Compile Data Set for Download or QSAR

Found 158 hits Enz. Inhib. hit(s) with all data for entry = 45   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM103887 (US10047086, 1 | US10640503, Example 1 | US9695168,...) Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C26H24N4O/c1-18-2-6-22(7-3-18)26-23(21-8-4-19(13-27)5-9-21)12-25(24-15-29-17-30(24)26)31-16-20-10-11-28-14-20/h2-9,12,15,17,20,28H,10-11,14,16H2,1H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM103889 (US10047086, 3 | US10640503, Example 3 | US9695168,...) Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2cncn12)-c1ccc(cc1)[N+]([O-])=O |r| Show InChI InChI=1S/C25H24N4O3/c1-17-2-4-20(5-3-17)25-22(19-6-8-21(9-7-19)29(30)31)12-24(23-14-27-16-28(23)25)32-15-18-10-11-26-13-18/h2-9,12,14,16,18,26H,10-11,13,15H2,1H3/t18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM103890 (US10047086, 4 | US10640503, Example 4 | US9695168,...) Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2cncn12)-c1ccc(C#N)c(F)c1 |r| Show InChI InChI=1S/C26H23FN4O/c1-17-2-4-19(5-3-17)26-22(20-6-7-21(12-28)23(27)10-20)11-25(24-14-30-16-31(24)26)32-15-18-8-9-29-13-18/h2-7,10-11,14,16,18,29H,8-9,13,15H2,1H3/t18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM103894 (US10047086, 8 | US10640503, Example 8 | US9695168,...) Show SMILES Cc1ccc(c(F)c1)-c1c(cc(OC[C@@H]2CCNC2)c2cncn12)-c1ccc(cc1)C#N |r,wD:14.14,(-6.52,-4.23,;-5.19,-3.46,;-5.19,-1.93,;-3.85,-1.15,;-2.52,-1.93,;-2.52,-3.46,;-1.18,-4.23,;-3.85,-4.23,;-1.18,-1.15,;-1.18,.38,;.15,1.15,;1.48,.38,;2.82,1.15,;4.15,.38,;5.48,1.15,;5.48,2.69,;6.95,3.17,;7.85,1.93,;6.95,.68,;1.48,-1.15,;2.63,-2.19,;2,-3.59,;.47,-3.43,;.15,-1.93,;-2.52,1.15,;-2.52,2.69,;-3.85,3.47,;-5.23,2.72,;-5.19,1.15,;-3.85,.38,;-6.57,3.49,;-7.9,4.26,)| Show InChI InChI=1S/C26H23FN4O/c1-17-2-7-21(23(27)10-17)26-22(20-5-3-18(12-28)4-6-20)11-25(24-14-30-16-31(24)26)32-15-19-8-9-29-13-19/h2-7,10-11,14,16,19,29H,8-9,13,15H2,1H3/t19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM103895 (US10047086, 9 | US10640503, Example 9 | US9695168,...) Show SMILES CCC1CCC(=CC1)c1c(cc(OC[C@@H]2CCNC2)c2cncn12)-c1ccc(cc1)C#N |r,c:5| Show InChI InChI=1S/C27H30N4O/c1-2-19-3-9-23(10-4-19)27-24(22-7-5-20(14-28)6-8-22)13-26(25-16-30-18-31(25)27)32-17-21-11-12-29-15-21/h5-9,13,16,18-19,21,29H,2-4,10-12,15,17H2,1H3/t19?,21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM103897 (US10047086, 11 | US10640503, Example 11 | US969516...) Show SMILES Cn1ncc2cc(ccc12)-c1c(cc(OC[C@@H]2CCNC2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C27H24N6O/c1-32-24-7-6-21(10-22(24)14-31-32)27-23(20-4-2-18(12-28)3-5-20)11-26(25-15-30-17-33(25)27)34-16-19-8-9-29-13-19/h2-7,10-11,14-15,17,19,29H,8-9,13,16H2,1H3/t19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM103898 (US10047086, 12 | US10640503, Example 12 | US969516...) Show SMILES