Compile Data Set for Download or QSAR

Found 35 hits of ic50 for UniProtKB: P21817   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ryanodine receptor 1 [4317-4329] ()	BDBM430056 (US10538528, Compound 43) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nc(no1)C(F)(F)F Show InChI InChI=1S/C27H34F3N9O2/c1-25(2,3)34-11-10-31-16-6-7-17(22-37-23(38-41-22)27(28,29)30)35-19(16)15-8-12-39(13-9-15)21-18-20(32-14-33-21)36-24(40)26(18,4)5/h6-7,14-15,31,34H,8-13H2,1-5H3,(H,32,33,36,40)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430051 (US10538528, Compound 37) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(s1)C(F)F Show InChI InChI=1S/C27H35F2N9OS/c1-26(2,3)33-11-10-30-16-6-7-17(23-36-37-24(40-23)20(28)29)34-19(16)15-8-12-38(13-9-15)22-18-21(31-14-32-22)35-25(39)27(18,4)5/h6-7,14-15,20,30,33H,8-13H2,1-5H3,(H,31,32,35,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430057 (US10538528, Compound 44) Show SMILES CC1(C)C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3nc(no3)C(F)(F)F)c12 Show InChI InChI=1S/C27H32F3N9O2/c1-26(2)19-21(35-25(26)40)32-15-33-22(19)39-12-7-16(8-13-39)20-17(31-9-14-38-10-3-4-11-38)5-6-18(34-20)23-36-24(37-41-23)27(28,29)30/h5-6,15-16,31H,3-4,7-14H2,1-2H3,(H,32,33,35,40)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430052 (US10538528, Compound 39) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(s1)C(F)F Show InChI InChI=1S/C26H33F2N9OS/c1-14(2)29-9-10-30-16-5-6-17(23-35-36-24(39-23)20(27)28)33-19(16)15-7-11-37(12-8-15)22-18-21(31-13-32-22)34-25(38)26(18,3)4/h5-6,13-15,20,29-30H,7-12H2,1-4H3,(H,31,32,34,38)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430047 (US10538528, Compound 32) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(o1)C(F)(F)F Show InChI InChI=1S/C27H34F3N9O2/c1-25(2,3)34-11-10-31-16-6-7-17(22-37-38-24(41-22)27(28,29)30)35-19(16)15-8-12-39(13-9-15)21-18-20(32-14-33-21)36-23(40)26(18,4)5/h6-7,14-15,31,34H,8-13H2,1-5H3,(H,32,33,36,40)	UniProtKB/SwissProt GoogleScholar AffyNet	MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430053 (US10538528, Compound 40) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(s1)C1CC1 Show InChI InChI=1S/C29H39N9OS/c1-28(2,3)33-13-12-30-19-8-9-20(26-37-36-25(40-26)18-6-7-18)34-22(19)17-10-14-38(15-11-17)24-21-23(31-16-32-24)35-27(39)29(21,4)5/h8-9,16-18,30,33H,6-7,10-15H2,1-5H3,(H,31,32,35,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430030 (US10538528, Compound 11) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cc(Cl)nn1C Show InChI InChI=1S/C27H36ClN9O/c1-16(2)29-10-11-30-19-7-6-18(20-14-21(28)35-36(20)5)33-23(19)17-8-12-37(13-9-17)25-22-24(31-15-32-25)34-26(38)27(22,3)4/h6-7,14-17,29-30H,8-13H2,1-5H3,(H,31,32,34,38)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430029 (US10538528, Compound 5) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cnc(F)c(F)c1 Show InChI InChI=1S/C28H34F2N8O/c1-16(2)31-9-10-32-21-6-5-20(18-13-19(29)24(30)33-14-18)36-23(21)17-7-11-38(12-8-17)26-22-25(34-15-35-26)37-27(39)28(22,3)4/h5-6,13-17,31-32H,7-12H2,1-4H3,(H,34,35,37,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430034 (US10538528, Compound 16) Show SMILES COc1cc(c(F)cn1)-c1ccc(NCCN2CCCC2)c(n1)C1CCN(CC1)c1ncnc2NC(=O)C(C)c12 Show InChI