BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 62 hits of ic50 for UniProtKB: Q00959   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50171881
PNG
((E)-(R)-2-Amino-4-methyl-5-phosphono-pent-3-enoic ...)
Show SMILES CC(CC(=N)C(O)=O)CP(O)(O)=O
Show InChI InChI=1S/C6H12NO5P/c1-4(3-13(10,11)12)2-5(7)6(8)9/h4,7H,2-3H2,1H3,(H,8,9)(H2,10,11,12)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Inhibition of [3H]CPP binding to rat N-methyl-D-aspartic acid receptor 2A

J Med Chem 48: 5489-94 (2005)


Article DOI: 10.1021/jm050174x
BindingDB Entry DOI: 10.7270/Q2HD7WFN
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50004927
PNG
(4-Phosphonomethyl-piperidine-2-carboxylic acid | 4...)
Show SMILES OC(=O)[C@@H]1C[C@H](CP(O)(O)=O)CCN1
Show InChI InChI=1S/C7H14NO5P/c9-7(10)6-3-5(1-2-8-6)4-14(11,12)13/h5-6,8H,1-4H2,(H,9,10)(H2,11,12,13)/t5-,6+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 95n/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Inhibition of [3H]CPP binding to rat N-methyl-D-aspartic acid receptor 2A

J Med Chem 48: 5489-94 (2005)


Article DOI: 10.1021/jm050174x
BindingDB Entry DOI: 10.7270/Q2HD7WFN
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50132483
PNG
(CHEMBL108043 | Pentyl-(1-phenethyloxy-4,5-dihydro-...)
Show SMILES CCCCCNC1=NCCN1OCCc1ccccc1 |t:6|
Show InChI InChI=1S/C16H25N3O/c1-2-3-7-11-17-16-18-12-13-19(16)20-14-10-15-8-5-4-6-9-15/h4-6,8-9H,2-3,7,10-14H2,1H3,(H,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a<100n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against N-methyl-D-aspartate glutamate receptor 2A in rat

Bioorg Med Chem Lett 13: 3155-9 (2003)


BindingDB Entry DOI: 10.7270/Q2VT1RHV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50010893
PNG
((R)-2-Amino-4-oxo-5-phosphono-pentanoic acid | 2-A...)
Show SMILES N[C@H](CC(=O)CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H10NO6P/c6-4(5(8)9)1-3(7)2-13(10,11)12/h4H,1-2,6H2,(H,8,9)(H2,10,11,12)/t4-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Inhibition of [3H]CPP binding to rat N-methyl-D-aspartic acid receptor 2A

J Med Chem 48: 5489-94 (2005)


Article DOI: 10.1021/jm050174x
BindingDB Entry DOI: 10.7270/Q2HD7WFN
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50399431
PNG
(CHEMBL2178919)
Show SMILES NCCCNCCCCNCCC(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1c[nH]c2ccccc12 |r|
Show InChI InChI=1S/C29H48N8O4/c30-12-8-15-32-13-6-7-14-33-18-11-27(39)34-16-4-1-5-17-35-29(41)25(20-26(31)38)37-28(40)19-22-21-36-24-10-3-2-9-23(22)24/h2-3,9-10,21,25,32-33,36H,1,4-8,11-20,30H2,(H2,31,38)(H,34,39)(H,35,41)(H,37,40)/t25-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 150n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat glutamate N1/2A receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrop...

J Med Chem 55: 10297-301 (2012)


Article DOI: 10.1021/jm301255m
BindingDB Entry DOI: 10.7270/Q27S7PXR
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50316373
PNG
(Argiotoxin-636 | CHEMBL1098240)
Show SMILES [#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#7]-[#6]-[#6]-[#6]-[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6]-c1ccc(-[#8])cc1-[#8] |r|
Show InChI InChI=1S/C29H52N10O6/c30-22(7-4-15-38-29(32)33)27(44)36-16-6-13-35-12-5-11-34-10-2-1-3-14-37-28(45)23(19-25(31)42)39-26(43)17-20-8-9-21(40)18-24(20)41/h8-9,18,22-23,34-35,40-41H,1-7,10-17,19,30H2,(H2,31,42)(H,36,44)(H,37,45)(H,39,43)(H4,32,33,38)/t22-,23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 177n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat glutamate N1/2A receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrop...

J Med Chem 55: 10297-301 (2012)


Article DOI: 10.1021/jm301255m
BindingDB Entry DOI: 10.7270/Q27S7PXR
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50132481
PNG
((1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl)-pentyl-...)
Show SMILES CCCCCNC1=NCCN1OCc1ccccc1 |t:6|
Show InChI InChI=1S/C15H23N3O/c1-2-3-7-10-16-15-17-11-12-18(15)19-13-14-8-5-4-6-9-14/h4-6,8-9H,2-3,7,10-13H2,1H3,(H,16,17)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 210n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against N-methyl-D-aspartate glutamate receptor 2A in rat

Bioorg Med Chem Lett 13: 3155-9 (2003)


BindingDB Entry DOI: 10.7270/Q2VT1RHV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50171881
PNG
((E)-(R)-2-Amino-4-methyl-5-phosphono-pent-3-enoic ...)
Show SMILES CC(CC(=N)C(O)=O)CP(O)(O)=O
Show InChI InChI=1S/C6H12NO5P/c1-4(3-13(10,11)12)2-5(7)6(8)9/h4,7H,2-3H2,1H3,(H,8,9)(H2,10,11,12)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Inhibition of [3H]Glu binding to rat N-methyl-D-aspartic acid receptor 2A