CN1C(=O)Cc2cc(ccc12)-c1c(cc(OC[C@@H]2CCNC2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C28H25N5O2/c1-32-24-7-6-21(10-22(24)11-27(32)34)28-23(20-4-2-18(13-29)3-5-20)12-26(25-15-31-17-33(25)28)35-16-19-8-9-30-14-19/h2-7,10,12,15,17,19,30H,8-9,11,14,16H2,1H3/t19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM103901 (US10047086, 15 | US10640503, Example 15 | US969516...) Show SMILES CN1CCOc2ccc(cc12)-c1c(cc(OC[C@@H]2CCNC2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C28H27N5O2/c1-32-10-11-34-26-7-6-22(12-24(26)32)28-23(21-4-2-19(14-29)3-5-21)13-27(25-16-31-18-33(25)28)35-17-20-8-9-30-15-20/h2-7,12-13,16,18,20,30H,8-11,15,17H2,1H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM103988 (US10047086, 16 | US10640503, Example 16 | US969516...) Show SMILES N#Cc1ccc(cc1)-c1cc(OC[C@@H]2CCNC2)c2cncn2c1-c1ccc2OCCOc2c1 |r| Show InChI InChI=1S/C27H24N4O3/c28-13-18-1-3-20(4-2-18)22-12-25(34-16-19-7-8-29-14-19)23-15-30-17-31(23)27(22)21-5-6-24-26(11-21)33-10-9-32-24/h1-6,11-12,15,17,19,29H,7-10,14,16H2/t19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104015 (US10047086, 18 | US10640503, Example 18 | US969516...) Show SMILES N#Cc1ccc(cc1)-c1cc(OC[C@@H]2CCNC2)c2cncn2c1-c1ccc(CCN2CCOCC2)cc1 |r| Show InChI InChI=1S/C31H33N5O2/c32-18-24-3-5-26(6-4-24)28-17-30(38-21-25-9-11-33-19-25)29-20-34-22-36(29)31(28)27-7-1-23(2-8-27)10-12-35-13-15-37-16-14-35/h1-8,17,20,22,25,33H,9-16,19,21H2/t25-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104017 (US10047086, 19 | US10640503, Example 19 | US969516...) Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc(OC[C@@H]3CCNC3)c3cncn23)-c2ccc(cc2)C#N)CC1 |r| Show InChI InChI=1S/C31H34N6O/c1-35-12-14-36(15-13-35)20-24-4-8-27(9-5-24)31-28(26-6-2-23(17-32)3-7-26)16-30(29-19-34-22-37(29)31)38-21-25-10-11-33-18-25/h2-9,16,19,22,25,33H,10-15,18,20-21H2,1H3/t25-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104019 (US10047086, 20 | US10640503, Example 20 | US969516...) Show SMILES CN1CC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3ccc(C)cc3)n3cncc23)C1 |r| Show InChI InChI=1S/C27H26N4O/c1-19-3-7-23(8-4-19)27-24(22-9-5-20(14-28)6-10-22)13-26(25-15-29-18-31(25)27)32-17-21-11-12-30(2)16-21/h3-10,13,15,18,21H,11-12,16-17H2,1-2H3/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104042 (US10047086, 23 | US10640503, Example 23 | US969516...) Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc4n(C)ncc4c3)n3cncc23)C1 |r| Show InChI InChI=1S/C28H27N7O/c1-33-11-3-4-20(16-33)17-36-28-25-15-30-18-35(25)27(22-9-10-24-23(12-22)14-31-34(24)2)26(32-28)21-7-5-19(13-29)6-8-21/h5-10,12,14-15,18,20H,3-4,11,16-17H2,1-2H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104075 (US10047086, 28 | US10640503, Example 28 | US969516...) Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc4n(C)cnc4c3)n3cncc23)C1 |r| Show InChI InChI=1S/C28H27N7O/c1-33-11-3-4-20(15-33)16-36-28-25-14-30-17-35(25)27(22-9-10-24-23(12-22)31-18-34(24)2)26(32-28)21-7-5-19(13-29)6-8-21/h5-10,12,14,17-18,20H,3-4,11,15-16H2,1-2H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104111 (US10047086, 29 | US10640503, Example 29 | US969516...) Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cnc4N(C)CCOc4c3)n3cncc23)C1 |r| Show InChI InChI=1S/C28H29N7O2/c1-33-9-3-4-20(16-33)17-37-28-23-15-30-18-35(23)26(25(32-28)21-7-5-19(13-29)6-8-21)22-12-24-27(31-14-22)34(2)10-11-36-24/h5-8,12,14-15,18,20H,3-4,9-11,16-17H2,1-2H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104112 (US10640503, Example 30 | US9695168, 30) Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cc4oc(=O)n(C)c4cc3F)n3cncc23)C1 |r,wD:5.5,(9.29,.9,;7.96,1.67,;7.96,3.21,;6.62,3.98,;5.29,3.21,;5.29,1.67,;3.96,.9,;2.62,1.67,;1.29,.9,;-.05,1.67,;-1.38,.9,;-2.71,1.67,;-2.71,3.21,;-4.05,3.98,;-5.43,3.24,;-5.38,1.67,;-4.05,.9,;-6.76,4.01,;-8.1,4.78,;-1.38,-.64,;-2.71,-1.41,;-4.05,-.64,;-5.38,-1.41,;-6.84,-.93,;-7.75,-2.18,;-9.29,-2.18,;-6.84,-3.42,;-7.61,-4.75,;-5.38,-2.95,;-4.05,-3.72,;-2.71,-2.95,;-1.38,-3.72,;-.05,-1.41,;.27,-2.91,;1.81,-3.07,;2.43,-1.67,;1.29,-.64,;6.62,.9,)| Show InChI InChI=1S/C28H25FN6O3/c1-33-9-3-4-18(14-33)15-37-27-23-13-31-16-35(23)26(25(32-27)19-7-5-17(12-30)6-8-19)20-10-24-22(11-21(20)29)34(2)28(36)38-24/h5-8,10-11,13,16,18H,3-4,9,14-15H2,1-2H3/t18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104116 (US10047086, 34 | US10640503, Example 34 | US969516...) Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc4scnc4c3)n3cncc23)C1 |r| Show InChI InChI=1S/C27H24N6OS/c1-32-10-2-3-19(14-32)15-34-27-23-13-29-16-33(23)26(21-8-9-24-22(11-21)30-17-35-24)25(31-27)20-6-4-18(12-28)5-7-20/h4-9,11,13,16-17,19H,2-3,10,14-15H2,1H3/t19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104117 (US10047086, 35 | US10640503, Example 35 | US969516...) Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc4sc(C)nc4c3)n3cncc23)C1 |r| Show InChI InChI=1S/C28H26N6OS/c1-18-31-23-12-22(9-10-25(23)36-18)27-26(21-7-5-19(13-29)6-8-21)32-28(24-14-30-17-34(24)27)35-16-20-4-3-11-33(2)15-20/h5-10,12,14,17,20H,3-4,11,15-16H2,1-2H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104118 (US10047086, 36 | US10640503, Example 36 | US969516...) Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(C#N)c(F)c3)c(-c3cnc4n(C)ncc4c3)n3cncc23)C1 |r| Show InChI InChI=1S/C27H25FN8O/c1-34-7-3-4-17(14-34)15-37-27-23-13-30-16-36(23)25(20-8-21-12-32-35(2)26(21)31-11-20)24(33-27)18-5-6-19(10-29)22(28)9-18/h5-6,8-9,11-13,16-17H,3-4,7,14-15H2,1-2H3/t17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104119 (US10047086, 37 | US10640503, Example 37 | US969516...) Show SMILES Cn1ncc2cc(cnc12)-c1c(nc(OC[C@@H]2CCCN(CCO)C2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C28H28N8O2/c1-34-27-23(14-32-34)11-22(13-31-27)26-25(21-6-4-19(12-29)5-7-21)33-28(24-15-30-18-36(24)26)38-17-20-3-2-8-35(16-20)9-10-37/h4-7,11,13-15,18,20,37H,2-3,8-10,16-17H2,1H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104120 (US10047086, 38 | US10640503, Example 38 | US969516...) Show SMILES Cn1ncc2cc(cnc12)-c1c(nc(OC[C@@H]2CCCN(CCC#N)C2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C29H27N9O/c1-36-28-24(15-34-36)12-23(14-33-28)27-26(22-7-5-20(13-31)6-8-22)35-29(25-16-32-19-38(25)27)39-18-21-4-2-10-37(17-21)11-3-9-30/h5-8,12,14-16,19,21H,2-4,10-11,17-18H2,1H3/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104122 (US10047086, 40 | US10640503, Example 40 | US969516...) Show SMILES COCCN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cnc4n(C)ncc4c3)n3cncc23)C1 |r| Show InChI InChI=1S/C29H30N8O2/c1-35-28-24(15-33-35)12-23(14-32-28)27-26(22-7-5-20(13-30)6-8-22)34-29(25-16-31-19-37(25)27)39-18-21-4-3-9-36(17-21)10-11-38-2/h5-8,12,14-16,19,21H,3-4,9-11,17-18H2,1-2H3/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104159 (US10047086, 42 | US10640503, Example 42 | US969516...) Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(C)c(CO)c3)n3cncc23)C1 |r| Show InChI InChI=1S/C28H29N5O2/c1-19-5-8-23(12-24(19)16-34)27-26(22-9-6-20(13-29)7-10-22)31-28(25-14-30-18-33(25)27)35-17-21-4-3-11-32(2)15-21/h5-10,12,14,18,21,34H,3-4,11,15-17H2,1-2H3/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104160 (US10047086, 43 | US10640503, Example 43 | US969516...) Show SMILES COc1ncc(cc1F)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C26H25FN6O2/c1-32-9-3-4-18(14-32)15-35-26-22-13-29-16-33(22)24(20-10-21(27)25(34-2)30-12-20)23(31-26)19-7-5-17(11-28)6-8-19/h5-8,10,12-13,16,18H,3-4,9,14-15H2,1-2H3/t18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104161 (US10640503, Example 44 | US9695168, 44) Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cc(C)c(CO)c(F)c3)n3cncc23)C1 |r| Show InChI InChI=1S/C28H28FN5O2/c1-18-10-22(11-24(29)23(18)15-35)27-26(21-7-5-19(12-30)6-8-21)32-28(25-13-31-17-34(25)27)36-16-20-4-3-9-33(2)14-20/h5-8,10-11,13,17,20,35H,3-4,9,14-16H2,1-2H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104176 (US10047086, 45 | US10640503, Example 45 | US969516...) Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3ccc(CO)c(C)c3)n3cncc23)C1 |r| Show InChI InChI=1S/C28H29N5O2/c1-19-12-23(9-10-24(19)16-34)27-26(22-7-5-20(13-29)6-8-22)31-28(25-14-30-18-33(25)27)35-17-21-4-3-11-32(2)15-21/h5-10,12,14,18,21,34H,3-4,11,15-17H2,1-2H3/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104330 (US10047086, 47 | US10640503, Example 47 | US969516...) Show SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cc(F)c(CO)c(F)c3)n3cncc23)C1 |r| Show InChI InChI=1S/C27H25F2N5O2/c1-33-8-2-3-18(13-33)15-36-27-24-12-31-16-34(24)26(20-9-22(28)21(14-35)23(29)10-20)25(32-27)19-6-4-17(11-30)5-7-19/h4-7,9-10,12,16,18,35H,2-3,8,13-15H2,1H3/t18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104351 (US10047086, 48 | US10640503, Example 48 | US969516...) Show SMILES COC(=O)N(C)Cc1ccc(cc1F)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C30H31FN6O3/c1-35-12-4-5-21(16-35)18-40-29-26-15-33-19-37(26)28(27(34-29)22-8-6-20(14-32)7-9-22)23-10-11-24(25(31)13-23)17-36(2)30(38)39-3/h6-11,13,15,19,21H,4-5,12,16-18H2,1-3H3/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104678 (US10640503, Example 50 | US9695168, 50) Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2cnc3n(C)ncc3c2)n2cncc12 Show InChI InChI=1S/C27H27N9/c1-33(2)22-8-10-35(11-9-22)27-23-16-29-17-36(23)25(20-12-21-15-31-34(3)26(21)30-14-20)24(32-27)19-6-4-18(13-28)5-7-19/h4-7,12,14-17,22H,8-11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104681 (US10047086, 51 | US10640503, Example 51 | US969516...) Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3n(C)c(=O)oc3c2)n2cncc12 Show InChI InChI=1S/C28H27N7O2/c1-32(2)21-10-12-34(13-11-21)27-23-16-30-17-35(23)26(25(31-27)19-6-4-18(15-29)5-7-19)20-8-9-22-24(14-20)37-28(36)33(22)3/h4-9,14,16-17,21H,10-13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104918 (US10047086, 53 | US10640503, Example 53 | US969516...) Show SMILES COc1ccc(cn1)-c1c(nc(N2CCC(CC2)N(C)C)c2cncn12)-c1ccc(cc1)C#N Show InChI InChI=1S/C26H27N7O/c1-31(2)21-10-12-32(13-11-21)26-22-16-28-17-33(22)25(20-8-9-23(34-3)29-15-20)24(30-26)19-6-4-18(14-27)5-7-19/h4-9,15-17,21H,10-13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104923 (US10047086, 54 | US10640503, Example 54 | US969516...) Show SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(nc2)N2CCCC2=O)n2cncc12 Show InChI InChI=1S/C29H30N8O/c1-34(2)23-11-14-35(15-12-23)29-24-18-31-19-37(24)28(27(33-29)21-7-5-20(16-30)6-8-21)22-9-10-25(32-17-22)36-13-3-4-26(36)38/h5-10,17-19,23H,3-4,11-15H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104926 (US10047086, 56 | US10640503, Example 56 | US969516...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3ccc4nccnc4c3)n3cncc23)C1 |r| Show InChI InChI=1S/C29H26N6O/c1-34-12-2-3-21(17-34)18-36-28-14-24(22-6-4-20(15-30)5-7-22)29(35-19-31-16-27(28)35)23-8-9-25-26(13-23)33-11-10-32-25/h4-11,13-14,16,19,21H,2-3,12,17-18H2,1H3/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104928 (US10047086, 57 | US10640503, Example 57 | US969516...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3cnc4n(C)c(=O)oc4c3)n3cncc23)C1 |r| Show InChI InChI=1S/C28H26N6O3/c1-32-9-3-4-19(15-32)16-36-24-11-22(20-7-5-18(12-29)6-8-20)26(34-17-30-14-23(24)34)21-10-25-27(31-13-21)33(2)28(35)37-25/h5-8,10-11,13-14,17,19H,3-4,9,15-16H2,1-2H3/t19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM104983 (US10047086, 58 | US10640503, Example 58 | US969516...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3cnc4n(C)cnc4c3)n3cncc23)C1 |r| Show InChI InChI=1S/C28H27N7O/c1-33-9-3-4-20(15-33)16-36-26-11-23(21-7-5-19(12-29)6-8-21)27(35-17-30-14-25(26)35)22-10-24-28(31-13-22)34(2)18-32-24/h5-8,10-11,13-14,17-18,20H,3-4,9,15-16H2,1-2H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105055 (US10047086, 62 | US10640503, Example 62 | US969516...