Found 309 hits of ic50 for UniProtKB: P22909 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Alpha-2A adrenergic receptor [16-465]
(Rattus norvegicus (rat)) | BDBM50034043
(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)Show SMILES COc1cc(ccc1OCCCN1CCC(CC1)c1noc2cc(F)ccc12)C(C)=O Show InChI InChI=1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3 | PDB
Reactome pathway
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| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst-Roussel Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description
Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand |
J Med Chem 38: 1119-31 (1995)
BindingDB Entry DOI: 10.7270/Q2S75H08 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225293
(CHEBI:5553 | Guanabenz | WY-8678)Show InChI InChI=1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+ | PDB
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KEGG
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| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranes |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50019646
(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)Show InChI InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15) | PDB
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| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb... |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225285
(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
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| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranes |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50226942
(CHEMBL39286)Show SMILES [H][C@@]1(C)c2ccccc2N(C)[C@]1([H])C1=NCCN1 |t:15| Show InChI InChI=1S/C13H17N3/c1-9-10-5-3-4-6-11(10)16(2)12(9)13-14-7-8-15-13/h3-6,9,12H,7-8H2,1-2H3,(H,14,15)/t9-,12+/m1/s1 | PDB
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| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Alpha-2 adrenergic receptor antagonistic activity in rat vas deferens. |
J Med Chem 30: 1555-62 (1987)
BindingDB Entry DOI: 10.7270/Q2NC63FN |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50226153
(CHEMBL545092)Show InChI InChI=1S/C12H14N2O2.BrH/c15-10-4-3-7-8(11(10)16)1-2-9(7)12-13-5-6-14-12;/h3-4,9,15-16H,1-2,5-6H2,(H,13,14);1H | PDB
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| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortex |
J Med Chem 29: 463-7 (1986)
BindingDB Entry DOI: 10.7270/Q26D5W7D |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM34572
(BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...)Show InChI InChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17) | PDB
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| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb... |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50295557
(7-Methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-...)Show SMILES CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13)C(=O)N[C@]1(C)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O |r| Show InChI InChI=1S/C33H37N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39)/t21-,23-,25-,26+,27+,32-,33+/m1/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of specific [3H]prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptor |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225285
(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
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| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
The compound was evaluated for the alpha-2 adrenergic receptor antagonistic activity in rat vas deferens vs clonidine |
J Med Chem 30: 1555-62 (1987)
BindingDB Entry DOI: 10.7270/Q2NC63FN |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50001922
(2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; ...)Show InChI InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16) | PDB
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| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb... |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM30712
(6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimet...)Show InChI InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18) | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranes |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50226155
(CHEMBL543684)Show InChI InChI=1S/C13H16N2O2.BrH/c16-11-5-4-8-9(12(11)17)2-1-3-10(8)13-14-6-7-15-13;/h4-5,10,16-17H,1-3,6-7H2,(H,14,15);1H | PDB
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortex |
J Med Chem 29: 463-7 (1986)
BindingDB Entry DOI: 10.7270/Q26D5W7D |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50070193
(1-((6aR,9R,10aR)-2-tert-Butyl-7-methyl-4,6,6a,7,8,...)Show SMILES CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](Cc3c[nH]c4cc(cc2c34)C(C)(C)C)N(C)C1 Show InChI InChI=1S/C28H43N5O2/c1-8-29-27(35)33(11-9-10-31(5)6)26(34)19-12-21-22-14-20(28(2,3)4)15-23-25(22)18(16-30-23)13-24(21)32(7)17-19/h14-16,19,21,24,30H,8-13,17H2,1-7H3,(H,29,35)/t19-,21-,24-/m1/s1 | PDB
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia & Upjohn S.p.A.-CNS Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]yohimbine from Alpha-2 adrenergic receptor in rat frontal cortex |
Bioorg Med Chem Lett 8: 1117-22 (1999)
BindingDB Entry DOI: 10.7270/Q2M61JF3 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225247
(CHEMBL44558)Show SMILES [H][C@@]12Cc3c[nH]c4cccc(C1OCCN2c1ccccc1)c34 Show InChI InChI=1S/C19H18N2O/c1-2-5-14(6-3-1)21-9-10-22-19-15-7-4-8-16-18(15)13(12-20-16)11-17(19)21/h1-8,12,17,19-20H,9-11H2/t17-,19?/m1/s1 | PDB
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranes |
J Med Chem 27: 1607-13 (1984)
BindingDB Entry DOI: 10.7270/Q2SJ1NT8 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50019646
(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)Show InChI InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15) | PDB
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| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability to inhibit specific binding of [3H]clonidine to alpha-2 adrenergic receptor in rat brain |
J Med Chem 29: 1183-8 (1986)
BindingDB Entry DOI: 10.7270/Q25H7JFF |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM29568
(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | PDB
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Angiotensin I converting enzyme |
J Med Chem 28: 1142-5 (1985)
BindingDB Entry DOI: 10.7270/Q21V5H5W |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50048608
(CHEMBL154488 | Indol-1-yl-pyridin-4-yl-amine)Show InChI InChI=1S/C13H11N3/c1-2-4-13-11(3-1)7-10-16(13)15-12-5-8-14-9-6-12/h1-10H,(H,14,15) | PDB
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst-Roussel Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortex |
J Med Chem 39: 570-81 (1996)
Article DOI: 10.1021/jm9506433
BindingDB Entry DOI: 10.7270/Q2BR8R7K |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225292
(HOE-440 | Symcor Base TTS | Tiamenidine)Show InChI InChI=1S/C8H10ClN3S/c1-5-4-13-7(9)6(5)12-8-10-2-3-11-8/h4H,2-3H2,1H3,(H2,10,11,12) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb... |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50013515
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r| Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 | PDB
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Institut de Pharmacologie (UA 589 CNRS)
Curated by ChEMBL
| Assay Description
Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparation |
J Med Chem 32: 1402-7 (1989)
BindingDB Entry DOI: 10.7270/Q2SQ92M9 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM31046
(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)Show InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19) | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Pharmacologie (UA 589 CNRS)
Curated by ChEMBL
| Assay Description
Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparation |
J Med Chem 32: 1402-7 (1989)
BindingDB Entry DOI: 10.7270/Q2SQ92M9 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225294
(CHEMBL146100)Show InChI InChI=1S/C9H11N3O2/c13-7-2-1-6(5-8(7)14)12-9-10-3-4-11-9/h1-2,5,13-14H,3-4H2,(H2,10,11,12) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Binding affinity against alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb... |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225288
(Tramazoline)Show InChI InChI=1S/C13H17N3/c1-2-6-11-10(4-1)5-3-7-12(11)16-13-14-8-9-15-13/h3,5,7H,1-2,4,6,8-9H2,(H2,14,15,16) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb... |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor/Alpha-1B adrenergic receptor/Alpha-1D adrenergic receptor/Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)-RA...) | BDBM50029051
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Binding affinity against Alpha adrenergic receptor using [3H]dihydroergocryptine radioligand in rat brain homogenate |
J Med Chem 24: 1258-60 (1981)
BindingDB Entry DOI: 10.7270/Q27W6FDS |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225290
(CHEMBL146419)Show InChI InChI=1S/C12H17NO2/c1-13(2)9-4-5-10-8(7-9)3-6-11(14)12(10)15/h3,6,9,14-15H,4-5,7H2,1-2H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranes |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor/Alpha-1B adrenergic receptor/Alpha-1D adrenergic receptor/Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)-RA...) | BDBM50029050
((-)-(R)-epinephrine | (-)-3,4-dihydroxy-alpha-((me...)Show InChI InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Binding affinity against Alpha adrenergic receptor using [3H]dihydroergocryptine radioligand in rat brain homogenate |
J Med Chem 24: 1258-60 (1981)
BindingDB Entry DOI: 10.7270/Q27W6FDS |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225285
(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability to inhibit specific binding of [3H]-clonidine to alpha-2-adrenoceptor. |
J Med Chem 29: 1183-8 (1986)
BindingDB Entry DOI: 10.7270/Q25H7JFF |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225235
(CHEMBL42909)Show InChI InChI=1S/C14H19NO/c1-2-15-9-10-16-14-12-6-4-3-5-11(12)7-8-13(14)15/h3-6,13-14H,2,7-10H2,1H3/t13-,14?/m1/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranes |
J Med Chem 27: 1607-13 (1984)
BindingDB Entry DOI: 10.7270/Q2SJ1NT8 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM31046
(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)Show InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of specific [3H]clonidine binding (0.4 nM) to rat brain membranes Alpha-2 adrenergic receptor |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM30703
(2-(4-tert-butyl-2,6-dimethyl-benzyl)-2-imidazoline...)Show InChI InChI=1S/C16H24N2/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15/h8-9H,6-7,10H2,1-5H3,(H,17,18) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb... |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50048589
(CHEMBL152842 | Indol-1-yl-methyl-pyridin-4-yl-amin...)Show InChI InChI=1S/C14H13N3/c1-16(13-6-9-15-10-7-13)17-11-8-12-4-2-3-5-14(12)17/h2-11H,1H3 | PDB
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Hoechst-Roussel Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortex |
J Med Chem 39: 570-81 (1996)
Article DOI: 10.1021/jm9506433
BindingDB Entry DOI: 10.7270/Q2BR8R7K |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM86053
(B-HT 920 | CAS_101626-70-4 | CHEMBL279085 | NSC_10...)Show InChI InChI=1S/C10H15N3S/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8/h2H,1,3-7H2,(H2,11,12) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb... |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225241
(CHEMBL42242)Show InChI InChI=1S/C14H19NO2/c1-2-15-7-8-17-14-12-9-11(16)5-3-10(12)4-6-13(14)15/h3,5,9,13-14,16H,2,4,6-8H2,1H3/t13-,14?/m1/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranes |
J Med Chem 27: 1607-13 (1984)
BindingDB Entry DOI: 10.7270/Q2SJ1NT8 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM96559
(2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-...)Show InChI InChI=1S/C13H16N2/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13/h1-2,4,6,12H,3,5,7-9H2,(H,14,15) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb... |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50029051
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortex |
J Med Chem 29: 463-7 (1986)
BindingDB Entry DOI: 10.7270/Q26D5W7D |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM31046
(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)Show InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability to inhibit specific binding of [3H]-clonidine to alpha-2-adrenoceptor. |
J Med Chem 29: 1183-8 (1986)
BindingDB Entry DOI: 10.7270/Q25H7JFF |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225248
(CHEMBL42309)Show InChI InChI=1S/C12H15NO2/c14-9-3-1-8-2-4-11-12(10(8)7-9)15-6-5-13-11/h1,3,7,11-14H,2,4-6H2/t11-,12?/m1/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranes |
J Med Chem 27: 1607-13 (1984)
BindingDB Entry DOI: 10.7270/Q2SJ1NT8 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Binding affinity against alpha-2 adrenergic receptor in rat brain using [3H]- clonidine |
J Med Chem 29: 1628-37 (1986)
BindingDB Entry DOI: 10.7270/Q2319TVF |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50017543
((6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,...)Show SMILES CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 |r| Show InChI InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranes |
J Med Chem 27: 1607-13 (1984)
BindingDB Entry DOI: 10.7270/Q2SJ1NT8 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM392076
(US10301272, Example 7/9)Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12 |r,wU:27.28,wD:29.33,(8.76,1.15,;7.67,.06,;6.19,.46,;7.28,1.55,;8.07,-1.42,;6.98,-2.51,;6.59,-4,;8.07,-3.6,;5.5,-2.11,;5.1,-.63,;3.61,-.23,;2.52,-1.32,;1.03,-.92,;.56,.55,;-.98,.55,;-1.46,-.92,;-.21,-1.82,;-.21,-3.36,;-1.55,-4.13,;-2.88,-3.36,;-4.21,-4.13,;-4.21,-5.67,;-2.88,-6.44,;-1.55,-5.67,;-2.07,1.64,;-1.67,3.12,;-3.56,1.24,;-4.65,2.33,;-6.19,2.33,;-6.19,3.87,;-4.65,3.87,;-7.28,4.96,;-6.88,6.44,;-8.76,4.56,;2.92,-2.8,;1.83,-3.89,;2.23,-5.38,;3.72,-5.78,;4.81,-4.69,;4.41,-3.2,)| Show InChI InChI=1S/C30H37N3O5S2/c1-30(2,3)33-40(37,38)25-14-13-23(21-11-7-8-12-22(21)25)26-24(15-18-9-5-4-6-10-18)32-28(39-26)27(34)31-20-16-19(17-20)29(35)36/h7-8,11-14,18-20,33H,4-6,9-10,15-17H2,1-3H3,(H,31,34)(H,35,36)/t19-,20- | PDB
