Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50403547 (ATROPEN | ATROPINE) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid UniChem Similars | PubMed | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Carolina Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity by displacing [3H]oxotremorine from mouse cerebral cortex tissue. | J Med Chem 35: 1102-8 (1992) BindingDB Entry DOI: 10.7270/Q28K79QR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50604668 (CHEMBL5180947) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2022.114305 BindingDB Entry DOI: 10.7270/Q26M3BX2 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50149201 (3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYD...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Binding affinity to mouse AChE | J Med Chem 51: 3154-70 (2008) Article DOI: 10.1021/jm701253t BindingDB Entry DOI: 10.7270/Q22Z16D4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50403547 (ATROPEN | ATROPINE) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid UniChem Similars | PubMed | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Carolina Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity by displacing [3H]oxotremorine from mouse cerebral cortex tissue. | J Med Chem 35: 1102-8 (1992) BindingDB Entry DOI: 10.7270/Q28K79QR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50585443 (CHEMBL5082250) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of mouse AChE assessed as inhibition constant using acetylthiocholine iodide as substrate measured every 2 mins by lineweaver-burk plot an... | Citation and Details Article DOI: 10.1016/j.ejmech.2021.114045 BindingDB Entry DOI: 10.7270/Q29K4G4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50004665 ((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | PubMed | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Carolina Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity by displacing [3H]oxotremorine from mouse cerebral cortex tissue. | J Med Chem 35: 1102-8 (1992) BindingDB Entry DOI: 10.7270/Q28K79QR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50004656 ((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Similars | PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Carolina Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity by displacing [3H]oxotremorine from mouse cerebral cortex tissue. | J Med Chem 35: 1102-8 (1992) BindingDB Entry DOI: 10.7270/Q28K79QR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50004656 ((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Similars | PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Carolina Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity by displacing [3H]oxotremorine from mouse cerebral cortex tissue. | J Med Chem 35: 1102-8 (1992) BindingDB Entry DOI: 10.7270/Q28K79QR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50377920 (CHEMBL540657) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Binding affinity to mouse AChE | J Med Chem 51: 3154-70 (2008) Article DOI: 10.1021/jm701253t BindingDB Entry DOI: 10.7270/Q22Z16D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM8961 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 18 | -10.6 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Mayo Clinic College of Medicine | Assay Description Assays were conducted at 25 C in 20 mM sodium phosphate buffer (pH 7.0) and 0.01% bovine serum albumin unless otherwise noted. AChE concentrations we... | Biochemistry 52: 7486-99 (2013) Article DOI: 10.1021/bi401043w BindingDB Entry DOI: 10.7270/Q24X56GT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM120262 (EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 250 | -9.00 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Mayo Clinic College of Medicine | Assay Description Assays were conducted at 25 C in 20 mM sodium phosphate buffer (pH 7.0) and 0.01% bovine serum albumin unless otherwise noted. AChE concentrations we... | Biochemistry 52: 7486-99 (2013) Article DOI: 10.1021/bi401043w BindingDB Entry DOI: 10.7270/Q24X56GT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM120263 (N-methylacridinium) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 310 | -8.87 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Mayo Clinic College of Medicine | Assay Description Assays were conducted at 25 C in 20 mM sodium phosphate buffer (pH 7.0) and 0.01% bovine serum albumin unless otherwise noted. AChE concentrations we... | Biochemistry 52: 7486-99 (2013) Article DOI: 10.1021/bi401043w BindingDB Entry DOI: 10.7270/Q24X56GT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50060582 (1,10-Bis(trimethyl ammonium)decane dibromide | 1,1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 460 | -8.64 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Mayo Clinic College of Medicine | Assay Description Assays were conducted at 25 C in 20 mM sodium phosphate buffer (pH 7.0) and 0.01% bovine serum albumin unless otherwise noted. AChE concentrations we... | Biochemistry 52: 7486-99 (2013) Article DOI: 10.1021/bi401043w BindingDB Entry DOI: 10.7270/Q24X56GT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50202489 (CHEMBL3910200) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Uncompetitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50202492 (CHEMBL3938124) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Uncompetitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50202494 (CHEMBL3893245) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 850 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Uncompetitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50202508 (CHEMBL3962271) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Competitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50202496 (CHEMBL3891487) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Competitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50292569 (2-[(1Z)-(hydroxyimino)methyl]-1-(7-{2-[(1E)-(hydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Binding affinity to mouse AChE | J Med Chem 51: 3154-70 (2008) Article DOI: 10.1021/jm701253t BindingDB Entry DOI: 10.7270/Q22Z16D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50004665 ((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | PubMed | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Carolina Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity by displacing [3H]methylscopolamine [3H]NMS from mouse cerebral cortex tissue. | J Med Chem 35: 1102-8 (1992) BindingDB Entry DOI: 10.7270/Q28K79QR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM31904 (CHEMBL345124 | Propidium | Propidium Iodide, 2 | p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 2.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Binding affinity to mouse AChE | J Med Chem 51: 3154-70 (2008) Article DOI: 10.1021/jm701253t BindingDB Entry DOI: 10.7270/Q22Z16D4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM152524 (N-(4-(3-(4-(pyridin-2-yl)piperazin-1-yl)propoxy)ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2.26E+3 | n/a | 1.67E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Panjab University | Assay Description An aliquot of diluted solution at five different concentration (1, 5, 10,15 and 25 µl) levels was mixed with phosphate buffer (pH 8.0, 3.0 ml), 100 µ... | Bioorg Chem 60: 64-73 (2015) Article DOI: 10.1016/j.bioorg.2015.04.004 BindingDB Entry DOI: 10.7270/Q25B016Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM152520 (N-[4-{3-(4-phenylpiperazin-1-yl)propoxy}phenyl]ace...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.28E+3 | n/a | 1.39E+3 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Panjab University | Assay Description An aliquot of diluted solution at five different concentration (1, 5, 10,15 and 25 µl) levels was mixed with phosphate buffer (pH 8.0, 3.0 ml), 100 µ... | Bioorg Chem 60: 64-73 (2015) Article DOI: 10.1016/j.bioorg.2015.04.004 BindingDB Entry DOI: 10.7270/Q25B016Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM152521 (N-(4-(3-(4-(2-fluorophenyl)piperazin-1-yl)propoxy)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.54E+3 | n/a | 1.36E+3 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Panjab University | Assay Description An aliquot of diluted solution at five different concentration (1, 5, 10,15 and 25 µl) levels was mixed with phosphate buffer (pH 8.0, 3.0 ml), 100 µ... | Bioorg Chem 60: 64-73 (2015) Article DOI: 10.1016/j.bioorg.2015.04.004 BindingDB Entry DOI: 10.7270/Q25B016Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50202499 (CHEMBL3960527) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Uncompetitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50060582 (1,10-Bis(trimethyl ammonium)decane dibromide | 1,1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Binding affinity to mouse AChE | J Med Chem 51: 3154-70 (2008) Article DOI: 10.1021/jm701253t BindingDB Entry DOI: 10.7270/Q22Z16D4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50202486 (CHEMBL3909539) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Uncompetitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50202495 (CHEMBL3980699) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Uncompetitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50202491 (CHEMBL3951830) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Competitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50202490 (CHEMBL3944788) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Uncompetitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM152522 (N-(4-(3-(4-(4-fluorophenyl)piperazin-1-yl)propoxy)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4.10E+3 | n/a | 490 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Panjab University | Assay Description An aliquot of diluted solution at five different concentration (1, 5, 10,15 and 25 µl) levels was mixed with phosphate buffer (pH 8.0, 3.0 ml), 100 µ... | Bioorg Chem 60: 64-73 (2015) Article DOI: 10.1016/j.bioorg.2015.04.004 BindingDB Entry DOI: 10.7270/Q25B016Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50202487 (CHEMBL3953512) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 5.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Uncompetitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM152515 (N-(4-(2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoet...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 5.45E+3 | n/a | 4.36E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Panjab University | Assay Description An aliquot of diluted solution at five different concentration (1, 5, 10,15 and 25 µl) levels was mixed with phosphate buffer (pH 8.0, 3.0 ml), 100 µ... | Bioorg Chem 60: 64-73 (2015) Article DOI: 10.1016/j.bioorg.2015.04.004 BindingDB Entry DOI: 10.7270/Q25B016Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50202493 (CHEMBL3974229) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 5.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Uncompetitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM11682 (2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | 5.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Competitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50202497 (CHEMBL3982229) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Uncompetitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50202488 (CHEMBL3979735) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 8.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Uncompetitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | Eur J Med Chem 122: 557-573 (2016) Article DOI: 10.1016/j.ejmech.2016.06.046 BindingDB Entry DOI: 10.7270/Q23X88NQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM152516 (N-(4-(2-oxo-2-(4-(pyridin-2-yl)piperazin-1-yl)etho...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 8.95E+3 | n/a | 5.11E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Panjab University | Assay Description An aliquot of diluted solution at five different concentration (1, 5, 10,15 and 25 µl) levels was mixed with phosphate buffer (pH 8.0, 3.0 ml), 100 µ... | Bioorg Chem 60: 64-73 (2015) Article DOI: 10.1016/j.bioorg.2015.04.004 BindingDB Entry DOI: 10.7270/Q25B016Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM152525 (N-(4-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propoxy)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 9.04E+3 | n/a | 2.75E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Panjab University | Assay Description An aliquot of diluted solution at five different concentration (1, 5, 10,15 and 25 µl) levels was mixed with phosphate buffer (pH 8.0, 3.0 ml), 100 µ... | Bioorg Chem 60: 64-73 (2015) Article DOI: 10.1016/j.bioorg.2015.04.004 BindingDB Entry DOI: 10.7270/Q25B016Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 9.30E+3 | -6.86 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Mayo Clinic College of Medicine | Assay Description Assays were conducted at 25 C in 20 mM sodium phosphate buffer (pH 7.0) and 0.01% bovine serum albumin unless otherwise noted. AChE concentrations we... | Biochemistry 52: 7486-99 (2013) Article DOI: 10.1021/bi401043w BindingDB Entry DOI: 10.7270/Q24X56GT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM152523 (N-(4-(3-(4-(3-chlorophenyl)piperazin-1-yl)propoxy)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 9.90E+3 | n/a | 1.03E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Panjab University | Assay Description An aliquot of diluted solution at five different concentration (1, 5, 10,15 and 25 µl) levels was mixed with phosphate buffer (pH 8.0, 3.0 ml), 100 µ... | Bioorg Chem 60: 64-73 (2015) Article DOI: 10.1016/j.bioorg.2015.04.004 BindingDB Entry DOI: 10.7270/Q25B016Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM152512 (N-[4-{2-(4-ethylpiperazin-1-yl)-2-oxoethoxy}phenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.58E+4 | n/a | 5.73E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Panjab University | Assay Description An aliquot of diluted solution at five different concentration (1, 5, 10,15 and 25 µl) levels was mixed with phosphate buffer (pH 8.0, 3.0 ml), 100 µ... | Bioorg Chem 60: 64-73 (2015) Article DOI: 10.1016/j.bioorg.2015.04.004 BindingDB Entry DOI: 10.7270/Q25B016Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM152518 (N-(4-(2-(4-(furan-2-carbonyl)piperazin-1-yl)-2-oxo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.95E+4 | n/a | 1.07E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Panjab University | Assay Description An aliquot of diluted solution at five different concentration (1, 5, 10,15 and 25 µl) levels was mixed with phosphate buffer (pH 8.0, 3.0 ml), 100 µ... | Bioorg Chem 60: 64-73 (2015) Article DOI: 10.1016/j.bioorg.2015.04.004 BindingDB Entry DOI: 10.7270/Q25B016Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50061568 (2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]bis(N,N,N...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Binding affinity to mouse AChE | J Med Chem 51: 3154-70 (2008) Article DOI: 10.1021/jm701253t BindingDB Entry DOI: 10.7270/Q22Z16D4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50055159 (CHEMBL136916 | CHEMBL150001 | Trimethyl-(4-oxo-pen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Binding affinity to mouse AChE | J Med Chem 51: 3154-70 (2008) Article DOI: 10.1021/jm701253t BindingDB Entry DOI: 10.7270/Q22Z16D4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM152517 (N-(4-(2-oxo-2-(4-(pyrimidin-2-yl)piperazin-1-yl)et...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 3.48E+4 | n/a | 1.56E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Panjab University | Assay Description An aliquot of diluted solution at five different concentration (1, 5, 10,15 and 25 µl) levels was mixed with phosphate buffer (pH 8.0, 3.0 ml), 100 µ... | Bioorg Chem 60: 64-73 (2015) Article DOI: 10.1016/j.bioorg.2015.04.004 BindingDB Entry DOI: 10.7270/Q25B016Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM152513 (N-[4-{2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy}pheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4.37E+4 | n/a | 1.66E+3 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Panjab University | Assay Description An aliquot of diluted solution at five different concentration (1, 5, 10,15 and 25 µl) levels was mixed with phosphate buffer (pH 8.0, 3.0 ml), 100 µ... | Bioorg Chem 60: 64-73 (2015) Article DOI: 10.1016/j.bioorg.2015.04.004 BindingDB Entry DOI: 10.7270/Q25B016Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM152514 (N-(4-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-oxoet...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 4.68E+4 | n/a | 3.02E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Panjab University | Assay Description An aliquot of diluted solution at five different concentration (1, 5, 10,15 and 25 µl) levels was mixed with phosphate buffer (pH 8.0, 3.0 ml), 100 µ... | Bioorg Chem 60: 64-73 (2015) Article DOI: 10.1016/j.bioorg.2015.04.004 BindingDB Entry DOI: 10.7270/Q25B016Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50217962 (CHEMBL39800) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Montana Curated by ChEMBL | Assay Description Inhibitory constant against wild type Acetylcholinesterase | Bioorg Med Chem Lett 10: 1523-6 (2000) BindingDB Entry DOI: 10.7270/Q21Z46MN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Mus musculus (mouse)) | BDBM50217963 (CHEMBL39854) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Montana Curated by ChEMBL | Assay Description Inhibitory constant against wild type Acetylcholinesterase | Bioorg Med Chem Lett 10: 1523-6 (2000) BindingDB Entry DOI: 10.7270/Q21Z46MN | |||||||||||
More data for this Ligand-Target Pair |
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