Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Polyunsaturated fatty acid lipoxygenase ALOX15 (Rattus norvegicus) | BDBM50011938 (2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid 2-th...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biomedical Research Curated by ChEMBL | Assay Description Inhibitory activity of the compound against 12-lipoxygenase in rat platelet rich plasma | J Med Chem 34: 1503-5 (1991) BindingDB Entry DOI: 10.7270/Q22Z14G6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Rattus norvegicus) | BDBM50009001 (5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biomedical Research Curated by ChEMBL | Assay Description Inhibitory activity of the compound against 12-lipoxygenase in rat platelet rich plasma | J Med Chem 34: 1503-5 (1991) BindingDB Entry DOI: 10.7270/Q22Z14G6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Rattus norvegicus) | BDBM50011932 (2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid ethy...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biomedical Research Curated by ChEMBL | Assay Description Inhibitory activity of the compound against 12-lipoxygenase in rat platelet rich plasma | J Med Chem 34: 1503-5 (1991) BindingDB Entry DOI: 10.7270/Q22Z14G6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM50054838 (3-(4-Tridec-2-ynyloxymethyl-phenyl)-propionic acid...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg... | J Med Chem 39: 4871-8 (1997) Article DOI: 10.1021/jm9606047 BindingDB Entry DOI: 10.7270/Q2BR8R81 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM50054833 (3-{4-[((E)-Tridec-2-enyl)oxymethyl]-phenyl}-propio...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg... | J Med Chem 39: 4871-8 (1997) Article DOI: 10.1021/jm9606047 BindingDB Entry DOI: 10.7270/Q2BR8R81 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM50054836 ((4-Tridec-2-ynyloxymethyl-phenyl)-acetic acid | CH...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg... | J Med Chem 39: 4871-8 (1997) Article DOI: 10.1021/jm9606047 BindingDB Entry DOI: 10.7270/Q2BR8R81 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Rattus norvegicus) | BDBM50011934 (2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid phen...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biomedical Research Curated by ChEMBL | Assay Description Inhibitory activity of the compound against 12-lipoxygenase in rat platelet rich plasma | J Med Chem 34: 1503-5 (1991) BindingDB Entry DOI: 10.7270/Q22Z14G6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Rattus norvegicus) | BDBM50011930 (2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid 3-ph...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biomedical Research Curated by ChEMBL | Assay Description Inhibitory activity of the compound against 12-lipoxygenase in rat platelet rich plasma | J Med Chem 34: 1503-5 (1991) BindingDB Entry DOI: 10.7270/Q22Z14G6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM50114094 (4-bromo-5-[(2R,3S)-4-(2-bromo-4,5-dihydroxyphenyl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibitory activity against soybean 1-lipoxygenase (SLO) | J Med Chem 45: 2659-61 (2002) BindingDB Entry DOI: 10.7270/Q2GT5NWN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM50054851 (4-Tridec-2-ynyloxymethyl-benzoic acid | CHEMBL1422...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg... | J Med Chem 39: 4871-8 (1997) Article DOI: 10.1021/jm9606047 BindingDB Entry DOI: 10.7270/Q2BR8R81 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Rattus norvegicus) | BDBM50011931 ((2E)‐3‐phenylprop‐2‐enR...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biomedical Research Curated by ChEMBL | Assay Description Inhibitory activity of the compound against 12-lipoxygenase in rat platelet rich plasma | J Med Chem 34: 1503-5 (1991) BindingDB Entry DOI: 10.7270/Q22Z14G6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Rattus norvegicus) | BDBM50011935 (2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid 2-(2...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biomedical Research Curated by ChEMBL | Assay Description Inhibitory activity of the compound against 12-lipoxygenase in rat platelet rich plasma | J Med Chem 34: 1503-5 (1991) BindingDB Entry DOI: 10.7270/Q22Z14G6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM50114093 (4-chloro-5-[(2R,3S)-4-(2-chloro-4,5-dihydroxypheny...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibitory activity against soybean 1-lipoxygenase (SLO) | J Med Chem 45: 2659-61 (2002) BindingDB Entry DOI: 10.7270/Q2GT5NWN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM50109702 (CHEMBL3604174) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Inhibition of pig 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arach... | Bioorg Med Chem Lett 25: 3024-9 (2015) Article DOI: 10.1016/j.bmcl.2015.05.004 BindingDB Entry DOI: 10.7270/Q2R21350 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM22364 (1,3-Diarylprop-2-yn-1-one, 23a | 1-(4-hydroxy-3-me...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description In vitro inhibitory activity against 15-lipoxygenase obtained from soybean | Bioorg Med Chem Lett 15: 4842-5 (2005) Article DOI: 10.1016/j.bmcl.2005.07.036 BindingDB Entry DOI: 10.7270/Q2RJ4K7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM22364 (1,3-Diarylprop-2-yn-1-one, 23a | 1-(4-hydroxy-3-me...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta | Assay Description The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen... | J Med Chem 49: 1668-83 (2006) Article DOI: 10.1021/jm0510474 BindingDB Entry DOI: 10.7270/Q2DV1H5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM50054840 (3-(4-Undec-2-ynyloxymethyl-phenyl)-propionic acid ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg... | J Med Chem 39: 4871-8 (1997) Article DOI: 10.1021/jm9606047 BindingDB Entry DOI: 10.7270/Q2BR8R81 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM50114096 (4-ethyl-5-[4-(2-ethyl-4,5-dihydroxyphenyl)-2,3-dim...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibitory activity against soybean 1-lipoxygenase (SLO) | J Med Chem 45: 2659-61 (2002) BindingDB Entry DOI: 10.7270/Q2GT5NWN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM50114097 (4-[4-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)-2,3-di...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibitory activity against soybean 1-lipoxygenase (SLO) | J Med Chem 45: 2659-61 (2002) BindingDB Entry DOI: 10.7270/Q2GT5NWN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM50065996 (4-[(2S,3R)-4-(4-Hydroxy-3-methoxy-phenyl)-2,3-dime...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibitory activity against soybean 1-lipoxygenase (SLO) | J Med Chem 45: 2659-61 (2002) BindingDB Entry DOI: 10.7270/Q2GT5NWN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Rattus norvegicus) | BDBM50011937 (2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid 8-(3...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biomedical Research Curated by ChEMBL | Assay Description Inhibitory activity of the compound against 12-lipoxygenase in rat platelet rich plasma | J Med Chem 34: 1503-5 (1991) BindingDB Entry DOI: 10.7270/Q22Z14G6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM22372 (4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibitory activity against soybean 1-lipoxygenase (SLO) | J Med Chem 45: 2659-61 (2002) BindingDB Entry DOI: 10.7270/Q2GT5NWN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM50054844 (3-(4-Tetradeca-2,3-dienyloxymethyl-phenyl)-propion...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg... | J Med Chem 39: 4871-8 (1997) Article DOI: 10.1021/jm9606047 BindingDB Entry DOI: 10.7270/Q2BR8R81 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM469007 (US10807974, Example 16 | US10995088, Example 16 | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.Assay Plates:Black, flat bottom 96 well platesProcedure:1. Dilute LOX en... | Citation and Details BindingDB Entry DOI: 10.7270/Q25M69MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM22365 (1,3-Diarylprop-2-yn-1-one, 23b | 1-(3-hydroxy-4-me...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description In vitro inhibitory activity against 15-lipoxygenase obtained from soybean | Bioorg Med Chem Lett 15: 4842-5 (2005) Article DOI: 10.1016/j.bmcl.2005.07.036 BindingDB Entry DOI: 10.7270/Q2RJ4K7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM22356 (1,3-Diarylprop-2-yn-1-one, 13m | 1-(3-hydroxypheny...