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Compile Data Set for Download or QSAR

Found 460 hits of ic50 for UniProtKB: P30291   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245523
PNG
(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Show SMILES NC(=O)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C23H16ClN3O4/c24-15-4-2-1-3-12(15)13-10-17-19(21-20(13)22(30)26-23(21)31)14-9-11(28)5-6-16(14)27(17)8-7-18(25)29/h1-6,9-10,28H,7-8H2,(H2,25,29)(H,26,30,31)
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n/an/a 6n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245523
PNG
(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Show SMILES NC(=O)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C23H16ClN3O4/c24-15-4-2-1-3-12(15)13-10-17-19(21-20(13)22(30)26-23(21)31)14-9-11(28)5-6-16(14)27(17)8-7-18(25)29/h1-6,9-10,28H,7-8H2,(H2,25,29)(H,26,30,31)
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n/an/a 6n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation


Eur J Med Chem 43: 1276-96 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.016
BindingDB Entry DOI: 10.7270/Q26M36MC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245496
PNG
(4-(2,6-Dichlorophenyl)-9-hydroxy-6-(3-hydroxypropy...)
Show SMILES OCCCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1c(Cl)cccc1Cl |(23.53,-35.27,;24.56,-34.12,;24.08,-32.66,;25.11,-31.51,;24.63,-30.05,;23.16,-29.57,;21.82,-30.34,;20.49,-29.57,;20.49,-28.02,;19.16,-27.25,;21.82,-27.25,;23.16,-28.02,;24.63,-27.54,;25.26,-26.13,;24.64,-24.72,;23.13,-24.4,;25.78,-23.7,;27.11,-24.47,;28.52,-23.85,;26.79,-25.97,;27.71,-27.22,;27.08,-28.64,;25.54,-28.79,;29.23,-27.06,;30.14,-28.31,;29.51,-29.72,;31.67,-28.15,;32.3,-26.75,;31.38,-25.5,;29.86,-25.66,;29.84,-24.12,)|
Show InChI InChI=1S/C23H16Cl2N2O4/c24-14-3-1-4-15(25)18(14)13-10-17-19(21-20(13)22(30)26-23(21)31)12-9-11(29)5-6-16(12)27(17)7-2-8-28/h1,3-6,9-10,28-29H,2,7-8H2,(H,26,30,31)
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n/an/a 7n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation


Eur J Med Chem 43: 1276-96 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.016
BindingDB Entry DOI: 10.7270/Q26M36MC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245387
PNG
(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Show SMILES Oc1ccc2n(CCC(=O)NS(=O)(=O)c3ccccc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C29H20ClN3O6S/c30-21-9-5-4-8-18(21)19-15-23-25(27-26(19)28(36)31-29(27)37)20-14-16(34)10-11-22(20)33(23)13-12-24(35)32-40(38,39)17-6-2-1-3-7-17/h1-11,14-15,34H,12-13H2,(H,32,35)(H,31,36,37)
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n/an/a 7n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation


Eur J Med Chem 43: 1276-96 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.016
BindingDB Entry DOI: 10.7270/Q26M36MC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245387
PNG
(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Show SMILES Oc1ccc2n(CCC(=O)NS(=O)(=O)c3ccccc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C29H20ClN3O6S/c30-21-9-5-4-8-18(21)19-15-23-25(27-26(19)28(36)31-29(27)37)20-14-16(34)10-11-22(20)33(23)13-12-24(35)32-40(38,39)17-6-2-1-3-7-17/h1-11,14-15,34H,12-13H2,(H,32,35)(H,31,36,37)
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n/an/a 7n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245496
PNG
(4-(2,6-Dichlorophenyl)-9-hydroxy-6-(3-hydroxypropy...)
Show SMILES OCCCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1c(Cl)cccc1Cl |(23.53,-35.27,;24.56,-34.12,;24.08,-32.66,;25.11,-31.51,;24.63,-30.05,;23.16,-29.57,;21.82,-30.34,;20.49,-29.57,;20.49,-28.02,;19.16,-27.25,;21.82,-27.25,;23.16,-28.02,;24.63,-27.54,;25.26,-26.13,;24.64,-24.72,;23.13,-24.4,;25.78,-23.7,;27.11,-24.47,;28.52,-23.85,;26.79,-25.97,;27.71,-27.22,;27.08,-28.64,;25.54,-28.79,;29.23,-27.06,;30.14,-28.31,;29.51,-29.72,;31.67,-28.15,;32.3,-26.75,;31.38,-25.5,;29.86,-25.66,;29.84,-24.12,)|
Show InChI InChI=1S/C23H16Cl2N2O4/c24-14-3-1-4-15(25)18(14)13-10-17-19(21-20(13)22(30)26-23(21)31)12-9-11(29)5-6-16(12)27(17)7-2-8-28/h1,3-6,9-10,28-29H,2,7-8H2,(H,26,30,31)
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n/an/a 7.10n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245457
PNG
(4-(2,6-Dichlorophenyl)-9-hydroxy-6-(2-hydroxyethyl...)
Show SMILES OCCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1c(Cl)cccc1Cl |(20.53,-24.9,;20.05,-23.43,;21.08,-22.29,;20.6,-20.82,;19.13,-20.34,;17.8,-21.11,;16.46,-20.34,;16.46,-18.8,;15.13,-18.03,;17.79,-18.03,;19.13,-18.79,;20.6,-18.31,;21.23,-16.9,;20.61,-15.5,;19.1,-15.18,;21.75,-14.47,;23.08,-15.24,;24.49,-14.62,;22.76,-16.75,;23.68,-18,;23.05,-19.41,;21.51,-19.57,;25.2,-17.84,;26.11,-19.09,;25.48,-20.49,;27.64,-18.93,;28.27,-17.52,;27.35,-16.27,;25.83,-16.44,;25.81,-14.89,)|
Show InChI InChI=1S/C22H14Cl2N2O4/c23-13-2-1-3-14(24)17(13)12-9-16-18(20-19(12)21(29)25-22(20)30)11-8-10(28)4-5-15(11)26(16)6-7-27/h1-5,8-9,27-28H,6-7H2,(H,25,29,30)
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n/an/a 8n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation


Eur J Med Chem 43: 1276-96 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.016
BindingDB Entry DOI: 10.7270/Q26M36MC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245457
PNG
(4-(2,6-Dichlorophenyl)-9-hydroxy-6-(2-hydroxyethyl...)
Show SMILES OCCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1c(Cl)cccc1Cl |(20.53,-24.9,;20.05,-23.43,;21.08,-22.29,;20.6,-20.82,;19.13,-20.34,;17.8,-21.11,;16.46,-20.34,;16.46,-18.8,;15.13,-18.03,;17.79,-18.03,;19.13,-18.79,;20.6,-18.31,;21.23,-16.9,;20.61,-15.5,;19.1,-15.18,;21.75,-14.47,;23.08,-15.24,;24.49,-14.62,;22.76,-16.75,;23.68,-18,;23.05,-19.41,;21.51,-19.57,;25.2,-17.84,;26.11,-19.09,;25.48,-20.49,;27.64,-18.93,;28.27,-17.52,;27.35,-16.27,;25.83,-16.44,;25.81,-14.89,)|
Show InChI InChI=1S/C22H14Cl2N2O4/c23-13-2-1-3-14(24)17(13)12-9-16-18(20-19(12)21(29)25-22(20)30)11-8-10(28)4-5-15(11)26(16)6-7-27/h1-5,8-9,27-28H,6-7H2,(H,25,29,30)
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n/an/a 8n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50232241
PNG
(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Show SMILES OCCCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C23H17ClN2O4/c24-16-5-2-1-4-13(16)14-11-18-19(21-20(14)22(29)25-23(21)30)15-10-12(28)6-7-17(15)26(18)8-3-9-27/h1-2,4-7,10-11,27-28H,3,8-9H2,(H,25,29,30)
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n/an/a 8.90n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50232241
PNG
(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Show SMILES OCCCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C23H17ClN2O4/c24-16-5-2-1-4-13(16)14-11-18-19(21-20(14)22(29)25-23(21)30)15-10-12(28)6-7-17(15)26(18)8-3-9-27/h1-2,4-7,10-11,27-28H,3,8-9H2,(H,25,29,30)
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n/an/a 9n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation


Eur J Med Chem 43: 1276-96 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.016
BindingDB Entry DOI: 10.7270/Q26M36MC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245384
PNG
(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Show SMILES OC(=O)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C23H15ClN2O5/c24-15-4-2-1-3-12(15)13-10-17-19(21-20(13)22(30)25-23(21)31)14-9-11(27)5-6-16(14)26(17)8-7-18(28)29/h1-6,9-10,27H,7-8H2,(H,28,29)(H,25,30,31)
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n/an/a 9n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation


Eur J Med Chem 43: 1276-96 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.016
BindingDB Entry DOI: 10.7270/Q26M36MC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50232241
PNG
(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Show SMILES OCCCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C23H17ClN2O4/c24-16-5-2-1-4-13(16)14-11-18-19(21-20(14)22(29)25-23(21)30)15-10-12(28)6-7-17(15)26(18)8-3-9-27/h1-2,4-7,10-11,27-28H,3,8-9H2,(H,25,29,30)
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n/an/a 9n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Bioorg Med Chem Lett 18: 929-33 (2008)


Article DOI: 10.1016/j.bmcl.2007.12.046
BindingDB Entry DOI: 10.7270/Q2ZS2XC3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50279633
PNG
(6-(2-(1H-1,2,3-triazol-1-ylsulfinyl)ethyl)-4-(2-ch...)
Show SMILES Oc1ccc2n(CCS(=O)n3ccnn3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C24H16ClN5O4S/c25-17-4-2-1-3-14(17)15-12-19-20(22-21(15)23(32)27-24(22)33)16-11-13(31)5-6-18(16)29(19)9-10-35(34)30-8-7-26-28-30/h1-8,11-12,31H,9-10H2,(H,27,32,33)
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n/an/a 9n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245384
PNG
(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Show SMILES OC(=O)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C23H15ClN2O5/c24-15-4-2-1-3-12(15)13-10-17-19(21-20(13)22(30)25-23(21)31)14-9-11(27)5-6-16(14)26(17)8-7-18(28)29/h1-6,9-10,27H,7-8H2,(H,28,29)(H,25,30,31)
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n/an/a 9n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245425
PNG
(4-(2-Chlorophenyl)-9-hydroxy-6-[2-(1H-1,2,4-triazo...)
Show SMILES Oc1ccc2n(CCS(=O)c3nnc[nH]3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C24H16ClN5O4S/c25-16-4-2-1-3-13(16)14-10-18-19(21-20(14)22(32)28-23(21)33)15-9-12(31)5-6-17(15)30(18)7-8-35(34)24-26-11-27-29-24/h1-6,9-11,31H,7-8H2,(H,26,27,29)(H,28,32,33)
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n/an/a 9n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation


Eur J Med Chem 43: 1276-96 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.016
BindingDB Entry DOI: 10.7270/Q26M36MC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM264255
PNG
(8-Bromo-6-(2,6-dichlorophenyl)-2-((4-(piperazin-1-...)
Show SMILES Clc1cccc(Cl)c1-n1cc(Br)c2nc(Nc3ccc(cc3)N3CCNCC3)ncc2c1=O |(5.33,3.46,;6.67,2.69,;8,3.46,;9.34,2.69,;9.34,1.15,;8,.39,;8,-1.15,;6.67,1.15,;5.33,.38,;5.33,-1.16,;4,-1.93,;4,-3.46,;2.67,-1.16,;1.33,-1.93,;,-1.16,;-1.33,-1.93,;-2.67,-1.16,;-4,-1.93,;-5.33,-1.16,;-5.33,.38,;-4,1.15,;-2.67,.38,;-6.67,1.15,;-8,.38,;-9.34,1.15,;-9.34,2.69,;-8,3.46,;-6.67,2.69,;,.38,;1.33,1.15,;2.67,.38,;4,1.15,;4,2.69,)|
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US Patent US9714244 (2017)


BindingDB Entry DOI: 10.7270/Q2GH9KZ4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM264260
PNG
(6-(2,6-Dichlorophenyl)-8-(3-hydroxyprop-1-yn-1-yl)...)
Show SMILES Cc1cc(Nc2ncc3c(n2)c(cn(-c2c(Cl)cccc2Cl)c3=O)C#CCO)ccc1N1CCNCC1 |(-4,4.62,;-4,3.08,;-2.67,2.31,;-2.67,.77,;-1.33,,;,.77,;,2.31,;1.33,3.08,;2.67,2.31,;2.67,.77,;1.33,,;4,,;5.33,.77,;5.33,2.31,;6.67,3.08,;6.67,4.62,;5.33,5.39,;8,5.39,;9.34,4.62,;9.34,3.08,;8,2.31,;8,.77,;4,3.08,;4,4.62,;4,-1.54,;4,-3.08,;4,-4.62,;2.67,-5.39,;-4,,;-5.33,.77,;-5.33,2.31,;-6.67,3.08,;-8,2.31,;-9.34,3.08,;-9.34,4.62,;-8,5.39,;-6.67,4.62,)|
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US Patent US9714244 (2017)


BindingDB Entry DOI: 10.7270/Q2GH9KZ4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM264267
PNG
(6-(2,6-Dichlorophenyl)-2-((4-(4-(2-hydroxyethyl)pi...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3c(ccn(-c4c(Cl)cccc4Cl)c3=O)n2)cc1 |(-11.34,2.7,;-10,1.92,;-8.67,2.7,;-7.34,1.92,;-7.34,.39,;-6,-.39,;-4.67,.39,;-4.67,1.92,;-6,2.7,;-3.33,-.39,;-3.33,-1.92,;-2,-2.7,;-.67,-1.92,;.67,-2.7,;2,-1.92,;2,-.39,;3.33,.39,;4.67,-.39,;4.67,-1.92,;6,-2.7,;7.34,-1.92,;7.34,-.39,;8.67,.39,;8.67,1.92,;7.34,2.7,;10,2.7,;11.34,1.92,;11.34,.39,;10,-.39,;10,-1.92,;6,.39,;6,1.92,;3.33,-2.7,;-.67,-.39,;-2,.39,)|
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US Patent US9714244 (2017)


BindingDB Entry DOI: 10.7270/Q2GH9KZ4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM264275
PNG
(6-(2,6-Dichlorophenyl)-2-((3-fluoro-4-(piperazin-1...)
Show SMILES Fc1cc(Nc2ncc3c(ccn(-c4c(Cl)cccc4Cl)c3=O)n2)ccc1N1CCNCC1 |(-4,1.92,;-4,.38,;-2.67,-.39,;-2.67,-1.93,;-1.33,-2.7,;,-1.93,;,-.39,;1.33,.39,;2.67,-.39,;2.67,-1.93,;4,-2.7,;5.33,-1.93,;5.33,-.39,;6.67,.38,;6.67,1.92,;5.33,2.69,;8,2.7,;9.34,1.92,;9.34,.38,;8,-.39,;8,-1.93,;4,.38,;4,1.92,;1.33,-2.7,;-4,-2.7,;-5.33,-1.93,;-5.33,-.39,;-6.67,.38,;-8,-.39,;-9.34,.38,;-9.34,1.92,;-8,2.69,;-6.67,1.92,)|
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US Patent US9714244 (2017)


BindingDB Entry DOI: 10.7270/Q2GH9KZ4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM264269
PNG
(6-(2,6-Dichlorophenyl)-2-((4-(piperazin-1-yl)pheny...)
Show SMILES Clc1cccc(Cl)c1-n1cc(-c2cccnc2)c2nc(Nc3ccc(cc3)N3CCNCC3)ncc2c1=O |(5.33,5,;6.67,4.23,;8,5,;9.34,4.23,;9.34,2.69,;8,1.93,;8,.38,;6.67,2.69,;5.33,1.93,;5.33,.38,;4,-.38,;4,-1.93,;2.67,-2.69,;2.67,-4.23,;4,-5,;5.33,-4.23,;5.33,-2.69,;2.67,.38,;1.33,-.38,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-5.33,.38,;-5.33,1.93,;-4,2.69,;-2.67,1.93,;-6.67,2.69,;-8,1.93,;-9.34,2.69,;-9.34,4.23,;-8,5,;-6.67,4.23,;,1.93,;1.33,2.69,;2.67,1.93,;4,2.69,;4,4.23,)|
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US Patent US9714244 (2017)


BindingDB Entry DOI: 10.7270/Q2GH9KZ4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM264270
PNG
(6-(2-Chlorophenyl)-2-((3-methyl-4-(piperazin-1-yl)...)
Show SMILES Cc1cc(Nc2ncc3c(ccn(-c4ccccc4Cl)c3=O)n2)ccc1N1CCNCC1
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US Patent US9714244 (2017)


BindingDB Entry DOI: 10.7270/Q2GH9KZ4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM264273
PNG
(2-((3-Chloro-4-(piperazin-1-yl)phenyl)amino)-6-(2,...)
Show SMILES Clc1cccc(Cl)c1-n1ccc2nc(Nc3ccc(N4CCNCC4)c(Cl)c3)ncc2c1=O |(5.33,2.69,;6.67,1.92,;8,2.7,;9.34,1.92,;9.34,.38,;8,-.39,;8,-1.93,;6.67,.38,;5.33,-.39,;5.33,-1.93,;4,-2.7,;2.67,-1.93,;1.33,-2.7,;,-1.93,;-1.33,-2.7,;-2.67,-1.93,;-4,-2.7,;-5.33,-1.93,;-5.33,-.39,;-6.67,.38,;-8,-.39,;-9.34,.38,;-9.34,1.92,;-8,2.69,;-6.67,1.92,;-4,.38,;-4,1.92,;-2.67,-.39,;,-.39,;1.33,.39,;2.67,-.39,;4,.38,;4,1.92,)|
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US Patent US9714244 (2017)


BindingDB Entry DOI: 10.7270/Q2GH9KZ4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM264268
PNG
(8-(3-Aminoprop-1-yn-1-yl)-6-(2,6-dichlorophenyl)-2...)
Show SMILES NCC#Cc1cn(-c2c(Cl)cccc2Cl)c(=O)c2cnc(Nc3ccc(cc3)N3CCOCC3)nc12 |(2.67,-5.39,;4,-4.62,;4,-3.08,;4,-1.54,;4,,;5.33,.77,;5.33,2.31,;6.67,3.08,;6.67,4.62,;5.33,5.39,;8,5.39,;9.34,4.62,;9.34,3.08,;8,2.31,;8,.77,;4,3.08,;4,4.62,;2.67,2.31,;1.33,3.08,;,2.31,;,.77,;-1.33,,;-2.67,.77,;-4,,;-5.33,.77,;-5.33,2.31,;-4,3.08,;-2.67,2.31,;-6.67,3.08,;-8,2.31,;-9.34,3.08,;-9.34,4.62,;-8,5.39,;-6.67,4.62,;1.33,,;2.67,.77,)|
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ALMAC DISCOVERY LIMITED

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US Patent US9714244 (2017)


BindingDB Entry DOI: 10.7270/Q2GH9KZ4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50192371
PNG
(4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazol...)
Show SMILES Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C20H11ClN2O3/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(25)23-20(18)26)12-7-9(24)5-6-14(12)22-15/h1-8,22,24H,(H,23,25,26)
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n/an/a 11n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 in presence of 9.5 uM ATP


J Med Chem 49: 4896-911 (2006)


Article DOI: 10.1021/jm0512591
BindingDB Entry DOI: 10.7270/Q23778BD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50192371
PNG
(4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazol...)
Show SMILES Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C20H11ClN2O3/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(25)23-20(18)26)12-7-9(24)5-6-14(12)22-15/h1-8,22,24H,(H,23,25,26)
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n/an/a 11n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50192371
PNG
(4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazol...)
Show SMILES Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C20H11ClN2O3/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(25)23-20(18)26)12-7-9(24)5-6-14(12)22-15/h1-8,22,24H,(H,23,25,26)
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n/an/a 11n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation


Eur J Med Chem 43: 1276-96 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.016
BindingDB Entry DOI: 10.7270/Q26M36MC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50192393
PNG
(4-(2-chloro-3-hydroxyphenyl)-9-hydroxypyrrolo[3,4-...)
Show SMILES Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1cccc(O)c1Cl
Show InChI InChI=1S/C20H11ClN2O4/c21-18-9(2-1-3-14(18)25)10-7-13-15(17-16(10)19(26)23-20(17)27)11-6-8(24)4-5-12(11)22-13/h1-7,22,24-25H,(H,23,26,27)
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 in presence of 9.5 uM ATP


J Med Chem 49: 4896-911 (2006)


Article DOI: 10.1021/jm0512591
BindingDB Entry DOI: 10.7270/Q23778BD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50192414
PNG
(4-(3-amino-2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]...)
Show SMILES Nc1cccc(c1Cl)-c1cc2[nH]c3ccc(O)cc3c2c2C(=O)NC(=O)c12
Show InChI InChI=1S/C20H12ClN3O3/c21-18-9(2-1-3-12(18)22)10-7-14-15(17-16(10)19(26)24-20(17)27)11-6-8(25)4-5-13(11)23-14/h1-7,23,25H,22H2,(H,24,26,27)
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n/an/a 12n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245386
PNG
(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Show SMILES CS(=O)(=O)NC(=O)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C24H18ClN3O6S/c1-35(33,34)27-19(30)8-9-28-17-7-6-12(29)10-15(17)20-18(28)11-14(13-4-2-3-5-16(13)25)21-22(20)24(32)26-23(21)31/h2-7,10-11,29H,8-9H2,1H3,(H,27,30)(H,26,31,32)
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Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245386
PNG
(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Show SMILES CS(=O)(=O)NC(=O)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C24H18ClN3O6S/c1-35(33,34)27-19(30)8-9-28-17-7-6-12(29)10-15(17)20-18(28)11-14(13-4-2-3-5-16(13)25)21-22(20)24(32)26-23(21)31/h2-7,10-11,29H,8-9H2,1H3,(H,27,30)(H,26,31,32)
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation


Eur J Med Chem 43: 1276-96 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.016
BindingDB Entry DOI: 10.7270/Q26M36MC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50192422
PNG
(4-(2-iodophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-...)
Show SMILES Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1I
Show InChI InChI=1S/C20H11IN2O3/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(25)23-20(18)26)12-7-9(24)5-6-14(12)22-15/h1-8,22,24H,(H,23,25,26)
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n/an/a 13n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 in presence of 9.5 uM ATP


J Med Chem 49: 4896-911 (2006)


Article DOI: 10.1021/jm0512591
BindingDB Entry DOI: 10.7270/Q23778BD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50192422
PNG
(4-(2-iodophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-...)
Show SMILES Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1I
Show InChI InChI=1S/C20H11IN2O3/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(25)23-20(18)26)12-7-9(24)5-6-14(12)22-15/h1-8,22,24H,(H,23,25,26)
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n/an/a 13n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245458
PNG
(4-(4-(2-Chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Show SMILES OC(=O)CCCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C24H17ClN2O5/c25-16-5-2-1-4-13(16)14-11-18-20(22-21(14)23(31)26-24(22)32)15-10-12(28)7-8-17(15)27(18)9-3-6-19(29)30/h1-2,4-5,7-8,10-11,28H,3,6,9H2,(H,29,30)(H,26,31,32)
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n/an/a 13n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation


Eur J Med Chem 43: 1276-96 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.016
BindingDB Entry DOI: 10.7270/Q26M36MC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245341
PNG
(3-(4-(2,6-dichlorophenyl)-9-hydroxy-1,3-dioxo-2,3-...)
Show SMILES CN(C)CCNC(=O)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1c(Cl)cccc1Cl |(18.95,-7.42,;19.98,-6.27,;19.49,-4.8,;21.48,-6.57,;22.51,-5.42,;24.02,-5.73,;25.04,-4.58,;26.55,-4.89,;24.55,-3.12,;25.57,-1.97,;25.09,-.51,;23.61,-.04,;22.27,-.81,;20.93,-.04,;20.94,1.51,;19.6,2.28,;22.26,2.28,;23.6,1.52,;25.07,2,;25.69,3.41,;25.05,4.81,;23.55,5.13,;26.19,5.85,;27.52,5.09,;28.93,5.72,;27.21,3.58,;28.14,2.34,;27.52,.93,;25.99,.76,;29.67,2.52,;30.58,1.28,;29.97,-.13,;32.11,1.45,;32.73,2.87,;31.8,4.11,;30.28,3.93,;30.26,5.47,)|
Show InChI InChI=1S/C27H24Cl2N4O4/c1-32(2)11-9-30-21(35)8-10-33-19-7-6-14(34)12-15(19)23-20(33)13-16(22-17(28)4-3-5-18(22)29)24-25(23)27(37)31-26(24)36/h3-7,12-13,34H,8-11H2,1-2H3,(H,30,35)(H,31,36,37)
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n/an/a 14n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245341
PNG
(3-(4-(2,6-dichlorophenyl)-9-hydroxy-1,3-dioxo-2,3-...)
Show SMILES CN(C)CCNC(=O)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1c(Cl)cccc1Cl |(18.95,-7.42,;19.98,-6.27,;19.49,-4.8,;21.48,-6.57,;22.51,-5.42,;24.02,-5.73,;25.04,-4.58,;26.55,-4.89,;24.55,-3.12,;25.57,-1.97,;25.09,-.51,;23.61,-.04,;22.27,-.81,;20.93,-.04,;20.94,1.51,;19.6,2.28,;22.26,2.28,;23.6,1.52,;25.07,2,;25.69,3.41,;25.05,4.81,;23.55,5.13,;26.19,5.85,;27.52,5.09,;28.93,5.72,;27.21,3.58,;28.14,2.34,;27.52,.93,;25.99,.76,;29.67,2.52,;30.58,1.28,;29.97,-.13,;32.11,1.45,;32.73,2.87,;31.8,4.11,;30.28,3.93,;30.26,5.47,)|
Show InChI InChI=1S/C27H24Cl2N4O4/c1-32(2)11-9-30-21(35)8-10-33-19-7-6-14(34)12-15(19)23-20(33)13-16(22-17(28)4-3-5-18(22)29)24-25(23)27(37)31-26(24)36/h3-7,12-13,34H,8-11H2,1-2H3,(H,30,35)(H,31,36,37)
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n/an/a 14n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation


Eur J Med Chem 43: 1276-96 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.016
BindingDB Entry DOI: 10.7270/Q26M36MC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50192377
PNG
(4-(2-chloro-6-methoxyphenyl)-9-hydroxypyrrolo[3,4-...)
Show SMILES COc1cccc(Cl)c1-c1cc2[nH]c3ccc(O)cc3c2c2C(=O)NC(=O)c12 |(32.88,-28.65,;32.26,-30.06,;33.17,-31.3,;34.7,-31.13,;35.61,-32.38,;34.99,-33.79,;33.46,-33.95,;32.84,-35.36,;32.55,-32.7,;31.03,-32.87,;30.4,-34.28,;28.86,-34.44,;27.96,-35.69,;26.48,-35.21,;25.15,-35.98,;23.82,-35.21,;23.82,-33.67,;22.49,-32.9,;25.15,-32.9,;26.48,-33.66,;27.96,-33.18,;28.58,-31.78,;27.96,-30.37,;26.46,-30.05,;29.1,-29.35,;30.43,-30.12,;31.84,-29.5,;30.11,-31.62,)|
Show InChI InChI=1S/C21H13ClN2O4/c1-28-15-4-2-3-12(22)16(15)11-8-14-17(19-18(11)20(26)24-21(19)27)10-7-9(25)5-6-13(10)23-14/h2-8,23,25H,1H3,(H,24,26,27)
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n/an/a 15n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 in presence of 9.5 uM ATP


J Med Chem 49: 4896-911 (2006)


Article DOI: 10.1021/jm0512591
BindingDB Entry DOI: 10.7270/Q23778BD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245525
PNG
(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Show SMILES Oc1ccc2n(CCC#N)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C23H14ClN3O3/c24-16-5-2-1-4-13(16)14-11-18-19(21-20(14)22(29)26-23(21)30)15-10-12(28)6-7-17(15)27(18)9-3-8-25/h1-2,4-7,10-11,28H,3,9H2,(H,26,29,30)
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n/an/a 15n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation


Eur J Med Chem 43: 1276-96 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.016
BindingDB Entry DOI: 10.7270/Q26M36MC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50279729
PNG
(CHEMBL472689 | N-(2-(1H-pyrrol-1-yl)ethyl)-4-(2-ch...)
Show SMILES Cn1c2cc(C(=O)NCCn3cccc3)c(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C28H21ClN4O4/c1-32-20-13-18(26(35)30-8-11-33-9-4-5-10-33)22(34)14-17(20)23-21(32)12-16(15-6-2-3-7-19(15)29)24-25(23)28(37)31-27(24)36/h2-7,9-10,12-14,34H,8,11H2,1H3,(H,30,35)(H,31,36,37)
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n/an/a 15n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50232227
PNG
(4-(2-chlorophenyl)-9-hydroxy-6-(2-hydroxyethyl)-8-...)
Show SMILES OCCn1c2cc(OCCCN3CCOCC3)c(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C29H28ClN3O6/c30-20-5-2-1-4-17(20)18-14-22-25(27-26(18)28(36)31-29(27)37)19-15-23(35)24(16-21(19)33(22)7-10-34)39-11-3-6-32-8-12-38-13-9-32/h1-2,4-5,14-16,34-35H,3,6-13H2,(H,31,36,37)
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n/an/a 15n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Bioorg Med Chem Lett 18: 929-33 (2008)


Article DOI: 10.1016/j.bmcl.2007.12.046
BindingDB Entry DOI: 10.7270/Q2ZS2XC3
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245525
PNG
(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Show SMILES Oc1ccc2n(CCC#N)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C23H14ClN3O3/c24-16-5-2-1-4-13(16)14-11-18-19(21-20(14)22(29)26-23(21)30)15-10-12(28)6-7-17(15)27(18)9-3-8-25/h1-2,4-7,10-11,28H,3,9H2,(H,26,29,30)
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n/an/a 15n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50192377
PNG
(4-(2-chloro-6-methoxyphenyl)-9-hydroxypyrrolo[3,4-...)
Show SMILES COc1cccc(Cl)c1-c1cc2[nH]c3ccc(O)cc3c2c2C(=O)NC(=O)c12 |(32.88,-28.65,;32.26,-30.06,;33.17,-31.3,;34.7,-31.13,;35.61,-32.38,;34.99,-33.79,;33.46,-33.95,;32.84,-35.36,;32.55,-32.7,;31.03,-32.87,;30.4,-34.28,;28.86,-34.44,;27.96,-35.69,;26.48,-35.21,;25.15,-35.98,;23.82,-35.21,;23.82,-33.67,;22.49,-32.9,;25.15,-32.9,;26.48,-33.66,;27.96,-33.18,;28.58,-31.78,;27.96,-30.37,;26.46,-30.05,;29.1,-29.35,;30.43,-30.12,;31.84,-29.5,;30.11,-31.62,)|
Show InChI InChI=1S/C21H13ClN2O4/c1-28-15-4-2-3-12(22)16(15)11-8-14-17(19-18(11)20(26)24-21(19)27)10-7-9(25)5-6-13(10)23-14/h2-8,23,25H,1H3,(H,24,26,27)
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n/an/a 15n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50374060
PNG
(CHEMBL272267)
Show SMILES Cn1c2cc(C(=O)NCCN3CCCC3)c(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C28H25ClN4O4/c1-32-20-13-18(26(35)30-8-11-33-9-4-5-10-33)22(34)14-17(20)23-21(32)12-16(15-6-2-3-7-19(15)29)24-25(23)28(37)31-27(24)36/h2-3,6-7,12-14,34H,4-5,8-11H2,1H3,(H,30,35)(H,31,36,37)
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n/an/a 15n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Bioorg Med Chem Lett 18: 929-33 (2008)


Article DOI: 10.1016/j.bmcl.2007.12.046
BindingDB Entry DOI: 10.7270/Q2ZS2XC3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50232227
PNG
(4-(2-chlorophenyl)-9-hydroxy-6-(2-hydroxyethyl)-8-...)
Show SMILES OCCn1c2cc(OCCCN3CCOCC3)c(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
Show InChI InChI=1S/C29H28ClN3O6/c30-20-5-2-1-4-17(20)18-14-22-25(27-26(18)28(36)31-29(27)37)19-15-23(35)24(16-21(19)33(22)7-10-34)39-11-3-6-32-8-12-38-13-9-32/h1-2,4-5,14-16,34-35H,3,6-13H2,(H,31,36,37)
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n/an/a 15n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245459
PNG
(4-(2-Chlorophenyl)-9-hydroxy-6-[3-(1H-tetrazol-5-y...)
Show SMILES Oc1ccc2n(CCCc3nnn[nH]3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C24H17ClN6O3/c25-16-5-2-1-4-13(16)14-11-18-20(22-21(14)23(33)26-24(22)34)15-10-12(32)7-8-17(15)31(18)9-3-6-19-27-29-30-28-19/h1-2,4-5,7-8,10-11,32H,3,6,9H2,(H,26,33,34)(H,27,28,29,30)
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n/an/a 16n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50245459
PNG
(4-(2-Chlorophenyl)-9-hydroxy-6-[3-(1H-tetrazol-5-y...)
Show SMILES Oc1ccc2n(CCCc3nnn[nH]3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C24H17ClN6O3/c25-16-5-2-1-4-13(16)14-11-18-20(22-21(14)23(33)26-24(22)34)15-10-12(32)7-8-17(15)31(18)9-3-6-19-27-29-30-28-19/h1-2,4-5,7-8,10-11,32H,3,6,9H2,(H,26,33,34)(H,27,28,29,30)
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n/an/a 16n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation


Eur J Med Chem 43: 1276-96 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.016
BindingDB Entry DOI: 10.7270/Q26M36MC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50192382
PNG
(4-(2,6-dichloro-3-hydroxyphenyl)-9-hydroxypyrrolo[...)
Show SMILES Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)ccc(O)c1Cl |(-8.42,-23.21,;-7.09,-23.98,;-7.09,-25.52,;-5.76,-26.29,;-4.43,-25.52,;-2.95,-26,;-2.05,-24.75,;-.51,-24.59,;.12,-23.18,;-.8,-21.93,;-.48,-20.43,;.93,-19.81,;-1.81,-19.66,;-2.95,-20.68,;-4.45,-20.36,;-2.33,-22.09,;-2.95,-23.49,;-4.43,-23.97,;-5.76,-23.21,;1.64,-23.01,;2.26,-21.61,;1.35,-20.37,;3.79,-21.44,;4.7,-22.69,;4.08,-24.1,;4.99,-25.34,;2.55,-24.26,;1.93,-25.67,)|
Show InChI InChI=1S/C20H10Cl2N2O4/c21-10-2-4-13(26)18(22)14(10)9-6-12-15(17-16(9)19(27)24-20(17)28)8-5-7(25)1-3-11(8)23-12/h1-6,23,25-26H,(H,24,27,28)
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n/an/a 18n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 in presence of 9.5 uM ATP


J Med Chem 49: 4896-911 (2006)


Article DOI: 10.1021/jm0512591
BindingDB Entry DOI: 10.7270/Q23778BD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50374066
PNG
(CHEMBL401776)
Show SMILES CN(C)CCCOc1cc2n(CCO)c3cc(c4C(=O)NC(=O)c4c3c2cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C27H26ClN3O5/c1-30(2)8-5-11-36-22-14-19-17(13-21(22)33)23-20(31(19)9-10-32)12-16(15-6-3-4-7-18(15)28)24-25(23)27(35)29-26(24)34/h3-4,6-7,12-14,32-33H,5,8-11H2,1-2H3,(H,29,34,35)
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n/an/a 18n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Bioorg Med Chem Lett 18: 929-33 (2008)


Article DOI: 10.1016/j.bmcl.2007.12.046
BindingDB Entry DOI: 10.7270/Q2ZS2XC3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50192382
PNG
(4-(2,6-dichloro-3-hydroxyphenyl)-9-hydroxypyrrolo[...)
Show SMILES Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)ccc(O)c1Cl |(-8.42,-23.21,;-7.09,-23.98,;-7.09,-25.52,;-5.76,-26.29,;-4.43,-25.52,;-2.95,-26,;-2.05,-24.75,;-.51,-24.59,;.12,-23.18,;-.8,-21.93,;-.48,-20.43,;.93,-19.81,;-1.81,-19.66,;-2.95,-20.68,;-4.45,-20.36,;-2.33,-22.09,;-2.95,-23.49,;-4.43,-23.97,;-5.76,-23.21,;1.64,-23.01,;2.26,-21.61,;1.35,-20.37,;3.79,-21.44,;4.7,-22.69,;4.08,-24.1,;4.99,-25.34,;2.55,-24.26,;1.93,-25.67,)|
Show InChI InChI=1S/C20H10Cl2N2O4/c21-10-2-4-13(26)18(22)14(10)9-6-12-15(17-16(9)19(27)24-20(17)28)8-5-7(25)1-3-11(8)23-12/h1-6,23,25-26H,(H,24,27,28)
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n/an/a 18n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50279690
PNG
(8-(3-(1H-pyrrol-1-yl)propoxy)-4-(2-chlorophenyl)-9...)
Show SMILES OCCn1c2cc(c3C(=O)NC(=O)c3c2c2=CC(O)(O)C(OCCCn3cccc3)C=c12)-c1ccccc1Cl |t:17,33|
Show InChI InChI=1S/C29H26ClN3O6/c30-20-7-2-1-6-17(20)18-14-22-24(26-25(18)27(35)31-28(26)36)19-16-29(37,38)23(15-21(19)33(22)11-12-34)39-13-5-10-32-8-3-4-9-32/h1-4,6-9,14-16,23,34,37-38H,5,10-13H2,(H,31,35,36)
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n/an/a 18n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of human Wee1


Eur J Med Chem 44: 1383-95 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.027
BindingDB Entry DOI: 10.7270/Q2X34XB6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50192402
PNG
(4-(4-amino-2-methoxyphenyl)-9-hydroxypyrrolo[3,4-c...)
Show SMILES COc1cc(N)ccc1-c1cc2[nH]c3ccc(O)cc3c2c2C(=O)NC(=O)c12
Show InChI InChI=1S/C21H15N3O4/c1-28-16-6-9(22)2-4-11(16)12-8-15-17(19-18(12)20(26)24-21(19)27)13-7-10(25)3-5-14(13)23-15/h2-8,23,25H,22H2,1H3,(H,24,26,27)
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n/an/a 19n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of human Wee1 in presence of 9.5 uM ATP


J Med Chem 49: 4896-911 (2006)


Article DOI: 10.1021/jm0512591
BindingDB Entry DOI: 10.7270/Q23778BD
More data for this
Ligand-Target Pair
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