new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 37 hits of ki for UniProtKB: Q9UBU7   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365698
PNG
(CHEMBL1958411)
Show SMILES CN(C1CCCCC1)c1nc(cc(=O)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C18H21N5O/c1-23(12-6-3-2-4-7-12)18-21-15(10-16(24)22-18)14-11-20-17-13(14)8-5-9-19-17/h5,8-12H,2-4,6-7H2,1H3,(H,19,20)(H,21,22,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.0900n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365703
PNG
(CHEMBL1958417)
Show SMILES CN1CCC(CC1)Nc1nc(cc(=O)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H20N6O/c1-23-7-4-11(5-8-23)20-17-21-14(9-15(24)22-17)13-10-19-16-12(13)3-2-6-18-16/h2-3,6,9-11H,4-5,7-8H2,1H3,(H,18,19)(H2,20,21,22,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.110n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365699
PNG
(CHEMBL1958412)
Show SMILES O=c1cc(nc(Nc2ccccc2)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H13N5O/c23-15-9-14(13-10-19-16-12(13)7-4-8-18-16)21-17(22-15)20-11-5-2-1-3-6-11/h1-10H,(H,18,19)(H2,20,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.120n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365702
PNG
(CHEMBL1958416)
Show SMILES O=c1cc(nc(NC2CCOCC2)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H17N5O2/c22-14-8-13(12-9-18-15-11(12)2-1-5-17-15)20-16(21-14)19-10-3-6-23-7-4-10/h1-2,5,8-10H,3-4,6-7H2,(H,17,18)(H2,19,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.140n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365701
PNG
(CHEMBL1958415)
Show SMILES O=c1cc(nc([nH]1)N1CCOCC1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C15H15N5O2/c21-13-8-12(11-9-17-14-10(11)2-1-3-16-14)18-15(19-13)20-4-6-22-7-5-20/h1-3,8-9H,4-7H2,(H,16,17)(H,18,19,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.180n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365700
PNG
(CHEMBL1958414)
Show SMILES COCCN(CCOC)c1nc(cc(=O)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H21N5O3/c1-24-8-6-22(7-9-25-2)17-20-14(10-15(23)21-17)13-11-19-16-12(13)4-3-5-18-16/h3-5,10-11H,6-9H2,1-2H3,(H,18,19)(H,20,21,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.180n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365706
PNG
(CHEMBL1958420)
Show SMILES COC1CCN(CC1)c1nc(cc(=O)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H19N5O2/c1-24-11-4-7-22(8-5-11)17-20-14(9-15(23)21-17)13-10-19-16-12(13)3-2-6-18-16/h2-3,6,9-11H,4-5,7-8H2,1H3,(H,18,19)(H,20,21,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.200n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365705
PNG
(CHEMBL1958419)
Show SMILES OC1CCN(CC1)c1nc(cc(=O)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H17N5O2/c22-10-3-6-21(7-4-10)16-19-13(8-14(23)20-16)12-9-18-15-11(12)2-1-5-17-15/h1-2,5,8-10,22H,3-4,6-7H2,(H,17,18)(H,19,20,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.200n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365704
PNG
(CHEMBL1958418)
Show SMILES O=c1cc(nc([nH]1)-c1ccccc1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H12N4O/c22-15-9-14(13-10-19-17-12(13)7-4-8-18-17)20-16(21-15)11-5-2-1-3-6-11/h1-10H,(H,18,19)(H,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.25n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365693
PNG
(CHEMBL1958406)
Show SMILES O=c1nc(nc(NC2CCCCC2)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H18N6O/c23-16-21-14(12-9-18-13-11(12)7-4-8-17-13)20-15(22-16)19-10-5-2-1-3-6-10/h4,7-10H,1-3,5-6H2,(H,17,18)(H2,19,20,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.300n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27427
PNG
(8-methyl-11-thia-9,14,16-triazatetracyclo[8.7.0.0^...)
Show SMILES Cc1nc2sc3c(N)ncnc3c2c2CCCCc12
Show InChI InChI=1S/C14H14N4S/c1-7-8-4-2-3-5-9(8)10-11-12(19-14(10)18-7)13(15)17-6-16-11/h6H,2-5H2,1H3,(H2,15,16,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
0.5 -13.2 5n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365692
PNG
(CHEMBL1958404)
Show SMILES O=c1cc(nc(NC2CCCCC2)[nH]1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C17H19N5O/c23-16-9-15(11-6-7-14-12(8-11)10-18-22-14)20-17(21-16)19-13-4-2-1-3-5-13/h6-10,13H,1-5H2,(H,18,22)(H2,19,20,21,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365695
PNG
(CHEMBL1958408)
Show SMILES O=c1cc(cc(NC2CCCCC2)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C18H20N4O/c23-17-10-12(15-11-20-18-14(15)7-4-8-19-18)9-16(22-17)21-13-5-2-1-3-6-13/h4,7-11,13H,1-3,5-6H2,(H,19,20)(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27428
PNG
(12-ethyl-11,13-dimethyl-8-thia-3,5,10-triazatricyc...)
Show SMILES CCc1c(C)nc2sc3c(N)ncnc3c2c1C
Show InChI InChI=1S/C13H14N4S/c1-4-8-6(2)9-10-11(12(14)16-5-15-10)18-13(9)17-7(8)3/h5H,4H2,1-3H3,(H2,14,15,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
1 -12.8 10n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365696
PNG
(CHEMBL1958409)
Show SMILES O=c1cc(NC2CCCCC2)cc([nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C18H20N4O/c23-17-10-13(21-12-5-2-1-3-6-12)9-16(22-17)15-11-20-18-14(15)7-4-8-19-18/h4,7-12H,1-3,5-6H2,(H,19,20)(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.10n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365694
PNG
(CHEMBL1958407)
Show SMILES O=c1nc(cc(NC2CCCCC2)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C17H19N5O/c23-17-21-14(13-10-19-16-12(13)7-4-8-18-16)9-15(22-17)20-11-5-2-1-3-6-11/h4,7-11H,1-3,5-6H2,(H,18,19)(H2,20,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.40n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27429
PNG
(9-methyl-17-thia-2,12,14-triazatetracyclo[8.7.0.0^...)
Show SMILES Cc1c2CCCCc2nc2sc3c(N)ncnc3c12
Show InChI InChI=1S/C14H14N4S/c1-7-8-4-2-3-5-9(8)18-14-10(7)11-12(19-14)13(15)17-6-16-11/h6H,2-5H2,1H3,(H2,15,16,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
2 -12.3 20n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27430
PNG
(11,13-dimethyl-12-(prop-2-en-1-yl)-8-thia-3,5,10-t...)
Show SMILES Cc1nc2sc3c(N)ncnc3c2c(C)c1CC=C
Show InChI InChI=1S/C14H14N4S/c1-4-5-9-7(2)10-11-12(13(15)17-6-16-11)19-14(10)18-8(9)3/h4,6H,1,5H2,2-3H3,(H2,15,16,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
2 -12.3 20n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365689
PNG
(CHEMBL1958401)
Show SMILES O=c1cc(nc(NC2CCCCC2)[nH]1)-c1ccncc1
Show InChI InChI=1S/C15H18N4O/c20-14-10-13(11-6-8-16-9-7-11)18-15(19-14)17-12-4-2-1-3-5-12/h6-10,12H,1-5H2,(H2,17,18,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
2n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27431
PNG
(7-methyl-10-thia-8,13,15-triazatetracyclo[7.7.0.0^...)
Show SMILES Cc1nc2sc3c(N)ncnc3c2c2CCCc12
Show InChI InChI=1S/C13H12N4S/c1-6-7-3-2-4-8(7)9-10-11(18-13(9)17-6)12(14)16-5-15-10/h5H,2-4H2,1H3,(H2,14,15,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
3 -12.1 30n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27432
PNG
(11,12,13-trimethyl-8-thia-3,5,10-triazatricyclo[7....)
Show SMILES Cc1nc2sc3c(N)ncnc3c2c(C)c1C
Show InChI InChI=1S/C12H12N4S/c1-5-6(2)8-9-10(11(13)15-4-14-9)17-12(8)16-7(5)3/h4H,1-3H3,(H2,13,14,15)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
4 -11.9 40n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27433
PNG
(16-methyl-8-thia-3,5,10-triazatetracyclo[7.7.0.0^{...)
Show SMILES Cc1c2CCCc2nc2sc3c(N)ncnc3c12
Show InChI InChI=1S/C13H12N4S/c1-6-7-3-2-4-8(7)17-13-9(6)10-11(18-13)12(14)16-5-15-10/h5H,2-4H2,1H3,(H2,14,15,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
5 -11.8 50n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365690
PNG
(CHEMBL1958402)
Show SMILES Nc1nccc(n1)-c1cc(=O)[nH]c(NC2CCCCC2)n1
Show InChI InChI=1S/C14H18N6O/c15-13-16-7-6-10(18-13)11-8-12(21)20-14(19-11)17-9-4-2-1-3-5-9/h6-9H,1-5H2,(H2,15,16,18)(H2,17,19,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365697
PNG
(CHEMBL1958410)
Show SMILES Oc1cc(NC2CCCCC2)nc(c1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C18H20N4O/c23-13-9-16(15-11-20-18-14(15)7-4-8-19-18)22-17(10-13)21-12-5-2-1-3-6-12/h4,7-12H,1-3,5-6H2,(H,19,20)(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
5.40n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365691
PNG
(CHEMBL1958403)
Show SMILES O=c1cc(nc(NC2CCCCC2)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C13H17N5O/c19-12-6-11(9-7-14-15-8-9)17-13(18-12)16-10-4-2-1-3-5-10/h6-8,10H,1-5H2,(H,14,15)(H2,16,17,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
15n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27434
PNG
(11,13-dimethyl-8-thia-3,5,10-triazatricyclo[7.4.0....)
Show SMILES Cc1cc(C)c2c(n1)sc1c(N)ncnc21
Show InChI InChI=1S/C11H10N4S/c1-5-3-6(2)15-11-7(5)8-9(16-11)10(12)14-4-13-8/h3-4H,1-2H3,(H2,12,13,14)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
40 -10.5 400n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27435
PNG
(12-benzyl-11,13-dimethyl-8-thia-3,5,10-triazatricy...)
Show SMILES Cc1nc2sc3c(N)ncnc3c2c(C)c1Cc1ccccc1
Show InChI InChI=1S/C18H16N4S/c1-10-13(8-12-6-4-3-5-7-12)11(2)22-18-14(10)15-16(23-18)17(19)21-9-20-15/h3-7,9H,8H2,1-2H3,(H2,19,20,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
200 -9.50 2.00E+3n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365687
PNG
(CHEMBL1958399)
Show SMILES O=c1cc(nc(NC2CCCCC2)[nH]1)-c1ccccc1
Show InChI InChI=1S/C16H19N3O/c20-15-11-14(12-7-3-1-4-8-12)18-16(19-15)17-13-9-5-2-6-10-13/h1,3-4,7-8,11,13H,2,5-6,9-10H2,(H2,17,18,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
230n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365707
PNG
(CHEMBL1958421)
Show SMILES O=c1cc(nc(NC(c2ccccc2)c2ccccc2)[nH]1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C24H19N5O/c30-21-14-20(19-15-26-23-18(19)12-7-13-25-23)27-24(28-21)29-22(16-8-3-1-4-9-16)17-10-5-2-6-11-17/h1-15,22H,(H,25,26)(H2,27,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
328n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27436
PNG
(11-cyclopropyl-13-(trifluoromethyl)-8-thia-3,5,10-...)
Show SMILES Nc1ncnc2c1sc1nc(cc(c21)C(F)(F)F)C1CC1
Show InChI InChI=1S/C13H9F3N4S/c14-13(15,16)6-3-7(5-1-2-5)20-12-8(6)9-10(21-12)11(17)19-4-18-9/h3-5H,1-2H2,(H2,17,18,19)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
400 -9.07 4.00E+3n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27437
PNG
(12-phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,...)
Show SMILES Nc1ncnc2c3cc(cnc3sc12)-c1ccccc1
Show InChI InChI=1S/C15H10N4S/c16-14-13-12(18-8-19-14)11-6-10(7-17-15(11)20-13)9-4-2-1-3-5-9/h1-8H,(H2,16,18,19)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
900 -8.57 9.00E+3n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27438
PNG
(ethyl 6-amino-11-methyl-8-thia-3,5,10-triazatricyc...)
Show SMILES CCOC(=O)c1cc2c(nc1C)sc1c(N)ncnc21
Show InChI InChI=1S/C13H12N4O2S/c1-3-19-13(18)7-4-8-9-10(11(14)16-5-15-9)20-12(8)17-6(7)2/h4-5H,3H2,1-2H3,(H2,14,15,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
1.00E+3 -8.51 1.00E+4n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27439
PNG
(8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca...)
Show SMILES Nc1ncnc2c3cccnc3sc12
Show InChI InChI=1S/C9H6N4S/c10-8-7-6(12-4-13-8)5-2-1-3-11-9(5)14-7/h1-4H,(H2,10,12,13)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
1.20E+3 -8.40 1.20E+4n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50365688
PNG
(CHEMBL1958400)
Show SMILES O=c1cc(nc(NC2CCCCC2)[nH]1)-c1cccnc1
Show InChI InChI=1S/C15H18N4O/c20-14-9-13(11-5-4-8-16-10-11)18-15(19-14)17-12-6-2-1-3-7-12/h4-5,8-10,12H,1-3,6-7H2,(H2,17,18,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
>1.20E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...


Bioorg Med Chem Lett 22: 1940-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.041
BindingDB Entry DOI: 10.7270/Q2DR2W0F
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27442
PNG
(11,13-dimethyl-N-phenyl-8-thia-3,5,10-triazatricyc...)
Show SMILES Cc1cc(C)c2c(n1)sc1c(Nc3ccccc3)ncnc21
Show InChI InChI=1S/C17H14N4S/c1-10-8-11(2)20-17-13(10)14-15(22-17)16(19-9-18-14)21-12-6-4-3-5-7-12/h3-9H,1-2H3,(H,18,19,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
>3.00E+3>-7.83>3.00E+4n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27441
PNG
(N,N,11,13-tetramethyl-8-thia-3,5,10-triazatricyclo...)
Show SMILES CN(C)c1ncnc2c1sc1nc(C)cc(C)c21
Show InChI InChI=1S/C13H14N4S/c1-7-5-8(2)16-13-9(7)10-11(18-13)12(17(3)4)15-6-14-10/h5-6H,1-4H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
>3.00E+3>-7.83>3.00E+4n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM27440
PNG
(N,11,13-trimethyl-8-thia-3,5,10-triazatricyclo[7.4...)
Show SMILES CNc1ncnc2c1sc1nc(C)cc(C)c21
Show InChI InChI=1S/C12H12N4S/c1-6-4-7(2)16-12-8(6)9-10(17-12)11(13-3)15-5-14-9/h4-5H,1-3H3,(H,13,14,15)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
>3.00E+3>-7.83>3.00E+4n/an/an/an/a7.537



Roche



Assay Description
The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...


Bioorg Med Chem Lett 19: 319-23 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.093
BindingDB Entry DOI: 10.7270/Q20G3HG2
More data for this
Ligand-Target Pair