Found 38 hits Enz. Inhib. hit(s) with all data for entry = 50040772 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399909
(CHEMBL2180945)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32N4O4S/c1-5-14-30-20-9-8-16(31(28,29)26-12-10-25(4)11-13-26)15-18(20)21-23-19(7-3)17(6-2)22(27)24-21/h8-9,15H,5-7,10-14H2,1-4H3,(H,23,24,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399893
(CHEMBL2180948)Show SMILES CCCOc1ccc(cc1-c1nc(C(C)C)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C23H34N4O4S/c1-6-14-31-20-9-8-17(32(29,30)27-12-10-26(5)11-13-27)15-19(20)22-24-21(16(3)4)18(7-2)23(28)25-22/h8-9,15-16H,6-7,10-14H2,1-5H3,(H,24,25,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399891
(CHEMBL2180950)Show SMILES CCCOc1ccc(cc1-c1nc(CCC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C23H34N4O4S/c1-5-8-20-18(7-3)23(28)25-22(24-20)19-16-17(9-10-21(19)31-15-6-2)32(29,30)27-13-11-26(4)12-14-27/h9-10,16H,5-8,11-15H2,1-4H3,(H,24,25,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399894
(CHEMBL2180947)Show SMILES CCCOc1ccc(cc1-c1nc(C(C)C)c(C)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32N4O4S/c1-6-13-30-19-8-7-17(31(28,29)26-11-9-25(5)10-12-26)14-18(19)21-23-20(15(2)3)16(4)22(27)24-21/h7-8,14-15H,6,9-13H2,1-5H3,(H,23,24,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399896
(CHEMBL2180943)Show SMILES CCCOc1ccc(cc1-c1nc(C(C)C)c(I)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H29IN4O4S/c1-5-12-30-17-7-6-15(31(28,29)26-10-8-25(4)9-11-26)13-16(17)20-23-19(14(2)3)18(22)21(27)24-20/h6-7,13-14H,5,8-12H2,1-4H3,(H,23,24,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399898
(CHEMBL2180941)Show SMILES CCCOc1ccc(cc1-c1nc(C(C)C)c(Cl)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H29ClN4O4S/c1-5-12-30-17-7-6-15(31(28,29)26-10-8-25(4)9-11-26)13-16(17)20-23-19(14(2)3)18(22)21(27)24-20/h6-7,13-14H,5,8-12H2,1-4H3,(H,23,24,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399897
(CHEMBL2180942)Show SMILES CCCOc1ccc(cc1-c1nc(C(C)C)c(Br)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H29BrN4O4S/c1-5-12-30-17-7-6-15(31(28,29)26-10-8-25(4)9-11-26)13-16(17)20-23-19(14(2)3)18(22)21(27)24-20/h6-7,13-14H,5,8-12H2,1-4H3,(H,23,24,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399890
(CHEMBL2180951)Show SMILES CCOc1ccc(cc1-c1nc(C(C)C)c(Br)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C20H27BrN4O4S/c1-5-29-16-7-6-14(30(27,28)25-10-8-24(4)9-11-25)12-15(16)19-22-18(13(2)3)17(21)20(26)23-19/h6-7,12-13H,5,8-11H2,1-4H3,(H,22,23,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399910
(CHEMBL2180944)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(C)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H30N4O4S/c1-5-13-29-19-8-7-16(30(27,28)25-11-9-24(4)10-12-25)14-17(19)20-22-18(6-2)15(3)21(26)23-20/h7-8,14H,5-6,9-13H2,1-4H3,(H,22,23,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399887
(CHEMBL2180954)Show SMILES CCOc1ccc(cc1-c1nc(C(C)C)c(Cl)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C20H27ClN4O4S/c1-5-29-16-7-6-14(30(27,28)25-10-8-24(4)9-11-25)12-15(16)19-22-18(13(2)3)17(21)20(26)23-19/h6-7,12-13H,5,8-11H2,1-4H3,(H,22,23,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399892
(CHEMBL2180949)Show SMILES CCCOc1ccc(cc1-c1nc(C)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H30N4O4S/c1-5-13-29-19-8-7-16(30(27,28)25-11-9-24(4)10-12-25)14-18(19)20-22-15(3)17(6-2)21(26)23-20/h7-8,14H,5-6,9-13H2,1-4H3,(H,22,23,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399903
