BindingDB PrimarySearch

Found 92 hits of ec50 for UniProtKB: P31645
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM30132 (CHEMBL450907 \| tetrahydrofuranyl ethylamine, 15) Show SMILES COc1ccc(F)cc1CCCC1CCC(CCN)O1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.10	-12.1	n/a	n/a	2.30	n/a	n/a	7.4	22
Human BioMolecular Research Institute					Assay Description Binding affinity of each compound was measured by assessing the potency of inhibition of binding of radiolabeled RTI-55. Membranes were preincubated ...				J Med Chem 52: 1530-9 (2009) Article DOI: 10.1021/jm8010993 BindingDB Entry DOI: 10.7270/Q2MK6B7M
Human BioMolecular Research Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM30131 (tetrahydrofuranyl ethylamine, 14) Show SMILES COc1ccc(F)cc1CCC1CCC(CCN)O1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	2.10	-11.7	n/a	n/a	2.5	n/a	n/a	7.4	22
Human BioMolecular Research Institute					Assay Description Binding affinity of each compound was measured by assessing the potency of inhibition of binding of radiolabeled RTI-55. Membranes were preincubated ...				J Med Chem 52: 1530-9 (2009) Article DOI: 10.1021/jm8010993 BindingDB Entry DOI: 10.7270/Q2MK6B7M
Human BioMolecular Research Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM30130 (CHEMBL1201082 \| CHEMBL41 \| Fluoxetin \| Fluoxetine ...) Show SMILES CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	2.70	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human SERT-mediated serotonin reuptake in HEK293 cells				ACS Med Chem Lett 2: 656-661 (2011) Article DOI: 10.1021/ml2000033 BindingDB Entry DOI: 10.7270/Q2S75HBR
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM30130 (CHEMBL1201082 \| CHEMBL41 \| Fluoxetin \| Fluoxetine ...) Show SMILES CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	1.10	-12.1	n/a	n/a	7.30	n/a	n/a	7.4	22
Human BioMolecular Research Institute					Assay Description Binding affinity of each compound was measured by assessing the potency of inhibition of binding of radiolabeled RTI-55. Membranes were preincubated ...				J Med Chem 52: 1530-9 (2009) Article DOI: 10.1021/jm8010993 BindingDB Entry DOI: 10.7270/Q2MK6B7M
Human BioMolecular Research Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM30133 (tetrahydrofuranyl ethylamine, 24) Show SMILES CNCCC1CCC(CCc2cc(F)ccc2OC)O1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	21.2	-10.4	n/a	n/a	18.4	n/a	n/a	7.4	22
Human BioMolecular Research Institute					Assay Description Binding affinity of each compound was measured by assessing the potency of inhibition of binding of radiolabeled RTI-55. Membranes were preincubated ...				J Med Chem 52: 1530-9 (2009) Article DOI: 10.1021/jm8010993 BindingDB Entry DOI: 10.7270/Q2MK6B7M
Human BioMolecular Research Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50236718 (CHEMBL4094396) Show SMILES CNC(C)C(=O)c1ccc(C)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	118	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Inhibition of [3H]dopamine uptake in HEK cells expressing human Dopamine transporter				J Med Chem 60: 2605-2628 (2017) Article DOI: 10.1021/acs.jmedchem.7b00085 BindingDB Entry DOI: 10.7270/Q2DJ5HWM
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM30128 (phthalazinone, 21) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	156	-9.19	n/a	n/a	127	n/a	n/a	7.4	22
Human BioMolecular Research Institute					Assay Description Binding affinity of each compound was measured by assessing the potency of inhibition of binding of radiolabeled RTI-55. Membranes were preincubated ...				J Med Chem 52: 1530-9 (2009) Article DOI: 10.1021/jm8010993 BindingDB Entry DOI: 10.7270/Q2MK6B7M
Human BioMolecular Research Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50299798 (4-(2-(3-chlorophenoxy)phenyl)piperidine \| CHEMBL57...) Show SMILES Clc1cccc(Oc2ccccc2C2CCNCC2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	186	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells				Bioorg Med Chem Lett 19: 6604-7 (2009) Article DOI: 10.1016/j.bmcl.2009.10.014 BindingDB Entry DOI: 10.7270/Q23B606Z
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50236725 (CHEMBL4061726) Show SMILES CNC(C)C(=O)c1ccc(cc1)C(F)(F)F Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	190	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Activity at SERT (unknown origin) assessed as release of [3H]HT				J Med Chem 60: 2605-2628 (2017) Article DOI: 10.1021/acs.jmedchem.7b00085 BindingDB Entry DOI: 10.7270/Q2DJ5HWM
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM30129 (phthalazinone, 22) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	194	-9.06	n/a	n/a	194	n/a	n/a	7.4	22
Human BioMolecular Research Institute					Assay Description Binding affinity of each compound was measured by assessing the potency of inhibition of binding of radiolabeled RTI-55. Membranes were preincubated ...				J Med Chem 52: 1530-9 (2009) Article DOI: 10.1021/jm8010993 BindingDB Entry DOI: 10.7270/Q2MK6B7M
Human BioMolecular Research Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22418 (Cocaine \| Cocaine (-) \| methyl (1R,2R,3S,5S)-3-(be...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	601	n/a	n/a	n/a	318	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22409 (5-(4-chlorophenyl)-2-[(1R,2S,3S,5S)-8-methyl-3-(4-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.32E+3	n/a	n/a	n/a	377	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50309519 (2-(2-chloro-6-fluorophenoxy)-3-(piperidin-4-yl)pyr...) Show SMILES Fc1cccc(Cl)c1Oc1ncccc1C1CCNCC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	409	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at SERT				Bioorg Med Chem Lett 20: 1114-7 (2010) Article DOI: 10.1016/j.bmcl.2009.12.023 BindingDB Entry DOI: 10.7270/Q2NS0V17
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22418 (Cocaine \| Cocaine (-) \| methyl (1R,2R,3S,5S)-3-(be...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	276	-8.85	n/a	n/a	416	n/a	n/a	7.4	22
Human BioMolecular Research Institute					Assay Description Binding affinity of each compound was measured by assessing the potency of inhibition of binding of radiolabeled RTI-55. Membranes were preincubated ...				J Med Chem 52: 1530-9 (2009) Article DOI: 10.1021/jm8010993 BindingDB Entry DOI: 10.7270/Q2MK6B7M
Human BioMolecular Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50309505 (4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine \|...) Show SMILES Fc1ccccc1Oc1cccc(F)c1C1CCNCC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	915	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at SERT				Bioorg Med Chem Lett 20: 1114-7 (2010) Article DOI: 10.1016/j.bmcl.2009.12.023 BindingDB Entry DOI: 10.7270/Q2NS0V17
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50299783 (4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine \|...) Show SMILES Fc1cccc(Oc2cccc(F)c2C2CCNCC2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	915	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells				Bioorg Med Chem Lett 19: 6604-7 (2009) Article DOI: 10.1016/j.bmcl.2009.10.014 BindingDB Entry DOI: 10.7270/Q23B606Z
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50010588 ((RS)-3,4-(methylenedioxy)methamphetamine \| 1-(1,3-...) Show SMILES CNC(C)Cc1ccc2OCOc2c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to human SERT expressed in HEK293 cells assessed as induction of [3H]5-HT release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22399 (2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	653	n/a	n/a	n/a	1.01E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50299788 (4-(2-(3-fluorophenoxy)phenyl)piperidine \| CHEMBL58...) Show SMILES Fc1cccc(Oc2ccccc2C2CCNCC2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells				Bioorg Med Chem Lett 19: 6604-7 (2009) Article DOI: 10.1016/j.bmcl.2009.10.014 BindingDB Entry DOI: 10.7270/Q23B606Z
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50234225 (CHEMBL4083258) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a
3D-2drug, LLC Curated by ChEMBL					Assay Description Inhibition of [3H]-S-citalopram dissociation from human SERT allosteric modulator site (S2) expressed in African green monkey COS7 cell membranes aft...				Bioorg Med Chem Lett 27: 470-478 (2017) Article DOI: 10.1016/j.bmcl.2016.12.037 BindingDB Entry DOI: 10.7270/Q2X63Q6K
3D-2drug, LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22404 (2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	740	n/a	n/a	n/a	1.61E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50299792 (4-(3-fluoro-2-phenoxyphenyl)piperidine \| CHEMBL583...) Show SMILES Fc1cccc(C2CCNCC2)c1Oc1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.76E+3	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells				Bioorg Med Chem Lett 19: 6604-7 (2009) Article DOI: 10.1016/j.bmcl.2009.10.014 BindingDB Entry DOI: 10.7270/Q23B606Z
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50022723 ((+)-(S)-amphetamine \| (+)-alpha-methylphenethylami...) Show SMILES C[C@H](N)Cc1ccccc1 \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.77E+3	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Inhibition of [3H]5-HT uptake at human SERT cloned in rat brain synaptosome by scintillation counting				Bioorg Med Chem 19: 7044-8 (2011) Article DOI: 10.1016/j.bmc.2011.10.007 BindingDB Entry DOI: 10.7270/Q2765FR0
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22419 (5-(4-bromophenyl)-2-[(1R,2S,3S,5S)-8-methyl-3-(4-m...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.87E+3	n/a	n/a	n/a	1.84E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50023181 (CHEMBL3298876) Show SMILES CCNC(C)C(=O)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.12E+3	n/a	n/a	n/a	n/a
RTI International Curated by ChEMBL					Assay Description Induction of SERT (unknown origin)-mediated serotonin release				ACS Med Chem Lett 5: 623-7 (2014) Article DOI: 10.1021/ml500113s BindingDB Entry DOI: 10.7270/Q2FN17SS
RTI International Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22412 (2-[(1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-aza...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	580	n/a	n/a	n/a	2.38E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22398 (2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.67E+3	n/a	n/a	n/a	2.71E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50234232 (CHEMBL4097442) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a
3D-2drug, LLC Curated by ChEMBL					Assay Description Inhibition of [3H]-S-citalopram dissociation from human SERT allosteric modulator site (S2) expressed in African green monkey COS7 cell membranes aft...				Bioorg Med Chem Lett 27: 470-478 (2017) Article DOI: 10.1016/j.bmcl.2016.12.037 BindingDB Entry DOI: 10.7270/Q2X63Q6K
3D-2drug, LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50299797 (1-(2-(benzyloxy)phenyl)piperazine \| CHEMBL582928) Show SMILES C(Oc1ccccc1N1CCNCC1)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.93E+3	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells				Bioorg Med Chem Lett 19: 6604-7 (2009) Article DOI: 10.1016/j.bmcl.2009.10.014 BindingDB Entry DOI: 10.7270/Q23B606Z
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50476262 (CHEMBL224476) Show SMILES C[N+](C)(C)CCSS(C)(=O)=O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.16E+3	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Decrease in [3H]5-HT uptake at human SERT G498C mutant transfected in HEK293 cells				Bioorg Med Chem 15: 305-11 (2007) Article DOI: 10.1016/j.bmc.2006.09.058 BindingDB Entry DOI: 10.7270/Q2DV1NNQ
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22411 (2-[(1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-aza...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.64E+3	n/a	n/a	n/a	3.17E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22408 (5-(4-fluorophenyl)-2-[(1R,2S,3S,5S)-8-methyl-3-(4-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.72E+3	n/a	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22403 (2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.82E+3	n/a	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22410 (5-(3-bromophenyl)-2-[(1R,2S,3S,5S)-8-methyl-3-(4-m...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	870	n/a	n/a	n/a	3.86E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM86285 (CAS_1576 \| Methcathinone, (-) \| NSC_1576) Show SMILES CNC(C)C(=O)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.86E+3	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Activity at SERT (unknown origin) assessed as release of [3H]HT				J Med Chem 60: 2605-2628 (2017) Article DOI: 10.1021/acs.jmedchem.7b00085 BindingDB Entry DOI: 10.7270/Q2DJ5HWM
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50476261 (4-(1-Methylpyridinium)Phenylmethanethiosulphonate ...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Decrease in [3H]5-HT uptake at human SERT G498C mutant transfected in HEK293 cells				Bioorg Med Chem 15: 305-11 (2007) Article DOI: 10.1016/j.bmc.2006.09.058 BindingDB Entry DOI: 10.7270/Q2DV1NNQ
