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Compile Data Set for Download or QSAR

Found 556 hits of ic50 for UniProtKB: P14324   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12578
PNG
(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)
Show SMILES OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
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n/an/a 0.240n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12576
PNG
(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)
Show SMILES OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
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n/an/a 0.360n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Inhibition of human FPPS using pre-incubation of compound with enzyme


ACS Med Chem Lett 6: 349-54 (2015)


Article DOI: 10.1021/ml500528x
BindingDB Entry DOI: 10.7270/Q2251KW1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422472
PNG
(CHEMBL100827)
Show SMILES CN(CCCSc1ccccc1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C13H23NO7P2S/c1-14(9-5-11-24-12-6-3-2-4-7-12)10-8-13(15,22(16,17)18)23(19,20)21/h2-4,6-7,15H,5,8-11H2,1H3,(H2,16,17,18)(H2,19,20,21)
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n/an/a 0.620n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM25290
PNG
(CHEMBL56073 | bisphosphonate, 39 | {1-hydroxy-3-[m...)
Show SMILES CN(CCCCc1ccccc1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C14H25NO7P2/c1-15(11-6-5-9-13-7-3-2-4-8-13)12-10-14(16,23(17,18)19)24(20,21)22/h2-4,7-8,16H,5-6,9-12H2,1H3,(H2,17,18,19)(H2,20,21,22)
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n/an/a 1n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50098389
PNG
(1-hydroxy-2-(1H-imidazol-5-yl)ethane-1,1-diyldipho...)
Show SMILES OC(Cc1cnc[nH]1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)1-4-2-6-3-7-4/h2-3,8H,1H2,(H,6,7)(H2,9,10,11)(H2,12,13,14)
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n/an/a 1.10n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422449
PNG
(CHEMBL101886)
Show SMILES CN(CCCOc1ccccc1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C13H23NO8P2/c1-14(9-5-11-22-12-6-3-2-4-7-12)10-8-13(15,23(16,17)18)24(19,20)21/h2-4,6-7,15H,5,8-11H2,1H3,(H2,16,17,18)(H2,19,20,21)
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n/an/a 1.30n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422469
PNG
(CHEMBL101472)
Show SMILES CN(CCCOc1ccc(F)cc1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C13H22FNO8P2/c1-15(8-2-10-23-12-5-3-11(14)4-6-12)9-7-13(16,24(17,18)19)25(20,21)22/h3-6,16H,2,7-10H2,1H3,(H2,17,18,19)(H2,20,21,22)
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n/an/a 1.40n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422457
PNG
(CHEMBL101230)
Show SMILES CN(CCCc1ccc(Cl)cc1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C13H22ClNO7P2/c1-15(9-2-3-11-4-6-12(14)7-5-11)10-8-13(16,23(17,18)19)24(20,21)22/h4-7,16H,2-3,8-10H2,1H3,(H2,17,18,19)(H2,20,21,22)
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n/an/a 1.70n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422470
PNG
(CHEMBL100508)
Show SMILES CN(CCSc1ccccc1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C12H21NO7P2S/c1-13(9-10-23-11-5-3-2-4-6-11)8-7-12(14,21(15,16)17)22(18,19)20/h2-6,14H,7-10H2,1H3,(H2,15,16,17)(H2,18,19,20)
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n/an/a 1.80n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM25308
PNG
((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)
Show SMILES OC(Cc1cnc2ccccn12)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18)
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n/an/a 1.90n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human FPPS


Bioorg Med Chem Lett 25: 1117-23 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.089
BindingDB Entry DOI: 10.7270/Q25X2BMF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422463
PNG
(CHEMBL101207)
Show SMILES Cn1ccnc1CC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C6H12N2O7P2/c1-8-3-2-7-5(8)4-6(9,16(10,11)12)17(13,14)15/h2-3,9H,4H2,1H3,(H2,10,11,12)(H2,13,14,15)
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n/an/a 2n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50117257
PNG
(1-hydroxy-3-(methyl(3-phenylpropyl)amino)propane-1...)
Show SMILES CN(CCCc1ccccc1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C13H23NO7P2/c1-14(10-5-8-12-6-3-2-4-7-12)11-9-13(15,22(16,17)18)23(19,20)21/h2-4,6-7,15H,5,8-11H2,1H3,(H2,16,17,18)(H2,19,20,21)
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n/an/a 2.60n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422455
PNG
(CHEMBL98476)
Show SMILES CCCCc1cnc(NC(P(O)(O)=O)P(O)(O)=O)s1
Show InChI InChI=1S/C8H16N2O6P2S/c1-2-3-4-6-5-9-7(19-6)10-8(17(11,12)13)18(14,15)16/h5,8H,2-4H2,1H3,(H,9,10)(H2,11,12,13)(H2,14,15,16)
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n/an/a 2.70n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50135839
PNG
(CHEMBL55464 | [1-Hydroxy-3-(4-phenyl-butylamino)-1...)
Show SMILES OC(CCNCCCCc1ccccc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C13H23NO7P2/c15-13(22(16,17)18,23(19,20)21)9-11-14-10-5-4-8-12-6-2-1-3-7-12/h1-3,6-7,14-15H,4-5,8-11H2,(H2,16,17,18)(H2,19,20,21)
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n/an/a 2.70n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422454
PNG
(CHEMBL316913)
Show SMILES COc1ccc(OCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O)cc1
Show InChI InChI=1S/C14H25NO9P2/c1-15(10-8-14(16,25(17,18)19)26(20,21)22)9-3-11-24-13-6-4-12(23-2)5-7-13/h4-7,16H,3,8-11H2,1-2H3,(H2,17,18,19)(H2,20,21,22)
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n/an/a 2.80n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12578
PNG
(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)
Show SMILES OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
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n/an/a 3n/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation counting


J Med Chem 54: 5955-80 (2011)


Article DOI: 10.1021/jm200587f
BindingDB Entry DOI: 10.7270/Q2PV6MGF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12578
PNG
(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)
Show SMILES OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
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n/an/a 3n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Allosteric inhibition of human recombinant FPPS using GPP and [3H]IPP as substrate incubated with enzyme for 10 mins prior to substrate addition by l...


J Med Chem 57: 5764-76 (2014)


Article DOI: 10.1021/jm500629e
BindingDB Entry DOI: 10.7270/Q2GH9KJR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM25308
PNG
((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)
Show SMILES OC(Cc1cnc2ccccn12)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18)
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n/an/a 3n/an/an/an/an/an/a



University of Southern California

Curated by ChEMBL


Assay Description
Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting


J Med Chem 53: 3454-64 (2010)

Checked by Author
Article DOI: 10.1021/jm900232u
BindingDB Entry DOI: 10.7270/Q21837FJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422446
PNG
(CHEMBL101407)
Show SMILES CN(CCCOc1ccc(Cl)cc1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C13H22ClNO8P2/c1-15(8-2-10-23-12-5-3-11(14)4-6-12)9-7-13(16,24(17,18)19)25(20,21)22/h3-6,16H,2,7-10H2,1H3,(H2,17,18,19)(H2,20,21,22)
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n/an/a 3.10n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50135831
PNG
(CHEMBL316844 | [1-Hydroxy-3-(3-phenoxy-propylamino...)
Show SMILES OC(CCNCCCOc1ccccc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C12H21NO8P2/c14-12(22(15,16)17,23(18,19)20)7-9-13-8-4-10-21-11-5-2-1-3-6-11/h1-3,5-6,13-14H,4,7-10H2,(H2,15,16,17)(H2,18,19,20)
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n/an/a 3.30n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422448
PNG
(CHEMBL100441)
Show SMILES CN(CCCc1cccc(C)c1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C14H25NO7P2/c1-12-5-3-6-13(11-12)7-4-9-15(2)10-8-14(16,23(17,18)19)24(20,21)22/h3,5-6,11,16H,4,7-10H2,1-2H3,(H2,17,18,19)(H2,20,21,22)
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n/an/a 3.90n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50117260
PNG
(1-hydroxy-3-(methyl(phenethyl)amino)propane-1,1-di...)
Show SMILES CN(CCc1ccccc1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C12H21NO7P2/c1-13(9-7-11-5-3-2-4-6-11)10-8-12(14,21(15,16)17)22(18,19)20/h2-6,14H,7-10H2,1H3,(H2,15,16,17)(H2,18,19,20)
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n/an/a 3.90n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50138041
PNG
(1-hydroxy-3-(methyl(2-phenoxyethyl)amino)propane-1...)
Show SMILES CN(CCOc1ccccc1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C12H21NO8P2/c1-13(9-10-21-11-5-3-2-4-6-11)8-7-12(14,22(15,16)17)23(18,19)20/h2-6,14H,7-10H2,1H3,(H2,15,16,17)(H2,18,19,20)
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n/an/a 4n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12578
PNG
(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)
Show SMILES OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
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n/an/a 4n/an/an/an/an/an/a



Academia Sinica



Assay Description
To measure the kinetic constants by radioactive assays, 0.2 μM wild-type E. coli OPPS and the wild-type or mutant S. cerevisiae GGPPS and human ...


Biochemistry 55: 4366-74 (2016)


Article DOI: 10.1021/acs.biochem.6b00486
BindingDB Entry DOI: 10.7270/Q2BR8QZK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422464
PNG
(CHEMBL319519)
Show SMILES CN(CCOc1ccc(Cl)cc1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C12H20ClNO8P2/c1-14(8-9-22-11-4-2-10(13)3-5-11)7-6-12(15,23(16,17)18)24(19,20)21/h2-5,15H,6-9H2,1H3,(H2,16,17,18)(H2,19,20,21)
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n/an/a 4.10n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12578
PNG
(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)
Show SMILES OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
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n/an/a 4.10n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate incubated for 10 mi...


J Med Chem 55: 3201-15 (2012)


Article DOI: 10.1021/jm201657x
BindingDB Entry DOI: 10.7270/Q29024V1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12578
PNG
(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)
Show SMILES OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
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n/an/a 4.10n/an/an/an/an/an/a



Universita di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3)


J Med Chem 51: 6800-7 (2008)


Article DOI: 10.1021/jm801003y
BindingDB Entry DOI: 10.7270/Q2F76CD8
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12578
PNG
(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)
Show SMILES OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
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n/an/a 4.10n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins


J Med Chem 51: 2187-95 (2008)


Article DOI: 10.1021/jm7015733
BindingDB Entry DOI: 10.7270/Q2W95B18
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12578
PNG
(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)
Show SMILES OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
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n/an/a 4.10n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human FPPS


