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Compile Data Set for Download or QSAR

Found 97 hits of ic50 for UniProtKB: P30082   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucagon receptor


(Rattus norvegicus)		BDBM50104037
PNG
(CHEMBL428460 | His-Ser-Gln-Gly-Lys-Phe-Thr-Ser-Glu...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C156H230N44O47S/c1-76(2)57-102(138(230)182-101(51-56-248-10)137(229)191-109(65-119(162)212)147(239)200-126(81(9)206)154(246)247)185-142(234)108(63-86-68-171-92-30-18-17-29-90(86)92)190-135(227)99(45-49-118(161)211)183-152(244)124(78(5)6)198-145(237)106(59-82-25-13-11-14-26-82)189-143(235)110(66-122(215)216)192-134(226)98(44-48-117(160)210)176-127(219)79(7)174-130(222)95(33-23-54-169-155(163)164)177-132(224)96(34-24-55-170-156(165)166)179-150(242)114(73-203)196-144(236)111(67-123(217)218)193-139(231)103(58-77(3)4)184-140(232)104(61-84-35-39-88(207)40-36-84)186-133(225)94(31-19-21-52-157)178-149(241)113(72-202)195-141(233)105(62-85-37-41-89(208)42-38-85)187-136(228)100-46-50-120(213)168-53-22-20-32-93(131(223)188-107(60-83-27-15-12-16-28-83)146(238)199-125(80(8)205)153(245)197-115(74-204)151(243)181-100)175-121(214)70-172-129(221)97(43-47-116(159)209)180-148(240)112(71-201)194-128(220)91(158)64-87-69-167-75-173-87/h11-18,25-30,35-42,68-69,75-81,91,93-115,124-126,171,201-208H,19-24,31-34,43-67,70-74,157-158H2,1-10H3,(H2,159,209)(H2,160,210)(H2,161,211)(H2,162,212)(H,167,173)(H,168,213)(H,172,221)(H,174,222)(H,175,214)(H,176,219)(H,177,224)(H,178,241)(H,179,242)(H,180,240)(H,181,243)(H,182,230)(H,183,244)(H,184,232)(H,185,234)(H,186,225)(H,187,228)(H,188,223)(H,189,235)(H,190,227)(H,191,229)(H,192,226)(H,193,231)(H,194,220)(H,195,233)(H,196,236)(H,197,245)(H,198,237)(H,199,238)(H,200,239)(H,215,216)(H,217,218)(H,246,247)(H4,163,164,169)(H4,165,166,170)/t79-,80+,81+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,124-,125-,126-/m0/s1
PDB

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KEGG

UniProtKB/SwissProt

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UniChem

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n/an/a 0.200n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration

J Med Chem 44: 3109-16 (2001)


BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50104040
PNG
(CHEMBL412488 | His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C154H225N41O48S/c1-74(2)55-100(136(225)176-99(50-54-244-11)135(224)184-107(63-117(160)208)145(234)195-125(80(10)202)153(242)243)179-140(229)106(61-85-66-166-91-30-19-18-29-89(85)91)183-133(222)97(44-48-116(159)207)177-150(239)122(76(5)6)193-143(232)104(57-81-25-14-12-15-26-81)181-134(223)98-45-49-118(209)164-52-23-21-32-93(130(219)171-94(33-24-53-165-154(161)162)129(218)169-77(7)126(215)170-96(132(221)175-98)43-47-115(158)206)173-148(237)112(71-198)190-142(231)109(65-121(213)214)185-137(226)101(56-75(3)4)178-138(227)102(59-83-34-38-87(203)39-35-83)180-131(220)92(31-20-22-51-155)172-147(236)111(70-197)189-139(228)103(60-84-36-40-88(204)41-37-84)182-141(230)108(64-120(211)212)186-149(238)113(72-199)191-152(241)124(79(9)201)194-144(233)105(58-82-27-16-13-17-28-82)187-151(240)123(78(8)200)192-119(210)68-167-128(217)95(42-46-114(157)205)174-146(235)110(69-196)188-127(216)90(156)62-86-67-163-73-168-86/h12-19,25-30,34-41,66-67,73-80,90,92-113,122-125,166,196-204H,20-24,31-33,42-65,68-72,155-156H2,1-11H3,(H2,157,205)(H2,158,206)(H2,159,207)(H2,160,208)(H,163,168)(H,164,209)(H,167,217)(H,169,218)(H,170,215)(H,171,219)(H,172,236)(H,173,237)(H,174,235)(H,175,221)(H,176,225)(H,177,239)(H,178,227)(H,179,229)(H,180,220)(H,181,223)(H,182,230)(H,183,222)(H,184,224)(H,185,226)(H,186,238)(H,187,240)(H,188,216)(H,189,228)(H,190,231)(H,191,241)(H,192,210)(H,193,232)(H,194,233)(H,195,234)(H,211,212)(H,213,214)(H,242,243)(H4,161,162,165)/t77-,78+,79+,80+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1
PDB

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KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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PubMed
n/an/a 0.240n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration

J Med Chem 44: 3109-16 (2001)


BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50122102
PNG
(3-Cyano-4-hydroxy-benzoic acid [1-(2,3,5,6-tetrame...)
Show SMILES Cc1cc(C)c(C)c(Cn2ccc3c(\C=N\NC(=O)c4ccc(O)c(c4)C#N)cccc23)c1C
Show InChI InChI=1S/C28H26N4O2/c1-17-12-18(2)20(4)25(19(17)3)16-32-11-10-24-22(6-5-7-26(24)32)15-30-31-28(34)21-8-9-27(33)23(13-21)14-29/h5-13,15,33H,16H2,1-4H3,(H,31,34)/b30-15+
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PubMed
n/an/a 0.430n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound towards rat glucagon receptor

J Med Chem 45: 5755-75 (2002)


BindingDB Entry DOI: 10.7270/Q26W99FD
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50110054
PNG
(3-Cyano-4-hydroxy-benzoic acid [1-[4-(4-isopropyl-...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)c(c2)C#N)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C27H27N3O5/c1-17(2)20-7-5-18(6-8-20)16-35-26-24(33-3)11-19(12-25(26)34-4)15-29-30-27(32)21-9-10-23(31)22(13-21)14-28/h5-13,15,17,31H,16H2,1-4H3,(H,30,32)/b29-15+
PDB

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n/an/a 1n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro for its inhibitory activity against rat glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50098571
PNG
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB

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KEGG

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon

J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50098571
PNG
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB

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KEGG

UniProtKB/SwissProt

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UniChem

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n/an/a 1.5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration

J Med Chem 44: 3109-16 (2001)


BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50098571
PNG
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay

J Med Chem 43: 1714-22 (2000)


BindingDB Entry DOI: 10.7270/Q2XG9RVJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50098571
PNG
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
n/an/a 1.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its ability to displace [I-125]-glucagon from the glucagon receptor

Bioorg Med Chem Lett 5: 1849-1852 (1995)


Article DOI: 10.1016/0960-894X(95)00307-F
BindingDB Entry DOI: 10.7270/Q2G44Q7P
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50098571
PNG
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
inhibition of [125]glucagon specific binding.

J Med Chem 44: 1372-9 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50051588
PNG
(CHEMBL429362 | His-Ser-Gln-thr-Phe-Thr-Ser-Asp-Tyr...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc1c[nH]cn1)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76-,77-,78+,88+,90-,91-,92-,93+,94-,95-,96-,97-,98-,99-,100+,101-,102+,103-,104-,105-,106+,107-,108+,109-,110-,111+,120-,121+,122+,123-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of [125I]glucagon binding towards Glucagon receptor

J Med Chem 39: 2449-55 (1996)


Article DOI: 10.1021/jm960130b
BindingDB Entry DOI: 10.7270/Q2JH3MT3
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50104030
PNG
(CHEMBL439885 | His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C149H221N41O49S/c1-70(2)51-94(131(221)171-93(46-50-240-11)130(220)178-100(58-111(155)202)140(230)190-120(76(10)197)148(238)239)174-134(224)99(56-80-62-161-85-30-19-18-29-83(80)85)177-129(219)91(40-44-110(154)201)172-145(235)117(72(5)6)188-138(228)97(53-77-25-14-12-15-26-77)176-135(225)101(59-114(205)206)179-128(218)90(39-43-109(153)200)165-121(211)73(7)164-124(214)88(33-24-49-160-149(156)157)167-127(217)92-41-45-112(203)159-48-23-21-32-87(126(216)173-95(52-71(3)4)132(222)180-103(61-116(209)210)137(227)185-106(67-193)143(233)170-92)166-125(215)86(31-20-22-47-150)168-142(232)105(66-192)184-133(223)96(55-79-34-36-82(198)37-35-79)175-136(226)102(60-115(207)208)181-144(234)107(68-194)186-147(237)119(75(9)196)189-139(229)98(54-78-27-16-13-17-28-78)182-146(236)118(74(8)195)187-113(204)64-162-123(213)89(38-42-108(152)199)169-141(231)104(65-191)183-122(212)84(151)57-81-63-158-69-163-81/h12-19,25-30,34-37,62-63,69-76,84,86-107,117-120,161,191-198H,20-24,31-33,38-61,64-68,150-151H2,1-11H3,(H2,152,199)(H2,153,200)(H2,154,201)(H2,155,202)(H,158,163)(H,159,203)(H,162,213)(H,164,214)(H,165,211)(H,166,215)(H,167,217)(H,168,232)(H,169,231)(H,170,233)(H,171,221)(H,172,235)(H,173,216)(H,174,224)(H,175,226)(H,176,225)(H,177,219)(H,178,220)(H,179,218)(H,180,222)(H,181,234)(H,182,236)(H,183,212)(H,184,223)(H,185,227)(H,186,237)(H,187,204)(H,188,228)(H,189,229)(H,190,230)(H,205,206)(H,207,208)(H,209,210)(H,238,239)(H4,156,157,160)/t73-,74+,75+,76+,84-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,117-,118-,119-,120-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.70n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration

J Med Chem 44: 3109-16 (2001)


BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50051586
PNG
(CHEMBL413666 | [des-His1,Tyr5,Glu9,D-Tyr10]glucago...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C153H223N41O47S/c1-74(2)57-100(136(226)177-99(52-56-242-10)135(225)186-108(65-117(159)207)146(236)193-123(78(8)199)125(160)215)180-141(231)107(64-85-68-167-91-28-18-17-27-89(85)91)185-133(223)97(46-50-116(158)206)178-150(240)122(76(5)6)192-144(234)105(59-80-23-13-11-14-24-80)184-142(232)109(66-120(211)212)187-132(222)96(45-49-115(157)205)171-126(216)77(7)169-129(219)93(30-21-54-165-152(161)162)173-130(220)94(31-22-55-166-153(163)164)175-148(238)112(72-197)190-143(233)110(67-121(213)214)188-137(227)101(58-75(3)4)179-139(229)103(62-83-34-40-87(202)41-35-83)181-131(221)92(29-19-20-53-154)174-147(237)111(71-196)189-140(230)104(63-84-36-42-88(203)43-37-84)182-134(224)98(47-51-119(209)210)176-149(239)113(73-198)191-151(241)124(79(9)200)194-145(235)106(60-81-25-15-12-16-26-81)183-138(228)102(61-82-32-38-86(201)39-33-82)170-118(208)69-168-128(218)95(44-48-114(156)204)172-127(217)90(155)70-195/h11-18,23-28,32-43,68,74-79,90,92-113,122-124,167,195-203H,19-22,29-31,44-67,69-73,154-155H2,1-10H3,(H2,156,204)(H2,157,205)(H2,158,206)(H2,159,207)(H2,160,215)(H,168,218)(H,169,219)(H,170,208)(H,171,216)(H,172,217)(H,173,220)(H,174,237)(H,175,238)(H,176,239)(H,177,226)(H,178,240)(H,179,229)(H,180,231)(H,181,221)(H,182,224)(H,183,228)(H,184,232)(H,185,223)(H,186,225)(H,187,222)(H,188,227)(H,189,230)(H,190,233)(H,191,241)(H,192,234)(H,193,236)(H,194,235)(H,209,210)(H,211,212)(H,213,214)(H4,161,162,165)(H4,163,164,166)/t77-,78+,79+,90-,92-,93-,94-,95-,96-,97-,98+,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.30n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of [125I]glucagon binding towards Glucagon receptor

J Med Chem 39: 2449-55 (1996)


Article DOI: 10.1021/jm960130b
BindingDB Entry DOI: 10.7270/Q2JH3MT3
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50104039
PNG
(CHEMBL267189 | His-Ser-Gln-Cys-Thr-Phe-Thr-Ser-Cys...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H227N43O47S3/c1-72(2)52-97(132(223)175-96(47-51-246-11)131(222)183-104(60-116(159)209)141(232)196-122(78(10)203)151(242)243)178-136(227)103(58-83-63-167-89-29-19-18-28-87(83)89)182-129(220)95(43-46-115(158)208)176-148(239)119(74(5)6)193-139(230)101(54-79-24-14-12-15-25-79)180-137(228)105(61-117(210)211)184-128(219)93(41-44-113(156)206)170-123(214)75(7)169-125(216)91(31-22-49-165-152(160)161)171-126(217)92(32-23-50-166-153(162)163)173-144(235)109(67-199)189-138(229)106(62-118(212)213)185-133(224)98(53-73(3)4)177-134(225)99(56-81-33-37-85(204)38-34-81)179-127(218)90(30-20-21-48-154)172-143(234)108(66-198)188-135(226)100(57-82-35-39-86(205)40-36-82)181-146(237)111(69-244)192-145(236)110(68-200)190-150(241)121(77(9)202)194-140(231)102(55-80-26-16-13-17-27-80)186-149(240)120(76(8)201)195-147(238)112(70-245)191-130(221)94(42-45-114(157)207)174-142(233)107(65-197)187-124(215)88(155)59-84-64-164-71-168-84/h12-19,24-29,33-40,63-64,71-78,88,90-112,119-122,167,197-205,244-245H,20-23,30-32,41-62,65-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,168)(H,169,216)(H,170,214)(H,171,217)(H,172,234)(H,173,235)(H,174,233)(H,175,223)(H,176,239)(H,177,225)(H,178,227)(H,179,218)(H,180,228)(H,181,237)(H,182,220)(H,183,222)(H,184,219)(H,185,224)(H,186,240)(H,187,215)(H,188,226)(H,189,229)(H,190,241)(H,191,221)(H,192,236)(H,193,230)(H,194,231)(H,195,238)(H,196,232)(H,210,211)(H,212,213)(H,242,243)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,119-,120-,121-,122-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 3.60n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration

J Med Chem 44: 3109-16 (2001)


BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50098563
PNG
(CHEMBL413890 | Ser-Gln-Gly-Thr-Phe-Thr-Ser-Glu-Tyr...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C148H221N41O47S/c1-70(2)54-95(131(221)171-94(49-53-237-11)130(220)179-102(61-111(154)202)140(230)188-117(74(8)194)120(155)210)174-135(225)101(60-81-64-162-86-29-19-18-28-84(81)86)178-128(218)92(43-47-110(153)201)172-144(234)116(72(5)6)187-138(228)99(56-77-24-14-12-15-25-77)177-136(226)103(62-114(206)207)180-127(217)91(42-46-109(152)200)165-121(211)73(7)164-124(214)88(31-22-51-160-147(156)157)167-125(215)89(32-23-52-161-148(158)159)169-142(232)106(68-192)184-137(227)104(63-115(208)209)181-132(222)96(55-71(3)4)173-133(223)97(58-79-33-37-82(197)38-34-79)175-126(216)87(30-20-21-50-149)168-141(231)105(67-191)183-134(224)98(59-80-35-39-83(198)40-36-80)176-129(219)93(44-48-113(204)205)170-143(233)107(69-193)185-146(236)119(76(10)196)189-139(229)100(57-78-26-16-13-17-27-78)182-145(235)118(75(9)195)186-112(203)65-163-123(213)90(41-45-108(151)199)166-122(212)85(150)66-190/h12-19,24-29,33-40,64,70-76,85,87-107,116-119,162,190-198H,20-23,30-32,41-63,65-69,149-150H2,1-11H3,(H2,151,199)(H2,152,200)(H2,153,201)(H2,154,202)(H2,155,210)(H,163,213)(H,164,214)(H,165,211)(H,166,212)(H,167,215)(H,168,231)(H,169,232)(H,170,233)(H,171,221)(H,172,234)(H,173,223)(H,174,225)(H,175,216)(H,176,219)(H,177,226)(H,178,218)(H,179,220)(H,180,217)(H,181,222)(H,182,235)(H,183,224)(H,184,227)(H,185,236)(H,186,203)(H,187,228)(H,188,230)(H,189,229)(H,204,205)(H,206,207)(H,208,209)(H4,156,157,160)(H4,158,159,161)/t73-,74+,75+,76+,85-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,116-,117-,118-,119-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 3.75n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace radiolabelled glucagon

J Med Chem 44: 1372-9 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50407844
PNG
(CHEMBL2115191)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C153H223N41O46S/c1-75(2)58-100(136(225)177-99(53-57-241-10)135(224)186-108(66-117(159)206)146(235)193-123(79(8)199)125(160)214)180-141(230)107(65-86-69-167-91-33-21-20-32-89(86)91)185-133(222)97(47-51-116(158)205)178-150(239)122(77(5)6)192-144(233)105(61-82-28-16-12-17-29-82)184-142(231)109(67-120(210)211)187-132(221)96(46-50-115(157)204)171-126(215)78(7)169-129(218)93(35-24-55-165-152(161)162)173-130(219)94(36-25-56-166-153(163)164)175-148(237)112(73-197)190-143(232)110(68-121(212)213)188-137(226)101(59-76(3)4)179-139(228)104(64-85-39-43-88(202)44-40-85)181-131(220)92(34-22-23-54-154)174-147(236)111(72-196)189-140(229)103(60-81-26-14-11-15-27-81)182-134(223)98(48-52-119(208)209)176-149(238)113(74-198)191-151(240)124(80(9)200)194-145(234)106(62-83-30-18-13-19-31-83)183-138(227)102(63-84-37-41-87(201)42-38-84)170-118(207)70-168-128(217)95(45-49-114(156)203)172-127(216)90(155)71-195/h11-21,26-33,37-44,69,75-80,90,92-113,122-124,167,195-202H,22-25,34-36,45-68,70-74,154-155H2,1-10H3,(H2,156,203)(H2,157,204)(H2,158,205)(H2,159,206)(H2,160,214)(H,168,217)(H,169,218)(H,170,207)(H,171,215)(H,172,216)(H,173,219)(H,174,236)(H,175,237)(H,176,238)(H,177,225)(H,178,239)(H,179,228)(H,180,230)(H,181,220)(H,182,223)(H,183,227)(H,184,231)(H,185,222)(H,186,224)(H,187,221)(H,188,226)(H,189,229)(H,190,232)(H,191,240)(H,192,233)(H,193,235)(H,194,234)(H,208,209)(H,210,211)(H,212,213)(H4,161,162,165)(H4,163,164,166)/t78-,79+,80+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.10n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of [125I]glucagon binding towards Glucagon receptor

J Med Chem 39: 2449-55 (1996)


Article DOI: 10.1021/jm960130b
BindingDB Entry DOI: 10.7270/Q2JH3MT3
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50057796
PNG
(CHEMBL3326188)
Show SMILES CCCCCc1ccc(cc1)-c1ccoc1C(=O)NNC(=O)c1ccc(O)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C23H23N3O6/c1-2-3-4-5-15-6-8-16(9-7-15)18-12-13-32-21(18)23(29)25-24-22(28)17-10-11-20(27)19(14-17)26(30)31/h6-14,27H,2-5H2,1H3,(H,24,28)(H,25,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.30n/an/an/an/an/an/a



Dainippon Sumitomo Pharma. Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of glucagon-induced glucagon receptor-mediated cAMP production in rat hepatocytes after 15 mins by cAMP dynamic2 assay

Bioorg Med Chem Lett 24: 4266-70 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.025
BindingDB Entry DOI: 10.7270/Q2ZW1NK4
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50104031
PNG
(CHEMBL263603 | His-Cys-Gln-Gly-Thr-Phe-Cys-Ser-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C152H223N43O47S3/c1-72(2)51-96(132(223)175-95(46-50-245-10)131(222)183-103(59-115(158)206)142(233)195-122(77(9)200)150(241)242)178-137(228)102(57-82-63-166-88-28-18-17-27-86(82)88)182-130(221)94(42-45-114(157)205)176-148(239)120(74(5)6)194-141(232)101(54-79-25-15-12-16-26-79)181-138(229)104(60-117(208)209)184-129(220)93(41-44-113(156)204)170-123(214)75(7)169-126(217)90(30-21-48-164-151(159)160)171-127(218)91(31-22-49-165-152(161)162)173-144(235)108(67-197)189-140(231)106(62-119(212)213)185-133(224)97(52-73(3)4)177-134(225)98(55-80-32-36-84(201)37-33-80)179-128(219)89(29-19-20-47-153)172-143(234)107(66-196)188-135(226)99(56-81-34-38-85(202)39-35-81)180-139(230)105(61-118(210)211)186-145(236)109(68-198)190-147(238)111(70-244)192-136(227)100(53-78-23-13-11-14-24-78)187-149(240)121(76(8)199)193-116(207)65-167-125(216)92(40-43-112(155)203)174-146(237)110(69-243)191-124(215)87(154)58-83-64-163-71-168-83/h11-18,23-28,32-39,63-64,71-77,87,89-111,120-122,166,196-202,243-244H,19-22,29-31,40-62,65-70,153-154H2,1-10H3,(H2,155,203)(H2,156,204)(H2,157,205)(H2,158,206)(H,163,168)(H,167,216)(H,169,217)(H,170,214)(H,171,218)(H,172,234)(H,173,235)(H,174,237)(H,175,223)(H,176,239)(H,177,225)(H,178,228)(H,179,219)(H,180,230)(H,181,229)(H,182,221)(H,183,222)(H,184,220)(H,185,224)(H,186,236)(H,187,240)(H,188,226)(H,189,231)(H,190,238)(H,191,215)(H,192,227)(H,193,207)(H,194,232)(H,195,233)(H,208,209)(H,210,211)(H,212,213)(H,241,242)(H4,159,160,164)(H4,161,162,165)/t75-,76+,77+,87-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 5.60n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration

J Med Chem 44: 3109-16 (2001)


BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50104043
PNG
(CHEMBL437648 | His-Ser-Lys-Gly-Thr-Phe-Glu-Ser-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2c[nH]cn2)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C155H227N43O48S/c1-75(2)55-100(136(228)179-99(49-54-247-10)135(227)187-107(63-117(160)209)146(238)198-125(80(9)204)153(245)246)182-141(233)106(61-85-67-169-91-30-18-17-29-89(85)91)186-133(225)97(44-47-116(159)208)180-151(243)123(77(5)6)197-145(237)105(58-82-27-15-12-16-28-82)185-142(234)108(64-120(212)213)188-132(224)96(43-46-115(158)207)173-126(218)78(7)172-129(221)94(33-23-52-167-154(161)162)175-130(222)95(34-24-53-168-155(163)164)177-149(241)113(72-201)195-144(236)110(66-122(216)217)189-137(229)101(56-76(3)4)181-139(231)102(59-83-35-39-87(205)40-36-83)183-131(223)93(31-19-21-50-156)176-148(240)112(71-200)194-140(232)103(60-84-37-41-88(206)42-38-84)184-143(235)109(65-121(214)215)190-150(242)114(73-202)193-134(226)98-45-48-118(210)166-51-22-20-32-92(174-147(239)111(70-199)192-127(219)90(157)62-86-68-165-74-171-86)128(220)170-69-119(211)196-124(79(8)203)152(244)191-104(138(230)178-98)57-81-25-13-11-14-26-81/h11-18,25-30,35-42,67-68,74-80,90,92-114,123-125,169,199-206H,19-24,31-34,43-66,69-73,156-157H2,1-10H3,(H2,158,207)(H2,159,208)(H2,160,209)(H,165,171)(H,166,210)(H,170,220)(H,172,221)(H,173,218)(H,174,239)(H,175,222)(H,176,240)(H,177,241)(H,178,230)(H,179,228)(H,180,243)(H,181,231)(H,182,233)(H,183,223)(H,184,235)(H,185,234)(H,186,225)(H,187,227)(H,188,224)(H,189,229)(H,190,242)(H,191,244)(H,192,219)(H,193,226)(H,194,232)(H,195,236)(H,196,211)(H,197,237)(H,198,238)(H,212,213)(H,214,215)(H,216,217)(H,245,246)(H4,161,162,167)(H4,163,164,168)/t78-,79+,80+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 6n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration

J Med Chem 44: 3109-16 (2001)


BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50104041
PNG
(CHEMBL414077 | His-Ser-Gln-Gly-Thr-Phe-Cys-Ser-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C149H216N42O48S3/c1-69(2)47-92(128(219)170-91(43-46-242-10)127(218)178-99(55-112(154)203)138(229)191-119(74(9)197)147(238)239)173-133(224)98(53-79-59-162-85-26-18-17-25-83(79)85)177-126(217)90(39-42-111(153)202)171-145(236)117(71(5)6)190-137(228)97(50-76-23-15-12-16-24-76)175-134(225)100(56-114(205)206)179-125(216)89(38-41-110(152)201)166-120(211)72(7)165-123(214)86(27-19-44-160-148(155)156)167-124(215)87(28-20-45-161-149(157)158)168-140(231)104(63-193)185-136(227)102(58-116(209)210)180-129(220)93(48-70(3)4)172-130(221)94(51-77-29-33-81(198)34-30-77)176-143(234)107(66-240)188-142(233)106(65-195)184-131(222)95(52-78-31-35-82(199)36-32-78)174-135(226)101(57-115(207)208)181-141(232)105(64-194)186-144(235)108(67-241)187-132(223)96(49-75-21-13-11-14-22-75)182-146(237)118(73(8)196)189-113(204)61-163-122(213)88(37-40-109(151)200)169-139(230)103(62-192)183-121(212)84(150)54-80-60-159-68-164-80/h11-18,21-26,29-36,59-60,68-74,84,86-108,117-119,162,192-199,240-241H,19-20,27-28,37-58,61-67,150H2,1-10H3,(H2,151,200)(H2,152,201)(H2,153,202)(H2,154,203)(H,159,164)(H,163,213)(H,165,214)(H,166,211)(H,167,215)(H,168,231)(H,169,230)(H,170,219)(H,171,236)(H,172,221)(H,173,224)(H,174,226)(H,175,225)(H,176,234)(H,177,217)(H,178,218)(H,179,216)(H,180,220)(H,181,232)(H,182,237)(H,183,212)(H,184,222)(H,185,227)(H,186,235)(H,187,223)(H,188,233)(H,189,204)(H,190,228)(H,191,229)(H,205,206)(H,207,208)(H,209,210)(H,238,239)(H4,155,156,160)(H4,157,158,161)/t72-,73+,74+,84-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 6.40n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration

J Med Chem 44: 3109-16 (2001)


BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50454201
PNG
(CHEMBL3037804)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)[C@H](C)c1ccccc1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C154H225N41O46S/c1-75(2)59-101(137(226)178-100(54-58-242-11)135(224)186-108(66-117(160)207)146(235)194-124(80(9)200)126(161)215)181-141(230)107(65-87-69-168-92-34-22-21-33-90(87)92)185-134(223)98(48-52-116(159)206)179-150(239)122(77(5)6)192-144(233)105(61-82-27-15-12-16-28-82)184-142(231)109(67-120(211)212)187-133(222)97(47-51-115(158)205)172-127(216)79(8)170-130(219)94(36-25-56-166-153(162)163)174-131(220)95(37-26-57-167-154(164)165)176-147(236)111(72-197)189-143(232)110(68-121(213)214)188-138(227)102(60-76(3)4)180-140(229)104(64-85-40-44-89(203)45-41-85)182-132(221)93(35-23-24-55-155)175-148(237)112(73-198)190-151(240)123(78(7)86-31-19-14-20-32-86)193-136(225)99(49-53-119(209)210)177-149(238)113(74-199)191-152(241)125(81(10)201)195-145(234)106(62-83-29-17-13-18-30-83)183-139(228)103(63-84-38-42-88(202)43-39-84)171-118(208)70-169-129(218)96(46-50-114(157)204)173-128(217)91(156)71-196/h12-22,27-34,38-45,69,75-81,91,93-113,122-125,168,196-203H,23-26,35-37,46-68,70-74,155-156H2,1-11H3,(H2,157,204)(H2,158,205)(H2,159,206)(H2,160,207)(H2,161,215)(H,169,218)(H,170,219)(H,171,208)(H,172,216)(H,173,217)(H,174,220)(H,175,237)(H,176,236)(H,177,238)(H,178,226)(H,179,239)(H,180,229)(H,181,230)(H,182,221)(H,183,228)(H,184,231)(H,185,223)(H,186,224)(H,187,222)(H,188,227)(H,189,232)(H,190,240)(H,191,241)(H,192,233)(H,193,225)(H,194,235)(H,195,234)(H,209,210)(H,211,212)(H,213,214)(H4,162,163,166)(H4,164,165,167)/t78-,79+,80-,81-,91+,93+,94+,95+,96+,97+,98+,99-,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113+,122+,123+,124+,125+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of [125I]glucagon binding towards Glucagon receptor

J Med Chem 39: 2449-55 (1996)


Article DOI: 10.1021/jm960130b
BindingDB Entry DOI: 10.7270/Q2JH3MT3
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50104033
PNG
(CHEMBL442135 | His-Ser-Gln-Gly-Thr-Phe-Lys-Ser-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C157H230N44O48S/c1-76(2)57-102(139(232)183-101(51-56-250-10)138(231)191-109(65-119(163)212)149(242)201-127(81(9)206)155(248)249)186-144(237)108(63-86-69-172-92-30-18-17-29-90(86)92)190-137(230)99(45-49-118(162)211)184-153(246)125(78(5)6)200-148(241)107(60-83-27-15-12-16-28-83)189-145(238)110(66-122(215)216)192-136(229)98(44-48-117(161)210)176-128(221)79(7)175-131(224)95(33-23-54-170-156(164)165)178-132(225)96(34-24-55-171-157(166)167)180-151(244)114(73-203)198-147(240)112(68-124(219)220)193-140(233)103(58-77(3)4)185-143(236)105(62-85-37-41-89(208)42-38-85)187-133(226)93(31-19-21-52-158)177-135(228)100-46-50-120(213)169-53-22-20-32-94(134(227)197-115(74-204)152(245)194-111(67-123(217)218)146(239)188-104(141(234)182-100)61-84-35-39-88(207)40-36-84)179-142(235)106(59-82-25-13-11-14-26-82)195-154(247)126(80(8)205)199-121(214)71-173-130(223)97(43-47-116(160)209)181-150(243)113(72-202)196-129(222)91(159)64-87-70-168-75-174-87/h11-18,25-30,35-42,69-70,75-81,91,93-115,125-127,172,202-208H,19-24,31-34,43-68,71-74,158-159H2,1-10H3,(H2,160,209)(H2,161,210)(H2,162,211)(H2,163,212)(H,168,174)(H,169,213)(H,173,223)(H,175,224)(H,176,221)(H,177,228)(H,178,225)(H,179,235)(H,180,244)(H,181,243)(H,182,234)(H,183,232)(H,184,246)(H,185,236)(H,186,237)(H,187,226)(H,188,239)(H,189,238)(H,190,230)(H,191,231)(H,192,229)(H,193,233)(H,194,245)(H,195,247)(H,196,222)(H,197,227)(H,198,240)(H,199,214)(H,200,241)(H,201,242)(H,215,216)(H,217,218)(H,219,220)(H,248,249)(H4,164,165,170)(H4,166,167,171)/t79-,80+,81+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,125-,126-,127-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 14n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration

J Med Chem 44: 3109-16 (2001)


BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50104044
PNG
(CHEMBL409654 | His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C150H219N43O49S3/c1-70(2)49-93(129(222)172-92(44-48-245-8)128(221)179-99(56-112(156)206)138(231)193-120(74(7)200)148(241)242)174-132(225)98(54-79-60-164-85-26-16-15-25-83(79)85)178-127(220)91(40-43-111(155)205)173-145(238)117(71(3)4)191-136(229)96(50-75-21-11-9-12-22-75)177-133(226)100(57-114(208)209)180-126(219)90(39-42-110(154)204)171-143(236)107(67-243)188-125(218)88(29-20-47-163-150(159)160)167-123(216)87(28-19-46-162-149(157)158)169-141(234)105(65-196)186-135(228)102(59-116(212)213)182-144(237)108(68-244)189-131(224)95(53-78-32-36-82(202)37-33-78)175-124(217)86(27-17-18-45-151)168-140(233)104(64-195)185-130(223)94(52-77-30-34-81(201)35-31-77)176-134(227)101(58-115(210)211)181-142(235)106(66-197)187-147(240)119(73(6)199)192-137(230)97(51-76-23-13-10-14-24-76)183-146(239)118(72(5)198)190-113(207)62-165-122(215)89(38-41-109(153)203)170-139(232)103(63-194)184-121(214)84(152)55-80-61-161-69-166-80/h9-16,21-26,30-37,60-61,69-74,84,86-108,117-120,164,194-202,243-244H,17-20,27-29,38-59,62-68,151-152H2,1-8H3,(H2,153,203)(H2,154,204)(H2,155,205)(H2,156,206)(H,161,166)(H,165,215)(H,167,216)(H,168,233)(H,169,234)(H,170,232)(H,171,236)(H,172,222)(H,173,238)(H,174,225)(H,175,217)(H,176,227)(H,177,226)(H,178,220)(H,179,221)(H,180,219)(H,181,235)(H,182,237)(H,183,239)(H,184,214)(H,185,223)(H,186,228)(H,187,240)(H,188,218)(H,189,224)(H,190,207)(H,191,229)(H,192,230)(H,193,231)(H,208,209)(H,210,211)(H,212,213)(H,241,242)(H4,157,158,162)(H4,159,160,163)/t72-,73-,74-,84+,86+,87+,88+,89+,90+,91+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,117+,118+,119+,120+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 14n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration

J Med Chem 44: 3109-16 (2001)


BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50098573
PNG
(CHEMBL267876 | N-trinitrophenyl-His-Ser-Gln-Gly-Th...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)Nc1c(cc(cc1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C160H229N49O54S/c1-74(2)52-99(139(239)186-98(47-51-264-11)138(238)194-107(62-120(164)222)150(250)205-126(78(8)214)130(165)230)189-143(243)105(58-85-66-176-91-29-19-18-28-90(85)91)193-137(237)97(43-46-119(163)221)187-155(255)125(76(5)6)204-148(248)103(54-81-24-14-12-15-25-81)192-145(245)108(63-122(224)225)195-136(236)96(42-45-118(162)220)181-131(231)77(7)179-133(233)93(31-22-49-174-159(168)169)182-134(234)94(32-23-50-175-160(170)171)184-152(252)112(70-211)201-147(247)110(65-124(228)229)196-140(240)100(53-75(3)4)188-141(241)101(56-83-33-37-88(217)38-34-83)190-135(235)92(30-20-21-48-173-158(166)167)183-151(251)111(69-210)199-142(242)102(57-84-35-39-89(218)40-36-84)191-146(246)109(64-123(226)227)197-154(254)114(72-213)202-157(257)128(80(10)216)206-149(249)104(55-82-26-16-13-17-27-82)198-156(256)127(79(9)215)203-121(223)68-177-132(232)95(41-44-117(161)219)185-153(253)113(71-212)200-144(244)106(59-86-67-172-73-178-86)180-129-115(208(260)261)60-87(207(258)259)61-116(129)209(262)263/h12-19,24-29,33-40,60-61,66-67,73-80,92-114,125-128,176,180,210-218H,20-23,30-32,41-59,62-65,68-72H2,1-11H3,(H2,161,219)(H2,162,220)(H2,163,221)(H2,164,222)(H2,165,230)(H,172,178)(H,177,232)(H,179,233)(H,181,231)(H,182,234)(H,183,251)(H,184,252)(H,185,253)(H,186,239)(H,187,255)(H,188,241)(H,189,243)(H,190,235)(H,191,246)(H,192,245)(H,193,237)(H,194,238)(H,195,236)(H,196,240)(H,197,254)(H,198,256)(H,199,242)(H,200,244)(H,201,247)(H,202,257)(H,203,223)(H,204,248)(H,205,250)(H,206,249)(H,224,225)(H,226,227)(H,228,229)(H4,166,167,173)(H4,168,169,174)(H4,170,171,175)/t77-,78+,79+,80+,92+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,125-,126-,127-,128-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace radiolabelled glucagon (inactive up to 100 microM)

J Med Chem 44: 1372-9 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50059352
PNG
(CHEMBL442499 | [des-His1, Trp6, Glu9] glucagon-NH2)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C150H222N42O47S/c1-70(2)53-97(133(224)174-96(48-52-240-11)132(223)182-104(60-113(156)205)142(233)191-119(74(8)197)122(157)213)177-137(228)102(58-80-63-164-87-27-17-15-25-84(80)87)181-130(221)94(42-46-112(155)204)175-146(237)118(72(5)6)190-140(231)101(55-77-23-13-12-14-24-77)180-138(229)105(61-116(209)210)183-129(220)93(41-45-111(154)203)168-123(214)73(7)167-126(217)90(30-21-50-162-149(158)159)170-127(218)91(31-22-51-163-150(160)161)172-144(235)108(68-195)187-139(230)106(62-117(211)212)184-134(225)98(54-71(3)4)176-135(226)99(56-78-32-36-82(200)37-33-78)178-128(219)89(29-19-20-49-151)171-143(234)107(67-194)186-136(227)100(57-79-34-38-83(201)39-35-79)179-131(222)95(43-47-115(207)208)173-145(236)109(69-196)188-148(239)121(76(10)199)192-141(232)103(59-81-64-165-88-28-18-16-26-85(81)88)185-147(238)120(75(9)198)189-114(206)65-166-125(216)92(40-44-110(153)202)169-124(215)86(152)66-193/h12-18,23-28,32-39,63-64,70-76,86,89-109,118-121,164-165,193-201H,19-22,29-31,40-62,65-69,151-152H2,1-11H3,(H2,153,202)(H2,154,203)(H2,155,204)(H2,156,205)(H2,157,213)(H,166,216)(H,167,217)(H,168,214)(H,169,215)(H,170,218)(H,171,234)(H,172,235)(H,173,236)(H,174,224)(H,175,237)(H,176,226)(H,177,228)(H,178,219)(H,179,222)(H,180,229)(H,181,221)(H,182,223)(H,183,220)(H,184,225)(H,185,238)(H,186,227)(H,187,230)(H,188,239)(H,189,206)(H,190,231)(H,191,233)(H,192,232)(H,207,208)(H,209,210)(H,211,212)(H4,158,159,162)(H4,160,161,163)/t73-,74+,75+,76+,86-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,118-,119-,120-,121-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon

J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50098566
PNG
(CHEMBL413208 | phenylbutyryl-Tyr-Ser-Lys-Tyr-Leu-A...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCc1ccccc1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C123H180N32O33S/c1-63(2)51-83(110(177)142-82(46-50-189-9)109(176)149-89(57-96(127)163)118(185)155-101(67(8)158)102(128)169)145-114(181)88(56-72-60-135-76-29-17-16-28-75(72)76)148-108(175)81(43-45-95(126)162)143-121(188)100(65(5)6)154-117(184)87(53-69-25-14-11-15-26-69)147-115(182)90(58-98(165)166)150-107(174)80(42-44-94(125)161)138-103(170)66(7)136-104(171)78(31-21-48-133-122(129)130)139-105(172)79(32-22-49-134-123(131)132)141-120(187)93(62-157)153-116(183)91(59-99(167)168)151-111(178)84(52-64(3)4)144-113(180)86(55-71-36-40-74(160)41-37-71)146-106(173)77(30-18-19-47-124)140-119(186)92(61-156)152-112(179)85(54-70-34-38-73(159)39-35-70)137-97(164)33-20-27-68-23-12-10-13-24-68/h10-17,23-26,28-29,34-41,60,63-67,77-93,100-101,135,156-160H,18-22,27,30-33,42-59,61-62,124H2,1-9H3,(H2,125,161)(H2,126,162)(H2,127,163)(H2,128,169)(H,136,171)(H,137,164)(H,138,170)(H,139,172)(H,140,186)(H,141,187)(H,142,177)(H,143,188)(H,144,180)(H,145,181)(H,146,173)(H,147,182)(H,148,175)(H,149,176)(H,150,174)(H,151,178)(H,152,179)(H,153,183)(H,154,184)(H,155,185)(H,165,166)(H,167,168)(H4,129,130,133)(H4,131,132,134)/t66-,67+,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,100-,101-/m0/s1
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n/an/a 21.2n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed as inhibition of [125]glucagon specific binding.

J Med Chem 44: 1372-9 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50171817
PNG
(3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluorom...)
Show SMILES CC(C)(C)C1CCC(CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |(6.78,6.58,;6.79,5.04,;8.33,5.04,;5.25,5.03,;6.79,3.5,;8.12,2.72,;8.12,1.19,;6.78,.42,;5.45,1.18,;5.45,2.73,;6.78,-1.12,;5.45,-1.89,;4.11,-1.12,;2.78,-1.9,;1.44,-1.12,;1.44,.42,;2.77,1.19,;4.11,.43,;.11,1.19,;.11,2.73,;-1.22,.42,;-2.56,1.19,;-3.89,.42,;-5.22,1.19,;-5.23,2.73,;-6.56,.42,;8.12,-1.89,;8.12,-3.43,;9.45,-1.12,;10.78,-1.88,;10.78,-3.42,;12.11,-4.19,;13.44,-3.42,;14.78,-4.19,;14.79,-5.73,;14.77,-7.26,;16.33,-5.73,;13.25,-5.72,;13.44,-1.87,;12.1,-1.11,)|
Show InChI InChI=1S/C29H36F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-7,10-11,14-15,21,23H,8-9,12-13,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37)
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n/an/a 23n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to GlucR in rat liver membrane

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50104096
PNG
(3-Chloro-4-hydroxy-benzoic acid (4-hydroxy-naphtha...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(O)c2ccccc12
Show InChI InChI=1S/C18H13ClN2O3/c19-15-9-11(5-8-17(15)23)18(24)21-20-10-12-6-7-16(22)14-4-2-1-3-13(12)14/h1-10,22-23H,(H,21,24)/b20-10+
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n/an/a 27n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards rat Glucagon Receptor

J Med Chem 44: 3141-9 (2001)


BindingDB Entry DOI: 10.7270/Q2QR4WFT
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50098572
PNG
(Ac-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C135H198N36O41S/c1-65(2)50-87(118(197)154-86(45-49-213-11)117(196)162-94(57-103(139)182)128(207)170-108(69(8)175)110(140)189)157-122(201)93(56-76-61-147-80-29-19-18-28-79(76)80)161-116(195)85(42-44-102(138)181)155-132(211)107(67(5)6)169-127(206)92(53-73-26-16-13-17-27-73)160-123(202)95(58-104(183)184)163-115(194)84(41-43-101(137)180)150-111(190)68(7)148-112(191)82(31-22-47-145-134(141)142)151-113(192)83(32-23-48-146-135(143)144)153-130(209)99(63-173)167-125(204)97(60-106(187)188)164-119(198)88(51-66(3)4)156-120(199)90(54-74-33-37-77(178)38-34-74)158-114(193)81(30-20-21-46-136)152-129(208)98(62-172)166-121(200)91(55-75-35-39-78(179)40-36-75)159-124(203)96(59-105(185)186)165-131(210)100(64-174)168-133(212)109(70(9)176)171-126(205)89(149-71(10)177)52-72-24-14-12-15-25-72/h12-19,24-29,33-40,61,65-70,81-100,107-109,147,172-176,178-179H,20-23,30-32,41-60,62-64,136H2,1-11H3,(H2,137,180)(H2,138,181)(H2,139,182)(H2,140,189)(H,148,191)(H,149,177)(H,150,190)(H,151,192)(H,152,208)(H,153,209)(H,154,197)(H,155,211)(H,156,199)(H,157,201)(H,158,193)(H,159,203)(H,160,202)(H,161,195)(H,162,196)(H,163,194)(H,164,198)(H,165,210)(H,166,200)(H,167,204)(H,168,212)(H,169,206)(H,170,207)(H,171,205)(H,183,184)(H,185,186)(H,187,188)(H4,141,142,145)(H4,143,144,146)/t68-,69+,70+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,107-,108-,109-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed as inhibition of [125]glucagon specific binding.

