Compile Data Set for Download or QSAR

Found 797 hits of ic50 for UniProtKB: P35346   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50468144 (CHEMBL4286244) Show SMILES CC(C)n1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c2c(cccc12)C1CC1 Show InChI InChI=1S/C29H33N3O4/c1-19(2)31-17-22(26-24(20-6-7-20)4-3-5-25(26)31)16-30-14-12-29(13-15-30)18-32(28(35)36-29)23-10-8-21(9-11-23)27(33)34/h3-5,8-11,17,19-20H,6-7,12-16,18H2,1-2H3,(H,33,34)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Antagonist activity at human SSR5 expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 15 mins fol...				ACS Med Chem Lett 9: 1088-1093 (2018) Article DOI: 10.1021/acsmedchemlett.8b00306 BindingDB Entry DOI: 10.7270/Q2V127H3
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123235 (US8742110, 3-20) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(C(O)=O)c(OC)c3)CC2)cc(OCC)c1-c1ccc(F)cc1 Show InChI InChI=1S/C32H35FN2O7/c1-4-40-27-16-21(17-28(41-5-2)29(27)22-6-8-23(33)9-7-22)19-34-14-12-32(13-15-34)20-35(31(38)42-32)24-10-11-25(30(36)37)26(18-24)39-3/h6-11,16-18H,4-5,12-15,19-20H2,1-3H3,(H,36,37)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.129	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123247 (US8742110, 4-11) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c(cc1C)-c1cc(F)c(F)cc1F Show InChI InChI=1S/C30H29F3N2O5/c1-3-39-27-13-20(22(12-18(27)2)23-14-25(32)26(33)15-24(23)31)16-34-10-8-30(9-11-34)17-35(29(38)40-30)21-6-4-19(5-7-21)28(36)37/h4-7,12-15H,3,8-11,16-17H2,1-2H3,(H,36,37)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.152	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123253 (US8742110, 4-17) Show SMILES OC(=O)c1ccc(cc1)N1CC2(CCN(Cc3cc(OC(F)(F)F)ccc3-c3ccc(F)c(F)c3F)CC2)OC1=O Show InChI InChI=1S/C28H22F6N2O5/c29-22-8-7-21(23(30)24(22)31)20-6-5-19(40-28(32,33)34)13-17(20)14-35-11-9-27(10-12-35)15-36(26(39)41-27)18-3-1-16(2-4-18)25(37)38/h1-8,13H,9-12,14-15H2,(H,37,38)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.165	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123270 (US8742110, 5-6) Show SMILES COc1cccc2c(OC)cc(CN3CCC4(CN(C(=O)O4)c4ccc(cc4)C(O)=O)CC3)cc12 Show InChI InChI=1S/C27H28N2O6/c1-33-23-5-3-4-21-22(23)14-18(15-24(21)34-2)16-28-12-10-27(11-13-28)17-29(26(32)35-27)20-8-6-19(7-9-20)25(30)31/h3-9,14-15H,10-13,16-17H2,1-2H3,(H,30,31)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.172	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123248 (US8742110, 4-12) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(C(O)=O)c(C)c3)CC2)c(cc1C)-c1ccc(F)c(F)c1F Show InChI InChI=1S/C31H31F3N2O5/c1-4-40-26-15-20(24(14-19(26)3)23-7-8-25(32)28(34)27(23)33)16-35-11-9-31(10-12-35)17-36(30(39)41-31)21-5-6-22(29(37)38)18(2)13-21/h5-8,13-15H,4,9-12,16-17H2,1-3H3,(H,37,38)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.188	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50468136 (CHEMBL4287248) Show SMILES OC(=O)c1ccc(cc1)N1CC2(CCN(Cc3cc(Cl)c(c(c3)C3CC3)-c3ccc(F)cc3F)CC2)OC1=O |(21.02,-19.09,;21.18,-20.63,;22.58,-21.25,;19.93,-21.53,;20.1,-23.06,;18.86,-23.97,;17.45,-23.35,;17.28,-21.81,;18.53,-20.9,;16.22,-24.26,;14.73,-23.79,;13.83,-25.05,;13.06,-26.37,;11.51,-26.37,;10.73,-25.04,;9.19,-25.04,;8.42,-23.71,;6.88,-23.71,;6.11,-22.39,;4.58,-22.39,;6.86,-21.06,;8.41,-21.06,;9.2,-22.38,;9.17,-19.71,;9.17,-18.18,;10.5,-18.93,;6.09,-19.73,;6.85,-18.39,;6.08,-17.07,;4.54,-17.07,;3.77,-15.74,;3.76,-18.41,;4.55,-19.73,;3.79,-21.07,;11.51,-23.69,;13.06,-23.69,;14.75,-26.3,;16.22,-25.81,;17.47,-26.71,)| Show