BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Beta-glucuronidase' and Ligand = 'BDBM163640'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-glucuronidase (Escherichia coli (Enterobacteria))	BDBM163640 (5,11Dimethyl3(piperazin1yl)8thia4,6diazatricyclo[7...) Show SMILES CC1CCc2c(C1)sc1nc(C)nc(N3CCNCC3)c21 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill					Assay Description Reactions were conducted similarly to the kinetic assays but the reaction consisted of 10 �L assay buffer, 5 �L inhibitor solution, 5 �L of 10 nM enz...				Chem Biol 22: 1238-49 (2015) Article DOI: 10.1016/j.chembiol.2015.08.005 BindingDB Entry DOI: 10.7270/Q2Q52NCD
University of North Carolina at Chapel Hill					More data for this Ligand-Target Pair
Beta-glucuronidase (Homo sapiens (Human))	BDBM163640 (5,11Dimethyl3(piperazin1yl)8thia4,6diazatricyclo[7...) Show SMILES CC1CCc2c(C1)sc1nc(C)nc(N3CCNCC3)c21 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	213	n/a	n/a	n/a	n/a	n/a	n/a
The University of North Carolina at Chapel Hill US Patent					Assay Description PheG Assay: Two �-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...				US Patent US9334288 (2016) BindingDB Entry DOI: 10.7270/Q270809V
The University of North Carolina at Chapel Hill US Patent					More data for this Ligand-Target Pair
Beta-glucuronidase (Homo sapiens (Human))	BDBM163640 (5,11Dimethyl3(piperazin1yl)8thia4,6diazatricyclo[7...) Show SMILES CC1CCc2c(C1)sc1nc(C)nc(N3CCNCC3)c21 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	231	n/a	n/a	n/a	n/a	n/a	n/a
The University of North Carolina at Chapel Hill US Patent					Assay Description PNPG Assay: Two �-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...				US Patent US9334288 (2016) BindingDB Entry DOI: 10.7270/Q270809V
The University of North Carolina at Chapel Hill US Patent					More data for this Ligand-Target Pair
Beta-glucuronidase (Homo sapiens (Human))	BDBM163640 (5,11Dimethyl3(piperazin1yl)8thia4,6diazatricyclo[7...) Show SMILES CC1CCc2c(C1)sc1nc(C)nc(N3CCNCC3)c21 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	99.9	n/a	n/a	n/a	n/a
The University of North Carolina at Chapel Hill US Patent					Assay Description PheG Assay: Two �-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...				US Patent US9334288 (2016) BindingDB Entry DOI: 10.7270/Q270809V
The University of North Carolina at Chapel Hill US Patent					More data for this Ligand-Target Pair
Beta-glucuronidase (Homo sapiens (Human))	BDBM163640 (5,11Dimethyl3(piperazin1yl)8thia4,6diazatricyclo[7...) Show SMILES CC1CCc2c(C1)sc1nc(C)nc(N3CCNCC3)c21 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	92.4	n/a	n/a	n/a	n/a
The University of North Carolina at Chapel Hill US Patent					Assay Description PNPG Assay: Two �-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...				US Patent US9334288 (2016) BindingDB Entry DOI: 10.7270/Q270809V
The University of North Carolina at Chapel Hill US Patent					More data for this Ligand-Target Pair