Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19284 (Acridone-Based Inhibitor, 4h | N-{2-[3-(dimethylsu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.90 | n/a | 380 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19279 (2-fluoro-9-oxo-N-[2-(pyridin-3-yl)propan-2-yl]-9,1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | 420 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19281 (2-fluoro-N-[2-(4-methanesulfonylphenyl)propan-2-yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 12 | n/a | 480 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19264 ((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 16 | n/a | 540 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19280 (Acridone-Based Inhibitor, 4d | N-(2-{4-[2-(dimethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 20 | n/a | 560 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19282 (2-fluoro-N-[2-(3-methanesulfonylphenyl)propan-2-yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 12 | n/a | 580 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19288 (Acridone-Based Inhibitor, 4l | N-{2-[2-(dimethylam...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 14 | n/a | 640 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19283 (Acridone-Based Inhibitor, 4g | N-{2-[4-(dimethylsu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | 660 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19290 (2-fluoro-N-{2-[6-(morpholin-4-yl)pyridin-3-yl]prop...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | 660 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19286 (2-fluoro-N-[2-(6-methylpyridin-3-yl)propan-2-yl]-9...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 23 | n/a | 750 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19289 (Acridone-Based Inhibitor, 4m | BMS-566419 | N-{2-[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | 770 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19291 (2-fluoro-N-{2-[5-methoxy-6-(morpholin-4-yl)pyridin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 20 | n/a | 810 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19277 (2-fluoro-9-oxo-N-(2-phenylpropan-2-yl)-9,10-dihydr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | 830 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19287 (Acridone-Based Inhibitor, 4k | N-{2-[6-(dimethylam...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 22 | n/a | 850 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19292 (2-fluoro-N-{2-[5-methyl-6-(morpholin-4-yl)pyridin-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 11 | n/a | 870 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19285 (2-fluoro-9-oxo-N-(2-{2H,3H,4H-pyrido[3,2-b][1,4]ox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 17 | n/a | 920 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19278 (2-fluoro-9-oxo-N-[2-(pyridin-2-yl)propan-2-yl]-9,1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 29 | n/a | 1.00E+3 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19270 (9-oxo-N-(2-phenylpropan-2-yl)-9,10-dihydroacridine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 19 | n/a | 2.10E+3 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19274 (9-oxo-N-[2-(pyridin-2-yl)propan-2-yl]-9,10-dihydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 53 | n/a | 2.20E+3 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19275 (9-oxo-N-[2-(pyridin-3-yl)propan-2-yl]-9,10-dihydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 42 | n/a | 2.20E+3 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19276 (9-oxo-N-[2-(pyridin-4-yl)propan-2-yl]-9,10-dihydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 53 | n/a | 2.30E+3 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19269 (Acridone-Based Inhibitor, 8a | N-tert-butyl-9-oxo-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 59 | n/a | 3.30E+3 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM19268 (Acridone-Based Inhibitor, 3 | ethyl 9-oxo-9,10-dih...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 59 | n/a | >1.00E+4 | n/a | n/a | 8.0 | 25 |
Bristol-Myers Squibb Company | Assay Description Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b... | J Med Chem 50: 3730-42 (2007) Article DOI: 10.1021/jm070299x BindingDB Entry DOI: 10.7270/Q2N58JPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase 2 (Homo sapiens (Human)) | BDBM50294184 (CHEMBL561640 | N-(4-chlorophenyl)-2-phenoxypropana...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a |
Brandeis University Curated by ChEMBL | Assay Description Inhibition of human recombinant IMPDH2 expressed in Escherichia coli guaB assessed as NADH production by fluorescence assay | J Med Chem 52: 4623-30 (2009) Article DOI: 10.1021/jm900410u BindingDB Entry DOI: 10.7270/Q2HM59C1 | |||||||||||
More data for this Ligand-Target Pair |