Compile Data Set for Download or QSAR

Found 54 hits Enz. Inhib. hit(s) with all data for entry = 50001126   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269769 (CHEMBL4086848) Show SMILES O[C@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccc(F)cc2)CC1 |r,wD:1.0,18.20,(13.05,-7.68,;13.82,-9.01,;12.28,-9.01,;11.51,-10.35,;12.28,-11.68,;9.97,-10.35,;9.2,-11.68,;9.98,-13.01,;9.21,-14.34,;7.67,-14.34,;6.64,-15.49,;5.22,-14.87,;3.89,-15.64,;5.38,-13.33,;6.89,-13.01,;7.67,-11.68,;15.15,-8.24,;16.48,-9.01,;16.48,-10.55,;17.81,-11.33,;19.15,-10.56,;20.48,-11.33,;21.81,-10.57,;21.81,-9.02,;23.15,-8.25,;20.47,-8.25,;19.14,-9.02,;15.15,-11.32,;13.82,-10.55,)| Show InChI InChI=1S/C22H23FN2O4/c23-16-3-1-14(2-4-16)11-15-7-9-22(28,10-8-15)13-20(26)24-17-5-6-18-19(12-17)29-21(27)25-18/h1-6,12,15,28H,7-11,13H2,(H,24,26)(H,25,27)/t15-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.631	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269772 (CHEMBL4094573) Show SMILES O[C@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,18.20,(12.23,-7.56,;13,-8.9,;11.46,-8.9,;10.69,-10.23,;11.46,-11.57,;9.15,-10.23,;8.38,-11.57,;9.16,-12.89,;8.4,-14.22,;6.85,-14.23,;5.82,-15.38,;4.41,-14.75,;3.08,-15.53,;4.56,-13.22,;6.07,-12.89,;6.85,-11.56,;14.33,-8.12,;15.66,-8.9,;15.66,-10.44,;17,-11.21,;18.33,-10.44,;19.66,-11.22,;20.99,-10.45,;21,-8.91,;19.65,-8.14,;18.33,-8.91,;14.33,-11.2,;13,-10.44,)| Show InChI InChI=1S/C22H24N2O4/c25-20(23-17-6-7-18-19(13-17)28-21(26)24-18)14-22(27)10-8-16(9-11-22)12-15-4-2-1-3-5-15/h1-7,13,16,27H,8-12,14H2,(H,23,25)(H,24,26)/t16-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.631	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269780 (CHEMBL4095807) Show SMILES COc1ccc(C[C@H]2CC[C@](O)(CC(=O)Nc3ccc4[nH]c(=O)oc4c3)CC2)cc1 |r,wD:10.10,7.6,(25.46,-11.71,;24.13,-10.94,;22.79,-11.71,;22.79,-13.25,;21.46,-14.02,;20.13,-13.24,;18.79,-14.01,;17.46,-13.24,;17.46,-11.7,;16.13,-10.92,;14.8,-11.7,;14.03,-10.36,;13.26,-11.7,;12.49,-13.03,;13.26,-14.37,;10.95,-13.03,;10.18,-14.37,;10.96,-15.69,;10.19,-17.02,;8.65,-17.03,;7.62,-18.18,;6.2,-17.55,;4.87,-18.33,;6.36,-16.02,;7.87,-15.69,;8.65,-14.36,;14.8,-13.24,;16.13,-14,;20.12,-11.71,;21.45,-10.94,)| Show InChI InChI=1S/C23H26N2O5/c1-29-18-5-2-15(3-6-18)12-16-8-10-23(28,11-9-16)14-21(26)24-17-4-7-19-20(13-17)30-22(27)25-19/h2-7,13,16,28H,8-12,14H2,1H3,(H,24,26)(H,25,27)/t16-,23+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269752 (CHEMBL4078903) Show SMILES O[C@]1(Cc2cc(on2)-c2ccc(=O)[nH]c2)CC[C@H](Cc2ccc(Cl)cc2)CC1 |r,wD:1.0,17.19,(15.69,-7.67,;16.46,-9,;14.92,-9,;14.15,-10.33,;12.62,-10.49,;12.3,-12,;13.63,-12.77,;14.77,-11.74,;10.89,-12.62,;9.65,-11.72,;8.25,-12.34,;8.08,-13.87,;6.67,-14.5,;9.34,-14.78,;10.74,-14.15,;17.79,-8.22,;19.12,-9,;19.12,-10.54,;20.45,-11.31,;21.78,-10.54,;23.11,-11.32,;24.45,-10.55,;24.45,-9.01,;25.78,-8.24,;23.11,-8.24,;21.78,-9.01,;17.79,-11.3,;16.46,-10.54,)| Show InChI InChI=1S/C22H23ClN2O3/c23-18-4-1-15(2-5-18)11-16-7-9-22(27,10-8-16)13-19-12-20(28-25-19)17-3-6-21(26)24-14-17/h1-6,12,14,16,27H,7-11,13H2,(H,24,26)/t16-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269783 (CHEMBL4059534) Show SMILES O[C@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccc(F)c(F)c2)CC1 |r,wD:1.0,18.20,(14.03,-10.36,;14.8,-11.7,;13.26,-11.7,;12.49,-13.03,;13.26,-14.37,;10.95,-13.03,;10.18,-14.37,;10.96,-15.69,;10.19,-17.02,;8.65,-17.03,;7.62,-18.18,;6.2,-17.55,;4.87,-18.33,;6.36,-16.02,;7.87,-15.69,;8.65,-14.36,;16.13,-10.92,;17.46,-11.7,;17.46,-13.24,;18.79,-14.01,;20.13,-13.24,;21.46,-14.02,;22.79,-13.25,;22.79,-11.71,;24.13,-10.94,;21.45,-10.94,;21.45,-9.4,;20.12,-11.71,;16.13,-14,;14.8,-13.24,)| Show InChI InChI=1S/C22H22F2N2O4/c23-16-3-1-14(10-17(16)24)9-13-5-7-22(29,8-6-13)12-20(27)25-15-2-4-18-19(11-15)30-21(28)26-18/h1-4,10-11,13,29H,5-9,12H2,(H,25,27)(H,26,28)/t13-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269782 (CHEMBL4091437) Show SMILES O[C@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccc(OC(F)(F)F)cc2)CC1 |r,wD:1.0,18.20,(14.03,-10.36,;14.8,-11.7,;13.26,-11.7,;12.49,-13.03,;13.26,-14.37,;10.95,-13.03,;10.18,-14.37,;10.96,-15.69,;10.19,-17.02,;8.65,-17.03,;7.62,-18.18,;6.2,-17.55,;4.87,-18.33,;6.36,-16.02,;7.87,-15.69,;8.65,-14.36,;16.13,-10.92,;17.46,-11.7,;17.46,-13.24,;18.79,-14.01,;20.13,-13.24,;21.46,-14.02,;22.79,-13.25,;22.79,-11.71,;24.13,-10.94,;25.46,-11.71,;26.79,-10.94,;25.46,-13.25,;26.79,-12.48,;21.45,-10.94,;20.12,-11.71,;16.13,-14,;14.8,-13.24,)| Show InChI InChI=1S/C23H23F3N2O5/c24-23(25,26)33-17-4-1-14(2-5-17)11-15-7-9-22(31,10-8-15)13-20(29)27-16-3-6-18-19(12-16)32-21(30)28-18/h1-6,12,15,31H,7-11,13H2,(H,27,29)(H,28,30)/t15-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50149684 (2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...) Show SMILES Fc1ccc(CC2CCN(CC2)C(=O)C(=O)Nc2ccc3[nH]c(=O)oc3c2)cc1 Show InChI InChI=1S/C21H20FN3O4/c22-15-3-1-13(2-4-15)11-14-7-9-25(10-8-14)20(27)19(26)23-16-5-6-17-18(12-16)29-21(28)24-17/h1-6,12,14H,7-11H2,(H,23,26)(H,24,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269779 (CHEMBL4069300) Show SMILES O[C@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccc(Cl)cc2)CC1 |r,wD:1.0,18.20,(14.03,-10.36,;14.8,-11.7,;13.26,-11.7,;12.49,-13.03,;13.26,-14.37,;10.95,-13.03,;10.18,-14.37,;10.96,-15.69,;10.19,-17.02,;8.65,-17.03,;7.62,-18.18,;6.2,-17.55,;4.87,-18.33,;6.36,-16.02,;7.87,-15.69,;8.65,-14.36,;16.13,-10.92,;17.46,-11.7,;17.46,-13.24,;18.79,-14.01,;20.13,-13.24,;21.46,-14.02,;22.79,-13.25,;22.79,-11.71,;24.13,-10.94,;21.45,-10.94,;20.12,-11.71,;16.13,-14,;14.8,-13.24,)| Show InChI InChI=1S/C22H23ClN2O4/c23-16-3-1-14(2-4-16)11-15-7-9-22(28,10-8-15)13-20(26)24-17-5-6-18-19(12-17)29-21(27)25-18/h1-6,12,15,28H,7-11,13H2,(H,24,26)(H,25,27)/t15-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269781 (CHEMBL4064453) Show SMILES O[C@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccc(cc2)C(F)(F)F)CC1 |r,wD:1.0,18.20,(14.03,-10.36,;14.8,-11.7,;13.26,-11.7,;12.49,-13.03,;13.26,-14.37,;10.95,-13.03,;10.18,-14.37,;10.96,-15.69,;10.19,-17.02,;8.65,-17.03,;7.62,-18.18,;6.2,-17.55,;4.87,-18.33,;6.36,-16.02,;7.87,-15.69,;8.65,-14.36,;16.13,-10.92,;17.46,-11.7,;17.46,-13.24,;18.79,-14.01,;20.13,-13.24,;21.46,-14.02,;22.79,-13.25,;22.79,-11.71,;21.45,-10.94,;20.12,-11.71,;24.13,-10.94,;25.46,-11.71,;24.13,-9.4,;25.46,-10.16,;16.13,-14,;14.8,-13.24,)| Show InChI InChI=1S/C23H23F3N2O4/c24-23(25,26)16-3-1-14(2-4-16)11-15-7-9-22(31,10-8-15)13-20(29)27-17-5-6-18-19(12-17)32-21(30)28-18/h1-6,12,15,31H,7-11,13H2,(H,27,29)(H,28,30)/t15-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269756 (CHEMBL4076727) Show SMILES O[C@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccc(Cl)cc2)CC1 |r,wD:1.0,15.17,(15.19,-7.36,;15.96,-8.7,;14.42,-8.7,;13.65,-10.03,;12.12,-10.19,;11.8,-11.69,;13.13,-12.46,;14.28,-11.43,;10.39,-12.32,;9.05,-11.55,;7.91,-12.58,;8.54,-13.99,;10.07,-13.83,;17.29,-7.92,;18.62,-8.7,;18.62,-10.24,;19.95,-11.01,;21.29,-10.24,;22.62,-11.01,;23.95,-10.25,;23.95,-8.7,;25.29,-7.93,;22.61,-7.93,;21.28,-8.7,;17.29,-11,;15.96,-10.24,)| Show InChI InChI=1S/C20H22ClN3O2/c21-17-3-1-14(2-4-17)9-15-5-7-20(25,8-6-15)11-18-10-19(26-24-18)16-12-22-23-13-16/h1-4,10,12-13,15,25H,5-9,11H2,(H,22,23)/t15-,20+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269751 (CHEMBL4065330) Show SMILES O[C@]1(Cc2cc(on2)-c2ccc(=O)[nH]c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,17.19,(15.39,-6.27,;16.16,-7.61,;14.62,-7.61,;13.85,-8.94,;12.32,-9.1,;12,-10.6,;13.33,-11.37,;14.48,-10.34,;10.59,-11.23,;9.35,-10.32,;7.95,-10.95,;7.79,-12.48,;6.38,-13.11,;9.04,-13.39,;10.44,-12.76,;17.49,-6.83,;18.82,-7.61,;18.82,-9.15,;20.15,-9.92,;21.49,-9.15,;22.82,-9.92,;24.15,-9.16,;24.16,-7.62,;22.81,-6.84,;21.48,-7.62,;17.49,-9.91,;16.16,-9.15,)| Show InChI InChI=1S/C22H24N2O3/c25-21-7-6-18(15-23-21)20-13-19(24-27-20)14-22(26)10-8-17(9-11-22)12-16-4-2-1-3-5-16/h1-7,13,15,17,26H,8-12,14H2,(H,23,25)/t17-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269753 (CHEMBL4103672) Show SMILES O[C@]1(CC(=O)Nc2ccc3NC(=O)CCc3c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,19.21,(14.58,-10.29,;15.35,-11.63,;13.81,-11.63,;13.04,-12.96,;13.81,-14.3,;11.5,-12.96,;10.73,-14.3,;11.51,-15.62,;10.75,-16.95,;9.2,-16.96,;8.43,-18.3,;6.89,-18.3,;6.12,-19.63,;6.11,-16.96,;6.89,-15.62,;8.42,-15.62,;9.2,-14.29,;16.68,-10.85,;18.01,-11.63,;18.01,-13.17,;19.34,-13.94,;20.68,-13.17,;22.01,-13.95,;23.34,-13.18,;23.35,-11.64,;22,-10.87,;20.68,-11.64,;16.68,-13.93,;15.35,-13.17,)| Show InChI InChI=1S/C24H28N2O3/c27-22-9-6-19-15-20(7-8-21(19)26-22)25-23(28)16-24(29)12-10-18(11-13-24)14-17-4-2-1-3-5-17/h1-5,7-8,15,18,29H,6,9-14,16H2,(H,25,28)(H,26,27)/t18-,24+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269758 (CHEMBL4103723) Show SMILES O[C@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccc(F)cc2)CC1 |r,wD:1.0,15.17,(15.19,-7.36,;15.96,-8.7,;14.42,-8.7,;13.65,-10.03,;12.12,-10.19,;11.8,-11.69,;13.13,-12.46,;14.28,-11.43,;10.39,-12.32,;9.05,-11.55,;7.91,-12.58,;8.54,-13.99,;10.07,-13.83,;17.29,-7.92,;18.62,-8.7,;18.62,-10.24,;19.95,-11.01,;21.29,-10.24,;22.62,-11.01,;23.95,-10.25,;23.95,-8.7,;25.29,-7.93,;22.61,-7.93,;21.28,-8.7,;17.29,-11,;15.96,-10.24,)| Show InChI InChI=1S/C20H22FN3O2/c21-17-3-1-14(2-4-17)9-15-5-7-20(25,8-6-15)11-18-10-19(26-24-18)16-12-22-23-13-16/h1-4,10,12-13,15,25H,5-9,11H2,(H,22,23)/t15-,20+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269770 (CHEMBL4065942) Show SMILES O[C@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccc(cc2)C(F)(F)F)CC1 |r,wD:1.0,15.17,(15.19,-7.36,;15.96,-8.7,;14.42,-8.7,;13.65,-10.03,;12.12,-10.19,;11.8,-11.69,;13.13,-12.46,;14.28,-11.43,;10.39,-12.32,;9.05,-11.55,;7.91,-12.58,;8.54,-13.99,;10.07,-13.83,;17.29,-7.92,;18.62,-8.7,;18.62,-10.24,;19.95,-11.01,;21.29,-10.24,;22.62,-11.01,;23.95,-10.25,;23.95,-8.7,;22.61,-7.93,;21.28,-8.7,;25.29,-7.93,;26.62,-8.7,;25.29,-6.39,;26.62,-7.16,;17.29,-11,;15.96,-10.24,)| Show InChI InChI=1S/C21H22F3N3O2/c22-21(23,24)17-3-1-14(2-4-17)9-15-5-7-20(28,8-6-15)11-18-10-19(29-27-18)16-12-25-26-13-16/h1-4,10,12-13,15,28H,5-9,11H2,(H,25,26)/t15-,20+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269758 (CHEMBL4103723) Show SMILES O[C@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccc(F)cc2)CC1 |r,wD:1.0,15.17,(15.19,-7.36,;15.96,-8.7,;14.42,-8.7,;13.65,-10.03,;12.12,-10.19,;11.8,-11.69,;13.13,-12.46,;14.28,-11.43,;10.39,-12.32,;9.05,-11.55,;7.91,-12.58,;8.54,-13.99,;10.07,-13.83,;17.29,-7.92,;18.62,-8.7,;18.62,-10.24,;19.95,-11.01,;21.29,-10.24,;22.62,-11.01,;23.95,-10.25,;23.95,-8.7,;25.29,-7.93,;22.61,-7.93,;21.28,-8.7,;17.29,-11,;15.96,-10.24,)| Show InChI InChI=1S/C20H22FN3O2/c21-17-3-1-14(2-4-17)9-15-5-7-20(25,8-6-15)11-18-10-19(26-24-18)16-12-22-23-13-16/h1-4,10,12-13,15,25H,5-9,11H2,(H,22,23)/t15-,20+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269754 (CHEMBL4077427) Show SMILES O[C@]1(Cc2cc(on2)-c2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,20.23,(15.39,-6.27,;16.16,-7.61,;14.62,-7.61,;13.85,-8.94,;12.32,-9.1,;12,-10.6,;13.33,-11.37,;14.48,-10.34,;10.59,-11.23,;10.44,-12.76,;9.04,-13.39,;7.79,-12.48,;6.28,-12.8,;5.51,-11.46,;3.98,-11.29,;6.54,-10.32,;7.95,-10.95,;9.35,-10.32,;17.49,-6.83,;18.82,-7.61,;18.82,-9.15,;20.15,-9.92,;21.49,-9.15,;22.82,-9.92,;24.15,-9.16,;24.16,-7.62,;22.81,-6.84,;21.48,-7.62,;17.49,-9.91,;16.16,-9.15,)| Show InChI InChI=1S/C24H24N2O4/c27-23-25-20-7-6-18(13-22(20)29-23)21-14-19(26-30-21)15-24(28)10-8-17(9-11-24)12-16-4-2-1-3-5-16/h1-7,13-14,17,28H,8-12,15H2,(H,25,27)/t17-,24+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269765 (CHEMBL4067110) Show SMILES O[C@@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccccc2)CC1 |r,wU:18.20,wD:1.0,(12.23,-7.56,;13,-8.9,;11.46,-8.9,;10.69,-10.23,;11.46,-11.57,;9.15,-10.23,;8.38,-11.57,;9.16,-12.89,;8.4,-14.22,;6.85,-14.23,;5.82,-15.38,;4.41,-14.75,;3.08,-15.53,;4.56,-13.22,;6.07,-12.89,;6.85,-11.56,;13,-10.44,;14.33,-11.2,;15.66,-10.44,;17,-11.21,;18.33,-10.44,;19.66,-11.22,;20.99,-10.45,;21,-8.91,;19.65,-8.14,;18.33,-8.91,;15.66,-8.9,;14.33,-8.12,)| Show InChI InChI=1S/C22H24N2O4/c25-20(23-17-6-7-18-19(13-17)28-21(26)24-18)14-22(27)10-8-16(9-11-22)12-15-4-2-1-3-5-15/h1-7,13,16,27H,8-12,14H2,(H,23,25)(H,24,26)/t16-,22-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269777 (CHEMBL4102419) Show SMILES O[C@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,15.17,(15.19,-7.36,;15.96,-8.7,;14.42,-8.7,;13.65,-10.03,;12.12,-10.19,;11.8,-11.69,;13.13,-12.46,;14.28,-11.43,;10.39,-12.32,;9.05,-11.55,;7.91,-12.59,;8.54,-13.99,;10.07,-13.83,;17.29,-7.92,;18.62,-8.7,;18.62,-10.24,;19.95,-11.01,;21.29,-10.24,;22.62,-11.01,;23.95,-10.25,;23.95,-8.7,;22.61,-7.93,;21.28,-8.7,;17.29,-11,;15.96,-10.24,)| Show InChI InChI=1S/C20H23N3O2/c24-20(12-18-11-19(25-23-18)17-13-21-22-14-17)8-6-16(7-9-20)10-15-4-2-1-3-5-15/h1-5,11,13-14,16,24H,6-10,12H2,(H,21,22)/t16-,20+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269784 (CHEMBL4104737) Show SMILES O[C@@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccc(F)cc2)CC1 |r,wU:18.20,wD:1.0,(13.05,-7.68,;13.82,-9.01,;12.28,-9.01,;11.51,-10.35,;12.28,-11.68,;9.97,-10.35,;9.2,-11.68,;9.98,-13.01,;9.21,-14.34,;7.67,-14.34,;6.64,-15.49,;5.22,-14.87,;3.89,-15.64,;5.38,-13.33,;6.89,-13.01,;7.67,-11.68,;13.82,-10.55,;15.15,-11.32,;16.48,-10.55,;17.81,-11.33,;19.15,-10.56,;20.48,-11.33,;21.81,-10.57,;21.81,-9.02,;23.15,-8.25,;20.47,-8.25,;19.14,-9.02,;16.48,-9.01,;15.15,-8.24,)| Show InChI InChI=1S/C22H23FN2O4/c23-16-3-1-14(2-4-16)11-15-7-9-22(28,10-8-15)13-20(26)24-17-5-6-18-19(12-17)29-21(27)25-18/h1-6,12,15,28H,7-11,13H2,(H,24,26)(H,25,27)/t15-,22-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269773 (CHEMBL4076130) Show SMILES O[C@]1(CC(=O)Nc2ccc3NC(=O)Cc3c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,18.20,(14.03,-10.36,;14.8,-11.7,;13.26,-11.7,;12.49,-13.03,;13.26,-14.37,;10.95,-13.03,;10.18,-14.37,;10.96,-15.69,;10.19,-17.02,;8.65,-17.03,;7.62,-18.18,;6.2,-17.55,;4.87,-18.33,;6.36,-16.02,;7.87,-15.69,;8.65,-14.36,;16.13,-10.92,;17.46,-11.7,;17.46,-13.24,;18.79,-14.01,;20.13,-13.24,;21.46,-14.02,;22.79,-13.25,;22.79,-11.71,;21.45,-10.94,;20.12,-11.71,;16.13,-14,;14.8,-13.24,)| Show InChI InChI=1S/C23H26N2O3/c26-21-14-18-13-19(6-7-20(18)25-21)24-22(27)15-23(28)10-8-17(9-11-23)12-16-4-2-1-3-5-16/h1-7,13,17,28H,8-12,14-15H2,(H,24,27)(H,25,26)/t17-,23+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269772 (CHEMBL4094573) Show SMILES O[C@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,18.20,(12.23,-7.56,;13,-8.9,;11.46,-8.9,;10.69,-10.23,;11.46,-11.57,;9.15,-10.23,;8.38,-11.57,;9.16,-12.89,;8.4,-14.22,;6.85,-14.23,;5.82,-15.38,;4.41,-14.75,;3.08,-15.53,;4.56,-13.22,;6.07,-12.89,;6.85,-11.56,;14.33,-8.12,;15.66,-8.9,;15.66,-10.44,;17,-11.21,;18.33,-10.44,;19.66,-11.22,;20.99,-10.45,;21,-8.91,;19.65,-8.14,;18.33,-8.91,;14.33,-11.2,;13,-10.44,)| Show InChI InChI=1S/C22H24N2O4/c25-20(23-17-6-7-18-19(13-17)28-21(26)24-18)14-22(27)10-8-16(9-11-22)12-15-4-2-1-3-5-15/h1-7,13,16,27H,8-12,14H2,(H,23,25)(H,24,26)/t16-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269760 (CHEMBL4101281) Show SMILES O[C@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccc(OC(F)(F)F)cc2)CC1 |r,wD:1.0,15.17,(15.19,-7.36,;15.96,-8.7,;14.42,-8.7,;13.65,-10.03,;12.12,-10.19,;11.8,-11.69,;13.13,-12.46,;14.28,-11.43,;10.39,-12.32,;9.05,-11.55,;7.91,-12.58,;8.54,-13.99,;10.07,-13.83,;17.29,-7.92,;18.62,-8.7,;18.62,-10.24,;19.95,-11.01,;21.29,-10.24,;22.62,-11.01,;23.95,-10.25,;23.95,-8.7,;25.29,-7.93,;26.62,-8.7,;27.95,-7.94,;26.62,-10.24,;27.95,-9.47,;22.61,-7.93,;21.28,-8.7,;17.29,-11,;15.96,-10.24,)| Show InChI InChI=1S/C21H22F3N3O3/c22-21(23,24)29-18-3-1-14(2-4-18)9-15-5-7-20(28,8-6-15)11-17-10-19(30-27-17)16-12-25-26-13-16/h1-4,10,12-13,15,28H,5-9,11H2,(H,25,26)/t15-,20+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269759 (CHEMBL4093543) Show SMILES COc1ccc(C[C@H]2CC[C@](O)(Cc3cc(on3)-c3cn[nH]c3)CC2)cc1 |r,wD:10.10,7.6,(26.62,-8.7,;25.29,-7.93,;23.95,-8.7,;23.95,-10.25,;22.62,-11.01,;21.29,-10.24,;19.95,-11.01,;18.62,-10.24,;18.62,-8.7,;17.29,-7.92,;15.96,-8.7,;15.19,-7.36,;14.42,-8.7,;13.65,-10.03,;12.12,-10.19,;11.8,-11.69,;13.13,-12.46,;14.28,-11.43,;10.39,-12.32,;9.05,-11.55,;7.91,-12.58,;8.54,-13.99,;10.07,-13.83,;15.96,-10.24,;17.29,-11,;21.28,-8.7,;22.61,-7.93,)| Show InChI InChI=1S/C21H25N3O3/c1-26-19-4-2-15(3-5-19)10-16-6-8-21(25,9-7-16)12-18-11-20(27-24-18)17-13-22-23-14-17/h2-5,11,13-14,16,25H,6-10,12H2,1H3,(H,22,23)/t16-,21+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269751 (CHEMBL4065330) Show SMILES O[C@]1(Cc2cc(on2)-c2ccc(=O)[nH]c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,17.19,(15.39,-6.27,;16.16,-7.61,;14.62,-7.61,;13.85,-8.94,;12.32,-9.1,;12,-10.6,;13.33,-11.37,;14.48,-10.34,;10.59,-11.23,;9.35,-10.32,;7.95,-10.95,;7.79,-12.48,;6.38,-13.11,;9.04,-13.39,;10.44,-12.76,;17.49,-6.83,;18.82,-7.61,;18.82,-9.15,;20.15,-9.92,;21.49,-9.15,;22.82,-9.92,;24.15,-9.16,;24.16,-7.62,;22.81,-6.84,;21.48,-7.62,;17.49,-9.91,;16.16,-9.15,)| Show InChI InChI=1S/C22H24N2O3/c25-21-7-6-18(15-23-21)20-13-19(24-27-20)14-22(26)10-8-17(9-11-22)12-16-4-2-1-3-5-16/h1-7,13,15,17,26H,8-12,14H2,(H,23,25)/t17-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269752 (CHEMBL4078903) Show SMILES O[C@]1(Cc2cc(on2)-c2ccc(=O)[nH]c2)CC[C@H](Cc2ccc(Cl)cc2)CC1 |r,wD:1.0,17.19,(15.69,-7.67,;16.46,-9,;14.92,-9,;14.15,-10.33,;12.62,-10.49,;12.3,-12,;13.63,-12.77,;14.77,-11.74,;10.89,-12.62,;9.65,-11.72,;8.25,-12.34,;8.08,-13.87,;6.67,-14.5,;9.34,-14.78,;10.74,-14.15,;17.79,-8.22,;19.12,-9,;19.12,-10.54,;20.45,-11.31,;21.78,-10.54,;23.11,-11.32,;24.45,-10.55,;24.45,-9.01,;25.78,-8.24,;23.11,-8.24,;21.78,-9.01,;17.79,-11.3,;16.46,-10.54,)| Show InChI InChI=1S/C22H23ClN2O3/c23-18-4-1-15(2-5-18)11-16-7-9-22(27,10-8-16)13-19-12-20(28-25-19)17-3-6-21(26)24-14-17/h1-6,12,14,16,27H,7-11,13H2,(H,24,26)/t16-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269783 (CHEMBL4059534) Show SMILES O[C@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccc(F)c(F)c2)CC1 |r,wD:1.0,18.20,(14.03,-10.36,;14.8,-11.7,;13.26,-11.7,;12.49,-13.03,;13.26,-14.37,;10.95,-13.03,;10.18,-14.37,;10.96,-15.69,;10.19,-17.02,;8.65,-17.03,;7.62,-18.18,;6.2,-17.55,;4.87,-18.33,;6.36,-16.02,;7.87,-15.69,;8.65,-14.36,;16.13,-10.92,;17.46,-11.7,;17.46,-13.24,;18.79,-14.01,;20.13,-13.24,;21.46,-14.02,;22.79,-13.25,;22.79,-11.71,;24.13,-10.94,;21.45,-10.94,;21.45,-9.4,;20.12,-11.71,;16.13,-14,;14.8,-13.24,)| Show InChI InChI=1S/C22H22F2N2O4/c23-16-3-1-14(10-17(16)24)9-13-5-7-22(29,8-6-13)12-20(27)25-15-2-4-18-19(11-15)30-21(28)26-18/h1-4,10-11,13,29H,5-9,12H2,(H,25,27)(H,26,28)/t13-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269781 (CHEMBL4064453) Show SMILES O[C@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccc(cc2)C(F)(F)F)CC1 |r,wD:1.0,18.20,(14.03,-10.36,;14.8,-11.7,;13.26,-11.7,;12.49,-13.03,;13.26,-14.37,;10.95,-13.03,;10.18,-14.37,;10.96,-15.69,;10.19,-17.02,;8.65,-17.03,;7.62,-18.18,;6.2,-17.55,;4.87,-18.33,;6.36,-16.02,;7.87,-15.69,;8.65,-14.36,;16.13,-10.92,;17.46,-11.7,;17.46,-13.24,;18.79,-14.01,;20.13,-13.24,;21.46,-14.02,;22.79,-13.25,;22.79,-11.71,;21.45,-10.94,;20.12,-11.71,;24.13,-10.94,;25.46,-11.71,;24.13,-9.4,;25.46,-10.16,;16.13,-14,;14.8,-13.24,)| Show InChI InChI=1S/C23H23F3N2O4/c24-23(25,26)16-3-1-14(2-4-16)11-15-7-9-22(31,10-8-15)13-20(29)27-17-5-6-18-19(12-17)32-21(30)28-18/h1-6,12,15,31H,7-11,13H2,(H,27,29)(H,28,30)/t15-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269779 (CHEMBL4069300) Show SMILES O[C@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccc(Cl)cc2)CC1 |r,wD:1.0,18.20,(14.03,-10.36,;14.8,-11.7,;13.26,-11.7,;12.49,-13.03,;13.26,-14.37,;10.95,-13.03,;10.18,-14.37,;10.96,-15.69,;10.19,-17.02,;8.65,-17.03,;7.62,-18.18,;6.2,-17.55,;4.87,-18.33,;6.36,-16.02,;7.87,-15.69,;8.65,-14.36,;16.13,-10.92,;17.46,-11.7,;17.46,-13.24,;18.79,-14.01,;20.13,-13.24,;21.46,-14.02,;22.79,-13.25,;22.79,-11.71,;24.13,-10.94,;21.45,-10.94,;20.12,-11.71,;16.13,-14,;14.8,-13.24,)| Show InChI InChI=1S/C22H23ClN2O4/c23-16-3-1-14(2-4-16)11-15-7-9-22(28,10-8-15)13-20(26)24-17-5-6-18-19(12-17)29-21(27)25-18/h1-6,12,15,28H,7-11,13H2,(H,24,26)(H,25,27)/t15-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269769 (CHEMBL4086848) Show SMILES O[C@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccc(F)cc2)CC1 |r,wD:1.0,18.20,(13.05,-7.68,;13.82,-9.01,;12.28,-9.01,;11.51,-10.35,;12.28,-11.68,;9.97,-10.35,;9.2,-11.68,;9.98,-13.01,;9.21,-14.34,;7.67,-14.34,;6.64,-15.49,;5.22,-14.87,;3.89,-15.64,;5.38,-13.33,;6.89,-13.01,;7.67,-11.68,;15.15,-8.24,;16.48,-9.01,;16.48,-10.55,;17.81,-11.33,;19.15,-10.56,;20.48,-11.33,;21.81,-10.57,;21.81,-9.02,;23.15,-8.25,;20.47,-8.25,;19.14,-9.02,;15.15,-11.32,;13.82,-10.55,)| Show InChI InChI=1S/C22H23FN2O4/c23-16-3-1-14(2-4-16)11-15-7-9-22(28,10-8-15)13-20(26)24-17-5-6-18-19(12-17)29-21(27)25-18/h1-6,12,15,28H,7-11,13H2,(H,24,26)(H,25,27)/t15-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269753 (CHEMBL4103672) Show SMILES O[C@]1(CC(=O)Nc2ccc3NC(=O)CCc3c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,19.21,(14.58,-10.29,;15.35,-11.63,;13.81,-11.63,;13.04,-12.96,;13.81,-14.3,;11.5,-12.96,;10.73,-14.3,;11.51,-15.62,;10.75,-16.95,;9.2,-16.96,;8.43,-18.3,;6.89,-18.3,;6.12,-19.63,;6.11,-16.96,;6.89,-15.62,;8.42,-15.62,;9.2,-14.29,;16.68,-10.85,;18.01,-11.63,;18.01,-13.17,;19.34,-13.94,;20.68,-13.17,;22.01,-13.95,;23.34,-13.18,;23.35,-11.64,;22,-10.87,;20.68,-11.64,;16.68,-13.93,;15.35,-13.17,)| Show InChI InChI=1S/C24H28N2O3/c27-22-9-6-19-15-20(7-8-21(19)26-22)25-23(28)16-24(29)12-10-18(11-13-24)14-17-4-2-1-3-5-17/h1-5,7-8,15,18,29H,6,9-14,16H2,(H,25,28)(H,26,27)/t18-,24+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269765 (CHEMBL4067110) Show SMILES O[C@@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccccc2)CC1 |r,wU:18.20,wD:1.0,(12.23,-7.56,;13,-8.9,;11.46,-8.9,;10.69,-10.23,;11.46,-11.57,;9.15,-10.23,;8.38,-11.57,;9.16,-12.89,;8.4,-14.22,;6.85,-14.23,;5.82,-15.38,;4.41,-14.75,;3.08,-15.53,;4.56,-13.22,;6.07,-12.89,;6.85,-11.56,;13,-10.44,;14.33,-11.2,;15.66,-10.44,;17,-11.21,;18.33,-10.44,;19.66,-11.22,;20.99,-10.45,;21,-8.91,;19.65,-8.14,;18.33,-8.91,;15.66,-8.9,;14.33,-8.12,)| Show InChI InChI=1S/C22H24N2O4/c25-20(23-17-6-7-18-19(13-17)28-21(26)24-18)14-22(27)10-8-16(9-11-22)12-15-4-2-1-3-5-15/h1-7,13,16,27H,8-12,14H2,(H,23,25)(H,24,26)/t16-,22-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50149684 (2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...) Show SMILES Fc1ccc(CC2CCN(CC2)C(=O)C(=O)Nc2ccc3[nH]c(=O)oc3c2)cc1 Show InChI InChI=1S/C21H20FN3O4/c22-15-3-1-13(2-4-15)11-14-7-9-25(10-8-14)20(27)19(26)23-16-5-6-17-18(12-16)29-21(28)24-17/h1-6,12,14H,7-11H2,(H,23,26)(H,24,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269773 (CHEMBL4076130) Show SMILES O[C@]1(CC(=O)Nc2ccc3NC(=O)Cc3c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,18.20,(14.03,-10.36,;14.8,-11.7,;13.26,-11.7,;12.49,-13.03,;13.26,-14.37,;10.95,-13.03,;10.18,-14.37,;10.96,-15.69,;10.19,-17.02,;8.65,-17.03,;7.62,-18.18,;6.2,-17.55,;4.87,-18.33,;6.36,-16.02,;7.87,-15.69,;8.65,-14.36,;16.13,-10.92,;17.46,-11.7,;17.46,-13.24,;18.79,-14.01,;20.13,-13.24,;21.46,-14.02,;22.79,-13.25,;22.79,-11.71,;21.45,-10.94,;20.12,-11.71,;16.13,-14,;14.8,-13.24,)| Show InChI InChI=1S/C23H26N2O3/c26-21-14-18-13-19(6-7-20(18)25-21)24-22(27)15-23(28)10-8-17(9-11-23)12-16-4-2-1-3-5-16/h1-7,13,17,28H,8-12,14-15H2,(H,24,27)(H,25,26)/t17-,23+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269761 (CHEMBL4074570) Show SMILES O[C@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccc(F)c(F)c2)CC1 |r,wD:1.0,15.17,(13.85,-7.13,;14.62,-8.46,;13.08,-8.46,;12.31,-9.8,;10.78,-9.95,;10.46,-11.46,;11.79,-12.23,;12.94,-11.2,;9.05,-12.09,;7.72,-11.32,;6.57,-12.35,;7.2,-13.76,;8.73,-13.6,;15.95,-7.68,;17.28,-8.46,;17.28,-10,;18.61,-10.77,;19.95,-10.01,;21.28,-10.78,;22.61,-10.01,;22.61,-8.47,;23.95,-7.7,;21.27,-7.7,;21.27,-6.16,;19.94,-8.47,;15.95,-10.76,;14.62,-10,)| Show InChI InChI=1S/C20H21F2N3O2/c21-17-2-1-14(8-18(17)22)7-13-3-5-20(26,6-4-13)10-16-9-19(27-25-16)15-11-23-24-12-15/h1-2,8-9,11-13,26H,3-7,10H2,(H,23,24)/t13-,20+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269777 (CHEMBL4102419) Show SMILES O[C@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,15.17,(15.19,-7.36,;15.96,-8.7,;14.42,-8.7,;13.65,-10.03,;12.12,-10.19,;11.8,-11.69,;13.13,-12.46,;14.28,-11.43,;10.39,-12.32,;9.05,-11.55,;7.91,-12.59,;8.54,-13.99,;10.07,-13.83,;17.29,-7.92,;18.62,-8.7,;18.62,-10.24,;19.95,-11.01,;21.29,-10.24,;22.62,-11.01,;23.95,-10.25,;23.95,-8.7,;22.61,-7.93,;21.28,-8.7,;17.29,-11,;15.96,-10.24,)| Show InChI InChI=1S/C20H23N3O2/c24-20(12-18-11-19(25-23-18)17-13-21-22-14-17)8-6-16(7-9-20)10-15-4-2-1-3-5-15/h1-5,11,13-14,16,24H,6-10,12H2,(H,21,22)/t16-,20+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269755 (CHEMBL4073589) Show SMILES O[C@]1(Cc2cc(on2)-c2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccc(Cl)cc2)CC1 |r,wD:1.0,20.23,(15.39,-6.27,;16.16,-7.61,;14.62,-7.61,;13.85,-8.94,;12.32,-9.1,;12,-10.6,;13.33,-11.37,;14.48,-10.34,;10.59,-11.23,;10.44,-12.76,;9.04,-13.39,;7.79,-12.48,;6.28,-12.8,;5.51,-11.46,;3.98,-11.29,;6.54,-10.32,;7.95,-10.95,;9.35,-10.32,;17.49,-6.83,;18.82,-7.61,;18.82,-9.15,;20.15,-9.92,;21.49,-9.15,;22.82,-9.92,;24.15,-9.16,;24.16,-7.62,;25.49,-6.85,;22.81,-6.84,;21.48,-7.62,;17.49,-9.91,;16.16,-9.15,)| Show InChI InChI=1S/C24H23ClN2O4/c25-18-4-1-15(2-5-18)11-16-7-9-24(29,10-8-16)14-19-13-21(31-27-19)17-3-6-20-22(12-17)30-23(28)26-20/h1-6,12-13,16,29H,7-11,14H2,(H,26,28)/t16-,24+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269771 (CHEMBL4084983) Show SMILES O[C@]1(CC(=O)Nc2ccc3[nH]ncc3c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,17.19,(14.88,-11.63,;15.65,-12.97,;14.11,-12.97,;13.34,-14.3,;14.11,-15.63,;11.8,-14.3,;11.03,-15.63,;11.81,-16.96,;11.04,-18.29,;9.49,-18.3,;8.46,-19.45,;7.05,-18.82,;7.21,-17.28,;8.72,-16.96,;9.49,-15.63,;16.98,-12.19,;18.31,-12.97,;18.31,-14.51,;19.64,-15.28,;20.97,-14.51,;22.3,-15.28,;23.64,-14.52,;23.64,-12.97,;22.3,-12.2,;20.97,-12.97,;16.98,-15.27,;15.65,-14.51,)| Show InChI InChI=1S/C22H25N3O2/c26-21(24-19-6-7-20-18(13-19)15-23-25-20)14-22(27)10-8-17(9-11-22)12-16-4-2-1-3-5-16/h1-7,13,15,17,27H,8-12,14H2,(H,23,25)(H,24,26)/t17-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269759 (CHEMBL4093543) Show SMILES COc1ccc(C[C@H]2CC[C@](O)(Cc3cc(on3)-c3cn[nH]c3)CC2)cc1 |r,wD:10.10,7.6,(26.62,-8.7,;25.29,-7.93,;23.95,-8.7,;23.95,-10.25,;22.62,-11.01,;21.29,-10.24,;19.95,-11.01,;18.62,-10.24,;18.62,-8.7,;17.29,-7.92,;15.96,-8.7,;15.19,-7.36,;14.42,-8.7,;13.65,-10.03,;12.12,-10.19,;11.8,-11.69,;13.13,-12.46,;14.28,-11.43,;10.39,-12.32,;9.05,-11.55,;7.91,-12.58,;8.54,-13.99,;10.07,-13.83,;15.96,-10.24,;17.29,-11,;21.28,-8.7,;22.61,-7.93,)| Show InChI InChI=1S/C21H25N3O3/c1-26-19-4-2-15(3-5-19)10-16-6-8-21(25,9-7-16)12-18-11-20(27-24-18)17-13-22-23-14-17/h2-5,11,13-14,16,25H,6-10,12H2,1H3,(H,22,23)/t16-,21+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269784 (CHEMBL4104737) Show SMILES O[C@@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccc(F)cc2)CC1 |r,wU:18.20,wD:1.0,(13.05,-7.68,;13.82,-9.01,;12.28,-9.01,;11.51,-10.35,;12.28,-11.68,;9.97,-10.35,;9.2,-11.68,;9.98,-13.01,;9.21,-14.34,;7.67,-14.34,;6.64,-15.49,;5.22,-14.87,;3.89,-15.64,;5.38,-13.33,;6.89,-13.01,;7.67,-11.68,;13.82,-10.55,;15.15,-11.32,;16.48,-10.55,;17.81,-11.33,;19.15,-10.56,;20.48,-11.33,;21.81,-10.57,;21.81,-9.02,;23.15,-8.25,;20.47,-8.25,;19.14,-9.02,;16.48,-9.01,;15.15,-8.24,)| Show InChI InChI=1S/C22H23FN2O4/c23-16-3-1-14(2-4-16)11-15-7-9-22(28,10-8-15)13-20(26)24-17-5-6-18-19(12-17)29-21(27)25-18/h1-6,12,15,28H,7-11,13H2,(H,24,26)(H,25,27)/t15-,22-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269756 (CHEMBL4076727) Show SMILES O[C@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccc(Cl)cc2)CC1 |r,wD:1.0,15.17,(15.19,-7.36,;15.96,-8.7,;14.42,-8.7,;13.65,-10.03,;12.12,-10.19,;11.8,-11.69,;13.13,-12.46,;14.28,-11.43,;10.39,-12.32,;9.05,-11.55,;7.91,-12.58,;8.54,-13.99,;10.07,-13.83,;17.29,-7.92,;18.62,-8.7,;18.62,-10.24,;19.95,-11.01,;21.29,-10.24,;22.62,-11.01,;23.95,-10.25,;23.95,-8.7,;25.29,-7.93,;22.61,-7.93,;21.28,-8.7,;17.29,-11,;15.96,-10.24,)| Show InChI InChI=1S/C20H22ClN3O2/c21-17-3-1-14(2-4-17)9-15-5-7-20(25,8-6-15)11-18-10-19(26-24-18)16-12-22-23-13-16/h1-4,10,12-13,15,25H,5-9,11H2,(H,22,23)/t15-,20+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269782 (CHEMBL4091437) Show SMILES O[C@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccc(OC(F)(F)F)cc2)CC1 |r,wD:1.0,18.20,(14.03,-10.36,;14.8,-11.7,;13.26,-11.7,;12.49,-13.03,;13.26,-14.37,;10.95,-13.03,;10.18,-14.37,;10.96,-15.69,;10.19,-17.02,;8.65,-17.03,;7.62,-18.18,;6.2,-17.55,;4.87,-18.33,;6.36,-16.02,;7.87,-15.69,;8.65,-14.36,;16.13,-10.92,;17.46,-11.7,;17.46,-13.24,;18.79,-14.01,;20.13,-13.24,;21.46,-14.02,;22.79,-13.25,;22.79,-11.71,;24.13,-10.94,;25.46,-11.71,;26.79,-10.94,;25.46,-13.25,;26.79,-12.48,;21.45,-10.94,;20.12,-11.71,;16.13,-14,;14.8,-13.24,)| Show InChI InChI=1S/C23H23F3N2O5/c24-23(25,26)33-17-4-1-14(2-5-17)11-15-7-9-22(31,10-8-15)13-20(29)27-16-3-6-18-19(12-16)32-21(30)28-18/h1-6,12,15,31H,7-11,13H2,(H,27,29)(H,28,30)/t15-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269780 (CHEMBL4095807) Show SMILES COc1ccc(C[C@H]2CC[C@](O)(CC(=O)Nc3ccc4[nH]c(=O)oc4c3)CC2)cc1 |r,wD:10.10,7.6,(25.46,-11.71,;24.13,-10.94,;22.79,-11.71,;22.79,-13.25,;21.46,-14.02,;20.13,-13.24,;18.79,-14.01,;17.46,-13.24,;17.46,-11.7,;16.13,-10.92,;14.8,-11.7,;14.03,-10.36,;13.26,-11.7,;12.49,-13.03,;13.26,-14.37,;10.95,-13.03,;10.18,-14.37,;10.96,-15.69,;10.19,-17.02,;8.65,-17.03,;7.62,-18.18,;6.2,-17.55,;4.87,-18.33,;6.36,-16.02,;7.87,-15.69,;8.65,-14.36,;14.8,-13.24,;16.13,-14,;20.12,-11.71,;21.45,-10.94,)| Show InChI InChI=1S/C23H26N2O5/c1-29-18-5-2-15(3-6-18)12-16-8-10-23(28,11-9-16)14-21(26)24-17-4-7-19-20(13-17)30-22(27)25-19/h2-7,13,16,28H,8-12,14H2,1H3,(H,24,26)(H,25,27)/t16-,23+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269778 (CHEMBL4103182) Show SMILES O[C@@]1(Cc2cc(on2)-c2ccc(=O)[nH]c2)CC[C@H](Cc2ccc(Cl)cc2)CC1 |r,wU:17.19,wD:1.0,(15.69,-7.67,;16.46,-9,;14.92,-9,;14.15,-10.33,;12.62,-10.49,;12.3,-12,;13.63,-12.77,;14.77,-11.74,;10.89,-12.62,;9.65,-11.72,;8.25,-12.34,;8.08,-13.87,;6.67,-14.5,;9.34,-14.78,;10.74,-14.15,;16.46,-10.54,;17.79,-11.3,;19.12,-10.54,;20.45,-11.31,;21.78,-10.54,;23.11,-11.32,;24.45,-10.55,;24.45,-9.01,;25.78,-8.24,;23.11,-8.24,;21.78,-9.01,;19.12,-9,;17.79,-8.22,)| Show InChI InChI=1S/C22H23ClN2O3/c23-18-4-1-15(2-5-18)11-16-7-9-22(27,10-8-16)13-19-12-20(28-25-19)17-3-6-21(26)24-14-17/h1-6,12,14,16,27H,7-11,13H2,(H,24,26)/t16-,22-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269771 (CHEMBL4084983) Show SMILES O[C@]1(CC(=O)Nc2ccc3[nH]ncc3c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,17.19,(14.88,-11.63,;15.65,-12.97,;14.11,-12.97,;13.34,-14.3,;14.11,-15.63,;11.8,-14.3,;11.03,-15.63,;11.81,-16.96,;11.04,-18.29,;9.49,-18.3,;8.46,-19.45,;7.05,-18.82,;7.21,-17.28,;8.72,-16.96,;9.49,-15.63,;16.98,-12.19,;18.31,-12.97,;18.31,-14.51,;19.64,-15.28,;20.97,-14.51,;22.3,-15.28,;23.64,-14.52,;23.64,-12.97,;22.3,-12.2,;20.97,-12.97,;16.98,-15.27,;15.65,-14.51,)| Show InChI InChI=1S/C22H25N3O2/c26-21(24-19-6-7-20-18(13-19)15-23-25-20)14-22(27)10-8-17(9-11-22)12-16-4-2-1-3-5-16/h1-7,13,15,17,27H,8-12,14H2,(H,23,25)(H,24,26)/t17-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269761 (CHEMBL4074570) Show SMILES O[C@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccc(F)c(F)c2)CC1 |r,wD:1.0,15.17,(13.85,-7.13,;14.62,-8.46,;13.08,-8.46,;12.31,-9.8,;10.78,-9.95,;10.46,-11.46,;11.79,-12.23,;12.94,-11.2,;9.05,-12.09,;7.72,-11.32,;6.57,-12.35,;7.2,-13.76,;8.73,-13.6,;15.95,-7.68,;17.28,-8.46,;17.28,-10,;18.61,-10.77,;19.95,-10.01,;21.28,-10.78,;22.61,-10.01,;22.61,-8.47,;23.95,-7.7,;21.27,-7.7,;21.27,-6.16,;19.94,-8.47,;15.95,-10.76,;14.62,-10,)| Show InChI InChI=1S/C20H21F2N3O2/c21-17-2-1-14(8-18(17)22)7-13-3-5-20(26,6-4-13)10-16-9-19(27-25-16)15-11-23-24-12-15/h1-2,8-9,11-13,26H,3-7,10H2,(H,23,24)/t13-,20+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269760 (CHEMBL4101281) Show SMILES O[C@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccc(OC(F)(F)F)cc2)CC1 |r,wD:1.0,15.17,(15.19,-7.36,;15.96,-8.7,;14.42,-8.7,;13.65,-10.03,;12.12,-10.19,;11.8,-11.69,;13.13,-12.46,;14.28,-11.43,;10.39,-12.32,;9.05,-11.55,;7.91,-12.58,;8.54,-13.99,;10.07,-13.83,;17.29,-7.92,;18.62,-8.7,;18.62,-10.24,;19.95,-11.01,;21.29,-10.24,;22.62,-11.01,;23.95,-10.25,;23.95,-8.7,;25.29,-7.93,;26.62,-8.7,;27.95,-7.94,;26.62,-10.24,;27.95,-9.47,;22.61,-7.93,;21.28,-8.7,;17.29,-11,;15.96,-10.24,)| Show InChI InChI=1S/C21H22F3N3O3/c22-21(23,24)29-18-3-1-14(2-4-18)9-15-5-7-20(28,8-6-15)11-17-10-19(30-27-17)16-12-25-26-13-16/h1-4,10,12-13,15,28H,5-9,11H2,(H,25,26)/t15-,20+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269754 (CHEMBL4077427) Show SMILES O[C@]1(Cc2cc(on2)-c2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,20.23,(15.39,-6.27,;16.16,-7.61,;14.62,-7.61,;13.85,-8.94,;12.32,-9.1,;12,-10.6,;13.33,-11.37,;14.48,-10.34,;10.59,-11.23,;10.44,-12.76,;9.04,-13.39,;7.79,-12.48,;6.28,-12.8,;5.51,-11.46,;3.98,-11.29,;6.54,-10.32,;7.95,-10.95,;9.35,-10.32,;17.49,-6.83,;18.82,-7.61,;18.82,-9.15,;20.15,-9.92,;21.49,-9.15,;22.82,-9.92,;24.15,-9.16,;24.16,-7.62,;22.81,-6.84,;21.48,-7.62,;17.49,-9.91,;16.16,-9.15,)| Show InChI InChI=1S/C24H24N2O4/c27-23-25-20-7-6-18(13-22(20)29-23)21-14-19(26-30-21)15-24(28)10-8-17(9-11-24)12-16-4-2-1-3-5-16/h1-7,13-14,17,28H,8-12,15H2,(H,25,27)/t17-,24+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269770 (CHEMBL4065942) Show SMILES O[C@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccc(cc2)C(F)(F)F)CC1 |r,wD:1.0,15.17,(15.19,-7.36,;15.96,-8.7,;14.42,-8.7,;13.65,-10.03,;12.12,-10.19,;11.8,-11.69,;13.13,-12.46,;14.28,-11.43,;10.39,-12.32,;9.05,-11.55,;7.91,-12.58,;8.54,-13.99,;10.07,-13.83,;17.29,-7.92,;18.62,-8.7,;18.62,-10.24,;19.95,-11.01,;21.29,-10.24,;22.62,-11.01,;23.95,-10.25,;23.95,-8.7,;22.61,-7.93,;21.28,-8.7,;25.29,-7.93,;26.62,-8.7,;25.29,-6.39,;26.62,-7.16,;17.29,-11,;15.96,-10.24,)| Show InChI InChI=1S/C21H22F3N3O2/c22-21(23,24)17-3-1-14(2-4-17)9-15-5-7-20(28,8-6-15)11-18-10-19(29-27-18)16-12-25-26-13-16/h1-4,10,12-13,15,28H,5-9,11H2,(H,25,26)/t15-,20+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269762 (CHEMBL4063195) Show SMILES O[C@]1(Cc2noc(n2)-c2ccc(=O)[nH]c2)CC[C@H](Cc2ccc(Cl)cc2)CC1 |r,wD:1.0,17.19,(13.85,-7.13,;14.62,-8.46,;13.08,-8.46,;12.31,-9.8,;12.94,-11.2,;11.79,-12.23,;10.46,-11.46,;10.78,-9.95,;9.05,-12.09,;7.81,-11.18,;6.41,-11.8,;6.24,-13.33,;4.83,-13.95,;7.49,-14.24,;8.9,-13.62,;15.95,-7.68,;17.28,-8.46,;17.28,-10,;18.61,-10.77,;19.95,-10.01,;21.28,-10.78,;22.61,-10.01,;22.61,-8.47,;23.95,-7.7,;21.27,-7.7,;19.94,-8.47,;15.95,-10.76,;14.62,-10,)| Show InChI InChI=1S/C21H22ClN3O3/c22-17-4-1-14(2-5-17)11-15-7-9-21(27,10-8-15)12-18-24-20(28-25-18)16-3-6-19(26)23-13-16/h1-6,13,15,27H,7-12H2,(H,23,26)/t15-,21+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269762 (CHEMBL4063195) Show SMILES O[C@]1(Cc2noc(n2)-c2ccc(=O)[nH]c2)CC[C@H](Cc2ccc(Cl)cc2)CC1 |r,wD:1.0,17.19,(13.85,-7.13,;14.62,-8.46,;13.08,-8.46,;12.31,-9.8,;12.94,-11.2,;11.79,-12.23,;10.46,-11.46,;10.78,-9.95,;9.05,-12.09,;7.81,-11.18,;6.41,-11.8,;6.24,-13.33,;4.83,-13.95,;7.49,-14.24,;8.9,-13.62,;15.95,-7.68,;17.28,-8.46,;17.28,-10,;18.61,-10.77,;19.95,-10.01,;21.28,-10.78,;22.61,-10.01,;22.61,-8.47,;23.95,-7.7,;21.27,-7.7,;19.94,-8.47,;15.95,-10.76,;14.62,-10,)| Show InChI InChI=1S/C21H22ClN3O3/c22-17-4-1-14(2-5-17)11-15-7-9-21(27,10-8-15)12-18-24-20(28-25-18)16-3-6-19(26)23-13-16/h1-6,13,15,27H,7-12H2,(H,23,26)/t15-,21+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair

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