Found 4 hits of ki for monomerid = 50200526 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glutamate receptor ionotropic, kainate 2
(Homo sapiens (Human)) | BDBM50200526
(CHEMBL1234118)Show SMILES OC(=O)[C@@H]1CC(F)(F)CN1C[C@H]1CC[C@H]2CN[C@@H](C[C@H]2C1)C(O)=O |r| Show InChI InChI=1S/C16H24F2N2O4/c17-16(18)5-13(15(23)24)20(8-16)7-9-1-2-10-6-19-12(14(21)22)4-11(10)3-9/h9-13,19H,1-8H2,(H,21,22)(H,23,24)/t9-,10-,11+,12-,13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-kainate from human recombinant GluK2 receptor expressed in HEK293 cell membranes after 60 mins |
Bioorg Med Chem Lett 26: 5568-5572 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.075 BindingDB Entry DOI: 10.7270/Q29S1T0N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, kainate 1
(Homo sapiens (Human)) | BDBM50200526
(CHEMBL1234118)Show SMILES OC(=O)[C@@H]1CC(F)(F)CN1C[C@H]1CC[C@H]2CN[C@@H](C[C@H]2C1)C(O)=O |r| Show InChI InChI=1S/C16H24F2N2O4/c17-16(18)5-13(15(23)24)20(8-16)7-9-1-2-10-6-19-12(14(21)22)4-11(10)3-9/h9-13,19H,1-8H2,(H,21,22)(H,23,24)/t9-,10-,11+,12-,13-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University
Curated by ChEMBL
| Assay Description Displacement of [3H]kainate from human GluK1 expressed in HEK293 cell membranes after 60 mins by scintillation counting method |
J Med Chem 60: 441-457 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01516 BindingDB Entry DOI: 10.7270/Q2G44SJJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50200526
(CHEMBL1234118)Show SMILES OC(=O)[C@@H]1CC(F)(F)CN1C[C@H]1CC[C@H]2CN[C@@H](C[C@H]2C1)C(O)=O |r| Show InChI InChI=1S/C16H24F2N2O4/c17-16(18)5-13(15(23)24)20(8-16)7-9-1-2-10-6-19-12(14(21)22)4-11(10)3-9/h9-13,19H,1-8H2,(H,21,22)(H,23,24)/t9-,10-,11+,12-,13-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University
Curated by ChEMBL
| Assay Description Inhibition of GluK3 (unknown origin) |
J Med Chem 60: 441-457 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01516 BindingDB Entry DOI: 10.7270/Q2G44SJJ |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 5
(Homo sapiens (Human)) | BDBM50200526
(CHEMBL1234118)Show SMILES OC(=O)[C@@H]1CC(F)(F)CN1C[C@H]1CC[C@H]2CN[C@@H](C[C@H]2C1)C(O)=O |r| Show InChI InChI=1S/C16H24F2N2O4/c17-16(18)5-13(15(23)24)20(8-16)7-9-1-2-10-6-19-12(14(21)22)4-11(10)3-9/h9-13,19H,1-8H2,(H,21,22)(H,23,24)/t9-,10-,11+,12-,13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-kainate from human recombinant GluK5 receptor expressed in HEK293 cell membranes after 60 mins |
Bioorg Med Chem Lett 26: 5568-5572 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.075 BindingDB Entry DOI: 10.7270/Q29S1T0N |
More data for this Ligand-Target Pair | |