Found 57 hits of ic50 for UniProtKB: P43114 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181274
(5-(3-((S)-2-((R)-4-(3-chlorophenyl)-3-hydroxybutyl...)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1cccc(Cl)c1 Show InChI InChI=1S/C22H26ClNO4S/c23-16-4-1-3-15(13-16)14-18(25)8-6-17-7-11-21(26)24(17)12-2-5-19-9-10-20(29-19)22(27)28/h1,3-4,9-10,13,17-18,25H,2,5-8,11-12,14H2,(H,27,28)/t17-,18+/m0/s1 | PDB
Reactome pathway
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PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM35847
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 | PDB
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CHEMBL
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PC cid
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PDB
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| PDB
Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181298
(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H26F3NO4S/c24-23(25,26)16-4-1-3-15(13-16)14-18(28)8-6-17-7-11-21(29)27(17)12-2-5-19-9-10-20(32-19)22(30)31/h1,3-4,9-10,13,17-18,28H,2,5-8,11-12,14H2,(H,30,31)/t17-,18+/m0/s1 | PDB
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CHEMBL
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| Article
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| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor |
J Med Chem 53: 4332-53 (2010)
Article DOI: 10.1021/jm9018756
BindingDB Entry DOI: 10.7270/Q21R6QPF |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181298
(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H26F3NO4S/c24-23(25,26)16-4-1-3-15(13-16)14-18(28)8-6-17-7-11-21(29)27(17)12-2-5-19-9-10-20(32-19)22(30)31/h1,3-4,9-10,13,17-18,28H,2,5-8,11-12,14H2,(H,30,31)/t17-,18+/m0/s1 | PDB
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| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM142234
(US8933098, 1 | US8933099, 1)Show SMILES Cc1ccc(nc1C(=O)Nc1c(C)cc(cc1C)C(O)=O)N1CCC(O)CC1 Show InChI InChI=1S/C21H25N3O4/c1-12-4-5-17(24-8-6-16(25)7-9-24)22-19(12)20(26)23-18-13(2)10-15(21(27)28)11-14(18)3/h4-5,10-11,16,25H,6-9H2,1-3H3,(H,23,26)(H,27,28) | PDB
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| Article
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity against rat EP4 assessed as inhibition of PGE2-stimulated production of cAMP |
Bioorg Med Chem Lett 26: 2303-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.041
BindingDB Entry DOI: 10.7270/Q22F7QBJ |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50446847
(CHEMBL3115074)Show SMILES C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C23H28N2O4/c1-17(18-10-12-19(13-11-18)23(27)28)24-22(26)21-9-5-6-14-25(21)15-16-29-20-7-3-2-4-8-20/h2-4,7-8,10-13,17,21H,5-6,9,14-16H2,1H3,(H,24,26)(H,27,28)/t17-,21+/m0/s1 | PDB
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| Article
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 30 mins by HTRF ass... |
ACS Med Chem Lett 5: 104-5 (2014)
Article DOI: 10.1021/ml5000367
BindingDB Entry DOI: 10.7270/Q2JH3NPQ |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181289