(CHEMBL2180659)Show SMILES CCCOc1ccc(cc1-c1nc(cc(=O)[nH]1)C(C)C)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H30N4O4S/c1-5-12-29-19-7-6-16(30(27,28)25-10-8-24(4)9-11-25)13-17(19)21-22-18(15(2)3)14-20(26)23-21/h6-7,13-15H,5,8-12H2,1-4H3,(H,22,23,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399895
(CHEMBL2180946)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CCC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C23H34N4O4S/c1-5-8-18-20(7-3)24-22(25-23(18)28)19-16-17(9-10-21(19)31-15-6-2)32(29,30)27-13-11-26(4)12-14-27/h9-10,16H,5-8,11-15H2,1-4H3,(H,24,25,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE6C at 1 uM by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399889
(CHEMBL2180952)Show SMILES CCCCOc1ccc(cc1-c1nc(C(C)C)c(Br)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H31BrN4O4S/c1-5-6-13-31-18-8-7-16(32(29,30)27-11-9-26(4)10-12-27)14-17(18)21-24-20(15(2)3)19(23)22(28)25-21/h7-8,14-15H,5-6,9-13H2,1-4H3,(H,24,25,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
(Homo sapiens (Human)) | BDBM50399909
(CHEMBL2180945)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32N4O4S/c1-5-14-30-20-9-8-16(31(28,29)26-12-10-25(4)11-13-26)15-18(20)21-23-19(7-3)17(6-2)22(27)24-21/h8-9,15H,5-7,10-14H2,1-4H3,(H,23,24,27) | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE6C at 1 uM by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399888
(CHEMBL2180953)Show SMILES CCCCCCOc1ccc(cc1-c1nc(C(C)C)c(Br)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C24H35BrN4O4S/c1-5-6-7-8-15-33-20-10-9-18(34(31,32)29-13-11-28(4)12-14-29)16-19(20)23-26-22(17(2)3)21(25)24(30)27-23/h9-10,16-17H,5-8,11-15H2,1-4H3,(H,26,27,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399904
(CHEMBL2180658)Show SMILES CCCOc1ccc(cc1-c1nc(CCC)cc(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H30N4O4S/c1-4-6-16-14-20(26)23-21(22-16)18-15-17(7-8-19(18)29-13-5-2)30(27,28)25-11-9-24(3)10-12-25/h7-8,14-15H,4-6,9-13H2,1-3H3,(H,22,23,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399905
(CHEMBL2180657)Show SMILES CCCOc1ccc(cc1-c1nc(C)cc(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C19H26N4O4S/c1-4-11-27-17-6-5-15(28(25,26)23-9-7-22(3)8-10-23)13-16(17)19-20-14(2)12-18(24)21-19/h5-6,12-13H,4,7-11H2,1-3H3,(H,20,21,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399902
(CHEMBL2180660)Show SMILES CCCOc1ccc(cc1-c1nc(CC(C)C)cc(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32N4O4S/c1-5-12-30-20-7-6-18(31(28,29)26-10-8-25(4)9-11-26)15-19(20)22-23-17(13-16(2)3)14-21(27)24-22/h6-7,14-16H,5,8-13H2,1-4H3,(H,23,24,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399901
(CHEMBL2180661)Show SMILES CCCOc1ccc(cc1-c1nc(cc(=O)[nH]1)-c1ccccc1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C24H28N4O4S/c1-3-15-32-22-10-9-19(33(30,31)28-13-11-27(2)12-14-28)16-20(22)24-25-21(17-23(29)26-24)18-7-5-4-6-8-18/h4-10,16-17H,3,11-15H2,1-2H3,(H,25,26,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399900
(CHEMBL2180662)Show SMILES CCCOc1ccc(cc1-c1nc(cc(=O)[nH]1)C(F)(F)F)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C19H23F3N4O4S/c1-3-10-30-15-5-4-13(31(28,29)26-8-6-25(2)7-9-26)11-14(15)18-23-16(19(20,21)22)12-17(27)24-18/h4-5,11-12H,3,6-10H2,1-2H3,(H,23,24,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 312 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399906
(CHEMBL2180656)Show SMILES CCCOc1ccc(cc1-c1nc(NC(C)=O)cc(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C20H27N5O5S/c1-4-11-30-17-6-5-15(31(28,29)25-9-7-24(3)8-10-25)12-16(17)20-22-18(21-14(2)26)13-19(27)23-20/h5-6,12-13H,4,7-11H2,1-3H3,(H2,21,22,23,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399911
(CHEMBL2180955)Show SMILES CCCOc1ccc(cc1-c1nc2CCCc2c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H28N4O4S/c1-3-13-29-19-8-7-15(30(27,28)25-11-9-24(2)10-12-25)14-17(19)20-22-18-6-4-5-16(18)21(26)23-20/h7-8,14H,3-6,9-13H2,1-2H3,(H,22,23,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399908
(CHEMBL2180654)Show SMILES CCCOc1ccc(cc1-c1nc(N)cc(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C18H25N5O4S/c1-3-10-27-15-5-4-13(28(25,26)23-8-6-22(2)7-9-23)11-14(15)18-20-16(19)12-17(24)21-18/h4-5,11-12H,3,6-10H2,1-2H3,(H3,19,20,21,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399899
(CHEMBL2180663)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(NC(C)=O)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H31N5O5S/c1-5-13-32-19-8-7-16(33(30,31)27-11-9-26(4)10-12-27)14-17(19)21-24-18(6-2)20(22(29)25-21)23-15(3)28/h7-8,14H,5-6,9-13H2,1-4H3,(H,23,28)(H,24,25,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399907
(CHEMBL2180655)Show SMILES CCCOc1ccc(cc1-c1nc(O)cc(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C18H24N4O5S/c1-3-10-27-15-5-4-13(28(25,26)22-8-6-21(2)7-9-22)11-14(15)18-19-16(23)12-17(24)20-18/h4-5,11-12H,3,6-10H2,1-2H3,(H2,19,20,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50399909
(CHEMBL2180945)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32N4O4S/c1-5-14-30-20-9-8-16(31(28,29)26-12-10-25(4)11-13-26)15-18(20)21-23-19(7-3)17(6-2)22(27)24-21/h8-9,15H,5-7,10-14H2,1-4H3,(H,23,24,27) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 3.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE11A4 at 1 uM by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE11A4 at 1 uM by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE7A1 at 1 uM by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50399909
(CHEMBL2180945)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32N4O4S/c1-5-14-30-20-9-8-16(31(28,29)26-12-10-25(4)11-13-26)15-18(20)21-23-19(7-3)17(6-2)22(27)24-21/h8-9,15H,5-7,10-14H2,1-4H3,(H,23,24,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE7A1 at 1 uM by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM50399909
(CHEMBL2180945)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32N4O4S/c1-5-14-30-20-9-8-16(31(28,29)26-12-10-25(4)11-13-26)15-18(20)21-23-19(7-3)17(6-2)22(27)24-21/h8-9,15H,5-7,10-14H2,1-4H3,(H,23,24,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE8A1 at 1 uM by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM50399909
(CHEMBL2180945)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32N4O4S/c1-5-14-30-20-9-8-16(31(28,29)26-12-10-25(4)11-13-26)15-18(20)21-23-19(7-3)17(6-2)22(27)24-21/h8-9,15H,5-7,10-14H2,1-4H3,(H,23,24,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE9A2 at 1 uM by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50399909
(CHEMBL2180945)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32N4O4S/c1-5-14-30-20-9-8-16(31(28,29)26-12-10-25(4)11-13-26)15-18(20)21-23-19(7-3)17(6-2)22(27)24-21/h8-9,15H,5-7,10-14H2,1-4H3,(H,23,24,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE10A2 at 1 uM by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE8A1 at 1 uM by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE9A2 at 1 uM by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE10A2 at 1 uM by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this Ligand-Target Pair | |