J Med Chem 44: 1372-9 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50407842
PNG
(CHEMBL2114176)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C153H223N41O46S/c1-75(2)58-100(136(225)177-99(53-57-241-10)135(224)186-108(66-117(159)206)146(235)193-123(79(8)199)125(160)214)180-141(230)107(65-86-69-167-91-33-21-20-32-89(86)91)185-133(222)97(47-51-116(158)205)178-150(239)122(77(5)6)192-144(233)105(61-82-28-16-12-17-29-82)184-142(231)109(67-120(210)211)187-132(221)96(46-50-115(157)204)171-126(215)78(7)169-129(218)93(35-24-55-165-152(161)162)173-130(219)94(36-25-56-166-153(163)164)175-148(237)112(73-197)190-143(232)110(68-121(212)213)188-137(226)101(59-76(3)4)179-139(228)104(64-85-39-43-88(202)44-40-85)181-131(220)92(34-22-23-54-154)174-147(236)111(72-196)189-140(229)103(60-81-26-14-11-15-27-81)182-134(223)98(48-52-119(208)209)176-149(238)113(74-198)191-151(240)124(80(9)200)194-145(234)106(62-83-30-18-13-19-31-83)183-138(227)102(63-84-37-41-87(201)42-38-84)170-118(207)70-168-128(217)95(45-49-114(156)203)172-127(216)90(155)71-195/h11-21,26-33,37-44,69,75-80,90,92-113,122-124,167,195-202H,22-25,34-36,45-68,70-74,154-155H2,1-10H3,(H2,156,203)(H2,157,204)(H2,158,205)(H2,159,206)(H2,160,214)(H,168,217)(H,169,218)(H,170,207)(H,171,215)(H,172,216)(H,173,219)(H,174,236)(H,175,237)(H,176,238)(H,177,225)(H,178,239)(H,179,228)(H,180,230)(H,181,220)(H,182,223)(H,183,227)(H,184,231)(H,185,222)(H,186,224)(H,187,221)(H,188,226)(H,189,229)(H,190,232)(H,191,240)(H,192,233)(H,193,235)(H,194,234)(H,208,209)(H,210,211)(H,212,213)(H4,161,162,165)(H4,163,164,166)/t78-,79+,80+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103+,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-/m0/s1
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n/an/a 34.5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of [125I]glucagon binding towards Glucagon receptor

J Med Chem 39: 2449-55 (1996)


Article DOI: 10.1021/jm960130b
BindingDB Entry DOI: 10.7270/Q2JH3MT3
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50202031
PNG
(3-(4-((1-(4-cyclohexenylphenyl)-3-(3,5-dichlorophe...)
Show SMILES OC(=O)CCNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1 |t:33|
Show InChI InChI=1S/C30H29Cl2N3O4/c31-24-16-25(32)18-26(17-24)34-30(39)35(27-12-10-22(11-13-27)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(38)33-15-14-28(36)37/h4,6-13,16-18H,1-3,5,14-15,19H2,(H,33,38)(H,34,39)(H,36,37)
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n/an/a 36n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to GlucR in rat liver membrane

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50059358
PNG
(CHEMBL267885 | [des-His1, Tyr6,Glu9] glucagon-NH2)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C148H221N41O48S/c1-69(2)53-95(131(222)171-94(48-52-238-11)130(221)179-102(60-111(154)203)140(231)188-117(73(8)194)120(155)211)174-135(226)101(59-80-63-162-86-24-16-15-23-84(80)86)178-128(219)92(42-46-110(153)202)172-144(235)116(71(5)6)187-138(229)99(55-76-21-13-12-14-22-76)177-136(227)103(61-114(207)208)180-127(218)91(41-45-109(152)201)165-121(212)72(7)164-124(215)88(26-19-50-160-147(156)157)167-125(216)89(27-20-51-161-148(158)159)169-142(233)106(67-192)184-137(228)104(62-115(209)210)181-132(223)96(54-70(3)4)173-133(224)97(56-77-28-34-81(197)35-29-77)175-126(217)87(25-17-18-49-149)168-141(232)105(66-191)183-134(225)98(57-78-30-36-82(198)37-31-78)176-129(220)93(43-47-113(205)206)170-143(234)107(68-193)185-146(237)119(75(10)196)189-139(230)100(58-79-32-38-83(199)39-33-79)182-145(236)118(74(9)195)186-112(204)64-163-123(214)90(40-44-108(151)200)166-122(213)85(150)65-190/h12-16,21-24,28-39,63,69-75,85,87-107,116-119,162,190-199H,17-20,25-27,40-62,64-68,149-150H2,1-11H3,(H2,151,200)(H2,152,201)(H2,153,202)(H2,154,203)(H2,155,211)(H,163,214)(H,164,215)(H,165,212)(H,166,213)(H,167,216)(H,168,232)(H,169,233)(H,170,234)(H,171,222)(H,172,235)(H,173,224)(H,174,226)(H,175,217)(H,176,220)(H,177,227)(H,178,219)(H,179,221)(H,180,218)(H,181,223)(H,182,236)(H,183,225)(H,184,228)(H,185,237)(H,186,204)(H,187,229)(H,188,231)(H,189,230)(H,205,206)(H,207,208)(H,209,210)(H4,156,157,160)(H4,158,159,161)/t72-,73+,74+,75+,85-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,116-,117-,118-,119-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon

J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50244455
PNG
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichl...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:31|
Show InChI InChI=1S/C30H29Cl2N3O5/c31-23-14-24(32)16-25(15-23)34-30(40)35(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(37)33-17-27(36)29(38)39/h4,6-16,27,36H,1-3,5,17-18H2,(H,33,37)(H,34,40)(H,38,39)/t27-/m1/s1
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n/an/a 43n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to GlucR in rat liver membrane

J Med Chem 51: 5387-96 (2008)


Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50059356
PNG
(CHEMBL2369990 | [des-His1, Nle6, Glu9] glucagon-NH...)
Show SMILES CCCCC(NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CO)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](C)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C148H221N41O47S/c1-70(2)54-95(131(221)171-94(49-53-237-11)130(220)179-102(61-111(154)202)140(230)188-117(74(8)194)120(155)210)174-135(225)101(60-81-64-162-86-29-19-18-28-84(81)86)178-128(218)92(43-47-110(153)201)172-144(234)116(72(5)6)187-138(228)99(56-77-24-14-12-15-25-77)177-136(226)103(62-114(206)207)180-127(217)91(42-46-109(152)200)165-121(211)73(7)164-124(214)88(31-22-51-160-147(156)157)167-125(215)89(32-23-52-161-148(158)159)169-142(232)106(68-192)184-137(227)104(63-115(208)209)181-132(222)96(55-71(3)4)173-133(223)97(58-79-33-37-82(197)38-34-79)175-126(216)87(30-20-21-50-149)168-141(231)105(67-191)183-134(224)98(59-80-35-39-83(198)40-36-80)176-129(219)93(44-48-113(204)205)170-143(233)107(69-193)185-146(236)119(76(10)196)189-139(229)100(57-78-26-16-13-17-27-78)182-145(235)118(75(9)195)186-112(203)65-163-123(213)90(41-45-108(151)199)166-122(212)85(150)66-190/h12-19,24-29,33-40,64,70-76,85,87-107,116-119,162,190-198H,20-23,30-32,41-63,65-69,149-150H2,1-11H3,(H2,151,199)(H2,152,200)(H2,153,201)(H2,154,202)(H2,155,210)(H,163,213)(H,164,214)(H,165,211)(H,166,212)(H,167,215)(H,168,231)(H,169,232)(H,170,233)(H,171,221)(H,172,234)(H,173,223)(H,174,225)(H,175,216)(H,176,219)(H,177,226)(H,178,218)(H,179,220)(H,180,217)(H,181,222)(H,182,235)(H,183,224)(H,184,227)(H,185,236)(H,186,203)(H,187,228)(H,188,230)(H,189,229)(H,204,205)(H,206,207)(H,208,209)(H4,156,157,160)(H4,158,159,161)/t73-,74+,75+,76+,85-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100+,101-,102-,103-,104-,105-,106-,107-,116-,117-,118-,119-/m1/s1
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n/an/a 48n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon

J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50098570
PNG
(CHEMBL438045 | Ser-Gln-Gly-Thr-Thr-Ser-Glu-Tyr-Ser...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C139H212N40O46S/c1-64(2)49-88(123(211)162-87(44-48-226-11)122(210)170-94(55-103(145)192)131(219)178-109(68(8)184)112(146)200)165-127(215)93(54-74-58-153-79-24-16-15-23-77(74)79)169-120(208)85(38-42-102(144)191)163-135(223)108(66(5)6)177-130(218)92(51-71-21-13-12-14-22-71)168-128(216)95(56-106(196)197)171-119(207)84(37-41-101(143)190)156-113(201)67(7)155-116(204)81(26-19-46-151-138(147)148)158-117(205)82(27-20-47-152-139(149)150)160-133(221)98(62-182)174-129(217)96(57-107(198)199)172-124(212)89(50-65(3)4)164-125(213)90(52-72-28-32-75(187)33-29-72)166-118(206)80(25-17-18-45-140)159-132(220)97(61-181)173-126(214)91(53-73-30-34-76(188)35-31-73)167-121(209)86(39-43-105(194)195)161-134(222)99(63-183)175-136(224)111(70(10)186)179-137(225)110(69(9)185)176-104(193)59-154-115(203)83(36-40-100(142)189)157-114(202)78(141)60-180/h12-16,21-24,28-35,58,64-70,78,80-99,108-111,153,180-188H,17-20,25-27,36-57,59-63,140-141H2,1-11H3,(H2,142,189)(H2,143,190)(H2,144,191)(H2,145,192)(H2,146,200)(H,154,203)(H,155,204)(H,156,201)(H,157,202)(H,158,205)(H,159,220)(H,160,221)(H,161,222)(H,162,211)(H,163,223)(H,164,213)(H,165,215)(H,166,206)(H,167,209)(H,168,216)(H,169,208)(H,170,210)(H,171,207)(H,172,212)(H,173,214)(H,174,217)(H,175,224)(H,176,193)(H,177,218)(H,178,219)(H,179,225)(H,194,195)(H,196,197)(H,198,199)(H4,147,148,151)(H4,149,150,152)/t67-,68+,69+,70+,78-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,108-,109-,110-,111-/m0/s1
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n/an/a 48n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace radiolabelled glucagon

J Med Chem 44: 1372-9 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50059362
PNG
(CHEMBL268636 | [des-His1, des-Phe6, Glu9] glucagon...)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C139H212N40O46S/c1-64(2)49-88(123(211)162-87(44-48-226-11)122(210)170-94(55-103(145)192)131(219)178-109(68(8)184)112(146)200)165-127(215)93(54-74-58-153-79-24-16-15-23-77(74)79)169-120(208)85(38-42-102(144)191)163-135(223)108(66(5)6)177-130(218)92(51-71-21-13-12-14-22-71)168-128(216)95(56-106(196)197)171-119(207)84(37-41-101(143)190)156-113(201)67(7)155-116(204)81(26-19-46-151-138(147)148)158-117(205)82(27-20-47-152-139(149)150)160-133(221)98(62-182)174-129(217)96(57-107(198)199)172-124(212)89(50-65(3)4)164-125(213)90(52-72-28-32-75(187)33-29-72)166-118(206)80(25-17-18-45-140)159-132(220)97(61-181)173-126(214)91(53-73-30-34-76(188)35-31-73)167-121(209)86(39-43-105(194)195)161-134(222)99(63-183)175-136(224)111(70(10)186)179-137(225)110(69(9)185)176-104(193)59-154-115(203)83(36-40-100(142)189)157-114(202)78(141)60-180/h12-16,21-24,28-35,58,64-70,78,80-99,108-111,153,180-188H,17-20,25-27,36-57,59-63,140-141H2,1-11H3,(H2,142,189)(H2,143,190)(H2,144,191)(H2,145,192)(H2,146,200)(H,154,203)(H,155,204)(H,156,201)(H,157,202)(H,158,205)(H,159,220)(H,160,221)(H,161,222)(H,162,211)(H,163,223)(H,164,213)(H,165,215)(H,166,206)(H,167,209)(H,168,216)(H,169,208)(H,170,210)(H,171,207)(H,172,212)(H,173,214)(H,174,217)(H,175,224)(H,176,193)(H,177,218)(H,178,219)(H,179,225)(H,194,195)(H,196,197)(H,198,199)(H4,147,148,151)(H4,149,150,152)/t67-,68+,69+,70+,78-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,108-,109-,110-,111-/m1/s1
PDB

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KEGG

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n/an/a 48n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon

J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50284992
PNG
(CHEMBL441209 | H-Ser-Gln-GlyThr-Thr-Ser-Glu-Tyr-Se...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C130H203N39O44S/c1-59(2)45-81(115(200)153-80(40-44-214-11)114(199)160-86(50-95(136)181)122(207)168-101(63(8)174)104(137)189)156-118(203)85(49-68-53-144-72-24-16-15-23-70(68)72)159-112(197)78(34-38-94(135)180)154-126(211)100(61(5)6)167-121(206)84(47-66-21-13-12-14-22-66)158-119(204)87(51-98(185)186)161-111(196)77(33-37-93(134)179)147-105(190)62(7)146-108(193)74(26-19-42-142-129(138)139)149-109(194)75(27-20-43-143-130(140)141)151-124(209)90(57-172)164-120(205)88(52-99(187)188)162-116(201)82(46-60(3)4)155-110(195)73(25-17-18-41-131)150-123(208)89(56-171)163-117(202)83(48-67-28-30-69(177)31-29-67)157-113(198)79(35-39-97(183)184)152-125(210)91(58-173)165-127(212)103(65(10)176)169-128(213)102(64(9)175)166-96(182)54-145-107(192)76(32-36-92(133)178)148-106(191)71(132)55-170/h12-16,21-24,28-31,53,59-65,71,73-91,100-103,144,170-177H,17-20,25-27,32-52,54-58,131-132H2,1-11H3,(H2,133,178)(H2,134,179)(H2,135,180)(H2,136,181)(H2,137,189)(H,145,192)(H,146,193)(H,147,190)(H,148,191)(H,149,194)(H,150,208)(H,151,209)(H,152,210)(H,153,200)(H,154,211)(H,155,195)(H,156,203)(H,157,198)(H,158,204)(H,159,197)(H,160,199)(H,161,196)(H,162,201)(H,163,202)(H,164,205)(H,165,212)(H,166,182)(H,167,206)(H,168,207)(H,169,213)(H,183,184)(H,185,186)(H,187,188)(H4,138,139,142)(H4,140,141,143)/t62-,63+,64+,65+,71-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,100-,101-,102-,103-/m0/s1
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n/an/a 48n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
pA2 value towards glucagon receptor relative to glucagon was calculated

Bioorg Med Chem Lett 5: 1849-1852 (1995)


Article DOI: 10.1016/0960-894X(95)00307-F
BindingDB Entry DOI: 10.7270/Q2G44Q7P
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50059359
PNG
(CHEMBL411289 | [des-His1, des-Gly4, Glu9] glucagon...)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C146H218N40O46S/c1-69(2)54-94(129(217)168-93(49-53-233-11)127(215)176-101(61-110(152)199)138(226)184-115(73(8)191)118(153)206)171-133(221)100(60-80-64-160-85-29-19-18-28-83(80)85)175-125(213)90(42-46-108(150)197)169-142(230)114(71(5)6)183-136(224)98(56-76-24-14-12-15-25-76)174-134(222)102(62-112(202)203)177-124(212)89(41-45-107(149)196)162-119(207)72(7)161-121(209)87(31-22-51-158-145(154)155)164-122(210)88(32-23-52-159-146(156)157)166-140(228)105(67-189)181-135(223)103(63-113(204)205)178-130(218)95(55-70(3)4)170-131(219)96(58-78-33-37-81(194)38-34-78)172-123(211)86(30-20-21-50-147)165-139(227)104(66-188)180-132(220)97(59-79-35-39-82(195)40-36-79)173-126(214)92(44-48-111(200)201)167-141(229)106(68-190)182-144(232)117(75(10)193)186-137(225)99(57-77-26-16-13-17-27-77)179-143(231)116(74(9)192)185-128(216)91(43-47-109(151)198)163-120(208)84(148)65-187/h12-19,24-29,33-40,64,69-75,84,86-106,114-117,160,187-195H,20-23,30-32,41-63,65-68,147-148H2,1-11H3,(H2,149,196)(H2,150,197)(H2,151,198)(H2,152,199)(H2,153,206)(H,161,209)(H,162,207)(H,163,208)(H,164,210)(H,165,227)(H,166,228)(H,167,229)(H,168,217)(H,169,230)(H,170,219)(H,171,221)(H,172,211)(H,173,214)(H,174,222)(H,175,213)(H,176,215)(H,177,212)(H,178,218)(H,179,231)(H,180,220)(H,181,223)(H,182,232)(H,183,224)(H,184,226)(H,185,216)(H,186,225)(H,200,201)(H,202,203)(H,204,205)(H4,154,155,158)(H4,156,157,159)/t72-,73+,74+,75+,84-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,114-,115-,116-,117-/m1/s1
PDB

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KEGG

UniProtKB/SwissProt

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n/an/a 52n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon

J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50087848
PNG
(CHEMBL427644 | c[Asp15, Lys18,] glucagon-NH2)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc2cnc[nH]2)[C@H](C)O)[C@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(N)=O)C(=O)N1)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C154H226N40O47S/c1-75(2)56-101(138(225)175-100(51-55-242-11)137(224)183-108(64-118(161)207)147(234)193-124(79(8)199)127(162)214)178-142(229)107(62-86-67-165-92-31-19-18-30-90(86)92)182-135(222)98(45-49-117(160)206)176-152(239)123(77(5)6)192-145(232)105(58-82-26-14-12-15-27-82)180-136(223)99-46-50-119(208)164-54-25-22-34-93(131(218)168-78(7)128(215)169-97(134(221)174-99)44-48-116(159)205)170-132(219)94(32-20-23-52-155)171-150(237)113(72-197)189-144(231)110(66-122(212)213)184-139(226)102(57-76(3)4)177-140(227)103(60-84-35-39-88(202)40-36-84)179-133(220)95(33-21-24-53-156)172-149(236)112(71-196)188-141(228)104(61-85-37-41-89(203)42-38-85)181-143(230)109(65-121(210)211)185-151(238)114(73-198)190-154(241)126(81(10)201)194-146(233)106(59-83-28-16-13-17-29-83)186-153(240)125(80(9)200)191-120(209)69-166-130(217)96(43-47-115(158)204)173-148(235)111(70-195)187-129(216)91(157)63-87-68-163-74-167-87/h12-19,26-31,35-42,67-68,74-81,91,93-114,123-126,165,195-203H,20-25,32-34,43-66,69-73,155-157H2,1-11H3,(H2,158,204)(H2,159,205)(H2,160,206)(H2,161,207)(H2,162,214)(H,163,167)(H,164,208)(H,166,217)(H,168,218)(H,169,215)(H,170,219)(H,171,237)(H,172,236)(H,173,235)(H,174,221)(H,175,225)(H,176,239)(H,177,227)(H,178,229)(H,179,220)(H,180,223)(H,181,230)(H,182,222)(H,183,224)(H,184,226)(H,185,238)(H,186,240)(H,187,216)(H,188,228)(H,189,231)(H,190,241)(H,191,209)(H,192,232)(H,193,234)(H,194,233)(H,210,211)(H,212,213)/t78-,79-,80-,81-,91+,93-,94-,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105-,106+,107+,108+,109+,110+,111+,112+,113+,114+,123+,124+,125+,126+/m0/s1
PDB

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UniProtKB/SwissProt

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n/an/a 54n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay

J Med Chem 43: 1714-22 (2000)


BindingDB Entry DOI: 10.7270/Q2XG9RVJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50144009
PNG
(3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorome...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |wU:4.3,wD:7.10,(10.18,2.9,;9.39,1.56,;8.05,2.34,;8.62,.21,;10.74,.78,;12.08,1.53,;13.41,.77,;13.41,-.77,;12.07,-1.54,;10.74,-.77,;14.74,-1.54,;14.74,-3.07,;13.39,-3.86,;12.07,-3.1,;10.74,-3.86,;10.74,-5.4,;12.07,-6.17,;13.41,-5.4,;9.41,-6.19,;9.43,-7.72,;8.06,-5.42,;6.74,-6.2,;5.4,-5.44,;4.07,-6.23,;2.73,-5.47,;4.07,-7.77,;16.06,-.77,;16.06,.77,;17.39,-1.54,;18.71,-.77,;20.04,-1.53,;21.38,-.77,;21.36,.78,;22.71,1.56,;22.7,3.09,;21.17,3.11,;24.23,3.11,;22.71,4.62,;20.04,1.55,;18.71,.77,)|
Show InChI InChI=1S/C29H36F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-7,10-11,14-15,21,23H,8-9,12-13,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37)/t21-,23-
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n/an/a 56n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Inhibition of rat glucagon receptor

J Med Chem 50: 113-28 (2007)


Article DOI: 10.1021/jm058026u
BindingDB Entry DOI: 10.7270/Q26M36GK
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50098565
PNG
(Ac-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C115H172N32O33S/c1-56(2)44-76(102(169)134-75(39-43-181-10)101(168)141-82(50-89(119)156)110(177)147-93(60(8)150)94(120)161)137-106(173)81(49-65-53-127-69-23-15-14-22-68(65)69)140-100(167)74(36-38-88(118)155)135-113(180)92(58(5)6)146-109(176)80(46-62-20-12-11-13-21-62)139-107(174)83(51-90(157)158)142-99(166)73(35-37-87(117)154)130-95(162)59(7)128-96(163)71(25-18-41-125-114(121)122)131-97(164)72(26-19-42-126-115(123)124)133-112(179)86(55-149)145-108(175)84(52-91(159)160)143-103(170)77(45-57(3)4)136-105(172)79(48-64-29-33-67(153)34-30-64)138-98(165)70(24-16-17-40-116)132-111(178)85(54-148)144-104(171)78(129-61(9)151)47-63-27-31-66(152)32-28-63/h11-15,20-23,27-34,53,56-60,70-86,92-93,127,148-150,152-153H,16-19,24-26,35-52,54-55,116H2,1-10H3,(H2,117,154)(H2,118,155)(H2,119,156)(H2,120,161)(H,128,163)(H,129,151)(H,130,162)(H,131,164)(H,132,178)(H,133,179)(H,134,169)(H,135,180)(H,136,172)(H,137,173)(H,138,165)(H,139,174)(H,140,167)(H,141,168)(H,142,166)(H,143,170)(H,144,171)(H,145,175)(H,146,176)(H,147,177)(H,157,158)(H,159,160)(H4,121,122,125)(H4,123,124,126)/t59-,60+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,92-,93-/m0/s1
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UniProtKB/SwissProt

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n/an/a 60n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed as inhibition of [125]glucagon specific binding.

J Med Chem 44: 1372-9 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50051585
PNG
(CHEMBL2369127 | [des-His1,Tyr5,Glu9,(2S,3R)-beta-M...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(C)c1ccccc1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C153H223N41O47S/c1-74(2)57-100(136(226)177-99(52-56-242-10)135(225)186-108(65-117(159)207)146(236)193-123(78(8)199)125(160)215)180-141(231)107(64-85-68-167-91-28-18-17-27-89(85)91)185-133(223)97(46-50-116(158)206)178-150(240)122(76(5)6)192-144(234)105(59-80-23-13-11-14-24-80)184-142(232)109(66-120(211)212)187-132(222)96(45-49-115(157)205)171-126(216)77(7)169-129(219)93(30-21-54-165-152(161)162)173-130(220)94(31-22-55-166-153(163)164)175-148(238)112(72-197)190-143(233)110(67-121(213)214)188-137(227)101(58-75(3)4)179-139(229)103(62-83-34-40-87(202)41-35-83)181-131(221)92(29-19-20-53-154)174-147(237)111(71-196)189-140(230)104(63-84-36-42-88(203)43-37-84)182-134(224)98(47-51-119(209)210)176-149(239)113(73-198)191-151(241)124(79(9)200)194-145(235)106(60-81-25-15-12-16-26-81)183-138(228)102(61-82-32-38-86(201)39-33-82)170-118(208)69-168-128(218)95(44-48-114(156)204)172-127(217)90(155)70-195/h11-18,23-28,32-43,68,74-79,90,92-113,122-124,167,195-203H,19-22,29-31,44-67,69-73,154-155H2,1-10H3,(H2,156,204)(H2,157,205)(H2,158,206)(H2,159,207)(H2,160,215)(H,168,218)(H,169,219)(H,170,208)(H,171,216)(H,172,217)(H,173,220)(H,174,237)(H,175,238)(H,176,239)(H,177,226)(H,178,240)(H,179,229)(H,180,231)(H,181,221)(H,182,224)(H,183,228)(H,184,232)(H,185,223)(H,186,225)(H,187,222)(H,188,227)(H,189,230)(H,190,233)(H,191,241)(H,192,234)(H,193,236)(H,194,235)(H,209,210)(H,211,212)(H,213,214)(H4,161,162,165)(H4,163,164,166)/t77-,78+,79+,90-,92-,93-,94-,95-,96-,97-,98+,99-,100-,101-,102-,103-,104+,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 74n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of [125I]glucagon binding towards Glucagon receptor

J Med Chem 39: 2449-55 (1996)


Article DOI: 10.1021/jm960130b
BindingDB Entry DOI: 10.7270/Q2JH3MT3
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50104036
PNG
(CHEMBL414490 | His-Ser-Gln-Cys-Thr-Phe-Thr-Ser-Cys...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2c[nH]cn2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H225N43O47S3/c1-72(2)52-97(132(223)175-96(47-51-244-11)131(222)183-104(60-116(159)209)141(232)196-122(78(10)203)151(242)243)178-136(227)103(58-83-63-167-89-29-19-18-28-87(83)89)182-129(220)95(43-46-115(158)208)176-148(239)119(74(5)6)193-139(230)101(54-79-24-14-12-15-25-79)180-137(228)105(61-117(210)211)184-128(219)93(41-44-113(156)206)170-123(214)75(7)169-125(216)91(31-22-49-165-152(160)161)171-126(217)92(32-23-50-166-153(162)163)173-144(235)109(67-199)189-138(229)106(62-118(212)213)185-133(224)98(53-73(3)4)177-134(225)99(56-81-33-37-85(204)38-34-81)179-127(218)90(30-20-21-48-154)172-143(234)108(66-198)188-135(226)100(57-82-35-39-86(205)40-36-82)181-146(237)111-69-245-246-70-112(191-130(221)94(42-45-114(157)207)174-142(233)107(65-197)187-124(215)88(155)59-84-64-164-71-168-84)147(238)195-120(76(8)201)149(240)186-102(55-80-26-16-13-17-27-80)140(231)194-121(77(9)202)150(241)190-110(68-200)145(236)192-111/h12-19,24-29,33-40,63-64,71-78,88,90-112,119-122,167,197-205H,20-23,30-32,41-62,65-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,168)(H,169,216)(H,170,214)(H,171,217)(H,172,234)(H,173,235)(H,174,233)(H,175,223)(H,176,239)(H,177,225)(H,178,227)(H,179,218)(H,180,228)(H,181,237)(H,182,220)(H,183,222)(H,184,219)(H,185,224)(H,186,240)(H,187,215)(H,188,226)(H,189,229)(H,190,241)(H,191,221)(H,192,236)(H,193,230)(H,194,231)(H,195,238)(H,196,232)(H,210,211)(H,212,213)(H,242,243)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,119-,120-,121-,122-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 85n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration

J Med Chem 44: 3109-16 (2001)


BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50057824
PNG
(CHEMBL3326175)
Show SMILES Oc1ccc(cc1[N+]([O-])=O)C(=O)NNC(=O)c1occ(c1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H17N3O6/c28-20-12-11-17(13-19(20)27(31)32)23(29)25-26-24(30)22-21(16-9-5-2-6-10-16)18(14-33-22)15-7-3-1-4-8-15/h1-14,28H,(H,25,29)(H,26,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 87n/an/an/an/an/an/a



Dainippon Sumitomo Pharma. Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-counting

Bioorg Med Chem Lett 24: 4266-70 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.025
BindingDB Entry DOI: 10.7270/Q2ZW1NK4
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50059364
PNG
(CHEMBL2369985 | [des-His1, D-Phe6, Glu9] glucagon-...)
Show SMILES CCCC[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CO)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](C)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O |wU:42.41,112.113,219.223,189.191,162.163,57.56,96.97,203.207,180.182,145.146,75.75,129.130,29.30,36.37,228.234,wD:35.34,227.231,69.69,4.4,173.175,104.105,154.155,16.21,84.84,8.8,48.47,211.215,118.119,25.25,140.142,(86.13,-.36,;84.69,-.91,;84.45,-2.43,;83.01,-2.97,;82.76,-4.49,;83.95,-5.47,;85.39,-4.92,;85.64,-3.4,;86.59,-5.89,;88.03,-5.35,;89.22,-6.32,;88.97,-7.84,;90.66,-5.77,;91.85,-6.75,;93.29,-6.2,;93.54,-4.68,;94.49,-7.18,;94.24,-8.7,;95.43,-9.67,;95.18,-11.19,;96.38,-12.16,;93.75,-11.74,;95.93,-6.63,;97.12,-7.6,;96.87,-9.12,;98.56,-7.06,;98.81,-5.54,;99.75,-8.03,;101.19,-7.48,;86.34,-7.41,;84.9,-7.96,;87.53,-8.39,;81.32,-5.04,;81.07,-6.56,;80.13,-4.06,;78.69,-4.61,;78.44,-6.13,;77,-6.68,;79.63,-7.1,;77.5,-3.64,;77.74,-2.12,;76.06,-4.18,;74.86,-3.21,;75.11,-1.69,;76.55,-1.14,;73.42,-3.76,;73.18,-5.28,;72.23,-2.78,;70.79,-3.33,;70.54,-4.85,;71.74,-5.82,;71.49,-7.34,;70.05,-7.89,;72.68,-8.32,;69.6,-2.35,;70.69,-1.27,;68.16,-2.9,;66.96,-1.93,;67.21,-.41,;68.65,.14,;69.84,-.83,;71.28,-.29,;71.53,1.23,;72.97,1.78,;70.34,2.21,;68.9,1.66,;65.52,-2.47,;65.28,-3.99,;64.33,-1.5,;62.89,-2.05,;62.64,-3.57,;61.2,-4.11,;61.7,-1.07,;61.94,.45,;60.26,-1.62,;59.07,-.64,;59.31,.88,;58.12,1.85,;58.37,3.37,;57.17,4.34,;57.42,5.86,;57.63,-1.19,;57.38,-2.71,;56.43,-.22,;54.99,-.76,;54.75,-2.28,;53.31,-2.83,;52.11,-1.86,;50.67,-2.4,;50.43,-3.92,;48.99,-4.47,;51.62,-4.9,;53.06,-4.35,;53.8,.21,;54.05,1.73,;52.36,-.34,;51.17,.64,;51.41,2.16,;50.22,3.13,;48.78,2.59,;50.47,4.65,;49.73,.09,;49.48,-1.43,;48.53,1.07,;47.09,.52,;46.85,-1,;45.41,-1.55,;45.16,-3.07,;44.21,-.57,;45.9,1.49,;46.15,3.01,;44.46,.95,;43.27,1.92,;43.51,3.44,;42.32,4.41,;41.83,1.37,;41.58,-.15,;40.64,2.35,;39.2,1.8,;38.95,.28,;37.51,-.26,;37.26,-1.78,;35.82,-2.33,;35.57,-3.85,;36.77,-4.82,;34.14,-4.4,;38,2.78,;38.25,4.3,;36.56,2.23,;35.37,3.2,;35.62,4.72,;37.06,5.27,;37.3,6.79,;38.74,7.34,;38.99,8.86,;37.8,9.83,;40.43,9.4,;33.93,2.66,;33.68,1.14,;32.74,3.63,;31.3,3.08,;31.05,1.56,;30.1,4.06,;30.35,5.58,;28.66,3.51,;27.47,4.49,;27.72,6.01,;26.52,6.98,;26.77,8.5,;28.21,9.05,;25.58,9.47,;26.03,3.94,;25.78,2.42,;24.84,4.91,;23.4,4.37,;23.15,2.85,;24.34,1.87,;24.1,.35,;25.83,1.47,;22.2,5.34,;22.45,6.86,;20.77,4.79,;19.57,5.77,;19.82,7.29,;18.63,8.26,;17.19,7.72,;15.99,8.69,;16.24,10.21,;17.68,10.76,;18.87,9.78,;18.13,5.22,;17.89,3.7,;16.94,6.2,;15.5,5.65,;15.25,4.13,;16.45,3.16,;13.81,3.58,;14.31,6.62,;14.55,8.14,;12.87,6.08,;11.67,7.05,;11.92,8.57,;10.73,9.55,;10.97,11.07,;12.41,11.61,;9.78,12.04,;10.23,6.5,;9.99,4.98,;9.04,7.48,;7.6,6.93,;6.41,7.91,;6.65,9.43,;8.03,10.12,;7.79,11.64,;6.27,11.89,;5.44,13.18,;3.9,13.11,;3.2,11.74,;4.03,10.44,;5.57,10.52,;7.35,5.41,;5.91,4.87,;8.55,4.44,;8.3,2.92,;6.86,2.37,;6.61,.85,;7.81,-.12,;5.17,.31,;9.49,1.94,;10.93,2.49,;9.25,.42,;10.44,-.55,;11.88,-0,;13.07,-.98,;14.51,-.43,;15.71,-1.4,;10.19,-2.07,;8.75,-2.62,;11.39,-3.04,;11.14,-4.56,;9.7,-5.11,;9.45,-6.63,;8.01,-7.18,;10.65,-7.6,;12.33,-5.54,;13.77,-4.99,;12.08,-7.06,;13.28,-8.03,;14.72,-7.48,;15.91,-8.46,;14.96,-5.96,;13.03,-9.55,;11.59,-10.1,;14.22,-10.53,)|
Show InChI InChI=1S/C145H223N41O47S/c1-13-14-27-84(169-142(232)115(73(10)192)183-109(200)63-160-120(210)88(40-44-105(148)196)163-119(209)82(147)64-187)128(218)186-116(74(11)193)143(233)182-104(67-190)140(230)167-91(43-47-110(201)202)126(216)174-96(57-77-34-38-80(195)39-35-77)132(222)180-102(65-188)138(228)165-85(29-20-21-49-146)123(213)173-95(56-76-32-36-79(194)37-33-76)131(221)171-94(54-69(4)5)130(220)179-101(61-112(205)206)135(225)181-103(66-189)139(229)166-87(31-23-51-158-145(155)156)122(212)164-86(30-22-50-157-144(153)154)121(211)161-71(8)118(208)162-89(41-45-106(149)197)124(214)178-100(60-111(203)204)134(224)175-97(55-75-24-16-15-17-25-75)136(226)184-113(70(6)7)141(231)170-90(42-46-107(150)198)125(215)176-98(58-78-62-159-83-28-19-18-26-81(78)83)133(223)172-93(53-68(2)3)129(219)168-92(48-52-234-12)127(217)177-99(59-108(151)199)137(227)185-114(72(9)191)117(152)207/h15-19,24-26,28,32-39,62,68-74,82,84-104,113-116,159,187-195H,13-14,20-23,27,29-31,40-61,63-67,146-147H2,1-12H3,(H2,148,196)(H2,149,197)(H2,150,198)(H2,151,199)(H2,152,207)(H,160,210)(H,161,211)(H,162,208)(H,163,209)(H,164,212)(H,165,228)(H,166,229)(H,167,230)(H,168,219)(H,169,232)(H,170,231)(H,171,221)(H,172,223)(H,173,213)(H,174,216)(H,175,224)(H,176,215)(H,177,217)(H,178,214)(H,179,220)(H,180,222)(H,181,225)(H,182,233)(H,183,200)(H,184,226)(H,185,227)(H,186,218)(H,201,202)(H,203,204)(H,205,206)(H4,153,154,157)(H4,155,156,158)/t71-,72+,73+,74+,82-,84+,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,113-,114-,115-,116-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon

J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50104032
PNG
(CHEMBL441011 | His-Cys-Gln-Gly-Thr-Phe-Cys-Ser-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)Cc2cnc[nH]2)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C152H221N43O47S3/c1-72(2)51-96(132(223)175-95(46-50-243-10)131(222)183-103(59-115(158)206)142(233)195-122(77(9)200)150(241)242)178-137(228)102(57-82-63-166-88-28-18-17-27-86(82)88)182-130(221)94(42-45-114(157)205)176-148(239)120(74(5)6)194-141(232)101(54-79-25-15-12-16-26-79)181-138(229)104(60-117(208)209)184-129(220)93(41-44-113(156)204)170-123(214)75(7)169-126(217)90(30-21-48-164-151(159)160)171-127(218)91(31-22-49-165-152(161)162)173-144(235)108(67-197)189-140(231)106(62-119(212)213)185-133(224)97(52-73(3)4)177-134(225)98(55-80-32-36-84(201)37-33-80)179-128(219)89(29-19-20-47-153)172-143(234)107(66-196)188-135(226)99(56-81-34-38-85(202)39-35-81)180-139(230)105(61-118(210)211)186-145(236)109(68-198)190-147(238)111-70-245-244-69-110(191-124(215)87(154)58-83-64-163-71-168-83)146(237)174-92(40-43-112(155)203)125(216)167-65-116(207)193-121(76(8)199)149(240)187-100(136(227)192-111)53-78-23-13-11-14-24-78/h11-18,23-28,32-39,63-64,71-77,87,89-111,120-122,166,196-202H,19-22,29-31,40-62,65-70,153-154H2,1-10H3,(H2,155,203)(H2,156,204)(H2,157,205)(H2,158,206)(H,163,168)(H,167,216)(H,169,217)(H,170,214)(H,171,218)(H,172,234)(H,173,235)(H,174,237)(H,175,223)(H,176,239)(H,177,225)(H,178,228)(H,179,219)(H,180,230)(H,181,229)(H,182,221)(H,183,222)(H,184,220)(H,185,224)(H,186,236)(H,187,240)(H,188,226)(H,189,231)(H,190,238)(H,191,215)(H,192,227)(H,193,207)(H,194,232)(H,195,233)(H,208,209)(H,210,211)(H,212,213)(H,241,242)(H4,159,160,164)(H4,161,162,165)/t75-,76+,77+,87-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-/m0/s1
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n/an/a 101n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration

J Med Chem 44: 3109-16 (2001)


BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50611795
PNG
(CHEMBL5277926)
Show SMILES CCCc1c(cc(C(C)C)c([C@@H](C)O)c1-c1ccc(F)cc1)C(C)C |r|
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n/an/a 110n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50059365
PNG
(CHEMBL412352 | [des-Phe6, Glu9] glucagon-NH2)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc1c[nH]cn1)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C145H219N43O47S/c1-67(2)49-92(128(220)170-91(44-48-236-11)127(219)178-98(56-108(151)201)136(228)187-114(71(8)193)117(152)209)173-132(224)97(54-77-59-160-83-24-16-15-23-81(77)83)177-125(217)89(38-42-107(150)200)171-141(233)113(69(5)6)186-135(227)96(51-74-21-13-12-14-22-74)176-133(225)99(57-111(205)206)179-124(216)88(37-41-106(149)199)164-118(210)70(7)163-121(213)85(26-19-46-158-144(153)154)165-122(214)86(27-20-47-159-145(155)156)167-139(231)103(64-191)183-134(226)100(58-112(207)208)180-129(221)93(50-68(3)4)172-130(222)94(52-75-28-32-79(196)33-29-75)174-123(215)84(25-17-18-45-146)166-138(230)102(63-190)182-131(223)95(53-76-30-34-80(197)35-31-76)175-126(218)90(39-43-110(203)204)169-140(232)104(65-192)184-142(234)116(73(10)195)188-143(235)115(72(9)194)185-109(202)61-161-120(212)87(36-40-105(148)198)168-137(229)101(62-189)181-119(211)82(147)55-78-60-157-66-162-78/h12-16,21-24,28-35,59-60,66-73,82,84-104,113-116,160,189-197H,17-20,25-27,36-58,61-65,146-147H2,1-11H3,(H2,148,198)(H2,149,199)(H2,150,200)(H2,151,201)(H2,152,209)(H,157,162)(H,161,212)(H,163,213)(H,164,210)(H,165,214)(H,166,230)(H,167,231)(H,168,229)(H,169,232)(H,170,220)(H,171,233)(H,172,222)(H,173,224)(H,174,215)(H,175,218)(H,176,225)(H,177,217)(H,178,219)(H,179,216)(H,180,221)(H,181,211)(H,182,223)(H,183,226)(H,184,234)(H,185,202)(H,186,227)(H,187,228)(H,188,235)(H,203,204)(H,205,206)(H,207,208)(H4,153,154,158)(H4,155,156,159)/t70-,71+,72+,73+,82-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,113-,114-,115-,116-/m1/s1
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n/an/a 113n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon

J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50202031
PNG
(3-(4-((1-(4-cyclohexenylphenyl)-3-(3,5-dichlorophe...)
Show SMILES OC(=O)CCNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1 |t:33|
Show InChI InChI=1S/C30H29Cl2N3O4/c31-24-16-25(32)18-26(17-24)34-30(39)35(27-12-10-22(11-13-27)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(38)33-15-14-28(36)37/h4,6-13,16-18H,1-3,5,14-15,19H2,(H,33,38)(H,34,39)(H,36,37)
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n/an/a 122n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Inhibition of rat glucagon receptor

J Med Chem 50: 113-28 (2007)


Article DOI: 10.1021/jm058026u
BindingDB Entry DOI: 10.7270/Q26M36GK
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50059363
PNG
(CHEMBL437095 | [des-His1,Ala6, Glu9] glucagon-NH2)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C142H217N41O47S/c1-65(2)50-90(126(216)166-89(45-49-231-12)125(215)174-96(56-105(148)196)134(224)182-111(70(9)188)114(149)204)169-130(220)95(55-76-59-156-81-25-17-16-24-79(76)81)173-123(213)87(39-43-104(147)195)167-138(228)110(67(5)6)181-133(223)94(52-73-22-14-13-15-23-73)172-131(221)97(57-108(200)201)175-122(212)86(38-42-103(146)194)160-115(205)68(7)158-119(209)83(27-20-47-154-141(150)151)162-120(210)84(28-21-48-155-142(152)153)164-136(226)100(63-186)178-132(222)98(58-109(202)203)176-127(217)91(51-66(3)4)168-128(218)92(53-74-29-33-77(191)34-30-74)170-121(211)82(26-18-19-46-143)163-135(225)99(62-185)177-129(219)93(54-75-31-35-78(192)36-32-75)171-124(214)88(40-44-107(198)199)165-137(227)101(64-187)179-140(230)113(72(11)190)183-116(206)69(8)159-139(229)112(71(10)189)180-106(197)60-157-118(208)85(37-41-102(145)193)161-117(207)80(144)61-184/h13-17,22-25,29-36,59,65-72,80,82-101,110-113,156,184-192H,18-21,26-28,37-58,60-64,143-144H2,1-12H3,(H2,145,193)(H2,146,194)(H2,147,195)(H2,148,196)(H2,149,204)(H,157,208)(H,158,209)(H,159,229)(H,160,205)(H,161,207)(H,162,210)(H,163,225)(H,164,226)(H,165,227)(H,166,216)(H,167,228)(H,168,218)(H,169,220)(H,170,211)(H,171,214)(H,172,221)(H,173,213)(H,174,215)(H,175,212)(H,176,217)(H,177,219)(H,178,222)(H,179,230)(H,180,197)(H,181,223)(H,182,224)(H,183,206)(H,198,199)(H,200,201)(H,202,203)(H4,150,151,154)(H4,152,153,155)/t68-,69-,70+,71+,72+,80-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,110-,111-,112-,113-/m1/s1
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n/an/a 126n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon

J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)		BDBM50059360
PNG
(CHEMBL429198 | [des-His1, des-Phe6] glucagon-NH2)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C138H210N40O46S/c1-63(2)47-86(121(209)160-85(42-46-225-11)120(208)168-92(53-102(144)191)130(218)177-108(67(8)183)111(145)199)163-125(213)91(52-73-57-152-78-24-16-15-23-76(73)78)167-119(207)84(38-41-101(143)190)161-134(222)107(65(5)6)176-129(217)90(49-70-21-13-12-14-22-70)166-126(214)93(54-104(193)194)169-118(206)83(37-40-100(142)189)155-112(200)66(7)154-115(203)80(26-19-44-150-137(146)147)157-116(204)81(27-20-45-151-138(148)149)159-132(220)97(61-181)173-128(216)95(56-106(197)198)170-122(210)87(48-64(3)4)162-123(211)88(50-71-28-32-74(186)33-29-71)164-117(205)79(25-17-18-43-139)158-131(219)96(60-180)172-124(212)89(51-72-30-34-75(187)35-31-72)165-127(215)94(55-105(195)196)171-133(221)98(62-182)174-135(223)110(69(10)185)178-136(224)109(68(9)184)175-103(192)58-153-114(202)82(36-39-99(141)188)156-113(201)77(140)59-179/h12-16,21-24,28-35,57,63-69,77,79-98,107-110,152,179-187H,17-20,25-27,36-56,58-62,139-140H2,1-11H3,(H2,141,188)(H2,142,189)(H2,143,190)(H2,144,191)(H2,145,199)(H,153,202)(H,154,203)(H,155,200)(H,156,201)(H,157,204)(H,158,219)(H,159,220)(H,160,209)(H,161,222)(H,162,211)(H,163,213)(H,164,205)(H,165,215)(H,166,214)(H,167,207)(H,168,208)(H,169,206)(H,170,210)(H,171,221)(H,172,212)(H,173,216)(H,174,223)(H,175,192)(H,176,217)(H,177,218)(H,178,224)(H,193,194)(H,195,196)(H,197,198)(H4,146,147,150)(H4,148,149,151)/t66-,67+,68+,69+,77-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,107-,108-,109-,110-/m1/s1
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n/an/a 128n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon

J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
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