(5-(3-((S)-2-(4-(3-fluorophenyl)-3-hydroxybutyl)-5-...)Show SMILES OC(CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1cccc(F)c1 Show InChI InChI=1S/C22H26FNO4S/c23-16-4-1-3-15(13-16)14-18(25)8-6-17-7-11-21(26)24(17)12-2-5-19-9-10-20(29-19)22(27)28/h1,3-4,9-10,13,17-18,25H,2,5-8,11-12,14H2,(H,27,28)/t17-,18?/m0/s1 | PDB
Reactome pathway
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50142488
(7-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)phen...)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCCCCC(O)=O)Cc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C22H30F3NO4/c23-22(24,25)17-7-5-6-16(14-17)15-19(27)11-9-18-10-12-20(28)26(18)13-4-2-1-3-8-21(29)30/h5-7,14,18-19,27H,1-4,8-13,15H2,(H,29,30)/t18-,19+/m0/s1 | PDB
Reactome pathway
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PC sid
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| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181296
(5-(3-((S)-2-(3-hydroxy-4-phenylbutyl)-5-oxopyrroli...)Show SMILES OC(CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1ccccc1 Show InChI InChI=1S/C22H27NO4S/c24-18(15-16-5-2-1-3-6-16)10-8-17-9-13-21(25)23(17)14-4-7-19-11-12-20(28-19)22(26)27/h1-3,5-6,11-12,17-18,24H,4,7-10,13-15H2,(H,26,27)/t17-,18?/m0/s1 | PDB
Reactome pathway
KEGG
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181279
(7-(2-(4-(3-chlorophenyl)-3-hydroxybutyl)-5-oxopyrr...)Show InChI InChI=1S/C21H30ClNO4/c22-17-7-5-6-16(14-17)15-19(24)11-9-18-10-12-20(25)23(18)13-4-2-1-3-8-21(26)27/h5-7,14,18-19,24H,1-4,8-13,15H2,(H,26,27) | PDB
Reactome pathway
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PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181277
(4-(3-(2-(4-(3-chlorophenyl)-3-hydroxybutyl)-5-oxop...)Show SMILES OC(CCC1CCC(=O)N1CCCc1ccc(cc1)C(O)=O)Cc1cccc(Cl)c1 Show InChI InChI=1S/C24H28ClNO4/c25-20-5-1-3-18(15-20)16-22(27)12-10-21-11-13-23(28)26(21)14-2-4-17-6-8-19(9-7-17)24(29)30/h1,3,5-9,15,21-22,27H,2,4,10-14,16H2,(H,29,30) | PDB
Reactome pathway
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| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181291
(4-{3-[2-(4-biphenyl-3-yl-3-hydroxy-butyl)-5-oxo-py...)Show SMILES OC(CCC1CCC(=O)N1CCCc1ccc(cc1)C(O)=O)Cc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C30H33NO4/c32-28(21-23-6-4-10-26(20-23)24-8-2-1-3-9-24)17-15-27-16-18-29(33)31(27)19-5-7-22-11-13-25(14-12-22)30(34)35/h1-4,6,8-14,20,27-28,32H,5,7,15-19,21H2,(H,34,35) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181290
(5-{3-[(S)-2-(4-biphenyl-3-yl-3-hydroxy-butyl)-5-ox...)Show SMILES OC(CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C28H31NO4S/c30-24(19-20-6-4-9-22(18-20)21-7-2-1-3-8-21)13-11-23-12-16-27(31)29(23)17-5-10-25-14-15-26(34-25)28(32)33/h1-4,6-9,14-15,18,23-24,30H,5,10-13,16-17,19H2,(H,32,33)/t23-,24?/m0/s1 | PDB
Reactome pathway
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PC cid
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UniChem
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| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181284
(7-((S)-2-(3-hydroxy-4-phenylbutyl)-5-oxopyrrolidin...)Show InChI InChI=1S/C21H31NO4/c23-19(16-17-8-4-3-5-9-17)13-11-18-12-14-20(24)22(18)15-7-2-1-6-10-21(25)26/h3-5,8-9,18-19,23H,1-2,6-7,10-16H2,(H,25,26)/t18-,19?/m0/s1 | PDB
Reactome pathway
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| Article
PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181271
(7-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethoxy)phe...)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCCCCC(O)=O)Cc1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C22H30F3NO5/c23-22(24,25)31-19-7-5-6-16(15-19)14-18(27)11-9-17-10-12-20(28)26(17)13-4-2-1-3-8-21(29)30/h5-7,15,17-18,27H,1-4,8-14H2,(H,29,30)/t17-,18+/m0/s1 | PDB
Reactome pathway
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PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181293
(7-((S)-2-((R)-3-hydroxy-4-(3-(methoxymethyl)phenyl...)Show SMILES COCc1cccc(C[C@H](O)CC[C@H]2CCC(=O)N2CCCCCCC(O)=O)c1 Show InChI InChI=1S/C23H35NO5/c1-29-17-19-8-6-7-18(15-19)16-21(25)12-10-20-11-13-22(26)24(20)14-5-3-2-4-9-23(27)28/h6-8,15,20-21,25H,2-5,9-14,16-17H2,1H3,(H,27,28)/t20-,21+/m0/s1 | PDB
Reactome pathway
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UniChem
Patents
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| Article
PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181295
(5-(3-((S)-2-(3-hydroxy-4-(naphthalen-2-yl)butyl)-5...)Show SMILES OC(CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1ccc2ccccc2c1 Show InChI InChI=1S/C26H29NO4S/c28-22(17-18-7-8-19-4-1-2-5-20(19)16-18)11-9-21-10-14-25(29)27(21)15-3-6-23-12-13-24(32-23)26(30)31/h1-2,4-5,7-8,12-13,16,21-22,28H,3,6,9-11,14-15,17H2,(H,30,31)/t21-,22?/m0/s1 | PDB
Reactome pathway
KEGG
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181286
(5-(3-((S)-2-((R)-4-(4-fluorophenyl)-3-hydroxybutyl...)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C22H26FNO4S/c23-16-5-3-15(4-6-16)14-18(25)9-7-17-8-12-21(26)24(17)13-1-2-19-10-11-20(29-19)22(27)28/h3-6,10-11,17-18,25H,1-2,7-9,12-14H2,(H,27,28)/t17-,18+/m0/s1 | PDB
Reactome pathway
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Similars
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PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181272
(4-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCc1ccc(cc1)C(O)=O)Cc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C25H28F3NO4/c26-25(27,28)20-5-1-3-18(15-20)16-22(30)12-10-21-11-13-23(31)29(21)14-2-4-17-6-8-19(9-7-17)24(32)33/h1,3,5-9,15,21-22,30H,2,4,10-14,16H2,(H,32,33)/t21-,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181282
(5-(3-((S)-2-(4-(4-chlorophenyl)-3-hydroxybutyl)-5-...)Show SMILES OC(CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1ccc(Cl)cc1 Show InChI InChI=1S/C22H26ClNO4S/c23-16-5-3-15(4-6-16)14-18(25)9-7-17-8-12-21(26)24(17)13-1-2-19-10-11-20(29-19)22(27)28/h3-6,10-11,17-18,25H,1-2,7-9,12-14H2,(H,27,28)/t17-,18?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181281
(4-(3-(2-(4-(3-fluorophenyl)-3-hydroxybutyl)-5-oxop...)Show SMILES OC(CCC1CCC(=O)N1CCCc1ccc(cc1)C(O)=O)Cc1cccc(F)c1 Show InChI InChI=1S/C24H28FNO4/c25-20-5-1-3-18(15-20)16-22(27)12-10-21-11-13-23(28)26(21)14-2-4-17-6-8-19(9-7-17)24(29)30/h1,3,5-9,15,21-22,27H,2,4,10-14,16H2,(H,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181280
(5-(3-((S)-2-(4-(4-ethylphenyl)-3-hydroxybutyl)-5-o...)Show SMILES CCc1ccc(CC(O)CC[C@H]2CCC(=O)N2CCCc2ccc(s2)C(O)=O)cc1 Show InChI InChI=1S/C24H31NO4S/c1-2-17-5-7-18(8-6-17)16-20(26)11-9-19-10-14-23(27)25(19)15-3-4-21-12-13-22(30-21)24(28)29/h5-8,12-13,19-20,26H,2-4,9-11,14-16H2,1H3,(H,28,29)/t19-,20?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181278
(7-((S)-2-((R)-3-hydroxy-4-(3-(2-methoxyethyl)pheny...)Show SMILES COCCc1cccc(C[C@H](O)CC[C@H]2CCC(=O)N2CCCCCCC(O)=O)c1 Show InChI InChI=1S/C24H37NO5/c1-30-16-14-19-7-6-8-20(17-19)18-22(26)12-10-21-11-13-23(27)25(21)15-5-3-2-4-9-24(28)29/h6-8,17,21-22,26H,2-5,9-16,18H2,1H3,(H,28,29)/t21-,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181285
(4-(3-(2-(3-hydroxy-4-(3-phenoxyphenyl)butyl)-5-oxo...)Show SMILES OC(CCC1CCC(=O)N1CCCc1ccc(cc1)C(O)=O)Cc1cccc(Oc2ccccc2)c1 Show InChI InChI=1S/C30H33NO5/c32-26(20-23-6-4-10-28(21-23)36-27-8-2-1-3-9-27)17-15-25-16-18-29(33)31(25)19-5-7-22-11-13-24(14-12-22)30(34)35/h1-4,6,8-14,21,25-26,32H,5,7,15-20H2,(H,34,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181283
(4-(3-(2-(3-hydroxy-4-phenylbutyl)-5-oxopyrrolidin-...)Show SMILES OC(CCC1CCC(=O)N1CCCc1ccc(cc1)C(O)=O)Cc1ccccc1 Show InChI InChI=1S/C24H29NO4/c26-22(17-19-5-2-1-3-6-19)14-12-21-13-15-23(27)25(21)16-4-7-18-8-10-20(11-9-18)24(28)29/h1-3,5-6,8-11,21-22,26H,4,7,12-17H2,(H,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181273
(7-[(S)-2-((R)-4-biphenyl-3-yl-3-hydroxy-butyl)-5-o...)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCCCCC(O)=O)Cc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C27H35NO4/c29-25(20-21-9-8-12-23(19-21)22-10-4-3-5-11-22)16-14-24-15-17-26(30)28(24)18-7-2-1-6-13-27(31)32/h3-5,8-12,19,24-25,29H,1-2,6-7,13-18,20H2,(H,31,32)/t24-,25+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 337 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181275
(7-((S)-2-((R)-4-(3-cyanophenyl)-3-hydroxybutyl)-5-...)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCCCCC(O)=O)Cc1cccc(c1)C#N Show InChI InChI=1S/C22H30N2O4/c23-16-18-7-5-6-17(14-18)15-20(25)11-9-19-10-12-21(26)24(19)13-4-2-1-3-8-22(27)28/h5-7,14,19-20,25H,1-4,8-13,15H2,(H,27,28)/t19-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 388 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181276
(7-((S)-2-(3-hydroxy-4-(3-phenoxyphenyl)butyl)-5-ox...)Show SMILES OC(CC[C@H]1CCC(=O)N1CCCCCCC(O)=O)Cc1cccc(Oc2ccccc2)c1 Show InChI InChI=1S/C27H35NO5/c29-23(19-21-9-8-12-25(20-21)33-24-10-4-3-5-11-24)16-14-22-15-17-26(30)28(22)18-7-2-1-6-13-27(31)32/h3-5,8-12,20,22-23,29H,1-2,6-7,13-19H2,(H,31,32)/t22-,23?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 536 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181287
(7-((S)-2-((R)-3-hydroxy-4-(3-hydroxyphenyl)butyl)-...)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCCCCC(O)=O)Cc1cccc(O)c1 Show InChI InChI=1S/C21H31NO5/c23-18-7-5-6-16(14-18)15-19(24)11-9-17-10-12-20(25)22(17)13-4-2-1-3-8-21(26)27/h5-7,14,17,19,23-24H,1-4,8-13,15H2,(H,26,27)/t17-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181294
(5-{3-[(S)-2-(4-biphenyl-2-yl-3-hydroxy-butyl)-5-ox...)Show SMILES OC(CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1ccccc1-c1ccccc1 Show InChI InChI=1S/C28H31NO4S/c30-23(19-21-9-4-5-11-25(21)20-7-2-1-3-8-20)14-12-22-13-17-27(31)29(22)18-6-10-24-15-16-26(34-24)28(32)33/h1-5,7-9,11,15-16,22-23,30H,6,10,12-14,17-19H2,(H,32,33)/t22-,23?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293504