J Med Chem 48: 5489-94 (2005)


Article DOI: 10.1021/jm050174x
BindingDB Entry DOI: 10.7270/Q2HD7WFN
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50171882
PNG
((E)-(R)-2-Amino-4-phosphonomethyl-hept-3-enoic aci...)
Show SMILES CCCC(CC(=N)C(O)=O)CP(O)(O)=O
Show InChI InChI=1S/C8H16NO5P/c1-2-3-6(5-15(12,13)14)4-7(9)8(10)11/h6,9H,2-5H2,1H3,(H,10,11)(H2,12,13,14)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 230n/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Inhibition of [3H]Glu binding to rat N-methyl-D-aspartic acid receptor 2A

J Med Chem 48: 5489-94 (2005)


Article DOI: 10.1021/jm050174x
BindingDB Entry DOI: 10.7270/Q2HD7WFN
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50017229
PNG
((S)-2-Amino-5-phosphono-pentanoic acid | (S)-2-ami...)
Show SMILES N[C@@H](CCCP(O)(O)=O)C(O)=O |r|
Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 290n/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Inhibition of [3H]CPP binding to rat N-methyl-D-aspartic acid receptor 2A

J Med Chem 48: 5489-94 (2005)


Article DOI: 10.1021/jm050174x
BindingDB Entry DOI: 10.7270/Q2HD7WFN
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50004927
PNG
(4-Phosphonomethyl-piperidine-2-carboxylic acid | 4...)
Show SMILES OC(=O)[C@@H]1C[C@H](CP(O)(O)=O)CCN1
Show InChI InChI=1S/C7H14NO5P/c9-7(10)6-3-5(1-2-8-6)4-14(11,12)13/h5-6,8H,1-4H2,(H,9,10)(H2,11,12,13)/t5-,6+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 840n/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Inhibition of [3H]Glu binding to rat N-methyl-D-aspartic acid receptor 2A

J Med Chem 48: 5489-94 (2005)


Article DOI: 10.1021/jm050174x
BindingDB Entry DOI: 10.7270/Q2HD7WFN
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50242450
PNG
(CHEMBL524886 | conantokin-R)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6](-[#6]-[#6](-[#6](-[#8])=O)-[#6](-[#8])=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6](-[#8])=O)-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#16]-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6](-[#8])=O)-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6](-[#8])=O)-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6]-[#7])-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#16])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#16])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](-[#8])=O |r|
Show InChI InChI=1S/C126H202N34O48S3/c1-15-57(8)93(115(189)141-62(13)96(170)145-71(24-16-19-36-127)100(174)136-51-89(165)143-83(52-209)111(185)147-73(26-18-21-38-129)104(178)157-92(56(6)7)114(188)154-80(48-86(131)162)108(182)156-84(53-210)112(186)155-82(43-63-29-31-64(161)32-30-63)116(190)160-40-23-28-85(160)125(207)208)159-110(184)81(49-87(132)163)150-99(173)65(44-66(117(191)192)118(193)194)70(27-22-39-135-126(133)134)144-95(169)60(11)139-105(179)76(42-54(2)3)151-106(180)77(45-67(119(195)196)120(197)198)149-98(172)59(10)137-94(168)58(9)138-101(175)75(35-41-211-14)148-102(176)72(25-17-20-37-128)146-97(171)61(12)140-113(187)91(55(4)5)158-109(183)79(47-69(123(203)204)124(205)206)153-107(181)78(46-68(121(199)200)122(201)202)152-103(177)74(33-34-90(166)167)142-88(164)50-130/h29-32,54-62,65-85,91-93,161,209-210H,15-28,33-53,127-130H2,1-14H3,(H2,131,162)(H2,132,163)(H,136,174)(H,137,168)(H,138,175)(H,139,179)(H,140,187)(H,141,189)(H,142,164)(H,143,165)(H,144,169)(H,145,170)(H,146,171)(H,147,185)(H,148,176)(H,149,172)(H,150,173)(H,151,180)(H,152,177)(H,153,181)(H,154,188)(H,155,186)(H,156,182)(H,157,178)(H,158,183)(H,159,184)(H,166,167)(H,191,192)(H,193,194)(H,195,196)(H,197,198)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H4,133,134,135)/t57-,58-,59-,60-,61-,62-,65?,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,91-,92-,93-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of rat NMDA NR2A receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...

J Biol Chem 282: 36905-13 (2007)


Article DOI: 10.1074/jbc.M706611200
BindingDB Entry DOI: 10.7270/Q2NP246H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50399430
PNG
(CHEMBL2178920)
Show SMILES NCCCNCCCCNCCC(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1c[nH]c2cccc(O)c12 |r|
Show InChI InChI=1S/C29H48N8O5/c30-11-7-14-32-12-4-5-13-33-17-10-26(40)34-15-2-1-3-16-35-29(42)23(19-25(31)39)37-27(41)18-21-20-36-22-8-6-9-24(38)28(21)22/h6,8-9,20,23,32-33,36,38H,1-5,7,10-19,30H2,(H2,31,39)(H,34,40)(H,35,42)(H,37,41)/t23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.39E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat glutamate N1/2A receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrop...