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22402 (5-(3-bromophenyl)-2-[(1R,2S,3S,5S)-3-(4-chlorophen...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.50E+3	n/a	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22400 (5-(4-chlorophenyl)-2-[(1R,2S,3S,5S)-3-(4-chlorophe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.39E+3	n/a	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22414 (5-(3,4-dichlorophenyl)-2-[(1R,2S,3S,5S)-8-methyl-3...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.94E+3	n/a	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50302225 ((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a
3D-2drug, LLC Curated by ChEMBL					Assay Description Inhibition of [3H]-S-citalopram dissociation from SERT allosteric modulator site (S2) (unknown origin) expressed in African green monkey COS1 cell me...				Bioorg Med Chem Lett 27: 470-478 (2017) Article DOI: 10.1016/j.bmcl.2016.12.037 BindingDB Entry DOI: 10.7270/Q2X63Q6K
3D-2drug, LLC Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22406 (2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.71E+3	n/a	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50302225 ((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a
3D-2drug, LLC Curated by ChEMBL					Assay Description Inhibition of [3H]-S-citalopram dissociation from human SERT allosteric modulator site (S2) expressed in African green monkey COS7 cell membranes aft...				Bioorg Med Chem Lett 27: 470-478 (2017) Article DOI: 10.1016/j.bmcl.2016.12.037 BindingDB Entry DOI: 10.7270/Q2X63Q6K
3D-2drug, LLC Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50234222 (CHEMBL4100796) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a
3D-2drug, LLC Curated by ChEMBL					Assay Description Inhibition of [3H]-S-citalopram dissociation from human SERT allosteric modulator site (S2) expressed in African green monkey COS7 cell membranes aft...				Bioorg Med Chem Lett 27: 470-478 (2017) Article DOI: 10.1016/j.bmcl.2016.12.037 BindingDB Entry DOI: 10.7270/Q2X63Q6K
3D-2drug, LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22405 (2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5.20E+3	n/a	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22407 (2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3.59E+3	n/a	n/a	n/a	>6.80E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22413 (5-(4-methoxyphenyl)-2-[(1R,2S,3S,5S)-8-methyl-3-(4...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3.67E+3	n/a	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50234231 (CHEMBL4093087) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a
3D-2drug, LLC Curated by ChEMBL					Assay Description Inhibition of [3H]-S-citalopram dissociation from human SERT allosteric modulator site (S2) expressed in African green monkey COS7 cell membranes aft...				Bioorg Med Chem Lett 27: 470-478 (2017) Article DOI: 10.1016/j.bmcl.2016.12.037 BindingDB Entry DOI: 10.7270/Q2X63Q6K
3D-2drug, LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22401 (5-(4-bromophenyl)-2-[(1R,2S,3S,5S)-3-(4-chlorophen...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5.70E+3	n/a	n/a	n/a	8.22E+3	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...				J Med Chem 50: 3686-95 (2007) Article DOI: 10.1021/jm0703035 BindingDB Entry DOI: 10.7270/Q25D8Q4T
Research Triangle Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM25870 (1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...) Show SMILES CN(C)CCCC1(OCc2cc(ccc12)C#N)c1ccc(F)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	8.70E+3	n/a	n/a	n/a	n/a
3D-2drug, LLC Curated by ChEMBL					Assay Description Inhibition of [3H]-S-citalopram dissociation from SERT allosteric modulator site (S2) (unknown origin) expressed in African green monkey COS1 cell me...				Bioorg Med Chem Lett 27: 470-478 (2017) Article DOI: 10.1016/j.bmcl.2016.12.037 BindingDB Entry DOI: 10.7270/Q2X63Q6K
3D-2drug, LLC Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50234227 (CHEMBL4071311) Show SMILES CN(C)CCCC1(OCc2ccccc12)c1cc(Cl)cc(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a
3D-2drug, LLC Curated by ChEMBL					Assay Description Inhibition of [3H]-S-citalopram dissociation from SERT allosteric modulator site (S2) (unknown origin) expressed in African green monkey COS1 cell me...				Bioorg Med Chem Lett 27: 470-478 (2017) Article DOI: 10.1016/j.bmcl.2016.12.037 BindingDB Entry DOI: 10.7270/Q2X63Q6K
3D-2drug, LLC Curated by ChEMBL					More data for this Ligand-Target Pair

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