Bioorg Med Chem Lett 25: 1117-23 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.089
BindingDB Entry DOI: 10.7270/Q25X2BMF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422458
PNG
(CHEMBL100835)
Show SMILES CN(CCCOc1cccc(C)c1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C14H25NO8P2/c1-12-5-3-6-13(11-12)23-10-4-8-15(2)9-7-14(16,24(17,18)19)25(20,21)22/h3,5-6,11,16H,4,7-10H2,1-2H3,(H2,17,18,19)(H2,20,21,22)
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n/an/a 4.30n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422467
PNG
(CHEMBL100830)
Show SMILES CCc1cnc(NC(P(O)(O)=O)P(O)(O)=O)s1
Show InChI InChI=1S/C6H12N2O6P2S/c1-2-4-3-7-5(17-4)8-6(15(9,10)11)16(12,13)14/h3,6H,2H2,1H3,(H,7,8)(H2,9,10,11)(H2,12,13,14)
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n/an/a 4.80n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422475
PNG
(CHEMBL98703)
Show SMILES Cc1ncn(CC(O)(P(O)(O)=O)P(O)(O)=O)c1C
Show InChI InChI=1S/C7H14N2O7P2/c1-5-6(2)9(4-8-5)3-7(10,17(11,12)13)18(14,15)16/h4,10H,3H2,1-2H3,(H2,11,12,13)(H2,14,15,16)
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n/an/a 5n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422461
PNG
(CHEMBL100335)
Show SMILES Cc1cnc(NC(P(O)(O)=O)P(O)(O)=O)s1
Show InChI InChI=1S/C5H10N2O6P2S/c1-3-2-6-4(16-3)7-5(14(8,9)10)15(11,12)13/h2,5H,1H3,(H,6,7)(H2,8,9,10)(H2,11,12,13)
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n/an/a 5.10n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422477
PNG
(CHEMBL317646)
Show SMILES Cc1nc[nH]c1CC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C6H12N2O7P2/c1-4-5(8-3-7-4)2-6(9,16(10,11)12)17(13,14)15/h3,9H,2H2,1H3,(H,7,8)(H2,10,11,12)(H2,13,14,15)
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n/an/a 5.10n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12576
PNG
(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)
Show SMILES OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
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n/an/a 5.20n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FPPS using GPP/[3H]IPP as substrate incubated for 10 mins prior to substrate addition measured after 8 mins by scinti...


J Med Chem 56: 7939-50 (2013)


Article DOI: 10.1021/jm400946f
BindingDB Entry DOI: 10.7270/Q20V8F6B
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12576
PNG
(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)
Show SMILES OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
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n/an/a 5.70n/an/an/an/an/an/a



University of Southern California

Curated by ChEMBL


Assay Description
Inhibition of human FPPS


Bioorg Med Chem Lett 18: 2878-82 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.088
BindingDB Entry DOI: 10.7270/Q2WM1F9P
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12576
PNG
(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)
Show SMILES OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
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n/an/a 5.70n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins


J Med Chem 51: 2187-95 (2008)


Article DOI: 10.1021/jm7015733
BindingDB Entry DOI: 10.7270/Q2W95B18
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12576
PNG
(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)
Show SMILES OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
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n/an/a 6n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Allosteric inhibition of human recombinant FPPS using GPP and [3H]IPP as substrate incubated with enzyme for 10 mins prior to substrate addition by l...


J Med Chem 57: 5764-76 (2014)


Article DOI: 10.1021/jm500629e
BindingDB Entry DOI: 10.7270/Q2GH9KJR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12576
PNG
(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)
Show SMILES OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
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n/an/a 6n/an/an/an/an/an/a



University of Iowa

Curated by ChEMBL


Assay Description
Inhibition of FDPS (unknown origin)


Bioorg Med Chem Lett 25: 2331-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.021
BindingDB Entry DOI: 10.7270/Q2M61MZN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50098390
PNG
((3-methylpyridin-2-ylamino)methylenediphosphonic a...)
Show SMILES Cc1cccnc1NC(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C7H12N2O6P2/c1-5-3-2-4-8-6(5)9-7(16(10,11)12)17(13,14)15/h2-4,7H,1H3,(H,8,9)(H2,10,11,12)(H2,13,14,15)
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n/an/a 6.20n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins


J Med Chem 51: 2187-95 (2008)


Article DOI: 10.1021/jm7015733
BindingDB Entry DOI: 10.7270/Q2W95B18
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422444
PNG
(CHEMBL100295)
Show SMILES CCCc1cnc(NC(P(O)(O)=O)P(O)(O)=O)s1
Show InChI InChI=1S/C7H14N2O6P2S/c1-2-3-5-4-8-6(18-5)9-7(16(10,11)12)17(13,14)15/h4,7H,2-3H2,1H3,(H,8,9)(H2,10,11,12)(H2,13,14,15)
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n/an/a 6.20n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422441
PNG
(CHEMBL101539)
Show SMILES OP(O)(=O)C(Nc1ncc(CCc2ccccc2)s1)P(O)(O)=O
Show InChI InChI=1S/C12H16N2O6P2S/c15-21(16,17)12(22(18,19)20)14-11-13-8-10(23-11)7-6-9-4-2-1-3-5-9/h1-5,8,12H,6-7H2,(H,13,14)(H2,15,16,17)(H2,18,19,20)
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n/an/a 7.10n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50273714
PNG
(CHEMBL446734 | [2-(Imidazol-1-yl)ethyl]-bisphospho...)
Show SMILES OP(O)(=O)C(Cn1ccnc1)P(O)(O)=O
Show InChI InChI=1S/C5H10N2O6P2/c8-14(9,10)5(15(11,12)13)3-7-2-1-6-4-7/h1-2,4-5H,3H2,(H2,8,9,10)(H2,11,12,13)
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n/an/a 9.03n/an/an/an/an/an/a



Universita di Ferrara

Curated by ChEMBL


Assay Description
Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3)


J Med Chem 51: 6800-7 (2008)


Article DOI: 10.1021/jm801003y
BindingDB Entry DOI: 10.7270/Q2F76CD8
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50098378
PNG
((1-Hydroxy-1-phosphono-2-pyridin-2-yl-ethyl)-phosp...)
Show SMILES OC(Cc1ccccn1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)5-6-3-1-2-4-8-6/h1-4,9H,5H2,(H2,10,11,12)(H2,13,14,15)
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n/an/a 9.20n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins


J Med Chem 51: 2187-95 (2008)


Article DOI: 10.1021/jm7015733
BindingDB Entry DOI: 10.7270/Q2W95B18
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422445
PNG
(CHEMBL318071)
Show SMILES Cc1nccn1CC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C6H12N2O7P2/c1-5-7-2-3-8(5)4-6(9,16(10,11)12)17(13,14)15/h2-3,9H,4H2,1H3,(H2,10,11,12)(H2,13,14,15)
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n/an/a 10n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50422450
PNG
(CHEMBL316663)
Show SMILES CN(CCCCOc1ccccc1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C14H25NO8P2/c1-15(10-5-6-12-23-13-7-3-2-4-8-13)11-9-14(16,24(17,18)19)25(20,21)22/h2-4,7-8,16H,5-6,9-12H2,1H3,(H2,17,18,19)(H2,20,21,22)
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n/an/a 10n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Negative logarithm of inhibitory concentration against bone resorption


J Med Chem 46: 2932-44 (2003)


Article DOI: 10.1021/jm030054u
BindingDB Entry DOI: 10.7270/Q2R78GHD
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12576
PNG
(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)
Show SMILES OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
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n/an/a 10n/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation counting


J Med Chem 54: 5955-80 (2011)


Article DOI: 10.1021/jm200587f
BindingDB Entry DOI: 10.7270/Q2PV6MGF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12576
PNG
(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)
Show SMILES OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
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n/an/a 10n/an/an/an/an/an/a



University of Illinois at Urbana-Champaign

Curated by ChEMBL


Assay Description
Inhibitory activity against the human recombinant FPPSase(Farnesyl diphosphate) enzyme


J Med Chem 45: 2185-96 (2002)


BindingDB Entry DOI: 10.7270/Q2KH0MN1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50373094
PNG
(CHEMBL408608)
Show SMILES CC1CCCN=C1N=C(P(O)(O)O)P(O)(O)=O |w:7.7,c:5|
Show InChI InChI=1S/C7H16N2O6P2/c1-5-3-2-4-8-6(5)9-7(16(10,11)12)17(13,14)15/h5,10-12,16H,2-4H2,1H3,(H2,13,14,15)
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n/an/a 10.3n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins


J Med Chem 51: 2187-95 (2008)


Article DOI: 10.1021/jm7015733
BindingDB Entry DOI: 10.7270/Q2W95B18
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM12576
PNG
(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)
Show SMILES OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
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n/an/a 11n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...


J Med Chem 55: 3201-15 (2012)


Article DOI: 10.1021/jm201657x
BindingDB Entry DOI: 10.7270/Q29024V1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
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