(7-(N-(4-tert-butylbenzyl)methylsulfonamido)heptano...)Show SMILES CC(C)(C)c1ccc(CN(CCCCCCC(O)=O)S(C)(=O)=O)cc1 Show InChI InChI=1S/C19H31NO4S/c1-19(2,3)17-12-10-16(11-13-17)15-20(25(4,23)24)14-8-6-5-7-9-18(21)22/h10-13H,5-9,14-15H2,1-4H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293497
(7-(N-(4-hydroxynonyl)methylsulfonamido)heptanoic a...)Show InChI InChI=1S/C17H35NO5S/c1-3-4-7-11-16(19)12-10-15-18(24(2,22)23)14-9-6-5-8-13-17(20)21/h16,19H,3-15H2,1-2H3,(H,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50410856
(CHEMBL2113220)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCCCCC(O)=O)CCc1ccccc1 Show InChI InChI=1S/C22H33NO4/c24-20(14-11-18-8-4-3-5-9-18)15-12-19-13-16-21(25)23(19)17-7-2-1-6-10-22(26)27/h3-5,8-9,19-20,24H,1-2,6-7,10-17H2,(H,26,27)/t19-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181288
(4-(3-(2-(4-(4-fluorophenyl)-3-hydroxybutyl)-5-oxop...)Show SMILES OC(CCC1CCC(=O)N1CCCc1ccc(cc1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C24H28FNO4/c25-20-9-5-18(6-10-20)16-22(27)13-11-21-12-14-23(28)26(21)15-1-2-17-3-7-19(8-4-17)24(29)30/h3-10,21-22,27H,1-2,11-16H2,(H,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity to rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293499
(7-(N-(4-hydroxy-6-methylheptyl)methylsulfonamido)h...)Show InChI InChI=1S/C16H33NO5S/c1-14(2)13-15(18)9-8-12-17(23(3,21)22)11-7-5-4-6-10-16(19)20/h14-15,18H,4-13H2,1-3H3,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293502
(7-(N-(4-butylbenzyl)methylsulfonamido)heptanoic ac...)Show InChI InChI=1S/C19H31NO4S/c1-3-4-9-17-11-13-18(14-12-17)16-20(25(2,23)24)15-8-6-5-7-10-19(21)22/h11-14H,3-10,15-16H2,1-2H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293503
(7-(N-(biphenyl-4-ylmethyl)methylsulfonamido)heptan...)Show SMILES CS(=O)(=O)N(CCCCCCC(O)=O)Cc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H27NO4S/c1-27(25,26)22(16-8-3-2-7-11-21(23)24)17-18-12-14-20(15-13-18)19-9-5-4-6-10-19/h4-6,9-10,12-15H,2-3,7-8,11,16-17H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293498
(7-(N-(4-(1-hydroxyhexyl)benzyl)methylsulfonamido)h...)Show SMILES CCCCCC(O)c1ccc(CN(CCCCCCC(O)=O)S(C)(=O)=O)cc1 Show InChI InChI=1S/C21H35NO5S/c1-3-4-7-10-20(23)19-14-12-18(13-15-19)17-22(28(2,26)27)16-9-6-5-8-11-21(24)25/h12-15,20,23H,3-11,16-17H2,1-2H3,(H,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293505
(2-(4-(N-(4-butylbenzyl)methylsulfonamido)butoxy)ac...)Show InChI InChI=1S/C18H29NO5S/c1-3-4-7-16-8-10-17(11-9-16)14-19(25(2,22)23)12-5-6-13-24-15-18(20)21/h8-11H,3-7,12-15H2,1-2H3,(H,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293506
(3-(3-(N-(4-butylbenzyl)methylsulfonamido)propoxy)b...)Show SMILES CCCCc1ccc(CN(CCCOc2cccc(c2)C(O)=O)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H29NO5S/c1-3-4-7-18-10-12-19(13-11-18)17-23(29(2,26)27)14-6-15-28-21-9-5-8-20(16-21)22(24)25/h5,8-13,16H,3-4,6-7,14-15,17H2,1-2H3,(H,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293507
(2-(4-(2-(N-(4-butylbenzyl)methylsulfonamido)ethyl)...)Show SMILES CCCCc1ccc(CN(CCc2ccc(CC(O)=O)cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H29NO4S/c1-3-4-5-18-8-12-21(13-9-18)17-23(28(2,26)27)15-14-19-6-10-20(11-7-19)16-22(24)25/h6-13H,3-5,14-17H2,1-2H3,(H,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293508
(2-(2-((N-(4-butylbenzyl)methylsulfonamido)methyl)p...)Show SMILES CCCCc1ccc(CN(Cc2ccccc2OCC(O)=O)S(C)(=O)=O)cc1 Show InChI InChI=1S/C21H27NO5S/c1-3-4-7-17-10-12-18(13-11-17)14-22(28(2,25)26)15-19-8-5-6-9-20(19)27-16-21(23)24/h5-6,8-13H,3-4,7,14-16H2,1-2H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293509
(4-(2-(N-(4-butylbenzyl)methylsulfonamido)phenyl)bu...)Show SMILES CCCCc1ccc(CN(c2ccccc2CCCC(O)=O)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H29NO4S/c1-3-4-8-18-13-15-19(16-14-18)17-23(28(2,26)27)21-11-6-5-9-20(21)10-7-12-22(24)25/h5-6,9,11,13-16H,3-4,7-8,10,12,17H2,1-2H3,(H,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293510
(4-(4-(N-(4-butylbenzyl)methylsulfonamido)phenyl)bu...)Show SMILES CCCCc1ccc(CN(c2ccc(CCCC(O)=O)cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H29NO4S/c1-3-4-6-18-9-11-20(12-10-18)17-23(28(2,26)27)21-15-13-19(14-16-21)7-5-8-22(24)25/h9-16H,3-8,17H2,1-2H3,(H,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293511
(3-(3-(N-(4-butylbenzyl)methylsulfonamido)phenyl)pr...)Show SMILES CCCCc1ccc(CN(c2cccc(CCC(O)=O)c2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C21H27NO4S/c1-3-4-6-17-9-11-19(12-10-17)16-22(27(2,25)26)20-8-5-7-18(15-20)13-14-21(23)24/h5,7-12,15H,3-4,6,13-14,16H2,1-2H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293489
(2-(3-((N-(4-tert-butylbenzyl)methylsulfonamido)met...)Show SMILES CC(C)(C)c1ccc(CN(Cc2cccc(OCC(O)=O)c2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C21H27NO5S/c1-21(2,3)18-10-8-16(9-11-18)13-22(28(4,25)26)14-17-6-5-7-19(12-17)27-15-20(23)24/h5-12H,13-15H2,1-4H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293490
(3-(3-((N-(4-butylbenzyl)methylsulfonamido)methyl)p...)Show SMILES CCCCc1ccc(CN(Cc2cccc(CCC(O)=O)c2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H29NO4S/c1-3-4-6-18-9-11-20(12-10-18)16-23(28(2,26)27)17-21-8-5-7-19(15-21)13-14-22(24)25/h5,7-12,15H,3-4,6,13-14,16-17H2,1-2H3,(H,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293491
(3-(3-((N-(4-tert-butylbenzyl)methylsulfonamido)met...)Show SMILES CC(C)(C)c1ccc(CN(Cc2cccc(CCC(O)=O)c2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H29NO4S/c1-22(2,3)20-11-8-18(9-12-20)15-23(28(4,26)27)16-19-7-5-6-17(14-19)10-13-21(24)25/h5-9,11-12,14H,10,13,15-16H2,1-4H3,(H,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293492
(3-(3-((N-(4-tert-butylbenzyl)phenylsulfonamido)met...)Show SMILES CC(C)(C)c1ccc(CN(Cc2cccc(CCC(O)=O)c2)S(=O)(=O)c2ccccc2)cc1 Show InChI InChI=1S/C27H31NO4S/c1-27(2,3)24-15-12-22(13-16-24)19-28(33(31,32)25-10-5-4-6-11-25)20-23-9-7-8-21(18-23)14-17-26(29)30/h4-13,15-16,18H,14,17,19-20H2,1-3H3,(H,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50293493
(3-(3-((N-(4-tert-butylbenzyl)pyridine-2-sulfonamid...)Show SMILES CC(C)(C)c1ccc(CN(Cc2cccc(CCC(O)=O)c2)S(=O)(=O)c2ccccn2)cc1 Show InChI InChI=1S/C26H30N2O4S/c1-26(2,3)23-13-10-21(11-14-23)18-28(33(31,32)24-9-4-5-16-27-24)19-22-8-6-7-20(17-22)12-15-25(29)30/h4-11,13-14,16-17H,12,15,18-19H2,1-3H3,(H,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | |
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