Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35167 (indazole-benzimidazole, 3) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35190 (pyrazolo[3,4-b]-pyridine, 2) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533751 (Preparation of 7-(4-(6-(6-acetyl-8-cyclopentyl-5-m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533754 (Preparation of 8-(4-(6-((6-acetyl-8-cyclopentyl-5-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533755 (Preparation of 4-((4-(6-((6-acetyl-8-cyclopentyl-5...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533741 (US11225492, Compound 7S) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533586 (2-(5-(3,7-diazabicyclo[3.3.1]nonan-3-yl)pyridin-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533726 (2-(5-(2,7-Diazaspiro[3.5]nonan-7-yl)pyridin-2-ylam...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533737 (Preparation of 2-(5-(3,9-diazaspiro[5.5]undecan-3-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533749 (Preparation of 8-(4-(6-(6-acetyl-8-cyclopentyl-5-m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533742 (Preparation of 6-acetyl-8-cyclopentyl-5-methyl-2-(...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533740 (US11225492, Compound 7R) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533739 (US11225492, Compound 7) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533738 (US11225492, Compound 6) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35168 (indazole-benzimidazole, 4) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13.3 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533621 (2-(5-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)pyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533727 (US11225492, Compound 4-1) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533750 (Preparation of 5-(4-(6-(6-acetyl-8-cyclopentyl-5-m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM50110183 (Abemaciclib | LY-2835219 | US10626107, Example LY2...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2959MRV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM515983 (US11053238, Com. EX. 6) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2959MRV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM515951 (US11053238, Com. EX. 5) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2959MRV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533728 (US11225492, Compound 4-2) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533757 (Preparation of 6-((6-acetyl-8-cyclopentyl-5-methyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533760 (Preparation of 6-((6-acetyl-8-cyclopentyl-5-methyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35166 (indazole-benzimidazole, 1) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 102 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35176 (indazole-benzimidazole, 12) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 247 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM515905 (N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2959MRV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM515923 (US11053238, Compound 16b | US11053238, Example 16b) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2959MRV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM515904 (4-(6-fluoro-1- methyl-1,2,3,4- tetrahydrobenzo[4,5...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2959MRV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35173 (indazole-benzimidazole, 9) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 1.04E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM172196 (US9090564, 10 | US9096594, 22) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
The Broad Institute, Inc.; The General Hospital Corporation; Dana-Farber Cancer Institute, Inc. US Patent | Assay Description The GSK3beta primary screen was conducted in assay ready 1536 plates (Aurora 29847) that contain 2.5 mL/well of 10 mM compound. Human GSK3beta as a G... | US Patent US9096594 (2015) BindingDB Entry DOI: 10.7270/Q21Z435K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35175 (indazole-benzimidazole, 11) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.73E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM172197 (US9090564, 11 | US9096594, 54) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
The Broad Institute, Inc.; The General Hospital Corporation; Dana-Farber Cancer Institute, Inc. US Patent | Assay Description The GSK3beta primary screen was conducted in assay ready 1536 plates (Aurora 29847) that contain 2.5 mL/well of 10 mM compound. Human GSK3beta as a G... | US Patent US9096594 (2015) BindingDB Entry DOI: 10.7270/Q21Z435K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35174 (indazole-benzimidazole, 10) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35172 (indazole-benzimidazole, 8) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35171 (indazole-benzimidazole, 7) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35170 (indazole-benzimidazole, 6) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35177 (indazole-benzimidazole, 13) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35178 (indazole-benzimidazole, 14) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35187 (indazole-benzimidazole, 23) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35186 (indazole-benzimidazole, 22) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35182 (indazole-benzimidazole, 18) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35181 (indazole-benzimidazole, 17) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35183 (indazole-benzimidazole, 19) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35169 (indazole-benzimidazole, 5) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.15E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM35179 (indazole-benzimidazole, 15) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.09E+5 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ... | Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) |