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Compile Data Set for Download or QSAR

Found 112 hits Enz. Inhib. hit(s) with all data for entry = 50045417   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061613
PNG
(CHEMBL3394164 | US9321756, 17)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C19H19N7S/c20-19-26-25-18(27-19)11-5-6-15-13(7-11)14(8-22-15)16-9-21-10-17(24-16)23-12-3-1-2-4-12/h5-10,12,22H,1-4H2,(H2,20,26)(H,23,24)
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061609
PNG
(CHEMBL3394074 | US9321756, 206)
Show SMILES CC(C)Nc1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C17H17N7S/c1-9(2)21-15-8-19-7-14(22-15)12-6-20-13-4-3-10(5-11(12)13)16-23-24-17(18)25-16/h3-9,20H,1-2H3,(H2,18,24)(H,21,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061613
PNG
(CHEMBL3394164 | US9321756, 17)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C19H19N7S/c20-19-26-25-18(27-19)11-5-6-15-13(7-11)14(8-22-15)16-9-21-10-17(24-16)23-12-3-1-2-4-12/h5-10,12,22H,1-4H2,(H2,20,26)(H,23,24)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061608
PNG
(CHEMBL3394165 | US9321756, 208)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(NC4CCCCC4)n3)c2c1
Show InChI InChI=1S/C20H21N7S/c21-20-27-26-19(28-20)12-6-7-16-14(8-12)15(9-23-16)17-10-22-11-18(25-17)24-13-4-2-1-3-5-13/h6-11,13,23H,1-5H2,(H2,21,27)(H,24,25)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061609
PNG
(CHEMBL3394074 | US9321756, 206)
Show SMILES CC(C)Nc1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C17H17N7S/c1-9(2)21-15-8-19-7-14(22-15)12-6-20-13-4-3-10(5-11(12)13)16-23-24-17(18)25-16/h3-9,20H,1-2H3,(H2,18,24)(H,21,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061603
PNG
(CHEMBL3394167 | US9321756, 157)
Show SMILES CC(C)Oc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C18H17N5OS/c1-10(2)24-16-5-3-4-15(21-16)13-9-20-14-7-6-11(8-12(13)14)17-22-23-18(19)25-17/h3-10,20H,1-2H3,(H2,19,23)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061602
PNG
(CHEMBL3394166 | US9321756, 164)
Show SMILES CCOc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C17H15N5OS/c1-2-23-15-5-3-4-14(20-15)12-9-19-13-7-6-10(8-11(12)13)16-21-22-17(18)24-16/h3-9,19H,2H2,1H3,(H2,18,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061622
PNG
(CHEMBL3394171 | US9321756, 187)
Show SMILES CC(C)Oc1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C17H16N6OS/c1-9(2)24-15-8-19-7-14(21-15)12-6-20-13-4-3-10(5-11(12)13)16-22-23-17(18)25-16/h3-9,20H,1-2H3,(H2,18,23)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061608
PNG
(CHEMBL3394165 | US9321756, 208)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(NC4CCCCC4)n3)c2c1
Show InChI InChI=1S/C20H21N7S/c21-20-27-26-19(28-20)12-6-7-16-14(8-12)15(9-23-16)17-10-22-11-18(25-17)24-13-4-2-1-3-5-13/h6-11,13,23H,1-5H2,(H2,21,27)(H,24,25)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061601
PNG
(CHEMBL3394073 | US9321756, 156)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(n3)N3CCOCC3)c2c1
Show InChI InChI=1S/C18H17N7OS/c19-18-24-23-17(27-18)11-1-2-14-12(7-11)13(8-21-14)15-9-20-10-16(22-15)25-3-5-26-6-4-25/h1-2,7-10,21H,3-6H2,(H2,19,24)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061601
PNG
(CHEMBL3394073 | US9321756, 156)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(n3)N3CCOCC3)c2c1
Show InChI InChI=1S/C18H17N7OS/c19-18-24-23-17(27-18)11-1-2-14-12(7-11)13(8-21-14)15-9-20-10-16(22-15)25-3-5-26-6-4-25/h1-2,7-10,21H,3-6H2,(H2,19,24)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061612
PNG
(CHEMBL3394168 | US9321756, 163)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(OC4CCCC4)n3)c2c1
Show InChI InChI=1S/C20H19N5OS/c21-20-25-24-19(27-20)12-8-9-16-14(10-12)15(11-22-16)17-6-3-7-18(23-17)26-13-4-1-2-5-13/h3,6-11,13,22H,1-2,4-5H2,(H2,21,25)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061611
PNG
(CHEMBL3394069 | US9321756, 16)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C20H20N6S/c21-20-26-25-19(27-20)12-8-9-16-14(10-12)15(11-22-16)17-6-3-7-18(24-17)23-13-4-1-2-5-13/h3,6-11,13,22H,1-2,4-5H2,(H2,21,26)(H,23,24)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061610
PNG
(CHEMBL3394068 | US9321756, 203)
Show SMILES CC(C)Nc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C18H18N6S/c1-10(2)21-16-5-3-4-15(22-16)13-9-20-14-7-6-11(8-12(13)14)17-23-24-18(19)25-17/h3-10,20H,1-2H3,(H2,19,24)(H,21,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061628
PNG
(CHEMBL3394067 | US9321756, 24)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H18N6OS/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)
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n/an/a 6n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50061613
PNG
(CHEMBL3394164 | US9321756, 17)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C19H19N7S/c20-19-26-25-18(27-19)11-5-6-15-13(7-11)14(8-22-15)16-9-21-10-17(24-16)23-12-3-1-2-4-12/h5-10,12,22H,1-4H2,(H2,20,26)(H,23,24)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061603
PNG
(CHEMBL3394167 | US9321756, 157)
Show SMILES CC(C)Oc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C18H17N5OS/c1-10(2)24-16-5-3-4-15(21-16)13-9-20-14-7-6-11(8-12(13)14)17-22-23-18(19)25-17/h3-10,20H,1-2H3,(H2,19,23)
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n/an/a 7n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061704
PNG
(CHEMBL3394059)
Show SMILES Nc1ncc(s1)-c1ccc2[nH]nc(-c3cnc4ccccc4c3)c2c1
Show InChI InChI=1S/C19H13N5S/c20-19-22-10-17(25-19)12-5-6-16-14(8-12)18(24-23-16)13-7-11-3-1-2-4-15(11)21-9-13/h1-10H,(H2,20,22)(H,23,24)
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n/an/a 7n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061605
PNG
(CHEMBL3394170 | US9321756, 19)
Show SMILES CCOc1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C16H14N6OS/c1-2-23-14-8-18-7-13(20-14)11-6-19-12-4-3-9(5-10(11)12)15-21-22-16(17)24-15/h3-8,19H,2H2,1H3,(H2,17,22)
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n/an/a 8n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061622
PNG
(CHEMBL3394171 | US9321756, 187)
Show SMILES CC(C)Oc1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C17H16N6OS/c1-9(2)24-15-8-19-7-14(21-15)12-6-20-13-4-3-10(5-11(12)13)16-22-23-17(18)25-16/h3-9,20H,1-2H3,(H2,18,23)
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n/an/a 8n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061600
PNG
(CHEMBL3394072)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(n3)N3CCCC3)c2c1
Show InChI InChI=1S/C18H17N7S/c19-18-24-23-17(26-18)11-3-4-14-12(7-11)13(8-21-14)15-9-20-10-16(22-15)25-5-1-2-6-25/h3-4,7-10,21H,1-2,5-6H2,(H2,19,24)
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n/an/a 9n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50061603
PNG
(CHEMBL3394167 | US9321756, 157)
Show SMILES CC(C)Oc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C18H17N5OS/c1-10(2)24-16-5-3-4-15(21-16)13-9-20-14-7-6-11(8-12(13)14)17-22-23-18(19)25-17/h3-10,20H,1-2H3,(H2,19,23)
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50061609
PNG
(CHEMBL3394074 | US9321756, 206)
Show SMILES CC(C)Nc1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C17H17N7S/c1-9(2)21-15-8-19-7-14(22-15)12-6-20-13-4-3-10(5-11(12)13)16-23-24-17(18)25-16/h3-9,20H,1-2H3,(H2,18,24)(H,21,22)
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061623
PNG
(CHEMBL3394172 | US9321756, 160)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(OC4CCCC4)n3)c2c1
Show InChI InChI=1S/C19H18N6OS/c20-19-25-24-18(27-19)11-5-6-15-13(7-11)14(8-22-15)16-9-21-10-17(23-16)26-12-3-1-2-4-12/h5-10,12,22H,1-4H2,(H2,20,25)
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n/an/a 11n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061623
PNG
(CHEMBL3394172 | US9321756, 160)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(OC4CCCC4)n3)c2c1
Show InChI InChI=1S/C19H18N6OS/c20-19-25-24-18(27-19)11-5-6-15-13(7-11)14(8-22-15)16-9-21-10-17(23-16)26-12-3-1-2-4-12/h5-10,12,22H,1-4H2,(H2,20,25)
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n/an/a 11n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061600
PNG
(CHEMBL3394072)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(n3)N3CCCC3)c2c1
Show InChI InChI=1S/C18H17N7S/c19-18-24-23-17(26-18)11-3-4-14-12(7-11)13(8-21-14)15-9-20-10-16(22-15)25-5-1-2-6-25/h3-4,7-10,21H,1-2,5-6H2,(H2,19,24)
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n/an/a 11n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061611
PNG
(CHEMBL3394069 | US9321756, 16)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C20H20N6S/c21-20-26-25-19(27-20)12-8-9-16-14(10-12)15(11-22-16)17-6-3-7-18(24-17)23-13-4-1-2-5-13/h3,6-11,13,22H,1-2,4-5H2,(H2,21,26)(H,23,24)
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n/an/a 12n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50061601
PNG
(CHEMBL3394073 | US9321756, 156)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(n3)N3CCOCC3)c2c1
Show InChI InChI=1S/C18H17N7OS/c19-18-24-23-17(27-18)11-1-2-14-12(7-11)13(8-21-14)15-9-20-10-16(22-15)25-3-5-26-6-4-25/h1-2,7-10,21H,3-6H2,(H2,19,24)
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n/an/a 12n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061612
PNG
(CHEMBL3394168 | US9321756, 163)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(OC4CCCC4)n3)c2c1
Show InChI InChI=1S/C20H19N5OS/c21-20-25-24-19(27-20)12-8-9-16-14(10-12)15(11-22-16)17-6-3-7-18(23-17)26-13-4-1-2-5-13/h3,6-11,13,22H,1-2,4-5H2,(H2,21,25)
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n/an/a 15n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061627
PNG
(CHEMBL3394066 | US9321756, 14)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCCC3)c2c1
Show InChI InChI=1S/C19H18N6S/c20-19-24-23-18(26-19)12-6-7-15-13(10-12)14(11-21-15)16-4-3-5-17(22-16)25-8-1-2-9-25/h3-7,10-11,21H,1-2,8-9H2,(H2,20,24)
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n/an/a 15n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061628
PNG
(CHEMBL3394067 | US9321756, 24)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H18N6OS/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)
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n/an/a 16n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061704
PNG
(CHEMBL3394059)
Show SMILES Nc1ncc(s1)-c1ccc2[nH]nc(-c3cnc4ccccc4c3)c2c1
Show InChI InChI=1S/C19H13N5S/c20-19-22-10-17(25-19)12-5-6-16-14(8-12)18(24-23-16)13-7-11-3-1-2-4-15(11)21-9-13/h1-10H,(H2,20,22)(H,23,24)
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061602
PNG
(CHEMBL3394166 | US9321756, 164)
Show SMILES CCOc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C17H15N5OS/c1-2-23-15-5-3-4-14(20-15)12-9-19-13-7-6-10(8-11(12)13)16-21-22-17(18)24-16/h3-9,19H,2H2,1H3,(H2,18,22)
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50061622
PNG
(CHEMBL3394171 | US9321756, 187)
Show SMILES CC(C)Oc1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C17H16N6OS/c1-9(2)24-15-8-19-7-14(21-15)12-6-20-13-4-3-10(5-11(12)13)16-22-23-17(18)25-16/h3-9,20H,1-2H3,(H2,18,23)
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50061608
PNG
(CHEMBL3394165 | US9321756, 208)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(NC4CCCCC4)n3)c2c1
Show InChI InChI=1S/C20H21N7S/c21-20-27-26-19(28-20)12-6-7-16-14(8-12)15(9-23-16)17-10-22-11-18(25-17)24-13-4-2-1-3-5-13/h6-11,13,23H,1-5H2,(H2,21,27)(H,24,25)
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n/an/a 18n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061604
PNG
(CHEMBL3394169 | US9321756, 173)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(OC4CCCCC4)n3)c2c1
Show InChI InChI=1S/C21H21N5OS/c22-21-26-25-20(28-21)13-9-10-17-15(11-13)16(12-23-17)18-7-4-8-19(24-18)27-14-5-2-1-3-6-14/h4,7-12,14,23H,1-3,5-6H2,(H2,22,26)
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n/an/a 18n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061605
PNG
(CHEMBL3394170 | US9321756, 19)
Show SMILES CCOc1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C16H14N6OS/c1-2-23-14-8-18-7-13(20-14)11-6-19-12-4-3-9(5-10(11)12)15-21-22-16(17)24-15/h3-8,19H,2H2,1H3,(H2,17,22)
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n/an/a 21n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50061611
PNG
(CHEMBL3394069 | US9321756, 16)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C20H20N6S/c21-20-26-25-19(27-20)12-8-9-16-14(10-12)15(11-22-16)17-6-3-7-18(24-17)23-13-4-1-2-5-13/h3,6-11,13,22H,1-2,4-5H2,(H2,21,26)(H,23,24)
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n/an/a 21n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061614
PNG
(CHEMBL3394070 | US9321756, 205)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(NC4CCCCC4)n3)c2c1
Show InChI InChI=1S/C21H22N6S/c22-21-27-26-20(28-21)13-9-10-17-15(11-13)16(12-23-17)18-7-4-8-19(25-18)24-14-5-2-1-3-6-14/h4,7-12,14,23H,1-3,5-6H2,(H2,22,27)(H,24,25)