J Med Chem 55: 10297-301 (2012)


Article DOI: 10.1021/jm301255m
BindingDB Entry DOI: 10.7270/Q27S7PXR
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50017229
PNG
((S)-2-Amino-5-phosphono-pentanoic acid | (S)-2-ami...)
Show SMILES N[C@@H](CCCP(O)(O)=O)C(O)=O |r|
Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Inhibition of [3H]Glu binding to rat N-methyl-D-aspartic acid receptor 2A

J Med Chem 48: 5489-94 (2005)


Article DOI: 10.1021/jm050174x
BindingDB Entry DOI: 10.7270/Q2HD7WFN
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50105843
PNG
(2-Amino-N-{3-[4-(3-amino-propylamino)-butylamino]-...)
Show SMILES NCCCNCCCCNCCC(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Show InChI InChI=1S/C27H47N7O6/c28-10-6-13-30-11-4-5-12-31-16-9-25(38)32-14-2-1-3-15-33-27(40)22(19-24(29)37)34-26(39)17-20-7-8-21(35)18-23(20)36/h7-8,18,22,30-31,35-36H,1-6,9-17,19,28H2,(H2,29,37)(H,32,38)(H,33,40)(H,34,39)/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.71E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat glutamate N1/2A receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrop...

J Med Chem 55: 10297-301 (2012)


Article DOI: 10.1021/jm301255m
BindingDB Entry DOI: 10.7270/Q27S7PXR
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440067
PNG
(CHEMBL2426072 | CHEMBL2426073)
Show SMILES OC(=O)C=CC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Br)cc2)c2ccccc2[nH]c1=O |w:3.2,c:8|
Show InChI InChI=1S/C28H19BrClN3O4/c29-18-9-5-17(6-10-18)26-20-3-1-2-4-21(20)31-28(37)27(26)22-15-23(16-7-11-19(30)12-8-16)33(32-22)24(34)13-14-25(35)36/h1-14,23H,15H2,(H,31,37)(H,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.30E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50399433
PNG
(CHEMBL2178917)
Show SMILES [#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6]-[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6]-c1ccc(-[#8])cc1-[#8] |r|
Show InChI InChI=1S/C30H52N10O7/c31-22(7-6-15-39-30(33)34)28(46)37-14-5-4-11-35-16-10-26(44)36-12-2-1-3-13-38-29(47)23(19-25(32)43)40-27(45)17-20-8-9-21(41)18-24(20)42/h8-9,18,22-23,35,41-42H,1-7,10-17,19,31H2,(H2,32,43)(H,36,44)(H,37,46)(H,38,47)(H,40,45)(H4,33,34,39)/t22-,23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.41E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat glutamate N1/2A receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrop...

J Med Chem 55: 10297-301 (2012)


Article DOI: 10.1021/jm301255m
BindingDB Entry DOI: 10.7270/Q27S7PXR
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440072
PNG
(CHEMBL2426067)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2cc(Cl)cc(Cl)c2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H20Cl3N3O4/c29-17-7-5-15(6-8-17)23-14-22(33-34(23)24(35)9-10-25(36)37)27-26(16-11-18(30)13-19(31)12-16)20-3-1-2-4-21(20)32-28(27)38/h1-8,11-13,23H,9-10,14H2,(H,32,38)(H,36,37)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.50E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440075
PNG
(CHEMBL2425979)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)c(Cl)c2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H20Cl3N3O4/c29-17-8-5-15(6-9-17)23-14-22(33-34(23)24(35)11-12-25(36)37)27-26(16-7-10-19(30)20(31)13-16)18-3-1-2-4-21(18)32-28(27)38/h1-10,13,23H,11-12,14H2,(H,32,38)(H,36,37)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7.70E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50242447
PNG
(CHEMBL525783)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6](-[#8])=O)-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6](-[#8])=O)-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6](-[#8])=O)-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6@@H](-[#8])-[#6]-[#7]-1-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6](-[#8])=O)-[#6@@H](-[#6])-[#6]-[#6])-[#6](-[#8])=O |r|
Show InChI InChI=1S/C108H159N25O41/c1-9-50(5)82(131-85(145)53(8)118-93(153)74(43-61(101(161)162)102(163)164)124-84(144)52(7)117-92(152)72(40-55-21-27-58(135)28-22-55)127-97(157)76(45-63(105(169)170)106(171)172)130-98(158)77-42-60(137)48-133(77)100(160)69(32-34-80(140)141)123-86(146)64(111)46-81(142)143)99(159)122-67(18-15-37-115-108(113)114)89(149)129-75(44-62(103(165)166)104(167)168)96(156)128-73(41-56-23-29-59(136)30-24-56)95(155)121-68(31-33-78(112)138)90(150)125-70(38-49(3)4)94(154)120-66(17-12-14-36-110)88(148)126-71(39-54-19-25-57(134)26-20-54)87(147)116-47-79(139)119-65(16-11-13-35-109)91(151)132-83(107(173)174)51(6)10-2/h19-30,49-53,60-77,82-83,134-137H,9-18,31-48,109-111H2,1-8H3,(H2,112,138)(H,116,147)(H,117,152)(H,118,153)(H,119,139)(H,120,154)(H,121,155)(H,122,159)(H,123,146)(H,124,144)(H,125,150)(H,126,148)(H,127,157)(H,128,156)(H,129,149)(H,130,158)(H,131,145)(H,132,151)(H,140,141)(H,142,143)(H,161,162)(H,163,164)(H,165,166)(H,167,168)(H,169,170)(H,171,172)(H,173,174)(H4,113,114,115)/t50-,51-,52-,53-,60+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,82-,83-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of rat NMDA NR2A receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...

J Biol Chem 282: 36905-13 (2007)


Article DOI: 10.1074/jbc.M706611200
BindingDB Entry DOI: 10.7270/Q2NP246H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50242448
PNG
(CHEMBL526324)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](CCC(O)=O)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(N)=O |r,wU:81.89,73.74,57.59,43.50,24.24,98.100,121.123,135.138,146.148,wD:61.71,52.54,29.41,12.20,4.4,109.111,130.133,140.142,75.77,(1.79,-21.01,;1.79,-19.47,;3.13,-18.7,;.46,-18.7,;.46,-17.15,;-.87,-16.38,;-2.2,-17.15,;-2.2,-18.69,;-3.53,-16.38,;-4.86,-17.15,;-6.2,-16.38,;-6.2,-14.84,;-7.52,-17.15,;-7.53,-18.69,;-6.74,-20.01,;-7.49,-21.35,;-9.03,-21.37,;-6.7,-22.67,;-5.2,-19.98,;-4.41,-21.3,;-4.45,-18.63,;-8.86,-16.37,;-10.19,-17.14,;-10.19,-18.68,;-11.52,-16.37,;-11.52,-14.84,;-12.87,-17.14,;-14.2,-16.37,;-14.2,-14.83,;-15.54,-17.14,;-15.54,-18.68,;-14.19,-19.45,;-12.96,-18.55,;-11.71,-19.45,;-12.18,-20.9,;-11.42,-22.23,;-12.18,-23.56,;-13.73,-23.57,;-14.49,-22.23,;-13.73,-20.9,;-16.87,-16.37,;-18.19,-17.13,;-18.19,-18.68,;-19.54,-16.36,;-19.54,-14.83,;-18.19,-14.06,;-18.19,-12.52,;-16.86,-11.75,;-16.86,-10.22,;-20.86,-17.13,;-22.19,-16.36,;-22.19,-14.82,;-23.53,-17.12,;-23.53,-18.67,;-24.86,-16.35,;-26.19,-17.12,;-26.19,-18.66,;-27.53,-16.35,;-28.86,-17.12,;-30.19,-16.35,;-30.19,-14.81,;-31.53,-17.12,;-31.53,-18.66,;-30.72,-19.97,;-31.46,-21.32,;-33.01,-21.37,;-30.66,-22.64,;-29.18,-19.93,;-28.38,-21.25,;-28.45,-18.58,;-32.86,-16.35,;-34.18,-17.11,;-34.18,-18.65,;-35.51,-16.34,;-35.43,-14.8,;-37.09,-14.46,;-37.78,-12.94,;-37.91,-15.92,;-36.77,-17.17,;-36.82,-18.69,;-35.52,-19.52,;-38.17,-19.43,;-39.49,-18.63,;-40.84,-19.37,;-42.16,-18.57,;-42.11,-17.03,;-43.5,-19.3,;-38.21,-20.97,;-36.91,-21.78,;-35.55,-21.04,;-36.95,-23.31,;-35.63,-24.11,;-27.53,-14.81,;-26.19,-14.05,;-28.86,-14.04,;1.79,-16.39,;1.79,-14.86,;3.13,-17.16,;4.45,-16.39,;4.45,-14.86,;5.79,-14.09,;5.79,-12.55,;7.13,-11.78,;7.13,-10.24,;5.8,-9.48,;8.46,-9.47,;5.79,-17.17,;5.79,-18.7,;7.13,-16.4,;8.45,-17.16,;8.45,-18.71,;9.2,-20.05,;8.41,-21.38,;6.87,-21.35,;9.16,-22.71,;10.75,-20.07,;11.5,-21.42,;11.54,-18.75,;9.79,-16.4,;9.79,-14.86,;11.13,-17.17,;12.45,-16.4,;12.45,-14.87,;13.79,-14.1,;13.79,-12.56,;15.13,-11.79,;15.13,-10.25,;13.79,-17.17,;13.79,-18.71,;15.12,-16.41,;16.45,-17.17,;16.45,-18.72,;17.78,-16.4,;17.78,-14.87,;19.12,-17.18,;20.45,-16.41,;20.45,-14.88,;21.78,-17.18,;21.78,-18.73,;23.11,-16.42,;24.45,-17.19,;24.45,-18.73,;25.78,-19.5,;25.78,-16.42,;25.78,-14.88,;27.11,-17.19,;28.44,-16.42,;28.44,-14.89,;29.78,-14.11,;31.11,-14.89,;29.78,-12.58,;29.78,-17.19,;31.1,-16.42,;29.78,-18.73,)|
Show InChI InChI=1S/C91H141N27O36/c1-38(2)26-56(78(136)110-53(20-15-25-99-91(97)98)76(134)114-59(30-48(87(147)148)88(149)150)79(137)109-51(18-11-13-23-92)74(132)103-40(5)69(127)102-41(6)72(130)116-61(37-119)81(139)111-55(68(96)126)32-63(95)121)107-65(123)35-101-73(131)58(29-47(85(143)144)86(145)146)112-71(129)42(7)104-77(135)57(27-44-34-100-50-17-10-9-16-46(44)50)113-75(133)52(19-12-14-24-93)108-70(128)43(8)105-83(141)67(39(3)4)117-80(138)60(31-49(89(151)152)90(153)154)115-82(140)62-28-45(120)36-118(62)84(142)54(21-22-66(124)125)106-64(122)33-94/h9-10,16-17,34,38-43,45,47-49,51-62,67,100,119-120H,11-15,18-33,35-37,92-94H2,1-8H3,(H2,95,121)(H2,96,126)(H,101,131)(H,102,127)(H,103,132)(H,104,135)(H,105,141)(H,106,122)(H,107,123)(H,108,128)(H,109,137)(H,110,136)(H,111,139)(H,112,129)(H,113,133)(H,114,134)(H,115,140)(H,116,130)(H,117,138)(H,124,125)(H,143,144)(H,145,146)(H,147,148)(H,149,150)(H,151,152)(H,153,154)(H4,97,98,99)/t40-,41-,42-,43-,45+,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,67-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of rat NMDA NR2A receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...

J Biol Chem 282: 36905-13 (2007)


Article DOI: 10.1074/jbc.M706611200
BindingDB Entry DOI: 10.7270/Q2NP246H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50242449
PNG
(CHEMBL525025 | conantokin-G)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6](-[#8])=O)-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6](-[#8])=O)-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6](-[#8])=O)-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6](-[#8])=O)-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6](-[#8])=O)-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](-[#7])=O |r|
Show InChI InChI=1S/C88H138N26O44/c1-7-34(6)61(77(138)103-41(12-10-20-98-88(96)97)63(124)107-48(23-35(78(139)140)79(141)142)69(130)100-40(11-8-9-19-89)64(125)113-54(31-115)76(137)104-45(62(95)123)28-57(93)118)114-75(136)47(22-33(4)5)106-70(131)49(24-36(80(143)144)81(145)146)109-67(128)44(14-17-56(92)117)102-74(135)53(29-58(94)119)112-73(134)51(26-38(84(151)152)85(153)154)110-66(127)43(13-16-55(91)116)101-68(129)46(21-32(2)3)105-71(132)52(27-39(86(155)156)87(157)158)111-72(133)50(25-37(82(147)148)83(149)150)108-65(126)42(15-18-60(121)122)99-59(120)30-90/h32-54,61,115H,7-31,89-90H2,1-6H3,(H2,91,116)(H2,92,117)(H2,93,118)(H2,94,119)(H2,95,123)(H,99,120)(H,100,130)(H,101,129)(H,102,135)(H,103,138)(H,104,137)(H,105,132)(H,106,131)(H,107,124)(H,108,126)(H,109,128)(H,110,127)(H,111,133)(H,112,134)(H,113,125)(H,114,136)(H,121,122)(H,139,140)(H,141,142)(H,143,144)(H,145,146)(H,147,148)(H,149,150)(H,151,152)(H,153,154)(H,155,156)(H,157,158)(H4,96,97,98)/t34-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,61-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of rat NMDA NR2A receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...

J Biol Chem 282: 36905-13 (2007)


Article DOI: 10.1074/jbc.M706611200
BindingDB Entry DOI: 10.7270/Q2NP246H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50103133
PNG
(1-[(R)-2-Hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4...)
Show SMILES Cc1ccc(CC2(O)CCN(C[C@H](O)Cc3ccc(O)cc3)CC2)cc1
Show InChI InChI=1S/C22H29NO3/c1-17-2-4-19(5-3-17)15-22(26)10-12-23(13-11-22)16-21(25)14-18-6-8-20(24)9-7-18/h2-9,21,24-26H,10-16H2,1H3/t21-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Evaluated for in vitro inhibition of recombinant rat NR1C/2A receptor expressed in xenopus oocytes

Bioorg Med Chem Lett 11: 2173-6 (2001)


BindingDB Entry DOI: 10.7270/Q2GF0SS8
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50399432
PNG
(CHEMBL2178918)
Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6]-[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6]-c1ccc(-[#8])cc1-[#8] |r|
Show InChI InChI=1S/C35H60N12O9/c1-22(46-31(53)21-45-33(55)25(36)8-7-16-44-35(38)39)32(54)42-15-6-5-12-40-17-11-29(51)41-13-3-2-4-14-43-34(56)26(20-28(37)50)47-30(52)18-23-9-10-24(48)19-27(23)49/h9-10,19,22,25-26,40,48-49H,2-8,11-18,20-21,36H2,1H3,(H2,37,50)(H,41,51)(H,42,54)(H,43,56)(H,45,55)(H,46,53)(H,47,52)(H4,38,39,44)/t22-,25-,26-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat glutamate N1/2A receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrop...

J Med Chem 55: 10297-301 (2012)


Article DOI: 10.1021/jm301255m
BindingDB Entry DOI: 10.7270/Q27S7PXR
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50242446
PNG
(CHEMBL524338)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)C(O)=O |r,wU:136.143,112.123,95.105,87.89,64.74,43.49,31.32,4.4,wD:144.152,124.135,107.109,155.158,76.85,52.62,35.40,159.162,21.28,8.13,2.2,(62.58,-11.62,;62.58,-13.15,;63.91,-13.93,;65.24,-13.15,;63.91,-15.47,;62.58,-16.24,;61.25,-15.47,;61.25,-13.93,;59.91,-16.24,;59.91,-17.77,;61.25,-18.55,;61.25,-20.08,;62.58,-20.86,;62.58,-22.4,;58.59,-15.47,;57.25,-16.24,;57.25,-17.77,;55.92,-15.47,;54.58,-16.24,;53.25,-15.47,;53.25,-13.93,;51.92,-16.24,;51.92,-17.77,;53.67,-18.68,;55.03,-18.01,;56.13,-19.12,;55.37,-20.44,;53.88,-20.2,;50.58,-15.47,;49.25,-16.24,;49.25,-17.77,;47.91,-15.47,;46.58,-16.24,;45.25,-15.47,;45.25,-13.93,;43.91,-16.24,;43.91,-17.77,;45.25,-18.55,;45.25,-20.08,;46.58,-17.77,;42.59,-15.47,;41.24,-16.24,;41.24,-17.77,;39.92,-15.47,;39.92,-13.93,;41.24,-13.15,;41.24,-11.62,;39.92,-10.85,;42.59,-10.85,;38.57,-16.24,;37.25,-15.47,;37.25,-13.93,;35.92,-16.24,;35.92,-17.77,;37.78,-18.86,;39.11,-18.09,;40.44,-18.86,;40.44,-20.38,;41.76,-21.16,;39.11,-21.15,;37.78,-20.38,;34.58,-15.47,;33.25,-16.24,;33.25,-17.77,;31.91,-15.47,;31.91,-13.92,;32.71,-12.6,;31.96,-11.26,;30.42,-11.23,;32.76,-9.93,;34.26,-12.64,;35.01,-13.98,;35.06,-11.31,;30.58,-16.24,;29.24,-15.47,;29.24,-13.93,;27.91,-16.24,;27.91,-17.77,;29.24,-18.55,;29.24,-20.08,;30.58,-20.86,;30.58,-22.4,;29.24,-23.16,;31.91,-23.16,;26.58,-15.47,;25.24,-16.24,;25.24,-17.77,;23.91,-15.47,;22.57,-16.24,;21.25,-15.47,;21.25,-13.93,;19.92,-16.24,;18.58,-15.47,;17.25,-16.24,;17.25,-17.77,;15.92,-15.47,;15.92,-13.93,;16.71,-12.61,;15.97,-11.26,;14.43,-11.22,;16.77,-9.94,;18.26,-12.64,;19,-13.99,;19.06,-11.31,;14.58,-16.24,;13.25,-15.47,;13.25,-13.93,;11.91,-16.24,;11.91,-17.77,;10.58,-15.47,;9.24,-16.24,;9.24,-17.77,;7.91,-15.47,;7.91,-13.91,;7.16,-12.57,;7.94,-11.25,;7.2,-9.92,;5.67,-9.9,;4.92,-8.54,;4.88,-11.21,;5.62,-12.55,;6.59,-16.24,;5.25,-15.47,;5.25,-13.93,;3.92,-16.24,;3.91,-17.77,;4.67,-19.1,;3.9,-20.43,;2.37,-20.43,;4.67,-21.77,;6.22,-19.11,;6.99,-20.46,;7,-17.78,;2.58,-15.47,;1.25,-16.24,;1.25,-17.77,;-.09,-15.47,;-.09,-13.93,;1.25,-13.15,;2.58,-13.93,;1.25,-11.62,;-1.42,-16.24,;-2.75,-15.47,;-2.75,-13.93,;-4.09,-16.24,;-4.09,-17.77,;-2.75,-18.55,;-2.75,-20.08,;-4.09,-20.86,;-1.42,-20.86,;-5.42,-15.47,;-6.76,-16.24,;-6.76,-17.77,;-8.08,-15.47,;-9.42,-16.24,;23.91,-13.93,;25.24,-13.15,;22.57,-13.15,;22.57,-11.62,;47.91,-13.93,;49.25,-13.15,;46.58,-13.15,;46.58,-11.62,;65.24,-16.24,;66.58,-15.47,;65.24,-17.77,)|
Show InChI InChI=1S/C101H150N26O39/c1-10-46(6)76(125-73(133)43-110-81(140)66(36-55(94(153)154)95(155)156)117-79(138)49(9)112-86(145)63(33-50-18-22-53(128)23-19-50)119-89(148)68(38-57(98(161)162)99(163)164)122-90(149)69(39-75(136)137)123-83(142)60(27-29-74(134)135)113-71(131)40-103)92(151)116-59(17-15-31-108-101(105)106)82(141)121-67(37-56(96(157)158)97(159)160)88(147)120-64(34-51-20-24-54(129)25-21-51)87(146)115-61(26-28-70(104)130)84(143)118-62(32-45(4)5)91(150)126-77(47(7)11-2)93(152)124-65(35-52-41-107-44-111-52)80(139)109-42-72(132)114-58(16-13-14-30-102)85(144)127-78(100(165)166)48(8)12-3/h18-25,41,44-49,55-69,76-78,128-129H,10-17,26-40,42-43,102-103H2,1-9H3,(H2,104,130)(H,107,111)(H,109,139)(H,110,140)(H,112,145)(H,113,131)(H,114,132)(H,115,146)(H,116,151)(H,117,138)(H,118,143)(H,119,148)(H,120,147)(H,121,141)(H,122,149)(H,123,142)(H,124,152)(H,125,133)(H,126,150)(H,127,144)(H,134,135)(H,136,137)(H,153,154)(H,155,156)(H,157,158)(H,159,160)(H,161,162)(H,163,164)(H,165,166)(H4,105,106,108)/t46-,47-,48-,49-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,76-,77-,78-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of rat NMDA NR2A receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...

J Biol Chem 282: 36905-13 (2007)


Article DOI: 10.1074/jbc.M706611200
BindingDB Entry DOI: 10.7270/Q2NP246H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440084
PNG
(CHEMBL2426093)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Br)cc2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H21BrClN3O4/c29-18-9-5-17(6-10-18)26-20-3-1-2-4-21(20)31-28(37)27(26)22-15-23(16-7-11-19(30)12-8-16)33(32-22)24(34)13-14-25(35)36/h1-12,23H,13-15H2,(H,31,37)(H,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440065
PNG
(CHEMBL2426075)
Show SMILES OC(=O)CCCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Br)cc2)c2ccccc2[nH]c1=O |c:9|
Show InChI InChI=1S/C29H23BrClN3O4/c30-19-12-8-18(9-13-19)27-21-4-1-2-5-22(21)32-29(38)28(27)23-16-24(17-10-14-20(31)15-11-17)34(33-23)25(35)6-3-7-26(36)37/h1-2,4-5,8-15,24H,3,6-7,16H2,(H,32,38)(H,36,37)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440077
PNG
(CHEMBL2425977)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)c(F)c2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H20Cl2FN3O4/c29-17-8-5-15(6-9-17)23-14-22(33-34(23)24(35)11-12-25(36)37)27-26(16-7-10-19(30)20(31)13-16)18-3-1-2-4-21(18)32-28(27)38/h1-10,13,23H,11-12,14H2,(H,32,38)(H,36,37)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.20E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440067
PNG
(CHEMBL2426072 | CHEMBL2426073)
Show SMILES OC(=O)C=CC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Br)cc2)c2ccccc2[nH]c1=O |w:3.2,c:8|
Show InChI InChI=1S/C28H19BrClN3O4/c29-18-9-5-17(6-10-18)26-20-3-1-2-4-21(20)31-28(37)27(26)22-15-23(16-7-11-19(30)12-8-16)33(32-22)24(34)13-14-25(35)36/h1-14,23H,15H2,(H,31,37)(H,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.20E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440060
PNG
(CHEMBL2426081)
Show SMILES OC(=O)CCC(=O)N1N=C(C[C@H]1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O |r,c:8|
Show InChI InChI=1S/C28H21Cl2N3O4/c29-18-9-5-16(6-10-18)23-15-22(32-33(23)24(34)13-14-25(35)36)27-26(17-7-11-19(30)12-8-17)20-3-1-2-4-21(20)31-28(27)37/h1-12,23H,13-15H2,(H,31,37)(H,35,36)/t23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.30E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440085
PNG
(CHEMBL2426092)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccc(Br)cc2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H21Br2N3O4/c29-18-9-5-16(6-10-18)23-15-22(32-33(23)24(34)13-14-25(35)36)27-26(17-7-11-19(30)12-8-17)20-3-1-2-4-21(20)31-28(27)37/h1-12,23H,13-15H2,(H,31,37)(H,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.30E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440081
PNG
(CHEMBL2426096)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H21BrClN3O4/c29-18-9-5-16(6-10-18)23-15-22(32-33(23)24(34)13-14-25(35)36)27-26(17-7-11-19(30)12-8-17)20-3-1-2-4-21(20)31-28(27)37/h1-12,23H,13-15H2,(H,31,37)(H,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.90E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440076
PNG
(CHEMBL2425978)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(F)c(Cl)c2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H20Cl2FN3O4/c29-17-8-5-15(6-9-17)23-14-22(33-34(23)24(35)11-12-25(36)37)27-26(16-7-10-20(31)19(30)13-16)18-3-1-2-4-21(18)32-28(27)38/h1-10,13,23H,11-12,14H2,(H,32,38)(H,36,37)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.90E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440051
PNG
(CHEMBL2425972)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2cccc(Cl)c2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H21Cl2N3O4/c29-18-10-8-16(9-11-18)23-15-22(32-33(23)24(34)12-13-25(35)36)27-26(17-4-3-5-19(30)14-17)20-6-1-2-7-21(20)31-28(27)37/h1-11,14,23H,12-13,15H2,(H,31,37)(H,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440073
PNG
(CHEMBL2426066)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2cc(F)cc(F)c2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H20ClF2N3O4/c29-17-7-5-15(6-8-17)23-14-22(33-34(23)24(35)9-10-25(36)37)27-26(16-11-18(30)13-19(31)12-16)20-3-1-2-4-21(20)32-28(27)38/h1-8,11-13,23H,9-10,14H2,(H,32,38)(H,36,37)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.10E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440058
PNG
(CHEMBL2426100)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(F)cc2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H21ClFN3O4/c29-18-9-5-16(6-10-18)23-15-22(32-33(23)24(34)13-14-25(35)36)27-26(17-7-11-19(30)12-8-17)20-3-1-2-4-21(20)31-28(27)37/h1-12,23H,13-15H2,(H,31,37)(H,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.10E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440074
PNG
(CHEMBL2426065)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(F)c(F)c2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H20ClF2N3O4/c29-17-8-5-15(6-9-17)23-14-22(33-34(23)24(35)11-12-25(36)37)27-26(16-7-10-19(30)20(31)13-16)18-3-1-2-4-21(18)32-28(27)38/h1-10,13,23H,11-12,14H2,(H,32,38)(H,36,37)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.10E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440057
PNG
(CHEMBL2426097)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H21Cl2N3O4/c29-18-9-5-16(6-10-18)23-15-22(32-33(23)24(34)13-14-25(35)36)27-26(17-7-11-19(30)12-8-17)20-3-1-2-4-21(20)31-28(27)37/h1-12,23H,13-15H2,(H,31,37)(H,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.10E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440050
PNG
(CHEMBL2425973)
Show SMILES Cc1cccc(c1)-c1c(C2=NN(C(C2)c2ccc(Cl)cc2)C(=O)CCC(O)=O)c(=O)[nH]c2ccccc12 |t:10|
Show InChI InChI=1S/C29H24ClN3O4/c1-17-5-4-6-19(15-17)27-21-7-2-3-8-22(21)31-29(37)28(27)23-16-24(18-9-11-20(30)12-10-18)33(32-23)25(34)13-14-26(35)36/h2-12,15,24H,13-14,16H2,1H3,(H,31,37)(H,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.40E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440047
PNG
(CHEMBL2425976)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2cccc(c2)C(F)(F)F)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C29H21ClF3N3O4/c30-19-10-8-16(9-11-19)23-15-22(35-36(23)24(37)12-13-25(38)39)27-26(17-4-3-5-18(14-17)29(31,32)33)20-6-1-2-7-21(20)34-28(27)40/h1-11,14,23H,12-13,15H2,(H,34,40)(H,38,39)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.80E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440053
PNG
(CHEMBL2426104)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(cc2)C(F)(F)F)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C29H21ClF3N3O4/c30-19-11-7-16(8-12-19)23-15-22(35-36(23)24(37)13-14-25(38)39)27-26(17-5-9-18(10-6-17)29(31,32)33)20-3-1-2-4-21(20)34-28(27)40/h1-12,23H,13-15H2,(H,34,40)(H,38,39)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.90E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440078
PNG
(CHEMBL2426101)
Show SMILES Cc1ccc(cc1)-c1c(C2=NN(C(C2)c2ccc(Cl)cc2)C(=O)CCC(O)=O)c(=O)[nH]c2ccccc12 |t:10|
Show InChI InChI=1S/C29H24ClN3O4/c1-17-6-8-19(9-7-17)27-21-4-2-3-5-22(21)31-29(37)28(27)23-16-24(18-10-12-20(30)13-11-18)33(32-23)25(34)14-15-26(35)36/h2-13,24H,14-16H2,1H3,(H,31,37)(H,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.30E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440062
PNG
(CHEMBL2426078)
Show SMILES NC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H22Cl2N4O3/c29-18-9-5-16(6-10-18)23-15-22(33-34(23)25(36)14-13-24(31)35)27-26(17-7-11-19(30)12-8-17)20-3-1-2-4-21(20)32-28(27)37/h1-12,23H,13-15H2,(H2,31,35)(H,32,37)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.40E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440083
PNG
(CHEMBL2426094)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(F)cc1)c1c(-c2ccc(Br)cc2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H21BrFN3O4/c29-18-9-5-17(6-10-18)26-20-3-1-2-4-21(20)31-28(37)27(26)22-15-23(16-7-11-19(30)12-8-16)33(32-22)24(34)13-14-25(35)36/h1-12,23H,13-15H2,(H,31,37)(H,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.40E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440059
PNG
(CHEMBL2426082)
Show SMILES OC(=O)CCC(=O)N1N=C(C[C@@H]1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O |r,c:8|
Show InChI InChI=1S/C28H21Cl2N3O4/c29-18-9-5-16(6-10-18)23-15-22(32-33(23)24(34)13-14-25(35)36)27-26(17-7-11-19(30)12-8-17)20-3-1-2-4-21(20)31-28(27)37/h1-12,23H,13-15H2,(H,31,37)(H,35,36)/t23-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.50E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440052
PNG
(CHEMBL2426105)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2cccc(F)c2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H21ClFN3O4/c29-18-10-8-16(9-11-18)23-15-22(32-33(23)24(34)12-13-25(35)36)27-26(17-4-3-5-19(30)14-17)20-6-1-2-7-21(20)31-28(27)37/h1-11,14,23H,12-13,15H2,(H,31,37)(H,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.60E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440080
PNG
(CHEMBL2426098)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(F)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H21ClFN3O4/c29-18-9-5-17(6-10-18)26-20-3-1-2-4-21(20)31-28(37)27(26)22-15-23(16-7-11-19(30)12-8-16)33(32-22)24(34)13-14-25(35)36/h1-12,23H,13-15H2,(H,31,37)(H,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.70E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440079
PNG
(CHEMBL2426099)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccccc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H22ClN3O4/c29-19-12-10-18(11-13-19)26-20-8-4-5-9-21(20)30-28(36)27(26)22-16-23(17-6-2-1-3-7-17)32(31-22)24(33)14-15-25(34)35/h1-13,23H,14-16H2,(H,30,36)(H,34,35)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.90E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440061
PNG
(CHEMBL2424674)
Show SMILES OC(=O)CCCN1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O |c:7|
Show InChI InChI=1S/C28H23Cl2N3O3/c29-19-11-7-17(8-12-19)24-16-23(32-33(24)15-3-6-25(34)35)27-26(18-9-13-20(30)14-10-18)21-4-1-2-5-22(21)31-28(27)36/h1-2,4-5,7-14,24H,3,6,15-16H2,(H,31,36)(H,34,35)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.80E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A


(Rattus norvegicus (Rat))		BDBM50440063
PNG
(CHEMBL2426077)
Show SMILES OC(=O)CCCC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1c(-c2ccc(Cl)cc2)c2ccccc2[nH]c1=O |c:9|
Show InChI InChI=1S/C29H23Cl2N3O4/c30-19-12-8-17(9-13-19)24-16-23(33-34(24)25(35)6-3-7-26(36)37)28-27(18-10-14-20(31)15-11-18)21-4-1-2-5-22(21)32-29(28)38/h1-2,4-5,8-15,24H,3,6-7,16H2,(H,32,38)(H,36,37)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.20E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method

J Med Chem 56: 6434-56 (2013)


Article DOI: 10.1021/jm400652r
BindingDB Entry DOI: 10.7270/Q26H4JTJ
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 62 total )  |  Next  |  Last  >>
Jump to: