Compile Data Set for Download or QSAR

Found 4416 hits of ic50 for UniProtKB: Q99685   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Monoglyceride lipase (Homo sapiens (Human))	BDBM640384 ((S)-(2-Chloro-6-fluorophenyl)(3-(3,5-difluoropheny...) Show SMILES C[C@@H]1N(CCc2c1nn(C)c2-c1cc(F)cc(F)c1)C(=O)c1c(F)cccc1Cl |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.00200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50582221 (CHEMBL5090028 | US11708359, Example 60) Show SMILES CC(C)(C)c1cccc(c1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:21.31,19.21,(59.02,-28.21,;59.02,-26.67,;60.35,-25.91,;60.34,-27.44,;57.69,-25.9,;56.35,-26.67,;55.02,-25.89,;55.03,-24.36,;56.37,-23.61,;57.69,-24.37,;56.38,-22.07,;57.7,-21.3,;56.37,-20.54,;55.04,-19.76,;53.72,-20.54,;53.7,-22.08,;55.03,-22.85,;52.38,-19.77,;52.38,-18.23,;51.05,-20.54,;50.65,-22.03,;49.16,-21.63,;49.56,-20.14,;48.84,-23.14,;47.3,-23.3,;46.68,-21.89,;45.17,-21.57,;47.82,-20.86,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.00700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2FRS
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50582221 (CHEMBL5090028 | US11708359, Example 60) Show SMILES CC(C)(C)c1cccc(c1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:21.31,19.21,(59.02,-28.21,;59.02,-26.67,;60.35,-25.91,;60.34,-27.44,;57.69,-25.9,;56.35,-26.67,;55.02,-25.89,;55.03,-24.36,;56.37,-23.61,;57.69,-24.37,;56.38,-22.07,;57.7,-21.3,;56.37,-20.54,;55.04,-19.76,;53.72,-20.54,;53.7,-22.08,;55.03,-22.85,;52.38,-19.77,;52.38,-18.23,;51.05,-20.54,;50.65,-22.03,;49.16,-21.63,;49.56,-20.14,;48.84,-23.14,;47.3,-23.3,;46.68,-21.89,;45.17,-21.57,;47.82,-20.86,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.00720	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50582221 (CHEMBL5090028 | US11708359, Example 60) Show SMILES CC(C)(C)c1cccc(c1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:21.31,19.21,(59.02,-28.21,;59.02,-26.67,;60.35,-25.91,;60.34,-27.44,;57.69,-25.9,;56.35,-26.67,;55.02,-25.89,;55.03,-24.36,;56.37,-23.61,;57.69,-24.37,;56.38,-22.07,;57.7,-21.3,;56.37,-20.54,;55.04,-19.76,;53.72,-20.54,;53.7,-22.08,;55.03,-22.85,;52.38,-19.77,;52.38,-18.23,;51.05,-20.54,;50.65,-22.03,;49.16,-21.63,;49.56,-20.14,;48.84,-23.14,;47.3,-23.3,;46.68,-21.89,;45.17,-21.57,;47.82,-20.86,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.00720	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human MGL expressed in human HeLa cells assessed as amount of cleaved glycerol measured after 1 hrs by flow through assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00679 BindingDB Entry DOI: 10.7270/Q2MS3XNZ
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581474 ((2s,4s)-2-(2-(3-(tert-Butyl)phenyl)-7-azaspiro[3.5...) Show SMILES CC(C)(C)c1cccc(c1)C1CC2(C1)CCN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:21.23,wD:23.26,(9.82,-.16,;8.48,-.93,;8.48,.61,;9.82,-1.7,;7.15,-1.7,;7.15,-3.24,;5.82,-4.01,;4.48,-3.24,;4.48,-1.7,;5.82,-.93,;3.15,-.93,;1.66,-1.33,;1.26,.16,;2.75,.56,;-.07,-.61,;-1.41,.16,;-1.41,1.7,;-.07,2.47,;1.26,1.7,;-2.74,2.47,;-2.74,4.01,;-4.07,1.7,;-4.47,.21,;-5.96,.61,;-5.56,2.1,;-5.96,-.93,;-7.42,-1.41,;-8.33,-.16,;-9.82,.24,;-7.42,1.09,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0140	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM609871 ((rac)-(2s,4s)-2-(6-(4-(tert-Butyl)phenyl)-3-azabic...) Show SMILES CC(C)(C)c1ccc(cc1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:19.21,wD:21.24,(5.59,-5.26,;6.36,-3.93,;7.9,-3.93,;7.13,-5.26,;5.59,-2.59,;4.05,-2.59,;3.28,-1.26,;4.05,.08,;5.59,.08,;6.36,-1.26,;3.28,1.41,;4.62,2.18,;3.28,2.95,;1.95,3.72,;.62,2.95,;.62,1.41,;1.95,.64,;-.72,3.72,;-.72,5.26,;-2.05,2.95,;-2.45,1.46,;-3.94,1.86,;-3.54,3.35,;-4.1,.33,;-5.6,.01,;-6.37,1.34,;-7.9,1.5,;-5.34,2.49,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.0190	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2FRS
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM609871 ((rac)-(2s,4s)-2-(6-(4-(tert-Butyl)phenyl)-3-azabic...) Show SMILES CC(C)(C)c1ccc(cc1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:19.21,wD:21.24,(5.59,-5.26,;6.36,-3.93,;7.9,-3.93,;7.13,-5.26,;5.59,-2.59,;4.05,-2.59,;3.28,-1.26,;4.05,.08,;5.59,.08,;6.36,-1.26,;3.28,1.41,;4.62,2.18,;3.28,2.95,;1.95,3.72,;.62,2.95,;.62,1.41,;1.95,.64,;-.72,3.72,;-.72,5.26,;-2.05,2.95,;-2.45,1.46,;-3.94,1.86,;-3.54,3.35,;-4.1,.33,;-5.6,.01,;-6.37,1.34,;-7.9,1.5,;-5.34,2.49,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.0190	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50582222 (CHEMBL5074982 | US11708359, Example 71) Show SMILES CC1(CC1)c1cccc(c1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:21.32,19.22,(81.16,-28.5,;81.16,-26.95,;81.56,-25.46,;82.65,-26.55,;79.83,-26.18,;78.5,-26.95,;77.17,-26.18,;77.18,-24.64,;78.52,-23.89,;79.83,-24.65,;78.52,-22.35,;79.85,-21.58,;78.52,-20.82,;77.18,-20.04,;75.86,-20.82,;75.85,-22.36,;77.18,-23.13,;74.53,-20.05,;74.53,-18.51,;73.2,-20.82,;72.8,-22.31,;71.31,-21.91,;71.71,-20.42,;70.99,-23.42,;69.45,-23.58,;68.82,-22.17,;67.31,-21.85,;69.97,-21.14,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.0240	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2FRS
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50582222 (CHEMBL5074982 | US11708359, Example 71) Show SMILES CC1(CC1)c1cccc(c1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:21.32,19.22,(81.16,-28.5,;81.16,-26.95,;81.56,-25.46,;82.65,-26.55,;79.83,-26.18,;78.5,-26.95,;77.17,-26.18,;77.18,-24.64,;78.52,-23.89,;79.83,-24.65,;78.52,-22.35,;79.85,-21.58,;78.52,-20.82,;77.18,-20.04,;75.86,-20.82,;75.85,-22.36,;77.18,-23.13,;74.53,-20.05,;74.53,-18.51,;73.2,-20.82,;72.8,-22.31,;71.31,-21.91,;71.71,-20.42,;70.99,-23.42,;69.45,-23.58,;68.82,-22.17,;67.31,-21.85,;69.97,-21.14,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0240	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human MGL expressed in human HeLa cells assessed as amount of cleaved glycerol measured after 1 hrs by flow through assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00679 BindingDB Entry DOI: 10.7270/Q2MS3XNZ
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50582222 (CHEMBL5074982 | US11708359, Example 71) Show SMILES CC1(CC1)c1cccc(c1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:21.32,19.22,(81.16,-28.5,;81.16,-26.95,;81.56,-25.46,;82.65,-26.55,;79.83,-26.18,;78.5,-26.95,;77.17,-26.18,;77.18,-24.64,;78.52,-23.89,;79.83,-24.65,;78.52,-22.35,;79.85,-21.58,;78.52,-20.82,;77.18,-20.04,;75.86,-20.82,;75.85,-22.36,;77.18,-23.13,;74.53,-20.05,;74.53,-18.51,;73.2,-20.82,;72.8,-22.31,;71.31,-21.91,;71.71,-20.42,;70.99,-23.42,;69.45,-23.58,;68.82,-22.17,;67.31,-21.85,;69.97,-21.14,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.0240	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581599 ((2r,4s)-2-(2-(5-(tert-Butyl)-2-methylphenyl)-7-aza...) Show SMILES Cc1ccc(cc1C1CC2(C1)CCN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2)C(C)(C)C |r,wU:18.20,wD:20.23,(3.21,-4.01,;4.54,-3.24,;5.88,-4.01,;7.21,-3.24,;7.21,-1.7,;5.88,-.93,;4.54,-1.7,;3.21,-.93,;1.72,-1.33,;1.32,.16,;2.81,.56,;-.01,-.61,;-1.35,.16,;-1.35,1.7,;-.01,2.47,;1.32,1.7,;-2.68,2.47,;-2.68,4.01,;-4.01,1.7,;-4.41,.21,;-5.9,.61,;-5.5,2.1,;-6.06,-.92,;-7.57,-1.24,;-8.34,.09,;-9.88,.09,;-7.31,1.24,;8.54,-.93,;9.88,-.16,;8.54,.61,;9.88,-1.7,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0270	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50552710 (CHEMBL4749516) Show SMILES [H][C@@]12CN(CC[C@]1([H])OCC(=O)N2)C(=O)N1CC(C1)c1ccc(cc1)-c1ccccc1OC(F)(F)F |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00055 BindingDB Entry DOI: 10.7270/Q2571GN8
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM609880 ((rac)-(2s,4s)-2-(6-(4-(1-Methylcyclopropyl)phenyl)...) Show SMILES CC1(CC1)c1ccc(cc1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:19.22,wD:21.25,(5.7,-5.26,;6.47,-3.93,;7.8,-4.7,;7.8,-3.16,;5.7,-2.59,;4.16,-2.59,;3.39,-1.26,;4.16,.08,;5.7,.08,;6.47,-1.26,;3.39,1.41,;4.72,2.18,;3.39,2.95,;2.05,3.72,;.72,2.95,;.72,1.41,;2.05,.64,;-.61,3.72,;-.61,5.26,;-1.95,2.95,;-2.35,1.46,;-3.83,1.86,;-3.43,3.35,;-3.99,.33,;-5.5,.01,;-6.27,1.34,;-7.8,1.5,;-5.24,2.49,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.0340	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2FRS
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM609880 ((rac)-(2s,4s)-2-(6-(4-(1-Methylcyclopropyl)phenyl)...) Show SMILES CC1(CC1)c1ccc(cc1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:19.22,wD:21.25,(5.7,-5.26,;6.47,-3.93,;7.8,-4.7,;7.8,-3.16,;5.7,-2.59,;4.16,-2.59,;3.39,-1.26,;4.16,.08,;5.7,.08,;6.47,-1.26,;3.39,1.41,;4.72,2.18,;3.39,2.95,;2.05,3.72,;.72,2.95,;.72,1.41,;2.05,.64,;-.61,3.72,;-.61,5.26,;-1.95,2.95,;-2.35,1.46,;-3.83,1.86,;-3.43,3.35,;-3.99,.33,;-5.5,.01,;-6.27,1.34,;-7.8,1.5,;-5.24,2.49,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.0340	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581624 ((rac)-(2s,4s)-2-(2-(4-(Trifluoromethyl)phenyl)-8-a...) Show SMILES FC(F)(F)c1ccc(cc1)C1CCC2(C1)CCN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:22.24,wD:24.27,(10.43,.68,;9.09,-.09,;9.49,1.39,;10.43,-.86,;7.6,-.49,;7.21,-1.98,;5.72,-2.38,;4.63,-1.29,;5.03,.2,;6.52,.6,;3.14,-1.69,;2.24,-2.93,;.77,-2.46,;.77,-.92,;2.24,-.44,;-.56,-1.69,;-1.9,-.92,;-1.9,.62,;-.56,1.39,;.77,.62,;-3.23,1.39,;-3.23,2.93,;-4.56,.62,;-4.96,-.86,;-6.45,-.47,;-6.05,1.02,;-6.61,-2,;-8.12,-2.32,;-8.89,-.98,;-10.43,-.98,;-7.86,.16,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0390	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581678 ((2s,4S)-N-((1s,3S)-3-(4-Isopropylphenyl)cyclobutyl...) Show SMILES CC(C)c1ccc(cc1)[C@@H]1C[C@@H](C1)N(C)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:17.18,11.14,9.9,wD:19.21,$;;;;;;;;;;;;;;;;;;;;;;;;;HN$,(9.21,2.4,;7.87,3.17,;7.87,4.71,;6.54,2.4,;6.54,.86,;5.2,.09,;3.87,.86,;3.87,2.4,;5.2,3.17,;2.54,.09,;1.05,.49,;.65,-1,;2.14,-1.4,;-.68,-1.77,;-.68,-3.31,;-2.02,-1,;-2.02,.54,;-3.35,-1.77,;-3.75,-3.26,;-5.24,-2.86,;-4.84,-1.37,;-5.4,-4.39,;-6.9,-4.71,;-7.67,-3.38,;-9.21,-3.22,;-6.64,-2.23,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human MAGL expressed in HeLa cells using [glycerol-1, 3-3H]-oleoyl glycerol as substrate incubated for 1 hr				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00019 BindingDB Entry DOI: 10.7270/Q2NZ8CJX
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50552709 (CHEMBL4759880) Show SMILES [H][C@@]12CN(CC[C@]1([H])OCC(=O)N2)C(=O)N1CC(C1)c1ccc(cc1)-c1ccc(Cl)cc1Cl |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00055 BindingDB Entry DOI: 10.7270/Q2571GN8
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50552711 (CHEMBL4785835) Show SMILES [H][C@@]12CN(CC[C@]1([H])OCC(=O)N2)C(=O)N1CC(C1)c1ccc(cc1)-c1ccccc1C(F)(F)F |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00055 BindingDB Entry DOI: 10.7270/Q2571GN8
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581678 ((2s,4S)-N-((1s,3S)-3-(4-Isopropylphenyl)cyclobutyl...) Show SMILES CC(C)c1ccc(cc1)[C@@H]1C[C@@H](C1)N(C)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:17.18,11.14,9.9,wD:19.21,$;;;;;;;;;;;;;;;;;;;;;;;;;HN$,(9.21,2.4,;7.87,3.17,;7.87,4.71,;6.54,2.4,;6.54,.86,;5.2,.09,;3.87,.86,;3.87,2.4,;5.2,3.17,;2.54,.09,;1.05,.49,;.65,-1,;2.14,-1.4,;-.68,-1.77,;-.68,-3.31,;-2.02,-1,;-2.02,.54,;-3.35,-1.77,;-3.75,-3.26,;-5.24,-2.86,;-4.84,-1.37,;-5.4,-4.39,;-6.9,-4.71,;-7.67,-3.38,;-9.21,-3.22,;-6.64,-2.23,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2HM5D9C
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581534 ((2s,4s)-2-[2-(3-Isopropylphenyl)-7-azaspiro[3.5]no...) Show SMILES CC(C)c1cccc(c1)C1CC2(C1)CCN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:20.22,wD:22.25,(9.82,-1.7,;8.48,-.93,;8.48,.61,;7.15,-1.7,;7.15,-3.24,;5.82,-4.01,;4.48,-3.24,;4.48,-1.7,;5.82,-.93,;3.15,-.93,;1.66,-1.33,;1.26,.16,;2.75,.56,;-.07,-.61,;-1.41,.16,;-1.41,1.7,;-.07,2.47,;1.26,1.7,;-2.74,2.47,;-2.74,4.01,;-4.07,1.7,;-4.47,.21,;-5.96,.61,;-5.56,2.1,;-5.96,-.93,;-7.42,-1.41,;-8.33,-.16,;-9.82,.24,;-7.42,1.09,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0410	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581597 ((2s,4s)-2-[2-(2,4-Dimethylphenyl)-7-azaspiro[3.5]n...) Show SMILES Cc1ccc(C2CC3(C2)CCN(CC3)C(=O)[C@H]2C[C@@]3(C2)COC(=O)N3)c(C)c1 |r,wU:16.17,wD:18.20,(9.15,-4.01,;7.82,-3.24,;7.82,-1.7,;6.48,-.93,;5.15,-1.7,;3.81,-.93,;2.33,-1.33,;1.93,.16,;3.42,.56,;.59,-.61,;-.74,.16,;-.74,1.7,;.59,2.47,;1.93,1.7,;-2.07,2.47,;-2.07,4.01,;-3.41,1.7,;-3.8,.21,;-5.29,.61,;-4.89,2.1,;-5.29,-.93,;-6.76,-1.41,;-7.66,-.16,;-9.15,.24,;-6.76,1.09,;5.15,-3.24,;3.81,-4.01,;6.48,-4.01,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0480	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50552713 (CHEMBL4745872) Show SMILES [H][C@@]12CN(CC[C@]1([H])OCC(=O)N2)C(=O)N1CC(C1)c1ccc(CC(C)(C)C)cc1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00055 BindingDB Entry DOI: 10.7270/Q2571GN8
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM609878 ((rac)-(2s,4s)-2-(6-(3-Chloro-4-methylphenyl)-3- az...) Show SMILES Cc1ccc(cc1Cl)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:17.19,wD:19.22,(6.36,-4.59,;5.59,-3.26,;4.05,-3.26,;3.28,-1.93,;4.05,-.59,;5.59,-.59,;6.36,-1.93,;7.9,-1.93,;3.28,.74,;4.62,1.51,;3.28,2.28,;1.95,3.05,;.62,2.28,;.62,.74,;1.95,-.03,;-.72,3.05,;-.72,4.59,;-2.05,2.28,;-2.45,.79,;-3.94,1.19,;-3.54,2.68,;-4.1,-.34,;-5.6,-.66,;-6.37,.68,;-7.9,.84,;-5.34,1.82,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.0750	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2FRS
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM609878 ((rac)-(2s,4s)-2-(6-(3-Chloro-4-methylphenyl)-3- az...) Show SMILES Cc1ccc(cc1Cl)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:17.19,wD:19.22,(6.36,-4.59,;5.59,-3.26,;4.05,-3.26,;3.28,-1.93,;4.05,-.59,;5.59,-.59,;6.36,-1.93,;7.9,-1.93,;3.28,.74,;4.62,1.51,;3.28,2.28,;1.95,3.05,;.62,2.28,;.62,.74,;1.95,-.03,;-.72,3.05,;-.72,4.59,;-2.05,2.28,;-2.45,.79,;-3.94,1.19,;-3.54,2.68,;-4.1,-.34,;-5.6,-.66,;-6.37,.68,;-7.9,.84,;-5.34,1.82,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.0750	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581596 ((2r,4s)-2-(2-(3-(tert-Butyl)phenyl)-7-azaspiro[3.5...) Show SMILES CC(C)(C)c1cccc(c1)C1CC2(C1)CCN(CC2)C(=O)[C@H]1C[C@@]2(C1)CCC(=O)N2 |r,wU:21.23,wD:23.26,(9.82,-1.7,;8.48,-.93,;8.48,.61,;9.82,-.16,;7.15,-1.7,;7.15,-3.24,;5.82,-4.01,;4.48,-3.24,;4.48,-1.7,;5.82,-.93,;3.15,-.93,;1.66,-1.33,;1.26,.16,;2.75,.56,;-.07,-.61,;-1.41,.16,;-1.41,1.7,;-.07,2.47,;1.26,1.7,;-2.74,2.47,;-2.74,4.01,;-4.07,1.7,;-4.47,.21,;-5.96,.61,;-5.56,2.1,;-5.96,-.93,;-7.42,-1.41,;-8.33,-.16,;-9.82,.24,;-7.42,1.09,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0820	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581635 ((rac)-(2s,4s)-2-(6-(3-(tert-Butyl)phenyl)-2-azaspi...) Show SMILES CC(C)(C)c1cccc(c1)C1CCC2(CN(C2)C(=O)[C@H]2C[C@@]3(C2)COC(=O)N3)C1 |r,wU:19.20,wD:21.23,(9.51,-2.32,;8,-2.58,;7.46,-4.03,;8.98,-3.77,;7.01,-1.4,;7.55,.05,;6.56,1.23,;5.04,.97,;4.51,-.47,;5.49,-1.66,;2.97,-.47,;2.07,-1.72,;.6,-1.24,;.6,.3,;.36,1.82,;-1.16,1.58,;-.92,.06,;-2.41,2.49,;-2.41,4.03,;-3.81,1.86,;-4.21,.37,;-5.7,.77,;-5.3,2.26,;-5.62,-.77,;-7.06,-1.32,;-8.03,-.12,;-9.51,.08,;-7.19,1.17,;2.07,.78,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0860	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581518 ((2s,4s)-2-[2-(3-Cyclopropylphenyl)-7-azaspiro[3.5]...) Show SMILES O=C([C@H]1C[C@@]2(C1)COC(=O)N2)N1CCC2(CC(C2)c2cccc(c2)C2CC2)CC1 |r,wU:2.1,wD:4.4,(-2.84,4.01,;-2.84,2.47,;-4.18,1.7,;-4.57,.21,;-6.06,.61,;-5.66,2.1,;-6.06,-.93,;-7.53,-1.41,;-8.43,-.16,;-9.92,.24,;-7.53,1.09,;-1.51,1.7,;-1.51,.16,;-.18,-.61,;1.16,.16,;1.56,-1.33,;3.04,-.93,;2.65,.56,;4.38,-1.7,;4.38,-3.24,;5.71,-4.01,;7.05,-3.24,;7.05,-1.7,;5.71,-.93,;8.38,-.93,;9.92,-.93,;9.15,.4,;1.16,1.7,;-.18,2.47,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0880	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581594 ((2s,4s)-2-[2-[3-(Trifluoromethoxy)phenyl]-7-azaspi...) Show SMILES FC(F)(F)Oc1cccc(c1)C1CC2(C1)CCN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:22.24,wD:24.27,(8.53,2.18,;8.53,.64,;10.07,.64,;6.99,.64,;8.53,-.9,;7.2,-1.67,;7.15,-3.24,;5.82,-4.01,;4.48,-3.24,;4.48,-1.7,;5.82,-.93,;3.15,-.93,;1.66,-1.33,;1.26,.16,;2.75,.56,;-.07,-.61,;-1.41,.16,;-1.41,1.7,;-.07,2.47,;1.26,1.7,;-2.74,2.47,;-2.74,4.01,;-4.07,1.7,;-4.47,.21,;-5.96,.61,;-5.56,2.1,;-5.96,-.93,;-7.42,-1.41,;-8.33,-.16,;-9.82,.24,;-7.42,1.09,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0940	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581601 ((2r,4s)-2-(2-(6-(tert-Butyl)pyridin-2-yl)-7-azaspi...) Show SMILES CC(C)(C)c1cccc(n1)C1CC2(C1)CCN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:21.23,wD:23.26,(9.88,-.16,;8.54,-.93,;8.54,.61,;9.88,-1.7,;7.21,-1.7,;7.21,-3.24,;5.88,-4.01,;4.54,-3.24,;4.54,-1.7,;5.88,-.93,;3.21,-.93,;1.72,-1.33,;1.32,.16,;2.81,.56,;-.01,-.61,;-1.35,.16,;-1.35,1.7,;-.01,2.47,;1.32,1.7,;-2.68,2.47,;-2.68,4.01,;-4.01,1.7,;-4.41,.21,;-5.9,.61,;-5.5,2.1,;-6.06,-.92,;-7.57,-1.24,;-8.34,.09,;-9.88,.09,;-7.31,1.24,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0950	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581650 ((2s,4s)-2-(6-(3-(tert-Butyl)phenyl)-2-azaspiro[3.3...) Show SMILES CC(C)(C)c1cccc(c1)C1CC2(C1)CN(C2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:19.21,wD:21.24,(8.07,.84,;8.07,-.7,;9.4,-1.47,;9.4,.07,;6.74,-1.47,;6.74,-3.01,;5.4,-3.78,;4.07,-3.01,;4.07,-1.47,;5.4,-.7,;2.74,-.7,;1.25,-1.1,;.85,.38,;2.34,.78,;-.64,-.01,;-1.04,1.47,;.45,1.87,;-2.37,2.24,;-2.37,3.78,;-3.7,1.47,;-4.1,-.01,;-5.59,.39,;-5.19,1.87,;-5.51,-1.15,;-6.95,-1.7,;-7.92,-.51,;-9.4,-.43,;-7.08,.78,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0970	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM630876 ((7-((3,6-Dimethyl-5-(trifluoromethyl)pyridin-2-yl)...) Show SMILES Cc1cc(c(C)nc1OC1CCC2(CN(C2)C(=O)[C@H]2C[C@@](C)(O)C2)CC1)C(F)(F)F |r,wU:20.23,18.19,wD:20.22,(5.29,-3.62,;5.29,-2.08,;6.62,-1.31,;6.62,.23,;5.29,1,;5.29,2.54,;3.95,.23,;3.95,-1.31,;2.62,-2.08,;1.29,-1.31,;-.05,-2.08,;-1.38,-1.31,;-1.38,.23,;-2.87,-.17,;-3.27,1.31,;-1.78,1.71,;-4.6,2.08,;-4.6,3.62,;-5.93,1.31,;-6.33,-.17,;-7.82,.23,;-8.22,-1.26,;-9.29,.64,;-7.42,1.71,;-.05,1,;1.29,.23,;7.95,1,;7.95,2.54,;9.29,.23,;9.29,1.77,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581631 ((2s,4R*)-2-((S*)-6-(4-(Trifluoromethyl)phenyl)-2-a...) Show SMILES FC(F)(F)c1ccc(cc1)[C@H]1CCC2(CN(C2)C(=O)[C@H]2C[C@@]3(C2)COC(=O)N3)C1 |r,wU:10.10,19.20,wD:21.23,(9.12,.44,;8.54,-.99,;9.48,-2.2,;10.06,-.77,;7.01,-1.2,;6.43,-2.63,;4.91,-2.84,;3.96,-1.62,;4.54,-.2,;6.07,.02,;2.42,-1.62,;1.52,-2.87,;.05,-2.39,;.05,-.85,;-.19,.67,;-1.71,.43,;-1.47,-1.1,;-2.96,1.33,;-2.96,2.87,;-4.36,.7,;-4.76,-.78,;-6.25,-.38,;-5.85,1.1,;-6.17,-1.92,;-7.61,-2.47,;-8.57,-1.28,;-10.06,-1.08,;-7.74,.01,;1.52,-.38,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50552712 (CHEMBL4749293) Show SMILES [H][C@@]12CN(CC[C@]1([H])OCC(=O)N2)C(=O)N1CC(C1)c1ccc(cc1)-c1c(Cl)cccc1C#N |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00055 BindingDB Entry DOI: 10.7270/Q2571GN8
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581648 ((rac)-(2s,4s)-2-(6-(4-Isopropylphenyl)-2-azaspiro[...) Show SMILES CC(C)c1ccc(cc1)C1CCC2(CN(C2)C(=O)[C@H]2C[C@@]3(C2)COC(=O)N3)C1 |r,wU:18.19,wD:20.22,(9.62,.42,;8.95,-.97,;9.82,-2.24,;7.41,-1.08,;6.74,-2.47,;5.21,-2.58,;4.34,-1.31,;5.01,.08,;6.55,.19,;2.81,-1.42,;1.9,-2.67,;.44,-2.19,;.44,-.65,;-1.05,-1.05,;-1.45,.43,;.04,.83,;-2.78,1.2,;-2.78,2.74,;-4.12,.43,;-4.52,-1.05,;-6,-.65,;-5.6,.83,;-5.92,-2.19,;-7.36,-2.74,;-8.33,-1.55,;-9.82,-1.41,;-7.49,-.26,;1.9,-.18,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50552708 (CHEMBL4756662) Show SMILES [H][C@@]12CN(CC[C@]1([H])OCC(=O)N2)C(=O)N1CCC(CC1)[C@H](c1ccccc1)c1ccc(C)cc1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00055 BindingDB Entry DOI: 10.7270/Q2571GN8
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581642 ((rac)-(2s,4s)-2-(2-(3-(tert-Butyl)phenyl)-8-azaspi...) Show SMILES CC(C)(C)c1cccc(c1)C1CCC2(C1)CCN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:22.24,wD:24.27,(7.66,-4.22,;8.36,-2.84,;9.9,-2.76,;9.2,-4.13,;7.52,-1.55,;8.1,-.13,;7.16,1.09,;5.63,.88,;5.05,-.54,;5.99,-1.76,;3.51,-.54,;2.6,-1.79,;1.14,-1.31,;1.14,.23,;2.6,.71,;-.19,-.54,;-1.53,.23,;-1.54,1.77,;-.19,2.54,;1.14,1.77,;-2.79,2.68,;-2.79,4.22,;-4.2,2.05,;-4.6,.56,;-6.08,.96,;-5.68,2.45,;-6,-.58,;-7.44,-1.13,;-8.41,.07,;-9.9,.21,;-7.57,1.36,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581634 ((rac)-(2s,4s)-2-(6-(4-(tert-Butyl)phenyl)-2-azaspi...) Show SMILES CC(C)(C)c1ccc(cc1)C1CCC2(CN(C2)C(=O)[C@H]2C[C@@]3(C2)COC(=O)N3)C1 |r,wU:19.20,wD:21.23,(9.17,.26,;8.54,-1.14,;9.45,-2.39,;10.08,-.98,;7.01,-1.3,;6.39,-2.71,;4.85,-2.87,;3.95,-1.62,;4.58,-.22,;6.11,-.06,;2.41,-1.62,;1.5,-2.87,;.04,-2.39,;.04,-.85,;-.2,.67,;-1.72,.43,;-1.48,-1.1,;-2.97,1.33,;-2.97,2.87,;-4.38,.7,;-4.77,-.78,;-6.26,-.38,;-5.86,1.1,;-6.18,-1.92,;-7.62,-2.47,;-8.59,-1.28,;-10.08,-1.15,;-7.75,.01,;1.5,-.38,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581595 ((2s,4s)-2-[2-(2,3-Dimethylphenyl)-7-azaspiro[3.5]n...) Show SMILES Cc1cccc(C2CC3(C2)CCN(CC3)C(=O)[C@H]2C[C@@]3(C2)COC(=O)N3)c1C |r,wU:17.18,wD:19.21,(9.15,-.93,;7.82,-1.7,;7.82,-3.24,;6.48,-4.01,;5.15,-3.24,;5.15,-1.7,;3.81,-.93,;2.33,-1.33,;1.93,.16,;3.42,.56,;.59,-.61,;-.74,.16,;-.74,1.7,;.59,2.47,;1.93,1.7,;-2.07,2.47,;-2.07,4.01,;-3.41,1.7,;-3.8,.21,;-5.29,.61,;-4.89,2.1,;-5.29,-.93,;-6.76,-1.41,;-7.66,-.16,;-9.15,.24,;-6.76,1.09,;6.48,-.93,;6.48,.61,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581643 ((rac)-(2s,4s)-2-(2-(4-(tert-Butyl)phenyl)-8-azaspi...) Show SMILES CC(C)(C)c1ccc(cc1)C1CCC2(C1)CCN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:22.24,wD:24.27,(9.63,-2.96,;8.76,-1.69,;9.41,-.3,;10.29,-1.57,;7.22,-1.81,;6.56,-3.21,;5.03,-3.33,;4.15,-2.06,;4.81,-.67,;6.34,-.55,;2.61,-2.06,;1.71,-3.31,;.24,-2.83,;.24,-1.29,;1.71,-.82,;-1.25,-1.69,;-2.34,-.6,;-1.94,.88,;-.45,1.28,;.64,.19,;-3.18,1.79,;-3.18,3.33,;-4.59,1.16,;-4.99,-.32,;-6.48,.07,;-6.08,1.56,;-6.4,-1.46,;-7.83,-2.01,;-8.8,-.82,;-10.29,-.69,;-7.96,.47,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM597443 ((4-Fluoropyrazolo[1,5-a]pyridin-3-yl)((5R,9S)-2-me...) Show SMILES Cn1nc2[C@H]3CCC[C@@H](Cc2c1-c1cc(F)c(F)c(F)c1)N3C(=O)c1cnn2cccc(F)c12 |r,TLB:22:21:3.10.9:7.6.5| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QN6BQH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581646 ((rac)-(2s,4s)-2-(6-(3-Isopropylphenyl)-2-azaspiro[...) Show SMILES CC(C)c1cccc(c1)C1CCC2(CN(C2)C(=O)[C@H]2C[C@@]3(C2)COC(=O)N3)C1 |r,wU:18.19,wD:20.22,(9.48,-2.44,;7.95,-2.55,;7.28,-3.94,;7.08,-1.28,;7.75,.11,;6.88,1.38,;5.35,1.27,;4.68,-.12,;5.54,-1.39,;3.14,-.23,;2.24,-1.48,;.77,-1,;.77,.54,;-.72,.14,;-1.11,1.63,;.37,2.03,;-2.45,2.4,;-2.45,3.94,;-3.78,1.63,;-4.18,.14,;-5.67,.54,;-5.27,2.03,;-5.59,-1,;-7.03,-1.55,;-7.99,-.35,;-9.48,-.22,;-7.16,.94,;2.24,1.01,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S186B3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM597214 ((4-Bromoquinolin-6-yl)((5R,9S)-3-(3,5-difluorophen...) Show SMILES Cn1nc2[C@H]3CCC[C@@H](Cc2c1-c1cc(F)cc(F)c1)N3C(=O)c1ccc2nccc(Br)c2c1 |r,TLB:21:20:10.3.9:7.6.5| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QN6BQH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50250848 (CHEMBL4059676) Show SMILES FC(F)(F)C(OC(=O)N1CC(C1)c1ccn(n1)-c1ccccc1)C(F)(F)F Show InChI InChI=1S/C16H13F6N3O2/c17-15(18,19)13(16(20,21)22)27-14(26)24-8-10(9-24)12-6-7-25(23-12)11-4-2-1-3-5-11/h1-7,10,13H,8-9H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MAGL in human brain vascular pericytes after 1 hr by TAMRA azide-based In-gel fluorescence method				J Med Chem 60: 9860-9873 (2017) Article DOI: 10.1021/acs.jmedchem.7b01531 BindingDB Entry DOI: 10.7270/Q2N300CG
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50250859 (CHEMBL4097203) Show SMILES Fc1ccc(cc1F)-n1ccc(n1)C1CN(C1)C(=O)OC(C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C16H11F8N3O2/c17-10-2-1-9(5-11(10)18)27-4-3-12(25-27)8-6-26(7-8)14(28)29-13(15(19,20)21)16(22,23)24/h1-5,8,13H,6-7H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MAGL in human brain vascular pericytes after 1 hr by TAMRA azide-based In-gel fluorescence method				J Med Chem 60: 9860-9873 (2017) Article DOI: 10.1021/acs.jmedchem.7b01531 BindingDB Entry DOI: 10.7270/Q2N300CG
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM630668 (((1s,3s)-3-Hydroxy-3-methylcyclobutyl)(7-(2-methyl...) Show SMILES Cc1cc(ccc1OC1CCC2(CN(C2)C(=O)[C@H]2C[C@@](C)(O)C2)CC1)C(F)(F)F |r,wU:17.18,19.22,wD:19.21,(2.85,.49,;4.18,-.28,;5.51,.49,;6.85,-.28,;6.85,-1.82,;5.51,-2.59,;4.18,-1.82,;2.85,-2.59,;1.51,-1.82,;.18,-2.59,;-1.15,-1.82,;-1.15,-.28,;-1.92,1.05,;-3.26,.28,;-2.49,-1.05,;-4.59,1.05,;-4.59,2.59,;-5.92,.28,;-6.69,-1.05,;-8.03,-.28,;-8.8,-1.62,;-9.52,.12,;-7.26,1.05,;.18,.49,;1.51,-.28,;8.18,.49,;9.52,-.28,;8.18,2.03,;9.52,1.26,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM626948 ((2s,4s)-2-(4-(4-(tert-Butyl)phenyl)piperidine-1-ca...) Show SMILES CC(C)(C)c1ccc(cc1)C1CCN(CC1)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:18.19,wD:20.22,(7.6,-4.23,;7.6,-2.69,;8.93,-1.93,;8.93,-3.47,;6.27,-1.93,;4.93,-2.69,;3.6,-1.93,;3.6,-.38,;4.93,.38,;6.27,-.38,;2.26,.38,;.93,-.38,;-.4,.38,;-.4,1.93,;.93,2.69,;2.26,1.93,;-1.74,2.69,;-1.74,4.23,;-3.07,1.93,;-3.47,.44,;-4.96,.84,;-4.56,2.32,;-5.12,-.7,;-6.62,-1.02,;-7.39,.32,;-8.93,.43,;-6.36,1.46,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM626965 ((racemic)-(2s,4S)-2-((3R,4R)-4-(4-(tert-Butyl)phen...) Show SMILES C[C@H]1CN(CC[C@H]1c1ccc(cc1)C(C)(C)C)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:19.20,wD:21.23,6.7,1.0,(3.62,2.72,;2.29,1.95,;.9,2.69,;-.43,1.93,;-.43,.38,;.9,-.38,;2.24,.38,;3.57,-.38,;3.57,-1.93,;4.91,-2.69,;6.24,-1.93,;6.24,-.38,;4.91,.39,;7.57,-2.69,;8.91,-3.47,;8.91,-1.93,;7.57,-4.23,;-1.76,2.69,;-1.76,4.23,;-3.1,1.93,;-3.49,.44,;-4.98,.84,;-4.58,2.32,;-5.14,-.7,;-6.65,-1.02,;-7.42,.32,;-8.91,.72,;-6.39,1.46,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581668 ((2s,4S)-N-((1s,3S)-3-(4-(tert-Butyl)phenyl)cyclobu...) Show SMILES CN([C@H]1C[C@H](C1)c1ccc(cc1)C(C)(C)C)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:18.19,2.1,4.6,wD:20.22,$;;;;;;;;;;;;;;;;;;;;;;;;;;HN$,(-.68,-3.31,;-.68,-1.77,;.65,-1,;1.05,.49,;2.54,.09,;2.14,-1.4,;3.87,.86,;5.2,.09,;6.54,.86,;6.54,2.4,;5.2,3.17,;3.87,2.4,;7.87,3.17,;9.21,2.4,;7.87,4.71,;9.21,3.94,;-2.02,-1,;-2.02,.54,;-3.35,-1.77,;-3.75,-3.26,;-5.24,-2.86,;-4.84,-1.37,;-5.4,-4.39,;-6.9,-4.71,;-7.67,-3.38,;-9.21,-3.22,;-6.64,-2.23,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2HM5D9C
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM597927 (US11608347, Example 55 | [(7R,9aR)-7-(3-chloro-4- ...) Show SMILES COc1cccc(C(=O)N2CCN3C[C@H](CC[C@@H]3C2)c2ccc(F)c(Cl)c2)c1Cl |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1HKS
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM581668 ((2s,4S)-N-((1s,3S)-3-(4-(tert-Butyl)phenyl)cyclobu...) Show SMILES CN([C@H]1C[C@H](C1)c1ccc(cc1)C(C)(C)C)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:18.19,2.1,4.6,wD:20.22,$;;;;;;;;;;;;;;;;;;;;;;;;;;HN$,(-.68,-3.31,;-.68,-1.77,;.65,-1,;1.05,.49,;2.54,.09,;2.14,-1.4,;3.87,.86,;5.2,.09,;6.54,.86,;6.54,2.4,;5.2,3.17,;3.87,2.4,;7.87,3.17,;9.21,2.4,;7.87,4.71,;9.21,3.94,;-2.02,-1,;-2.02,.54,;-3.35,-1.77,;-3.75,-3.26,;-5.24,-2.86,;-4.84,-1.37,;-5.4,-4.39,;-6.9,-4.71,;-7.67,-3.38,;-9.21,-3.22,;-6.64,-2.23,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human MAGL expressed in HeLa cells using [glycerol-1, 3-3H]-oleoyl glycerol as substrate incubated for 1 hr				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00019 BindingDB Entry DOI: 10.7270/Q2NZ8CJX
					More data for this Ligand-Target Pair

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