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n/an/a 22n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50061602
PNG
(CHEMBL3394166 | US9321756, 164)
Show SMILES CCOc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C17H15N5OS/c1-2-23-15-5-3-4-14(20-15)12-9-19-13-7-6-10(8-11(12)13)16-21-22-17(18)24-16/h3-9,19H,2H2,1H3,(H2,18,22)
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n/an/a 22n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061610
PNG
(CHEMBL3394068 | US9321756, 203)
Show SMILES CC(C)Nc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C18H18N6S/c1-10(2)21-16-5-3-4-15(22-16)13-9-20-14-7-6-11(8-12(13)14)17-23-24-18(19)25-17/h3-10,20H,1-2H3,(H2,19,24)(H,21,22)
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n/an/a 24n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50061623
PNG
(CHEMBL3394172 | US9321756, 160)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(OC4CCCC4)n3)c2c1
Show InChI InChI=1S/C19H18N6OS/c20-19-25-24-18(27-19)11-5-6-15-13(7-11)14(8-22-15)16-9-21-10-17(23-16)26-12-3-1-2-4-12/h5-10,12,22H,1-4H2,(H2,20,25)
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n/an/a 25n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50061605
PNG
(CHEMBL3394170 | US9321756, 19)
Show SMILES CCOc1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C16H14N6OS/c1-2-23-14-8-18-7-13(20-14)11-6-19-12-4-3-9(5-10(11)12)15-21-22-16(17)24-15/h3-8,19H,2H2,1H3,(H2,17,22)
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n/an/a 28n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061620
PNG
(CHEMBL3394071 | US9321756, 210)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(N)n3)c2c1
Show InChI InChI=1S/C14H11N7S/c15-12-6-17-5-11(19-12)9-4-18-10-2-1-7(3-8(9)10)13-20-21-14(16)22-13/h1-6,18H,(H2,15,19)(H2,16,21)
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n/an/a 29n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50061704
PNG
(CHEMBL3394059)
Show SMILES Nc1ncc(s1)-c1ccc2[nH]nc(-c3cnc4ccccc4c3)c2c1
Show InChI InChI=1S/C19H13N5S/c20-19-22-10-17(25-19)12-5-6-16-14(8-12)18(24-23-16)13-7-11-3-1-2-4-15(11)21-9-13/h1-10H,(H2,20,22)(H,23,24)
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n/an/a 31n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50061610
PNG
(CHEMBL3394068 | US9321756, 203)
Show SMILES CC(C)Nc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C18H18N6S/c1-10(2)21-16-5-3-4-15(22-16)13-9-20-14-7-6-11(8-12(13)14)17-23-24-18(19)25-17/h3-10,20H,1-2H3,(H2,19,24)(H,21,22)
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n/an/a 37n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061609
PNG
(CHEMBL3394074 | US9321756, 206)
Show SMILES CC(C)Nc1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C17H17N7S/c1-9(2)21-15-8-19-7-14(22-15)12-6-20-13-4-3-10(5-11(12)13)16-23-24-17(18)25-16/h3-9,20H,1-2H3,(H2,18,24)(H,21,22)
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n/an/a 40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 in human U2OS cells assessed as phosphorylation of BAD

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061604
PNG
(CHEMBL3394169 | US9321756, 173)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(OC4CCCCC4)n3)c2c1
Show InChI InChI=1S/C21H21N5OS/c22-21-26-25-20(28-21)13-9-10-17-15(11-13)16(12-23-17)18-7-4-8-19(24-18)27-14-5-2-1-3-6-14/h4,7-12,14,23H,1-3,5-6H2,(H2,22,26)
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n/an/a 41n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50061612
PNG
(CHEMBL3394168 | US9321756, 163)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(OC4CCCC4)n3)c2c1
Show InChI InChI=1S/C20H19N5OS/c21-20-25-24-19(27-20)12-8-9-16-14(10-12)15(11-22-16)17-6-3-7-18(23-17)26-13-4-1-2-5-13/h3,6-11,13,22H,1-2,4-5H2,(H2,21,25)
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n/an/a 41n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50061600
PNG
(CHEMBL3394072)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(n3)N3CCCC3)c2c1
Show InChI InChI=1S/C18H17N7S/c19-18-24-23-17(26-18)11-3-4-14-12(7-11)13(8-21-14)15-9-20-10-16(22-15)25-5-1-2-6-25/h3-4,7-10,21H,1-2,5-6H2,(H2,19,24)
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n/an/a 42n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair
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