Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350239 (US10208056, Compound 66) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.191 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50189412 (CHEMBL3827983) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24... | ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350249 (US10208056, Compound 76) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.262 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350256 (US10208056, Compound 83) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.278 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350253 (US10208056, Compound 80) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.314 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350262 (US10208056, Compound 89) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.407 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350240 (US10208056, Compound 67) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.466 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50189417 (CHEMBL3828116) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24... | ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50189435 (CHEMBL3828003) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24... | ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50191472 (CHEMBL3956719) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA Curated by ChEMBL | Assay Description Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ... | J Med Chem 59: 9337-9349 (2016) BindingDB Entry DOI: 10.7270/Q2K64M1C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM640341 (8-Amino-N-(cyclopropylmethyl)-5-(4- (1-(2-(dimethy...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.880 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50189415 (CHEMBL3828637) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of CDK8 (unknown origin) | ACS Med Chem Lett 11: 127-132 (2020) Article DOI: 10.1021/acsmedchemlett.9b00480 BindingDB Entry DOI: 10.7270/Q20Z76K1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM640350 (2-(4-(4-(8-amino-3-(azetidine-1- carbonyl)-1,7-nap...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.960 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM532287 (US11213520, Example I-005) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VQ35V1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM540074 (US11261184, Example I-021) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2Z322TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM640351 (2-(4-(4-(8-amino-3-(azetidine-1- carbonyl)-1,7-nap...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 1.01 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM640354 (8-amino-N-(2-methoxyethyl)-N- methyl-5-(4-(1-(2-(4...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 1.07 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM640346 (8-amino-N-cyclopropyl-5-(4-(1-(2-(2- methoxyethyl)...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50509567 (CHEMBL4455382 | US11213520, Example I-003) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VQ35V1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50189436 (CHEMBL3827327) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24... | ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM640345 (8-amino-N-cyclopropyl-5-(4-(1-(2-(4- methylpiperaz...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM640344 (8-amino-N-cyclopropyl-5-(4-(1-(2- (dimethylamino)-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 1.11 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350252 (US10208056, Compound 79) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.11 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM532311 (US11213520, Example I-007) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VQ35V1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM540069 (US11261184, Example I-016) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2Z322TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM540071 (US11261184, Example I-018) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2Z322TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM540066 (US11261184, Example I-013) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2Z322TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM640353 (8-amino-5-(4-(1-(2-(dimethylamino)- 2-oxoethyl)-1H...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 1.24 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM640352 ((8-amino-5-(4-(1-(2-methoxyethyl)- 1H-pyrazole-4-y...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 1.27 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM532312 (US11213520, Example I-008) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VQ35V1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM540062 (US11261184, Example I-007) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2Z322TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM540063 (US11261184, Example I-010) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2Z322TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM540065 (US11261184, Example I-012) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2Z322TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM532314 (US11213520, Example I-010) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VQ35V1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350263 (US10208056, Compound 90) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.36 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM540077 (US11261184, Example I-024) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2Z322TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM532315 (US11213520, Example I-011) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VQ35V1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50509567 (CHEMBL4455382 | US11213520, Example I-003) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02190 BindingDB Entry DOI: 10.7270/Q2BV7MPD | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM640342 (8-amino-N-(cyclopropylmethyl)-5-(4- (1-(2-(4-methy...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM540073 (US11261184, Example I-020) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2Z322TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350270 (US10208056, Compound 105) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1.41 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350265 (US10208056, Compound 92) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1.41 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350257 (US10208056, Compound 84) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.41 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350227 (US10208056, Compound 57) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.41 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350220 (US10208056, Compound 52) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.41 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350211 (US10208056, Compound 43) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.41 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350268 (US10208056, Compound 96) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1.41 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM350267 (US10208056, Compound 95) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1.41 | n/a | n/a | n/a | n/a | n/a | n/a |
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent | Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and... | US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM640349 ((8-amino-5-(4-(1-(2-methoxyethyl)- 1H-pyrazole-4-y...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 1.44 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM540064 (US11261184, Example I-011) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation... | Citation and Details BindingDB Entry DOI: 10.7270/Q2Z322TP | |||||||||||
More data for this Ligand-Target Pair |
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