InChI=1S/C29H35FN8O2/c1-18-25-27(36-29(18)39)33-17-34-28(25)38-12-7-19(8-13-38)26-23(31-9-14-37-10-3-4-11-37)6-5-22(35-26)20-15-24(40-2)32-16-21(20)30/h5-6,15-19,31H,3-4,7-14H2,1-2H3,(H,33,34,36,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430063 (US10538528, Compound 10) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cc(nn1C)C(F)(F)F Show InChI InChI=1S/C28H36F3N9O/c1-16(2)32-10-11-33-19-7-6-18(20-14-21(28(29,30)31)38-39(20)5)36-23(19)17-8-12-40(13-9-17)25-22-24(34-15-35-25)37-26(41)27(22,3)4/h6-7,14-17,32-33H,8-13H2,1-5H3,(H,34,35,37,41)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430038 (US10538528, Compound 20) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3cc(nn3C)C(F)(F)F)c12 Show InChI InChI=1S/C28H34F3N9O/c1-17-23-25(36-27(17)41)33-16-34-26(23)40-12-7-18(8-13-40)24-20(32-9-14-39-10-3-4-11-39)6-5-19(35-24)21-15-22(28(29,30)31)37-38(21)2/h5-6,15-18,32H,3-4,7-14H2,1-2H3,(H,33,34,36,41)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430066 (US10538528, Compound 38) Show SMILES CN(C)CCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(s1)C(F)F Show InChI InChI=1S/C25H31F2N9OS/c1-25(2)17-20(32-24(25)37)29-13-30-21(17)36-10-7-14(8-11-36)18-15(28-9-12-35(3)4)5-6-16(31-18)22-33-34-23(38-22)19(26)27/h5-6,13-14,19,28H,7-12H2,1-4H3,(H,29,30,32,37)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430050 (US10538528, Compound 34) Show SMILES CN(CCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(o1)C(F)(F)F)C(C)(C)C Show InChI InChI=1S/C28H36F3N9O2/c1-26(2,3)39(6)14-11-32-17-7-8-18(23-37-38-25(42-23)28(29,30)31)35-20(17)16-9-12-40(13-10-16)22-19-21(33-15-34-22)36-24(41)27(19,4)5/h7-8,15-16,32H,9-14H2,1-6H3,(H,33,34,36,41)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430037 (US10538528, Compound 19) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3cncc(F)c3)c12 Show InChI InChI=1S/C28H33FN8O/c1-18-24-26(35-28(18)38)32-17-33-27(24)37-11-6-19(7-12-37)25-23(31-8-13-36-9-2-3-10-36)5-4-22(34-25)20-14-21(29)16-30-15-20/h4-5,14-19,31H,2-3,6-13H2,1H3,(H,32,33,35,38)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430049 (US10538528, Compound 33) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(o1)C(F)(F)F Show InChI InChI=1S/C26H32F3N9O2/c1-14(2)30-9-10-31-16-5-6-17(22-36-37-24(40-22)26(27,28)29)34-19(16)15-7-11-38(12-8-15)21-18-20(32-13-33-21)35-23(39)25(18,3)4/h5-6,13-15,30-31H,7-12H2,1-4H3,(H,32,33,35,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430059 (US10538528, Compound 6) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1sc(C)nc1C Show InChI InChI=1S/C28H38N8OS/c1-16(2)29-11-12-30-20-7-8-21(24-17(3)33-18(4)38-24)34-23(20)19-9-13-36(14-10-19)26-22-25(31-15-32-26)35-27(37)28(22,5)6/h7-8,15-16,19,29-30H,9-14H2,1-6H3,(H,31,32,35,37)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430035 (US10538528, Compound 17) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3cccnc3F)c12 Show InChI InChI=1S/C28H33FN8O/c1-18-23-26(35-28(18)38)32-17-33-27(23)37-14-8-19(9-15-37)24-22(30-11-16-36-12-2-3-13-36)7-6-21(34-24)20-5-4-10-31-25(20)29/h4-7,10,17-19,30H,2-3,8-9,11-16H2,1H3,(H,32,33,35,38)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430033 (US10538528, Compound 15) Show SMILES COc1cncc(c1)-c1ccc(NCCNC(C)C)c(n1)C1CCN(CC1)c1ncnc2NC(=O)C(C)c12 