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3cnc4OCCOc4c3)n3cncc23)C1 |r| Show InChI InChI=1S/C28H27N5O3/c1-32-8-2-3-20(16-32)17-36-25-12-23(21-6-4-19(13-29)5-7-21)27(33-18-30-15-24(25)33)22-11-26-28(31-14-22)35-10-9-34-26/h4-7,11-12,14-15,18,20H,2-3,8-10,16-17H2,1H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105087 (US10047086, 63 | US10640503, Example 63 | US969516...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3ccc4n(C)c(=O)oc4c3)n3cncc23)C1 |r| Show InChI InChI=1S/C29H27N5O3/c1-32-11-3-4-20(16-32)17-36-26-13-23(21-7-5-19(14-30)6-8-21)28(34-18-31-15-25(26)34)22-9-10-24-27(12-22)37-29(35)33(24)2/h5-10,12-13,15,18,20H,3-4,11,16-17H2,1-2H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105122 (US10047086, 64 | US10640503, Example 64 | US969516...) Show SMILES CN1C(=O)Cc2cc(ccc12)-c1c(cc(OC[C@@H]2CCCN(C)C2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C30H29N5O2/c1-33-11-3-4-21(17-33)18-37-28-14-25(22-7-5-20(15-31)6-8-22)30(35-19-32-16-27(28)35)23-9-10-26-24(12-23)13-29(36)34(26)2/h5-10,12,14,16,19,21H,3-4,11,13,17-18H2,1-2H3/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105127 (US10047086, 65 | US10640503, Example 65 | US969516...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3ccc4N(C)C(=O)COc4c3)n3cncc23)C1 |r| Show InChI InChI=1S/C30H29N5O3/c1-33-11-3-4-21(16-33)17-37-28-13-24(22-7-5-20(14-31)6-8-22)30(35-19-32-15-26(28)35)23-9-10-25-27(12-23)38-18-29(36)34(25)2/h5-10,12-13,15,19,21H,3-4,11,16-18H2,1-2H3/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105136 (US10047086, 67 | US10640503, Example 67 | US969516...) Show SMILES CCN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3cnc4OCCOc4c3)n3cncc23)C1 |r| Show InChI InChI=1S/C29H29N5O3/c1-2-33-9-3-4-21(17-33)18-37-26-13-24(22-7-5-20(14-30)6-8-22)28(34-19-31-16-25(26)34)23-12-27-29(32-15-23)36-11-10-35-27/h5-8,12-13,15-16,19,21H,2-4,9-11,17-18H2,1H3/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105170 (US10047086, 70 | US10640503, Example 70 | US969516...) Show SMILES COc1ncc(cc1F)-c1c(cc(OC[C@@H]2CCCN(C)C2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C27H26FN5O2/c1-32-9-3-4-19(15-32)16-35-25-11-22(20-7-5-18(12-29)6-8-20)26(33-17-30-14-24(25)33)21-10-23(28)27(34-2)31-13-21/h5-8,10-11,13-14,17,19H,3-4,9,15-16H2,1-2H3/t19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105503 (US10047086, 71 | US10640503, Example 71 | US969516...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3ccc(nc3)N3CCCC3=O)n3cncc23)C1 |r| Show InChI InChI=1S/C30H30N6O2/c1-34-12-2-4-22(18-34)19-38-27-14-25(23-8-6-21(15-31)7-9-23)30(36-20-32-17-26(27)36)24-10-11-28(33-16-24)35-13-3-5-29(35)37/h6-11,14,16-17,20,22H,2-5,12-13,18-19H2,1H3/t22-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105507 (US10047086, 72 | US10640503, Example 72 | US969516...) Show SMILES COc1ccc(cn1)-c1c(cc(OC[C@@H]2CCCN(C)C2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C27H27N5O2/c1-31-11-3-4-20(16-31)17-34-25-12-23(21-7-5-19(13-28)6-8-21)27(32-18-29-15-24(25)32)22-9-10-26(33-2)30-14-22/h5-10,12,14-15,18,20H,3-4,11,16-17H2,1-2H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105508 (US10047086, 73 | US10640503, Example 73 | US969516...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3cc(F)c(CO)c(F)c3)n3cncc23)C1 |r| Show InChI InChI=1S/C28H26F2N4O2/c1-33-8-2-3-19(14-33)16-36-27-11-22(20-6-4-18(12-31)5-7-20)28(34-17-32-13-26(27)34)21-9-24(29)23(15-35)25(30)10-21/h4-7,9-11,13,17,19,35H,2-3,8,14-16H2,1H3/t19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105512 (US10047086, 74 | US10640503, Example 74 | US969516...) Show SMILES COC(=O)N(C)c1ccc(cn1)-c1c(cc(OC[C@@H]2CCCN(C)C2)c2cncn12)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C29H30N6O3/c1-33-12-4-5-21(17-33)18-38-26-13-24(22-8-6-20(14-30)7-9-22)28(35-19-31-16-25(26)35)23-10-11-27(32-15-23)34(2)29(36)37-3/h6-11,13,15-16,19,21H,4-5,12,17-18H2,1-3H3/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105513 (US10047086, 75 | US10640503, Example 75 | US969516...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3cc(C)c(CO)c(F)c3)n3cncc23)C1 |r| Show InChI InChI=1S/C29H29FN4O2/c1-19-10-23(11-26(30)25(19)16-35)29-24(22-7-5-20(13-31)6-8-22)12-28(27-14-32-18-34(27)29)36-17-21-4-3-9-33(2)15-21/h5-8,10-12,14,18,21,35H,3-4,9,15-17H2,1-2H3/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105514 (US10047086, 76 | US10640503, Example 76 | US969516...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3cnc(C)c(O)c3)n3cncc23)C1 |r| Show InChI InChI=1S/C27H27N5O2/c1-18-25(33)10-22(13-30-18)27-23(21-7-5-19(12-28)6-8-21)11-26(24-14-29-17-32(24)27)34-16-20-4-3-9-31(2)15-20/h5-8,10-11,13-14,17,20,33H,3-4,9,15-16H2,1-2H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105515 (US10047086, 77 | US10640503, Example 77 | US969516...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3ccc(cc3)C(C)(C)O)n3cncc23)C1 |r| Show InChI InChI=1S/C30H32N4O2/c1-30(2,35)25-12-10-24(11-13-25)29-26(23-8-6-21(16-31)7-9-23)15-28(27-17-32-20-34(27)29)36-19-22-5-4-14-33(3)18-22/h6-13,15,17,20,22,35H,4-5,14,18-19H2,1-3H3/t22-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105525 (US10047086, 78 | US10640503, Example 78 | US969516...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3cnc(N4CCOCC4)c(F)c3)n3cncc23)C1 |r| Show InChI InChI=1S/C30H31FN6O2/c1-35-8-2-3-22(18-35)19-39-28-14-25(23-6-4-21(15-32)5-7-23)29(37-20-33-17-27(28)37)24-13-26(31)30(34-16-24)36-9-11-38-12-10-36/h4-7,13-14,16-17,20,22H,2-3,8-12,18-19H2,1H3/t22-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM105526 (US10047086, 79 | US10640503, Example 79 | US969516...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3ccc(CO)c(C)c3)n3cncc23)C1 |r| Show InChI InChI=1S/C29H30N4O2/c1-20-12-24(9-10-25(20)17-34)29-26(23-7-5-21(14-30)6-8-23)13-28(27-15-31-19-33(27)29)35-18-22-4-3-11-32(2)16-22/h5-10,12-13,15,19,22,34H,3-4,11,16-18H2,1-2H3/t22-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair

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