InChI InChI=1S/C30H27ClF2N2O4/c31-25-14-18(13-24(19-1-2-19)27(25)23-8-5-21(32)15-26(23)33)16-34-11-9-30(10-12-34)17-35(29(38)39-30)22-6-3-20(4-7-22)28(36)37/h3-8,13-15,19H,1-2,9-12,16-17H2,(H,36,37)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Displacement of [3-125I-Tyr11]-SRIF-14 or [3-125I-Tyr11]-SRIF-28 from human SSR5 expressed in CHOK1 cell membranes				ACS Med Chem Lett 9: 1088-1093 (2018) Article DOI: 10.1021/acsmedchemlett.8b00306 BindingDB Entry DOI: 10.7270/Q2V127H3
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50468160 (CHEMBL4293458) Show SMILES CC(C)n1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c2c(cccc12)-c1ccc(F)c(F)c1F Show InChI InChI=1S/C32H30F3N3O4/c1-19(2)37-17-21(27-23(4-3-5-26(27)37)24-10-11-25(33)29(35)28(24)34)16-36-14-12-32(13-15-36)18-38(31(41)42-32)22-8-6-20(7-9-22)30(39)40/h3-11,17,19H,12-16,18H2,1-2H3,(H,39,40)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Displacement of [3-125I-Tyr11]-SRIF-14 or [3-125I-Tyr11]-SRIF-28 from human SSR5 expressed in CHOK1 cell membranes				ACS Med Chem Lett 9: 1088-1093 (2018) Article DOI: 10.1021/acsmedchemlett.8b00306 BindingDB Entry DOI: 10.7270/Q2V127H3
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123300 (US8742110, 6-18) Show SMILES CC(C)n1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c2c(OCc3ccccc3)cccc12 Show InChI InChI=1S/C33H35N3O5/c1-23(2)35-20-26(30-28(35)9-6-10-29(30)40-21-24-7-4-3-5-8-24)19-34-17-15-33(16-18-34)22-36(32(39)41-33)27-13-11-25(12-14-27)31(37)38/h3-14,20,23H,15-19,21-22H2,1-2H3,(H,37,38)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.225	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123254 (US8742110, 4-18) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(C(O)=O)c(OC)c3)CC2)c(cc1C)-c1ccc(F)c(F)c1F Show InChI InChI=1S/C31H31F3N2O6/c1-4-41-25-14-19(23(13-18(25)2)21-7-8-24(32)28(34)27(21)33)16-35-11-9-31(10-12-35)17-36(30(39)42-31)20-5-6-22(29(37)38)26(15-20)40-3/h5-8,13-15H,4,9-12,16-17H2,1-3H3,(H,37,38)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.228	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123271 (US8742110, 5-7) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)cc2c(OC)ccc(Cl)c12 Show InChI InChI=1S/C28H29ClN2O6/c1-3-36-24-15-18(14-21-23(35-2)9-8-22(29)25(21)24)16-30-12-10-28(11-13-30)17-31(27(34)37-28)20-6-4-19(5-7-20)26(32)33/h4-9,14-15H,3,10-13,16-17H2,1-2H3,(H,32,33)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.233	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123255 (US8742110, 4-19) Show SMILES OC(=O)c1ccc(cc1)N1CC2(CCN(Cc3cc4CCCc4cc3-c3cc(F)c(F)cc3F)CC2)OC1=O Show InChI InChI=1S/C30H27F3N2O4/c31-25-15-27(33)26(32)14-24(25)23-13-20-3-1-2-19(20)12-21(23)16-34-10-8-30(9-11-34)17-35(29(38)39-30)22-6-4-18(5-7-22)28(36)37/h4-7,12-15H,1-3,8-11,16-17H2,(H,36,37)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.243	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123296 (US8742110, 6-14) Show SMILES CC(C)n1nc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c2cc(OCc3ccccc3)ccc12 Show InChI InChI=1S/C32H34N4O5/c1-22(2)36-29-13-12-26(40-20-23-6-4-3-5-7-23)18-27(29)28(33-36)19-34-16-14-32(15-17-34)21-35(31(39)41-32)25-10-8-24(9-11-25)30(37)38/h3-13,18,22H,14-17,19-21H2,1-2H3,(H,37,38)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123252 (US8742110, 4-16) Show SMILES CC(C)Oc1ccc(c(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c1)-c1cc(F)c(F)cc1F Show InChI InChI=1S/C30H29F3N2O5/c1-18(2)39-22-7-8-23(24-14-26(32)27(33)15-25(24)31)20(13-22)16-34-11-9-30(10-12-34)17-35(29(38)40-30)21-5-3-19(4-6-21)28(36)37/h3-8,13-15,18H,9-12,16-17H2,1-2H3,(H,36,37)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.272	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50468144 (CHEMBL4286244) Show SMILES CC(C)n1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c2c(cccc12)C1CC1 Show InChI InChI=1S/C29H33N3O4/c1-19(2)31-17-22(26-24(20-6-7-20)4-3-5-25(26)31)16-30-14-12-29(13-15-30)18-32(28(35)36-29)23-10-8-21(9-11-23)27(33)34/h3-5,8-11,17,19-20H,6-7,12-16,18H2,1-2H3,(H,33,34)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Displacement of [3-125I-Tyr11]-SRIF-14 or [3-125I-Tyr11]-SRIF-28 from human SSR5 expressed in CHOK1 cell membranes				ACS Med Chem Lett 9: 1088-1093 (2018) Article DOI: 10.1021/acsmedchemlett.8b00306 BindingDB Entry DOI: 10.7270/Q2V127H3
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50254292 (2-((3S,5S)-5-(3-(aminomethyl)benzyl)-1-(biphenyl-4...) Show SMILES NCc1cccc(C[C@@H]2O[C@@H](CC(=O)NCc3ccccc3F)C(=O)N(Cc3ccc(cc3)-c3ccccc3)c3ccccc23)c1 |r| Show InChI InChI=1S/C39H36FN3O3/c40-34-15-6-4-13-32(34)25-42-38(44)23-37-39(45)43(26-27-17-19-31(20-18-27)30-11-2-1-3-12-30)35-16-7-5-14-33(35)36(46-37)22-28-9-8-10-29(21-28)24-41/h1-21,36-37H,22-26,41H2,(H,42,44)/t36-,37-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombinant sst5 receptor expressed in chinese hamster CCL39 cells				J Med Chem 52: 95-104 (2009) Article DOI: 10.1021/jm801205x BindingDB Entry DOI: 10.7270/Q27W6D3B
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123277 (US8742110, 5-13) Show SMILES Cc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)cc2c1OCCC2(C)C Show InChI InChI=1S/C27H32N2O5/c1-18-14-19(15-22-23(18)33-13-10-26(22,2)3)16-28-11-8-27(9-12-28)17-29(25(32)34-27)21-6-4-20(5-7-21)24(30)31/h4-7,14-15H,8-13,16-17H2,1-3H3,(H,30,31)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.317	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123227 (US8742110, 3-12) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)-c3nnn[nH]3)CC2)cc(OCC)c1-c1ccc(F)cc1 Show InChI InChI=1S/C31H33FN6O4/c1-3-40-26-17-21(18-27(41-4-2)28(26)22-5-9-24(32)10-6-22)19-37-15-13-31(14-16-37)20-38(30(39)42-31)25-11-7-23(8-12-25)29-33-35-36-34-29/h5-12,17-18H,3-4,13-16,19-20H2,1-2H3,(H,33,34,35,36)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.323	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123306 (US8742110, 6-24) Show SMILES CC(C)n1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c2cc(ccc12)-c1ccc(F)c(F)c1F Show InChI InChI=1S/C32H30F3N3O4/c1-19(2)37-17-22(25-15-21(5-10-27(25)37)24-8-9-26(33)29(35)28(24)34)16-36-13-11-32(12-14-36)18-38(31(41)42-32)23-6-3-20(4-7-23)30(39)40/h3-10,15,17,19H,11-14,16,18H2,1-2H3,(H,39,40)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.342	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123234 (US8742110, 3-19) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3Cl)C(O)=O)CC2)cc(OCC)c1-c1ccc(F)cc1 Show InChI InChI=1S/C31H32ClFN2O6/c1-3-39-26-15-20(16-27(40-4-2)28(26)21-5-8-23(33)9-6-21)18-34-13-11-31(12-14-34)19-35(30(38)41-31)25-10-7-22(29(36)37)17-24(25)32/h5-10,15-17H,3-4,11-14,18-19H2,1-2H3,(H,36,37)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.359	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123264 (US8742110, 4-28) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c(cc1C)-n1cc(C)cn1 Show InChI InChI=1S/C28H32N4O5/c1-4-36-25-14-22(24(13-20(25)3)32-16-19(2)15-29-32)17-30-11-9-28(10-12-30)18-31(27(35)37-28)23-7-5-21(6-8-23)26(33)34/h5-8,13-16H,4,9-12,17-18H2,1-3H3,(H,33,34)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.395	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123257 (US8742110, 4-21) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3F)C(O)=O)CC2)c(cc1C)-c1ccc(F)c(F)c1F Show InChI InChI=1S/C30H28F4N2O5/c1-3-40-25-14-19(21(12-17(25)2)20-5-6-22(31)27(34)26(20)33)15-35-10-8-30(9-11-35)16-36(29(39)41-30)24-7-4-18(28(37)38)13-23(24)32/h4-7,12-14H,3,8-11,15-16H2,1-2H3,(H,37,38)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.397	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50468146 (CHEMBL4285917) Show SMILES OC(=O)c1ccc(cc1)N1CC2(CCN(Cc3cc(c(Cl)cc3C3CC3)C(F)(F)F)CC2)OC1=O Show InChI InChI=1S/C25H24ClF3N2O4/c26-21-12-19(15-1-2-15)17(11-20(21)25(27,28)29)13-30-9-7-24(8-10-30)14-31(23(34)35-24)18-5-3-16(4-6-18)22(32)33/h3-6,11-12,15H,1-2,7-10,13-14H2,(H,32,33)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Antagonist activity at human SSR5 expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 15 mins fol...				ACS Med Chem Lett 9: 1088-1093 (2018) Article DOI: 10.1021/acsmedchemlett.8b00306 BindingDB Entry DOI: 10.7270/Q2V127H3
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50468157 (CHEMBL4289661) Show SMILES CC(C)n1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c2c(ccnc12)-c1ccc(F)cc1 Show InChI InChI=1S/C31H31FN4O4/c1-20(2)35-18-23(27-26(11-14-33-28(27)35)21-3-7-24(32)8-4-21)17-34-15-12-31(13-16-34)19-36(30(39)40-31)25-9-5-22(6-10-25)29(37)38/h3-11,14,18,20H,12-13,15-17,19H2,1-2H3,(H,37,38)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Antagonist activity at human SSR5 expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 15 mins fol...				ACS Med Chem Lett 9: 1088-1093 (2018) Article DOI: 10.1021/acsmedchemlett.8b00306 BindingDB Entry DOI: 10.7270/Q2V127H3
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50232821 ((S)-((S)-2-aminopropyl) 6-amino-2-(2-(2-(naphthale...) Show SMILES C[C@H](N)COC(=O)[C@H](CCCCN)NC(=O)Cc1c([nH]c2c1ccc1ccccc21)-c1ccc2ccccc2c1 Show InChI InChI=1S/C33H36N4O3/c1-21(35)20-40-33(39)29(12-6-7-17-34)36-30(38)19-28-27-16-15-23-9-4-5-11-26(23)32(27)37-31(28)25-14-13-22-8-2-3-10-24(22)18-25/h2-5,8-11,13-16,18,21,29,37H,6-7,12,17,19-20,34-35H2,1H3,(H,36,38)/t21-,29-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
University of Firenze Curated by ChEMBL					Assay Description Binding affinity to sst5 receptor				J Med Chem 51: 512-20 (2008) Article DOI: 10.1021/jm070886i BindingDB Entry DOI: 10.7270/Q26974D8
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50254261 ((R)-((S)-2-aminopropyl) 6-amino-2-(2-(2-(naphthale...) Show SMILES C[C@H](N)COC(=O)[C@@H](CCCCN)NC(=O)Cc1c([nH]c2c1ccc1ccccc21)-c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C33H36N4O3/c1-21(35)20-40-33(39)29(12-6-7-17-34)36-30(38)19-28-27-16-15-23-9-4-5-11-26(23)32(27)37-31(28)25-14-13-22-8-2-3-10-24(22)18-25/h2-5,8-11,13-16,18,21,29,37H,6-7,12,17,19-20,34-35H2,1H3,(H,36,38)/t21-,29+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombinant sst5 receptor expressed in chinese hamster CCL39 cells				J Med Chem 52: 95-104 (2009) Article DOI: 10.1021/jm801205x BindingDB Entry DOI: 10.7270/Q27W6D3B
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50468136 (CHEMBL4287248) Show SMILES OC(=O)c1ccc(cc1)N1CC2(CCN(Cc3cc(Cl)c(c(c3)C3CC3)-c3ccc(F)cc3F)CC2)OC1=O |(21.02,-19.09,;21.18,-20.63,;22.58,-21.25,;19.93,-21.53,;20.1,-23.06,;18.86,-23.97,;17.45,-23.35,;17.28,-21.81,;18.53,-20.9,;16.22,-24.26,;14.73,-23.79,;13.83,-25.05,;13.06,-26.37,;11.51,-26.37,;10.73,-25.04,;9.19,-25.04,;8.42,-23.71,;6.88,-23.71,;6.11,-22.39,;4.58,-22.39,;6.86,-21.06,;8.41,-21.06,;9.2,-22.38,;9.17,-19.71,;9.17,-18.18,;10.5,-18.93,;6.09,-19.73,;6.85,-18.39,;6.08,-17.07,;4.54,-17.07,;3.77,-15.74,;3.76,-18.41,;4.55,-19.73,;3.79,-21.07,;11.51,-23.69,;13.06,-23.69,;14.75,-26.3,;16.22,-25.81,;17.47,-26.71,)| Show InChI InChI=1S/C30H27ClF2N2O4/c31-25-14-18(13-24(19-1-2-19)27(25)23-8-5-21(32)15-26(23)33)16-34-11-9-30(10-12-34)17-35(29(38)39-30)22-6-3-20(4-7-22)28(36)37/h3-8,13-15,19H,1-2,9-12,16-17H2,(H,36,37)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Antagonist activity at human SSR5 expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 15 mins fol...				ACS Med Chem Lett 9: 1088-1093 (2018) Article DOI: 10.1021/acsmedchemlett.8b00306 BindingDB Entry DOI: 10.7270/Q2V127H3
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50468157 (CHEMBL4289661) Show SMILES CC(C)n1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c2c(ccnc12)-c1ccc(F)cc1 Show InChI InChI=1S/C31H31FN4O4/c1-20(2)35-18-23(27-26(11-14-33-28(27)35)21-3-7-24(32)8-4-21)17-34-15-12-31(13-16-34)19-36(30(39)40-31)25-9-5-22(6-10-25)29(37)38/h3-11,14,18,20H,12-13,15-17,19H2,1-2H3,(H,37,38)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Displacement of [3-125I-Tyr11]-SRIF-14 or [3-125I-Tyr11]-SRIF-28 from human SSR5 expressed in CHOK1 cell membranes				ACS Med Chem Lett 9: 1088-1093 (2018) Article DOI: 10.1021/acsmedchemlett.8b00306 BindingDB Entry DOI: 10.7270/Q2V127H3
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123250 (US8742110, 4-14) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c(cc1C)-c1ccc(F)nc1 Show InChI InChI=1S/C29H30FN3O5/c1-3-37-25-15-22(24(14-19(25)2)21-6-9-26(30)31-16-21)17-32-12-10-29(11-13-32)18-33(28(36)38-29)23-7-4-20(5-8-23)27(34)35/h4-9,14-16H,3,10-13,17-18H2,1-2H3,(H,34,35)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.407	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123243 (US8742110, 4-7) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c(cc1C)-c1ccc(F)c(F)c1F Show InChI InChI=1S/C30H29F3N2O5/c1-3-39-25-15-20(23(14-18(25)2)22-8-9-24(31)27(33)26(22)32)16-34-12-10-30(11-13-34)17-35(29(38)40-30)21-6-4-19(5-7-21)28(36)37/h4-9,14-15H,3,10-13,16-17H2,1-2H3,(H,36,37)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.409	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123179 (US8742110, 1-28) Show SMILES CC(C)(C)n1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c(n1)-c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C28H30ClFN4O4/c1-27(2,3)34-16-20(24(31-34)19-6-9-23(30)22(29)14-19)15-32-12-10-28(11-13-32)17-33(26(37)38-28)21-7-4-18(5-8-21)25(35)36/h4-9,14,16H,10-13,15,17H2,1-3H3,(H,35,36)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.421	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123272 (US8742110, 5-8) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)cc2cnc(cc12)C(F)(F)F Show InChI InChI=1S/C27H26F3N3O5/c1-2-37-22-12-17(11-19-14-31-23(13-21(19)22)27(28,29)30)15-32-9-7-26(8-10-32)16-33(25(36)38-26)20-5-3-18(4-6-20)24(34)35/h3-6,11-14H,2,7-10,15-16H2,1H3,(H,34,35)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.424	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123236 (US8742110, 3-21) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3F)C(O)=O)CC2)cc(OCC)c1-c1ccc(F)cc1 Show InChI InChI=1S/C31H32F2N2O6/c1-3-39-26-15-20(16-27(40-4-2)28(26)21-5-8-23(32)9-6-21)18-34-13-11-31(12-14-34)19-35(30(38)41-31)25-10-7-22(29(36)37)17-24(25)33/h5-10,15-17H,3-4,11-14,18-19H2,1-2H3,(H,36,37)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.437	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123245 (US8742110, 4-9) Show SMILES OC(=O)c1ccc(cc1)N1CC2(CCN(Cc3cc(ccc3-c3ccc(F)c(F)c3F)C(F)(F)F)CC2)OC1=O Show InChI InChI=1S/C28H22F6N2O4/c29-22-8-7-21(23(30)24(22)31)20-6-3-18(28(32,33)34)13-17(20)14-35-11-9-27(10-12-35)15-36(26(39)40-27)19-4-1-16(2-5-19)25(37)38/h1-8,13H,9-12,14-15H2,(H,37,38)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.439	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123258 (US8742110, 4-22) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3Cl)C(O)=O)CC2)c(cc1C)-c1ccc(F)c(F)c1F Show InChI InChI=1S/C30H28ClF3N2O5/c1-3-40-25-14-19(21(12-17(25)2)20-5-6-23(32)27(34)26(20)33)15-35-10-8-30(9-11-35)16-36(29(39)41-30)24-7-4-18(28(37)38)13-22(24)31/h4-7,12-14H,3,8-11,15-16H2,1-2H3,(H,37,38)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.468	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123244 (US8742110, 4-8) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3C)C(O)=O)CC2)c(cc1C)-c1ccc(F)c(F)c1F Show InChI InChI=1S/C31H31F3N2O5/c1-4-40-26-15-21(23(14-19(26)3)22-6-7-24(32)28(34)27(22)33)16-35-11-9-31(10-12-35)17-36(30(39)41-31)25-8-5-20(29(37)38)13-18(25)2/h5-8,13-15H,4,9-12,16-17H2,1-3H3,(H,37,38)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.474	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123239 (US8742110, 4-3) Show SMILES CCOc1ccc(c(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c1)-c1ccc(F)cc1F Show InChI InChI=1S/C29H28F2N2O5/c1-2-37-23-8-10-24(25-9-5-21(30)16-26(25)31)20(15-23)17-32-13-11-29(12-14-32)18-33(28(36)38-29)22-6-3-19(4-7-22)27(34)35/h3-10,15-16H,2,11-14,17-18H2,1H3,(H,34,35)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.490	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50468160 (CHEMBL4293458) Show SMILES CC(C)n1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c2c(cccc12)-c1ccc(F)c(F)c1F Show InChI InChI=1S/C32H30F3N3O4/c1-19(2)37-17-21(27-23(4-3-5-26(27)37)24-10-11-25(33)29(35)28(24)34)16-36-14-12-32(13-15-36)18-38(31(41)42-32)22-8-6-20(7-9-22)30(39)40/h3-11,17,19H,12-16,18H2,1-2H3,(H,39,40)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Antagonist activity at human SSR5 expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 15 mins fol...				ACS Med Chem Lett 9: 1088-1093 (2018) Article DOI: 10.1021/acsmedchemlett.8b00306 BindingDB Entry DOI: 10.7270/Q2V127H3
