879 (US10988462, Example 1) Show SMILES C[C@@H]1[C@H](CNC1=O)C(=O)Nc1cc(-c2cc(F)cc(OC(C)(C)C(F)(F)F)c2)n(n1)-c1cnc(nc1)C(F)(F)F |r| Show InChI InChI=1S/C24H21F7N6O3/c1-11-16(10-32-19(11)38)20(39)35-18-7-17(37(36-18)14-8-33-21(34-9-14)23(26,27)28)12-4-13(25)6-15(5-12)40-22(2,3)24(29,30)31/h4-9,11,16H,10H2,1-3H3,(H,32,38)(H,35,36,39)/t11-,16+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Japan Tobacco Inc. US Patent					Assay Description Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...				US Patent US10988462 (2021) BindingDB Entry DOI: 10.7270/Q2TH8QV5
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM493925 (US10988462, Example 36) Show SMILES COc1ncc(cn1)-n1nc(NC(=O)[C@H]2CNC(=O)[C@@H]2C)cc1-c1cc(F)cc(OC(C)(C)C(F)(F)F)c1 |r| Show InChI InChI=1S/C24H24F4N6O4/c1-12-17(11-29-20(12)35)21(36)32-19-8-18(34(33-19)15-9-30-22(37-4)31-10-15)13-5-14(25)7-16(6-13)38-23(2,3)24(26,27)28/h5-10,12,17H,11H2,1-4H3,(H,29,35)(H,32,33,36)/t12-,17+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Japan Tobacco Inc. US Patent					Assay Description Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...				US Patent US10988462 (2021) BindingDB Entry DOI: 10.7270/Q2TH8QV5
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM133136 (US8846746, 454) Show SMILES CC(C)Oc1cccc(c1)-n1nc(NC(=O)[C@@H]2CNC(=O)C2)cc1-c1cccc(CO[C@H](C)C(F)(F)F)c1 |r| Show InChI InChI=1S/C27H29F3N4O4/c1-16(2)38-22-9-5-8-21(12-22)34-23(13-24(33-34)32-26(36)20-11-25(35)31-14-20)19-7-4-6-18(10-19)15-37-17(3)27(28,29)30/h4-10,12-13,16-17,20H,11,14-15H2,1-3H3,(H,31,35)(H,32,33,36)/t17-,20+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM132810 (US8846746, 77) Show SMILES CCCc1cccc(c1)-c1cc(NC(=O)[C@@H]2CNC(=O)C2)nn1-c1cccc(C)c1 |r| Show InChI InChI=1S/C24H26N4O2/c1-3-6-17-8-5-9-18(12-17)21-14-22(26-24(30)19-13-23(29)25-15-19)27-28(21)20-10-4-7-16(2)11-20/h4-5,7-12,14,19H,3,6,13,15H2,1-2H3,(H,25,29)(H,26,27,30)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
Japan Tobacco Inc. US Patent					Assay Description The stable cell line expressing human SGLT1 was seeded at 5x104 cells/well on BioCoat Poly-D-Lysine 96 well plate with Lid (Becton Dickinson and Comp...				US Patent US8846746 (2014) BindingDB Entry DOI: 10.7270/Q27M06MJ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50242615 (CHEMBL486028 | QCPac) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CS)C(O)=O |r| Show InChI InChI=1S/C13H21N3O5S/c1-7(11(18)15-9(6-22)13(20)21)14-12(19)10-4-3-5-16(10)8(2)17/h7,9-10,22H,3-6H2,1-2H3,(H,14,19)(H,15,18)(H,20,21)/t7-,9-,10-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University Würzburg Curated by ChEMBL					Assay Description Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibition of methyl-alpha-D-[14C]glucopyranoside uptake after 1 hrs				J Biol Chem 282: 28501-13 (2007) Article DOI: 10.1074/jbc.M705416200 BindingDB Entry DOI: 10.7270/Q2SJ1KCM
					More data for this Ligand-Target Pair

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