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Phenex Pharmaceuticals AG
Curated by ChEMBL
| Assay Description
Displacement of [3H]-RX 821002 from rat alpha2 adrenoceptor after 60 mins by scintillation counting analysis |
Bioorg Med Chem Lett 28: 1446-1455 (2018)
Article DOI: 10.1016/j.bmcl.2018.03.093
BindingDB Entry DOI: 10.7270/Q27W6FPC |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50019646
(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)Show InChI InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability to inhibit specific binding of [3H]clonidine to alpha-2-adrenoceptor in rat brain |
J Med Chem 29: 1183-8 (1986)
BindingDB Entry DOI: 10.7270/Q25H7JFF |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50019646
(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)Show InChI InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability to inhibit specific binding of [3H]clonidine to alpha-2-adrenoceptor in rat brain |
J Med Chem 29: 1183-8 (1986)
BindingDB Entry DOI: 10.7270/Q25H7JFF |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50226156
(CHEMBL544627)Show InChI InChI=1S/C11H12N2O2.BrH/c14-9-2-1-6-7(10(9)15)5-8(6)11-12-3-4-13-11;/h1-2,8,14-15H,3-5H2,(H,12,13);1H | PDB
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TBA
Curated by ChEMBL
| Assay Description
The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortex |
J Med Chem 29: 463-7 (1986)
BindingDB Entry DOI: 10.7270/Q26D5W7D |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225250
(CHEMBL42237)Show InChI InChI=1S/C15H21NO/c1-2-9-16-10-11-17-15-13-6-4-3-5-12(13)7-8-14(15)16/h3-6,14-15H,2,7-11H2,1H3/t14-,15?/m1/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranes |
J Med Chem 27: 1607-13 (1984)
BindingDB Entry DOI: 10.7270/Q2SJ1NT8 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225251
(CHEMBL295359)Show InChI InChI=1S/C14H19NO2/c1-2-15-8-9-17-14-11-4-3-5-13(16)10(11)6-7-12(14)15/h3-5,12,14,16H,2,6-9H2,1H3/t12-,14?/m1/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranes |
J Med Chem 27: 1607-13 (1984)
BindingDB Entry DOI: 10.7270/Q2SJ1NT8 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50027060
(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)Show InChI InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]-clonidine binding (0.4 nM) to rat isolated brain mem... |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranes |
J Med Chem 27: 1607-13 (1984)
BindingDB Entry DOI: 10.7270/Q2SJ1NT8 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225234
(CHEMBL41980)Show InChI InChI=1S/C13H17NO2/c1-14-6-7-16-13-11-8-10(15)4-2-9(11)3-5-12(13)14/h2,4,8,12-13,15H,3,5-7H2,1H3/t12-,13?/m1/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranes |
J Med Chem 27: 1607-13 (1984)
BindingDB Entry DOI: 10.7270/Q2SJ1NT8 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50067212
(CHEBI:8093 | Cyclomydril | Duo-Medihaler | Phenyle...)Show InChI InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1 | PDB
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Reckitt& Colman plc
Curated by ChEMBL
| Assay Description
Inhibitory activity against Alpha-2 adrenergic receptor in rat vas deferens |
J Med Chem 32: 1627-30 (1989)
BindingDB Entry DOI: 10.7270/Q28S4S4V |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50070186
(1-Acetyl-3-((6aR,9S,10aR)-7-methyl-4,6,6a,7,8,9,10...)Show SMILES CN1C[C@H](CNC(=S)NC(C)=O)C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 Show InChI InChI=1S/C19H24N4OS/c1-11(24)22-19(25)21-8-12-6-15-14-4-3-5-16-18(14)13(9-20-16)7-17(15)23(2)10-12/h3-5,9,12,15,17,20H,6-8,10H2,1-2H3,(H2,21,22,24,25)/t12-,15+,17+/m0/s1 | PDB
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Pharmacia & Upjohn S.p.A.-CNS Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]yohimbine from Alpha-2 adrenergic receptor in rat frontal cortex |
Bioorg Med Chem Lett 8: 1117-22 (1999)
BindingDB Entry DOI: 10.7270/Q2M61JF3 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50026553
((+)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene...)Show InChI InChI=1S/C16H25NO2/c1-3-9-17(10-4-2)13-6-7-14-12(11-13)5-8-15(18)16(14)19/h5,8,13,18-19H,3-4,6-7,9-11H2,1-2H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of specific [3H]prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptor |
J Med Chem 27: 495-503 (1984)
BindingDB Entry DOI: 10.7270/Q24B31WH |
More data for this
Ligand-Target Pair | |
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