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description In vitro inhibitory activity against 5-lipoxygenase obtained from potato | Bioorg Med Chem Lett 15: 4842-5 (2005) Article DOI: 10.1016/j.bmcl.2005.07.036 BindingDB Entry DOI: 10.7270/Q2RJ4K7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM22354 (1,3-Diarylprop-2-yn-1-one, 13k | 1-(4-hydroxypheny...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description In vitro inhibitory activity against 5-lipoxygenase obtained from potato | Bioorg Med Chem Lett 15: 4842-5 (2005) Article DOI: 10.1016/j.bmcl.2005.07.036 BindingDB Entry DOI: 10.7270/Q2RJ4K7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Rattus norvegicus) | BDBM50016680 (5-Phenyl-pentanoic acid benzyl-hydroxy-amide | CHE...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Rorer Central Research Curated by ChEMBL | Assay Description Invitro inhibition of rat platelet 12-lipoxygenase | J Med Chem 32: 1836-42 (1989) BindingDB Entry DOI: 10.7270/Q2VT1R21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM22365 (1,3-Diarylprop-2-yn-1-one, 23b | 1-(3-hydroxy-4-me...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta | Assay Description The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen... | J Med Chem 49: 1668-83 (2006) Article DOI: 10.1021/jm0510474 BindingDB Entry DOI: 10.7270/Q2DV1H5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM22363 (1,3-Diarylprop-2-yn-1-one, 17c | 3-(4-methanesulfo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta | Assay Description The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen... | J Med Chem 49: 1668-83 (2006) Article DOI: 10.1021/jm0510474 BindingDB Entry DOI: 10.7270/Q2DV1H5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM50054846 (3-(4-Pentadec-2-ynyloxymethyl-phenyl)-propionic ac...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg... | J Med Chem 39: 4871-8 (1997) Article DOI: 10.1021/jm9606047 BindingDB Entry DOI: 10.7270/Q2BR8R81 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM22354 (1,3-Diarylprop-2-yn-1-one, 13k | 1-(4-hydroxypheny...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description In vitro inhibitory activity against 15-lipoxygenase obtained from soybean | Bioorg Med Chem Lett 15: 4842-5 (2005) Article DOI: 10.1016/j.bmcl.2005.07.036 BindingDB Entry DOI: 10.7270/Q2RJ4K7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM50054832 (3-(3-Tridec-2-ynyloxymethyl-phenyl)-propionic acid...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg... | J Med Chem 39: 4871-8 (1997) Article DOI: 10.1021/jm9606047 BindingDB Entry DOI: 10.7270/Q2BR8R81 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM22354 (1,3-Diarylprop-2-yn-1-one, 13k | 1-(4-hydroxypheny...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta | Assay Description The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen... | J Med Chem 49: 1668-83 (2006) Article DOI: 10.1021/jm0510474 BindingDB Entry DOI: 10.7270/Q2DV1H5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM469005 (US10807974, Example 9 | US10995088, Example 9 | US...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.Assay Plates:Black, flat bottom 96 well platesProcedure:1. Dilute LOX en... | Citation and Details BindingDB Entry DOI: 10.7270/Q25M69MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM22370 (1,3-Diarylprop-2-yn-1-one, 27 | 3-(4-methanesulfon...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta | Assay Description The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen... | J Med Chem 49: 1668-83 (2006) Article DOI: 10.1021/jm0510474 BindingDB Entry DOI: 10.7270/Q2DV1H5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM22348 (1,3-Diarylprop-2-yn-1-one, 13e | 3-(4-methanesulfo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta | Assay Description The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen... | J Med Chem 49: 1668-83 (2006) Article DOI: 10.1021/jm0510474 BindingDB Entry DOI: 10.7270/Q2DV1H5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM469011 (US10807974, Example 27 | US10995088, Example 27 | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.Assay Plates:Black, flat bottom 96 well platesProcedure:1. Dilute LOX en... | Citation and Details BindingDB Entry DOI: 10.7270/Q25M69MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Rattus norvegicus) | BDBM50016675 (CHEMBL55053 | N-Hydroxy-N-phenethyl-4-phenyl-butyr...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Rorer Central Research Curated by ChEMBL | Assay Description Invitro inhibition of rat platelet 12-lipoxygenase | J Med Chem 32: 1836-42 (1989) BindingDB Entry DOI: 10.7270/Q2VT1R21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM50135282 (CHEMBL3746867) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Lomonosov Moscow State University Curated by ChEMBL | Assay Description Inhibition of soybean LOX1 assessed as reduction in linoleic acid oxidation measured every 10 s for 10 mins by spectrophotometry analysis | Bioorg Med Chem 24: 712-20 (2016) Article DOI: 10.1016/j.bmc.2015.12.040 BindingDB Entry DOI: 10.7270/Q28C9Z37 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM22352 (1,3-Diarylprop-2-yn-1-one, 13i | 1-(3,4-difluoroph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description In vitro inhibitory activity against 5-lipoxygenase obtained from potato | Bioorg Med Chem Lett 15: 4842-5 (2005) Article DOI: 10.1016/j.bmcl.2005.07.036 BindingDB Entry DOI: 10.7270/Q2RJ4K7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM469032 (US10807974, Example 43 | US10995088, Example 43 | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.Assay Plates:Black, flat bottom 96 well platesProcedure:1. Dilute LOX en... | Citation and Details BindingDB Entry DOI: 10.7270/Q25M69MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM469023 (US10807974, Example 39 | US10995088, Example 39 | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.Assay Plates:Black, flat bottom 96 well platesProcedure:1. Dilute LOX en... | Citation and Details BindingDB Entry DOI: 10.7270/Q25M69MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM469008 (US10807974, Example 17 | US10995088, Example 17 | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.Assay Plates:Black, flat bottom 96 well platesProcedure:1. Dilute LOX en... | Citation and Details BindingDB Entry DOI: 10.7270/Q25M69MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM469019 (US10807974, Example 35 | US10995088, Example 35 | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.Assay Plates:Black, flat bottom 96 well platesProcedure:1. Dilute LOX en... | Citation and Details BindingDB Entry DOI: 10.7270/Q25M69MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Rattus norvegicus) | BDBM50011933 (2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid 4-ph...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biomedical Research Curated by ChEMBL | Assay Description Inhibitory activity of the compound against 12-lipoxygenase in rat platelet rich plasma | J Med Chem 34: 1503-5 (1991) BindingDB Entry DOI: 10.7270/Q22Z14G6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Rattus norvegicus) | BDBM50011936 (2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid 3-py...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biomedical Research Curated by ChEMBL | Assay Description Inhibitory activity of the compound against 12-lipoxygenase in rat platelet rich plasma | J Med Chem 34: 1503-5 (1991) BindingDB Entry DOI: 10.7270/Q22Z14G6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM469024 (US10807974, Example 40 | US10995088, Example 40 | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.Assay Plates:Black, flat bottom 96 well platesProcedure:1. Dilute LOX en... | Citation and Details BindingDB Entry DOI: 10.7270/Q25M69MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Sus scrofa) | BDBM469004 (US10807974, Example 5 | US10995088, Example 5 | US...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.Assay Plates:Black, flat bottom 96 well platesProcedure:1. Dilute LOX en... | Citation and Details BindingDB Entry DOI: 10.7270/Q25M69MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Rattus norvegicus) | BDBM50016682 (CHEMBL53028 | N-Benzyl-N-hydroxy-4-phenyl-butyrami...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Rorer Central Research Curated by ChEMBL | Assay Description Invitro inhibition of rat platelet 12-lipoxygenase | J Med Chem 32: 1836-42 (1989) BindingDB Entry DOI: 10.7270/Q2VT1R21 | |||||||||||
More data for this Ligand-Target Pair |
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