Show InChI InChI=1S/C28H36N8O2/c1-17(2)30-9-10-31-23-6-5-22(20-13-21(38-4)15-29-14-20)34-25(23)19-7-11-36(12-8-19)27-24-18(3)28(37)35-26(24)32-16-33-27/h5-6,13-19,30-31H,7-12H2,1-4H3,(H,32,33,35,37)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430062 (US10538528, Compound 9) Show SMILES CN(C)CCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cc(Cl)nn1C Show InChI InChI=1S/C26H34ClN9O/c1-26(2)21-23(32-25(26)37)29-15-30-24(21)36-11-8-16(9-12-36)22-18(28-10-13-34(3)4)7-6-17(31-22)19-14-20(27)33-35(19)5/h6-7,14-16,28H,8-13H2,1-5H3,(H,29,30,32,37)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430055 (US10538528, Compound 42) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1noc(n1)C(F)(F)F Show InChI InChI=1S/C26H32F3N9O2/c1-14(2)30-9-10-31-16-5-6-17(20-36-24(40-37-20)26(27,28)29)34-19(16)15-7-11-38(12-8-15)22-18-21(32-13-33-22)35-23(39)25(18,3)4/h5-6,13-15,30-31H,7-12H2,1-4H3,(H,32,33,35,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430039 (US10538528, Compound 21) Show SMILES COc1cncc(c1)-c1ccc(NCCN(C)C)c(n1)C1CCN(CC1)c1ncnc2NC(=O)C(C)c12 Show InChI InChI=1S/C27H34N8O2/c1-17-23-25(33-27(17)36)30-16-31-26(23)35-10-7-18(8-11-35)24-22(29-9-12-34(2)3)6-5-21(32-24)19-13-20(37-4)15-28-14-19/h5-6,13-18,29H,7-12H2,1-4H3,(H,30,31,33,36)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430031 (US10538528, Compound 13) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3ccnc(F)c3)c12 Show InChI InChI=1S/C28H33FN8O/c1-18-24-26(35-28(18)38)32-17-33-27(24)37-13-7-19(8-14-37)25-22(30-10-15-36-11-2-3-12-36)5-4-21(34-25)20-6-9-31-23(29)16-20/h4-6,9,16-19,30H,2-3,7-8,10-15H2,1H3,(H,32,33,35,38)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430036 (US10538528, Compound 18) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3ccsc3)c12 Show InChI InChI=1S/C27H33N7OS/c1-18-23-25(32-27(18)35)29-17-30-26(23)34-12-6-19(7-13-34)24-22(28-9-14-33-10-2-3-11-33)5-4-21(31-24)20-8-15-36-16-20/h4-5,8,15-19,28H,2-3,6-7,9-14H2,1H3,(H,29,30,32,35)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430028 (US10538528, Compound 1) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cncc(F)c1 Show InChI InChI=1S/C29H37FN8O/c1-28(2,3)35-11-10-32-22-7-6-21(19-14-20(30)16-31-15-19)36-24(22)18-8-12-38(13-9-18)26-23-25(33-17-34-26)37-27(39)29(23,4)5/h6-7,14-18,32,35H,8-13H2,1-5H3,(H,33,34,37,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430058 (US10538528, Compound 2) Show SMILES CC1(C)C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3ccc(F)nc3)c12 Show InChI InChI=1S/C29H35FN8O/c1-29(2)24-26(36-28(29)39)33-18-34-27(24)38-14-9-19(10-15-38)25-22(31-11-16-37-12-3-4-13-37)7-6-21(35-25)20-5-8-23(30)32-17-20/h5-8,17-19,31H,3-4,9-16H2,1-2H3,(H,33,34,36,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430041 (US10538528, Compound 23) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN(C)C)-c3ccsc3)c12 Show InChI InChI=1S/C25H31N7OS/c1-16-21-23(30-25(16)33)27-15-28-24(21)32-10-6-17(7-11-32)22-20(26-9-12-31(2)3)5-4-19(29-22)18-8-13-34-14-18/h4-5,8,13-17,26H,6-7,9-12H2,1-3H3,(H,27,28,30,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430065 (US10538528, Compound 35) Show SMILES CC1(C)C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCC3CCCN3)-c3nnc(o3)C(F)(F)F)c12 Show InChI InChI=1S/C26H30F3N9O2/c1-25(2)18-20(35-23(25)39)32-13-33-21(18)38-10-7-14(8-11-38)19-16(31-12-15-4-3-9-30-15)5-6-17(34-19)22-36-37-24(40-22)26(27,28)29/h5-6,13-15,30-31H,3-4,7-12H2,1-2H3,(H,32,33,35,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430054 (US10538528, Compound 41) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1noc(n1)C(F)F Show InChI InChI=1S/C27H35F2N9O2/c1-26(2,3)33-11-10-30-16-6-7-17(21-35-24(20(28)29)40-37-21)34-19(16)15-8-12-38(13-9-15)23-18-22(31-14-32-23)36-25(39)27(18,4)5/h6-7,14-15,20,30,33H,8-13H2,1-5H3,(H,31,32,36,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430060 (US10538528, Compound 7) Show SMILES COc1cncc(c1)-c1ccc(NCCN2CCCC2)c(n1)C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12 Show InChI InChI=1S/C30H38N8O2/c1-30(2)25-27(36-29(30)39)33-19-34-28(25)38-13-8-20(9-14-38)26-24(32-10-15-37-11-4-5-12-37)7-6-23(35-26)21-16-22(40-3)18-31-17-21/h6-7,16-20,32H,4-5,8-15H2,1-3H3,(H,33,34,36,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430032 (US10538528, Compound 14) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3ccoc3)c12 Show InChI InChI=1S/C27H33N7O2/c1-18-23-25(32-27(18)35)29-17-30-26(23)34-12-6-19(7-13-34)24-22(28-9-14-33-10-2-3-11-33)5-4-21(31-24)20-8-15-36-16-20/h4-5,8,15-19,28H,2-3,6-7,9-14H2,1H3,(H,29,30,32,35)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430045 (US10538528, Compound 30) Show SMILES CC1(C)C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3nnc(o3)C(F)F)c12 Show InChI InChI=1S/C27H33F2N9O2/c1-27(2)19-22(34-26(27)39)31-15-32-23(19)38-12-7-16(8-13-38)20-17(30-9-14-37-10-3-4-11-37)5-6-18(33-20)24-35-36-25(40-24)21(28)29/h5-6,15-16,21,30H,3-4,7-14H2,1-2H3,(H,31,32,34,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430061 (US10538528, Compound 8) Show SMILES CC1(C)C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3cncc(F)c3)c12 Show InChI InChI=1S/C29H35FN8O/c1-29(2)24-26(36-28(29)39)33-18-34-27(24)38-12-7-19(8-13-38)25-23(32-9-14-37-10-3-4-11-37)6-5-22(35-25)20-15-21(30)17-31-16-20/h5-6,15-19,32H,3-4,7-14H2,1-2H3,(H,33,34,36,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430046 (US10538528, Compound 31) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(o1)C(F)F Show InChI InChI=1S/C26H33F2N9O2/c1-14(2)29-9-10-30-16-5-6-17(23-35-36-24(39-23)20(27)28)33-19(16)15-7-11-37(12-8-15)22-18-21(31-13-32-22)34-25(38)26(18,3)4/h5-6,13-15,20,29-30H,7-12H2,1-4H3,(H,31,32,34,38)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430064 (US10538528, Compound 12) Show SMILES CCNCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cncc(F)c1 Show InChI InChI=1S/C27H33FN8O/c1-4-29-9-10-31-21-6-5-20(18-13-19(28)15-30-14-18)34-23(21)17-7-11-36(12-8-17)25-22-24(32-16-33-25)35-26(37)27(22,2)3/h5-6,13-17,29,31H,4,7-12H2,1-3H3,(H,32,33,35,37)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430044 (US10538528, Compound 27) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3cc(cnc3NCCN3CCCC3)-c3cc(nn3C)C(F)(F)F)c12 Show InChI InChI=1S/C28H34F3N9O/c1-17-23-25(36-27(17)41)34-16-35-26(23)40-10-5-18(6-11-40)20-13-19(21-14-22(28(29,30)31)37-38(21)2)15-33-24(20)32-7-12-39-8-3-4-9-39/h13-18H,3-12H2,1-2H3,(H,32,33)(H,34,35,36,41)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair