Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor [668-1210] (Homo sapiens (Human)) | BDBM4567 (4-anilinoquinazoline deriv. 2 | BMC163482 Compound...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Chemical Genomics Centre of the Max Planck Society | Assay Description The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati... | Bioorg Med Chem 16: 3482-8 (2008) Article DOI: 10.1016/j.bmc.2008.02.053 BindingDB Entry DOI: 10.7270/Q2R20ZQ4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [668-1210] (Homo sapiens (Human)) | BDBM4583 ((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 0.220 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Chemical Genomics Centre of the Max Planck Society | Assay Description The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati... | Bioorg Med Chem 16: 3482-8 (2008) Article DOI: 10.1016/j.bmc.2008.02.053 BindingDB Entry DOI: 10.7270/Q2R20ZQ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210] (Homo sapiens (Human)) | BDBM31826 (4-aminoquinazoline, 2a | BMC163482 Compound 3 | CH...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.430 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Chemical Genomics Centre of the Max Planck Society | Assay Description The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati... | Bioorg Med Chem 16: 3482-8 (2008) Article DOI: 10.1016/j.bmc.2008.02.053 BindingDB Entry DOI: 10.7270/Q2R20ZQ4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [668-1210] (Homo sapiens (Human)) | BDBM50123162 (CHEMBL3622673 | US9388160, 11) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Teligene Ltd US Patent | Assay Description The assay was performed using Kinase-Glo Plus luminescence kinase assay kit (Promega). The compounds were diluted in 10% DMSO and 5 μl of the dilu... | US Patent US9388160 (2016) BindingDB Entry DOI: 10.7270/Q2T152J9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210] (Homo sapiens (Human)) | BDBM5446 (CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Chemical Genomics Centre of the Max Planck Society | Assay Description The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati... | Bioorg Med Chem 16: 3482-8 (2008) Article DOI: 10.1016/j.bmc.2008.02.053 BindingDB Entry DOI: 10.7270/Q2R20ZQ4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [668-1210] (Homo sapiens (Human)) | BDBM238271 (US9409887, I-2) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210] (Homo sapiens (Human)) | BDBM238270 (US9409887, I-1) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210] (Homo sapiens (Human)) | BDBM50123162 (CHEMBL3622673 | US9388160, 11) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Teligene Ltd US Patent | Assay Description The assay was performed using Kinase-Glo Plus luminescence kinase assay kit (Promega). The compounds were diluted in 10% DMSO and 5 μl of the dilu... | US Patent US9388160 (2016) BindingDB Entry DOI: 10.7270/Q2T152J9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210] (Homo sapiens (Human)) | BDBM238274 (US9409887, I-5) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210] (Homo sapiens (Human)) | BDBM238273 (US9409887, I-4) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 65 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210] (Homo sapiens (Human)) | BDBM238272 (US9409887, I-3) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 200 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair |