Compile Data Set for Download or QSAR

Found 156 hits Enz. Inhib. hit(s) with all data for entry = 1067   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM306756 (N-(2-((5-((1R,3R)-2-(2,2-Difluoropropyl)-3-methyl-...) Show SMILES COc1cc(OCCNCCCF)ncc1[C@H]1N(CC(C)(F)F)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0790	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306718 (N-(2-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methyl...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306731 (3-((1R,3R)-1- (2,6-difluoro- 4-(2-((3- fluoropropy...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(F)CO)c1c(F)cc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0860	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306772 (2,2-difluoro-3- ((1R,3R)-1-(4- (2-((3- fluoropropy...) Show SMILES COc1cc(OCCNCCCF)ccc1[C@H]1N(CC(F)(F)CO)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0870	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306764 (BDBM306765 | N-(2-(3,5- difluoro-4- ((1R,3R)-2-(2-...) Show SMILES COCC(C)(F)CN1[C@H](C)Cc2c([nH]c3ccccc23)[C@H]1c1c(F)cc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0870	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306760 (3-((1R,3R)-1-(2,6-difluoro-4-((2-((3-fluoropropyl)...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(F)(F)CO)c1c(F)cc(NCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0930	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306787 (3-fluoro-N-(2- (3-methoxy-4- ((1R,3R)-3- methyl-2-...) Show SMILES COc1cc(OCCNCCCF)ccc1[C@H]1N(CC(F)(F)F)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0940	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306724 (3-((1R,3R)-1-(2,6-difluoro-4-(2-((3-fluoropropyl)a...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(F)(F)CO)c1c(F)cc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306768 (N1-(4- ((1R,3R)-2- (2,2- difluoroethyl)- 3-methyl-...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(F)F)c1c(F)cc(NCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306788 (N-(2-(4- ((1R,3R)-2- (2,2-difluoro- propyl)-3- met...) Show SMILES COc1cc(OCCNCCCF)ccc1[C@H]1N(CC(C)(F)F)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306717 (N-(2-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methyl...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(OCCNCCC(F)F)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306734 (3-(3,5- difluoro-4- ((1R,3R)-2-(2- fluoro-2-methyl...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(OCC(CO)NCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306755 (3-Fluoro-N-(2-((4-methoxy-5-((1R,3R)-3-methyl-2-(2...) Show SMILES COc1cc(OCCNCCCF)ncc1[C@H]1N(CC(F)(F)F)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306750 ((6-chloro-4-methoxypyridin-3-yl)methanol | US10149...) Show SMILES COc1cc(OCCNCCCF)ncc1[C@H]1N(CC(C)(C)F)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306757 (N-(2-(4-((1R,3R)-2-(2,2-Difluoroethyl)-3-methyl-2,...) Show SMILES COc1cc(OCCNCCCF)ccc1[C@H]1N(CC(F)F)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306722 (3-fluoro-N-(2-(4-((1R,3R)-2-((3-fluorooxetan-3-yl)...) Show SMILES COc1cc(OCCNCCCF)ccc1[C@H]1N(CC2(F)COC2)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306758 (N1-(3,5-difluoro-4-((1R,3R)-2-((3-fluorooxetan-3-y...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC1(F)COC1)c1c(F)cc(NCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306754 (N-(2-((5-((1R,3R)-2-(2,2-difluoroethyl)-3-methyl-2...) Show SMILES COc1cc(OCCNCCCF)ncc1[C@H]1N(CC(F)F)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306726 (N-(2-(4- ((1R,3R)-2- (2,2- difluoropropyl)- 3-meth...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(F)F)c1c(F)cc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306718 (N-(2-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methyl...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description Compounds were dosed directly from a compound source microplate containing serially diluted compound (4 wells containing 10 mM, 0.1 mM, 1 mM and 10 n...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306769 (N-(2-(4- ((1R,3R)-2- (2,2-difluoro- propyl)-3- met...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(F)F)c1ccc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306778 (2,2-difluoro-3- ((1R,3R)-1-(6- (2-((3- fluoropropy...) Show SMILES COc1cc(OCCNCCCF)ncc1[C@H]1N(CC(F)(F)CO)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306792 (US10149839, Example 78(NT) Show SMILES COc1nc(NCCNCCCF)ccc1[C@H]1N(CC(C)(F)F)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306723 (N1-(3,5-difluoro-4-((1R,3R)-2-((1-fluorocyclopropy...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC1(F)CC1)c1c(F)cc(NCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306775 (N1-(4- ((1R,3R)-2- (2,2- difluoroethyl)- 3-methyl-...) Show SMILES COc1cc(NCCNCCCF)ccc1[C@H]1N(CC(F)F)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306761 (N1-(4-((1R,3R)-2-((3-fluorooxetan-3-yl)methyl)-3-m...) Show SMILES COc1cc(NCCNCCCF)ccc1[C@H]1N(CC2(F)COC2)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306734 (3-(3,5- difluoro-4- ((1R,3R)-2-(2- fluoro-2-methyl...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(OCC(CO)NCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306773 (2,2-difluoro-3- ((1R,3R)-1-(4- ((2-((3- fluoroprop...) Show SMILES COc1cc(NCCNCCCF)ccc1[C@H]1N(CC(F)(F)CO)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306763 (N1-(4-((1R,3R)-2-(2,2-difluoroethyl)-3-methyl-2,3,...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(F)F)c1c(F)cc(cc1F)N(C)CCNCCCF |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306734 (3-(3,5- difluoro-4- ((1R,3R)-2-(2- fluoro-2-methyl...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(OCC(CO)NCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306762 (N-(2-(4-((1R,3R)-2-(2,2-difluoroethyl)-3-methyl-2,...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(F)F)c1ccc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306720 (N-(2-(3,5-difluoro-4-((1R,3R)-2-((1-fluorocyclopro...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC1(F)CC1)c1c(F)cc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306771 (N-(2-(4- ((1R,3R)-2- (2,2-difluoro- propyl)- 3-met...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(F)F)c1ccc(OCCNCCCF)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306749 ((5-bromo-3-methoxypyridin-2-yl)methanol | US101498...) Show SMILES COc1cc(OCCNCCCF)cnc1[C@H]1N(CC(C)(C)F)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.280	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306759 (N1-(3,5-difluoro-4-((1R,3R)-2-((1-fluorocyclopropy...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC1(F)CC1)c1c(F)cc(cc1F)N(C)CCNCCCF |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306790 (N1-(5- ((1R,3R)-2- (2,2- difluoroethyl)- 3-methyl-...) Show SMILES COc1nc(NCCNCCCF)ccc1[C@H]1N(CC(F)F)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306782 (N1-(5- ((1R,3R)-2- (2,2-difluoro- propyl)-3- methy...) Show SMILES COc1cc(NCCNCCCF)ncc1[C@H]1N(CC(C)(F)F)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306739 (BDBM306740 | N-(2-(4- ((1R,3R)-2- (2,3-difluoro- p...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1C[C@H](F)CF)c1ccc(OCCNCCCF)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306729 (BDBM306730 | N-(2-(4- ((1R,3R)-2- (2,3-difluoro- p...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1C[C@H](F)CF)c1c(F)cc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306739 (BDBM306740 | N-(2-(4- ((1R,3R)-2- (2,3-difluoro- p...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1C[C@H](F)CF)c1ccc(OCCNCCCF)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.380	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306770 (N-(2-(4- ((1R,3R)-2- (2,2- difluoroethyl)- 3-methy...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(F)F)c1ccc(OCCNCCCF)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306733 (2-(3,5- difluoro-4- ((1R,3R)-2-(2- fluoro-2- methy...) Show SMILES CC(CNCCCF)Oc1cc(F)c([C@H]2N(CC(C)(C)F)[C@H](C)Cc3c2[nH]c2ccccc32)c(F)c1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.410	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306727 (N-(2-(4- ((1R,3R)-2- (2,2- difluoroethyl)- 3-methy...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(F)F)c1c(F)cc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306752 (5-chloropyrazine-2-carbaldehyde | US10149839, Exam...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1cnc(OCCNCCCF)cn1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.430	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306716 (3-fluoro-N-(2-(4-((1R,3R)-2-isobutyl-3-methyl-2,3,...) Show SMILES CC(C)CN1[C@H](C)Cc2c([nH]c3ccccc23)[C@H]1c1ccc(OCCNCCCF)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.430	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306725 (3-fluoro-N-(2-(4-((1R,3R)-2-((1-fluorocyclopropyl)...) Show SMILES COc1cc(OCCNCCCF)ccc1[C@H]1N(CC2(F)CC2)[C@H](C)Cc2c1[nH]c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306786 (N-(2-(3,5- difluoro-4- ((1R,3R)-2-((3- (fluorometh...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC1(CF)COC1)c1c(F)cc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306735 (3-fluoro-N-(2- (3-fluoro-4- ((1R,3R)-2-((1- fluoro...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC1(F)CC1)c1ccc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306719 (N-(2-(3,5-difluoro-4-((1R,3R)-2-((3-fluorooxetan-3...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC1(F)COC1)c1c(F)cc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.490	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306729 (BDBM306730 | N-(2-(4- ((1R,3R)-2- (2,3-difluoro- p...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1C[C@H](F)CF)c1c(F)cc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair

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