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123240 (US8742110, 4-4) Show SMILES CCOc1ccc(c(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c1)-c1ccc(F)c(F)c1 Show InChI InChI=1S/C29H28F2N2O5/c1-2-37-23-8-9-24(20-5-10-25(30)26(31)16-20)21(15-23)17-32-13-11-29(12-14-32)18-33(28(36)38-29)22-6-3-19(4-7-22)27(34)35/h3-10,15-16H,2,11-14,17-18H2,1H3,(H,34,35)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.502	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123242 (US8742110, 4-6) Show SMILES CC(C)Oc1ccc(c(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c1)-c1ccc(F)c(F)c1F Show InChI InChI=1S/C30H29F3N2O5/c1-18(2)39-22-7-8-23(24-9-10-25(31)27(33)26(24)32)20(15-22)16-34-13-11-30(12-14-34)17-35(29(38)40-30)21-5-3-19(4-6-21)28(36)37/h3-10,15,18H,11-14,16-17H2,1-2H3,(H,36,37)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.546	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123307 (US8742110, 6-25) Show SMILES CC(C)n1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c2cc(Br)ccc12 Show InChI InChI=1S/C26H28BrN3O4/c1-17(2)29-15-19(22-13-20(27)5-8-23(22)29)14-28-11-9-26(10-12-28)16-30(25(33)34-26)21-6-3-18(4-7-21)24(31)32/h3-8,13,15,17H,9-12,14,16H2,1-2H3,(H,31,32)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123241 (US8742110, 4-5) Show SMILES CCOc1ccc(c(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c1)-c1ccc(F)c(F)c1F Show InChI InChI=1S/C29H27F3N2O5/c1-2-38-21-7-8-22(23-9-10-24(30)26(32)25(23)31)19(15-21)16-33-13-11-29(12-14-33)17-34(28(37)39-29)20-5-3-18(4-6-20)27(35)36/h3-10,15H,2,11-14,16-17H2,1H3,(H,35,36)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.556	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50254259 ((5S)-5-[(4R)-4-(acetylamino)-3-oxo-3,4,5,10-tetrah...) Show SMILES CC(=O)N[C@@H]1Cc2c(CN([C@@H](CCCCN)C(=O)NCCc3ccccc3)C1=O)[nH]c1ccccc21 |r| Show InChI InChI=1S/C28H35N5O3/c1-19(34)31-24-17-22-21-11-5-6-12-23(21)32-25(22)18-33(28(24)36)26(13-7-8-15-29)27(35)30-16-14-20-9-3-2-4-10-20/h2-6,9-12,24,26,32H,7-8,13-18,29H2,1H3,(H,30,35)(H,31,34)/t24-,26+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.560	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombinant sst5 receptor expressed in chinese hamster CCL39 cells				J Med Chem 52: 95-104 (2009) Article DOI: 10.1021/jm801205x BindingDB Entry DOI: 10.7270/Q27W6D3B
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123180 (US8742110, 1-29) Show SMILES CC(C)(C)n1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)-c3nnn[nH]3)CC2)c(n1)-c1cc(F)c(Cl)cc1F Show InChI InChI=1S/C28H29ClF2N8O2/c1-27(2,3)39-15-18(24(34-39)20-12-23(31)21(29)13-22(20)30)14-37-10-8-28(9-11-37)16-38(26(40)41-28)19-6-4-17(5-7-19)25-32-35-36-33-25/h4-7,12-13,15H,8-11,14,16H2,1-3H3,(H,32,33,35,36)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.582	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50254253 ((5S)-6-oxo-5-[(4R)-3-oxo-4-[(phenylacetyl)amino]-3...) Show SMILES NCCCC[C@H](N1Cc2[nH]c3ccccc3c2C[C@@H](NC(=O)Cc2ccccc2)C1=O)C(=O)NCCc1ccccc1 |r| Show InChI InChI=1S/C34H39N5O3/c35-19-10-9-17-31(33(41)36-20-18-24-11-3-1-4-12-24)39-23-30-27(26-15-7-8-16-28(26)37-30)22-29(34(39)42)38-32(40)21-25-13-5-2-6-14-25/h1-8,11-16,29,31,37H,9-10,17-23,35H2,(H,36,41)(H,38,40)/t29-,31+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombinant sst5 receptor expressed in chinese hamster CCL39 cells				J Med Chem 52: 95-104 (2009) Article DOI: 10.1021/jm801205x BindingDB Entry DOI: 10.7270/Q27W6D3B
