Compile Data Set for Download or QSAR

Found 7 hits Enz. Inhib. hit(s) with Target = 'Cytochrome P450 26A1' and Ligand = 'BDBM50176808'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 26A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of human CYP26A1 assessed using [11,12-3H]ATRA as substrate by scintillation counting				J Med Chem 54: 6803-11 (2011) Article DOI: 10.1021/jm200695m BindingDB Entry DOI: 10.7270/Q2WM1DSJ
					More data for this Ligand-Target Pair
Cytochrome P450 26A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of CYP26A1 in human MCF7 cell microsomes using [3H]ATRA after 1 hr by scintillation counting				J Med Chem 54: 2778-91 (2011) Article DOI: 10.1021/jm101583w BindingDB Entry DOI: 10.7270/Q2TT4R8J
					More data for this Ligand-Target Pair
Cytochrome P450 26A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of CYP26A1 in ATRA-induced human HL60 cell microsomes incubated for 30 mins in dark condition with NADPH and ATRA by HPLC method				Bioorg Med Chem 23: 6763-73 (2015) Article DOI: 10.1016/j.bmc.2015.08.019 BindingDB Entry DOI: 10.7270/Q2668G0C
					More data for this Ligand-Target Pair
Cytochrome P450 26A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of CYP26A1 in ATRA-induced human HL60 cell microsomes incubated for 30 mins using ATRA and NADPH by HPLC method				Bioorg Med Chem 23: 1356-65 (2015) Article DOI: 10.1016/j.bmc.2014.11.036 BindingDB Entry DOI: 10.7270/Q2416ZQG
					More data for this Ligand-Target Pair
Cytochrome P450 26A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
OSI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Potency towards cytochrome P 450 26 enzyme activity				Bioorg Med Chem Lett 15: 1669-73 (2005) Article DOI: 10.1016/j.bmcl.2005.01.044 BindingDB Entry DOI: 10.7270/Q2WW7H5R
					More data for this Ligand-Target Pair
Cytochrome P450 26A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of CYP26A1 in human MCF7 cells				Bioorg Med Chem 16: 8301-13 (2008) Article DOI: 10.1016/j.bmc.2007.06.048 BindingDB Entry DOI: 10.7270/Q2M61M5B
					More data for this Ligand-Target Pair
Cytochrome P450 26A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a
Cardiff University					Assay Description The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...				J Enzyme Inhib Med Chem 24: 487-98 (2009) Article DOI: 10.1080/14756360802218334 BindingDB Entry DOI: 10.7270/Q2CR5RZ5
					More data for this Ligand-Target Pair