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50468153 (CHEMBL4279392) Show SMILES CC1(C)CCSc2ccc(CN3CCC4(CN(C(=O)O4)c4ccc(cc4)C(O)=O)CC3)cc12 Show InChI InChI=1S/C26H30N2O4S/c1-25(2)11-14-33-22-8-3-18(15-21(22)25)16-27-12-9-26(10-13-27)17-28(24(31)32-26)20-6-4-19(5-7-20)23(29)30/h3-8,15H,9-14,16-17H2,1-2H3,(H,29,30)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Displacement of [3-125I-Tyr11]-SRIF-14 or [3-125I-Tyr11]-SRIF-28 from human SSR5 expressed in CHOK1 cell membranes				ACS Med Chem Lett 9: 1088-1093 (2018) Article DOI: 10.1021/acsmedchemlett.8b00306 BindingDB Entry DOI: 10.7270/Q2V127H3
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123256 (US8742110, 4-20) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)c(cc1C)-c1ccc(nc1)C(F)(F)F Show InChI InChI=1S/C30H30F3N3O5/c1-3-40-25-15-22(24(14-19(25)2)21-6-9-26(34-16-21)30(31,32)33)17-35-12-10-29(11-13-35)18-36(28(39)41-29)23-7-4-20(5-8-23)27(37)38/h4-9,14-16H,3,10-13,17-18H2,1-2H3,(H,37,38)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.632	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50175599 ((4-amino-3-iodo)-D-Phe-c[Cys-(3-iodo)-Tyr-D-Trp-Ly...) Show SMILES CC(C)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)c(I)c2)NC(=O)[C@H](CSSC[C@@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(N)c(I)c1 Show InChI InChI=1S/C50H66I2N12O10S2/c1-24(2)41-50(74)62-39(49(73)64-42(25(3)65)43(56)67)23-76-75-22-38(61-44(68)33(55)18-26-11-13-32(54)30(51)16-26)48(72)59-36(19-27-12-14-40(66)31(52)17-27)46(70)60-37(20-28-21-57-34-9-5-4-8-29(28)34)47(71)58-35(45(69)63-41)10-6-7-15-53/h4-5,8-9,11-14,16-17,21,24-25,33,35-39,41-42,57,65-66H,6-7,10,15,18-20,22-23,53-55H2,1-3H3,(H2,56,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,74)(H,63,69)(H,64,73)/t25-,33+,35+,36+,37-,38+,39-,41-,42+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
University of California-San Diego Curated by ChEMBL					Assay Description Inhibitory concentration against human somatostatin receptor type 5 in CHO-K1 cells				J Med Chem 48: 6643-52 (2005) Article DOI: 10.1021/jm050376t BindingDB Entry DOI: 10.7270/Q2D50NRS
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM123269 (US8742110, 5-5) Show SMILES CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)cc2c(OC)cc(Cl)cc12 Show InChI InChI=1S/C28H29ClN2O6/c1-3-36-25-13-18(12-22-23(25)14-20(29)15-24(22)35-2)16-30-10-8-28(9-11-30)17-31(27(34)37-28)21-6-4-19(5-7-21)26(32)33/h4-7,12-15H,3,8-11,16-17H2,1-2H3,(H,32,33)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	7.8	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description SSTR5 binding assays can be performed by labeling somatostatin and determining the ability of a compound to inhibit somatostatin binding. (Poitout et...				US Patent US8742110 (2014) BindingDB Entry DOI: 10.7270/Q26H4G39
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50468146 (CHEMBL4285917) Show SMILES OC(=O)c1ccc(cc1)N1CC2(CCN(Cc3cc(c(Cl)cc3C3CC3)C(F)(F)F)CC2)OC1=O Show InChI InChI=1S/C25H24ClF3N2O4/c26-21-12-19(15-1-2-15)17(11-20(21)25(27,28)29)13-30-9-7-24(8-10-30)14-31(23(34)35-24)18-5-3-16(4-6-18)22(32)33/h3-6,11-12,15H,1-2,7-10,13-14H2,(H,32,33)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Displacement of [3-125I-Tyr11]-SRIF-14 or [3-125I-Tyr11]-SRIF-28 from human SSR5 expressed in CHOK1 cell membranes				ACS Med Chem Lett 9: 1088-1093 (2018) Article DOI: 10.1021/acsmedchemlett.8b00306 BindingDB Entry DOI: 10.7270/Q2V127H3
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 797 total )  |  Next  |  Last  >>

Jump to: