Compile Data Set for Download or QSAR

Found 1465 hits of ic50 for UniProtKB: P28223   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM117016 (US8664258, 32 | US9987252, 32) Show SMILES Cn1nccc1-c1cc(NC(=O)C(=O)c2ccc(F)cc2)ccc1OCCN Show InChI InChI=1S/C20H19FN4O3/c1-25-17(8-10-23-25)16-12-15(6-7-18(16)28-11-9-22)24-20(27)19(26)13-2-4-14(21)5-3-13/h2-8,10,12H,9,11,22H2,1H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	7.4	25
Arena Pharmaceuticals, Inc. US Patent					Assay Description Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125]DOI as radioligand. To define nonspecific binding, 10...				US Patent US8664258 (2014) BindingDB Entry DOI: 10.7270/Q2WQ02G1
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM117016 (US8664258, 32 | US9987252, 32) Show SMILES Cn1nccc1-c1cc(NC(=O)C(=O)c2ccc(F)cc2)ccc1OCCN Show InChI InChI=1S/C20H19FN4O3/c1-25-17(8-10-23-25)16-12-15(6-7-18(16)28-11-9-22)24-20(27)19(26)13-2-4-14(21)5-3-13/h2-8,10,12H,9,11,22H2,1H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	n/a	n/a
University of Virginia at Charlottesville					Assay Description Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...				Chem Biol 14: 1186-97 (2007) BindingDB Entry DOI: 10.7270/Q29K4DKC
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50001775 ((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...) Show SMILES [#6]-c1nc2sccn2c(=O)c1-[#6]-[#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](\c1ccc(F)cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.0690	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals Inc.					Assay Description R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...				J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM119676 (US8680119, 15) Show SMILES COCCNCCOc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1c(Cl)cnn1C |(-2.52,3.08,;-1.18,3.85,;.15,3.08,;1.48,3.85,;2.82,3.08,;4.15,3.85,;5.48,3.08,;5.48,1.54,;4.15,.77,;2.82,1.54,;1.48,.77,;1.48,-.77,;.15,-1.54,;-1.18,-.77,;-1.18,.77,;-2.52,-1.54,;-2.52,-3.08,;-3.85,-3.85,;-5.19,-3.08,;-5.19,-1.54,;-3.85,-.77,;-6.52,-.77,;-5.75,.56,;-7.29,-2.1,;-7.85,,;2.82,-1.54,;4.15,-.77,;5.48,-1.54,;5.48,-3.08,;4.15,-3.85,;6.95,-3.56,;7.85,-2.31,;6.95,-1.06,;7.72,.27,)| Show InChI InChI=1S/C23H24ClF3N4O3/c1-31-21(19(24)14-29-31)18-13-17(6-7-20(18)34-11-9-28-8-10-33-2)30-22(32)15-4-3-5-16(12-15)23(25,26)27/h3-7,12-14,28H,8-11H2,1-2H3,(H,30,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0820	n/a	n/a	n/a	n/a	7.4	n/a
Arena Pharmaceuticals, Inc. US Patent					Assay Description Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...				US Patent US8680119 (2014) BindingDB Entry DOI: 10.7270/Q2RV0MB0
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM117019 (US8664258, 303 | US9987252, 303) Show SMILES Cn1ncc(Cl)c1-c1cc(NC(=O)C2CCC(CC2)C(F)(F)F)ccc1OCCN |(7.64,.46,;6.87,-.87,;7.35,-2.34,;6.1,-3.24,;4.86,-2.34,;3.53,-3.11,;5.33,-.87,;4,-.1,;2.67,-.87,;1.33,-.1,;,-.87,;-1.33,-.1,;-1.33,1.44,;-2.67,-.87,;-4,-.1,;-5.33,-.87,;-5.33,-2.41,;-4,-3.18,;-2.67,-2.41,;-6.67,-3.18,;-8,-3.95,;-7.44,-1.85,;-5.9,-4.52,;1.33,1.44,;2.67,2.21,;4,1.44,;5.33,2.21,;5.33,3.75,;6.67,4.52,;8,3.75,)| Show InChI InChI=1S/C20H24ClF3N4O2/c1-28-18(16(21)11-26-28)15-10-14(6-7-17(15)30-9-8-25)27-19(29)12-2-4-13(5-3-12)20(22,23)24/h6-7,10-13H,2-5,8-9,25H2,1H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	7.4	25
Arena Pharmaceuticals, Inc. US Patent					Assay Description Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125]DOI as radioligand. To define nonspecific binding, 10...				US Patent US8664258 (2014) BindingDB Entry DOI: 10.7270/Q2WQ02G1
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM117019 (US8664258, 303 | US9987252, 303) Show SMILES Cn1ncc(Cl)c1-c1cc(NC(=O)C2CCC(CC2)C(F)(F)F)ccc1OCCN |(7.64,.46,;6.87,-.87,;7.35,-2.34,;6.1,-3.24,;4.86,-2.34,;3.53,-3.11,;5.33,-.87,;4,-.1,;2.67,-.87,;1.33,-.1,;,-.87,;-1.33,-.1,;-1.33,1.44,;-2.67,-.87,;-4,-.1,;-5.33,-.87,;-5.33,-2.41,;-4,-3.18,;-2.67,-2.41,;-6.67,-3.18,;-8,-3.95,;-7.44,-1.85,;-5.9,-4.52,;1.33,1.44,;2.67,2.21,;4,1.44,;5.33,2.21,;5.33,3.75,;6.67,4.52,;8,3.75,)| Show InChI InChI=1S/C20H24ClF3N4O2/c1-28-18(16(21)11-26-28)15-10-14(6-7-17(15)30-9-8-25)27-19(29)12-2-4-13(5-3-12)20(22,23)24/h6-7,10-13H,2-5,8-9,25H2,1H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
University of Virginia at Charlottesville					Assay Description Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...				Chem Biol 14: 1186-97 (2007) BindingDB Entry DOI: 10.7270/Q29K4DKC
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM86525 (AMI-193 | CAS_77445 | CHEMBL79834 | NSC_77445) Show SMILES Fc1ccc(OCCCN2CCC3(CC2)N(CNC3=O)c2ccccc2)cc1 Show InChI InChI=1S/C22H26FN3O2/c23-18-7-9-20(10-8-18)28-16-4-13-25-14-11-22(12-15-25)21(27)24-17-26(22)19-5-2-1-3-6-19/h1-3,5-10H,4,11-17H2,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.316	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals A/S Curated by ChEMBL					Assay Description Compound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptor				Bioorg Med Chem Lett 10: 2435-9 (2001) BindingDB Entry DOI: 10.7270/Q2V69HTT
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM21395 (3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...) Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 Show InChI InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in HEK293 cells measured after 60 mins by scintillation counting metho...				Bioorg Med Chem 25: 471-482 (2017) Article DOI: 10.1016/j.bmc.2016.11.014 BindingDB Entry DOI: 10.7270/Q2CF9S3S
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM21395 (3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...) Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 Show InChI InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in HEK293 cells				Bioorg Med Chem 24: 1793-810 (2016) Article DOI: 10.1016/j.bmc.2016.03.006 BindingDB Entry DOI: 10.7270/Q2J67JS7
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50540335 (CHEMBL4635010) Show SMILES CN1CCC(CC1)N(Cc1ccc(F)cc1)C(=O)NCc1ccc(OCC(O)CN2CCC(CC2)c2noc3cc(F)ccc23)cc1 Show InChI InChI=1S/C36H43F2N5O4/c1-41-16-14-30(15-17-41)43(22-26-2-6-28(37)7-3-26)36(45)39-21-25-4-9-32(10-5-25)46-24-31(44)23-42-18-12-27(13-19-42)35-33-11-8-29(38)20-34(33)47-40-35/h2-11,20,27,30-31,44H,12-19,21-24H2,1H3,(H,39,45)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.390	n/a	n/a	n/a	n/a	n/a	n/a
Gwangju Institute of Science and Technology Curated by ChEMBL					Assay Description Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium fl...				J Med Chem 63: 4171-4182 (2020) Article DOI: 10.1021/acs.jmedchem.0c00002 BindingDB Entry DOI: 10.7270/Q2CZ3BPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50048803 (5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...) Show SMILES Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12 Show InChI InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a	n/a
Organon Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against 5-hydroxytryptamine 2 receptor				J Med Chem 48: 6523-43 (2005) Article DOI: 10.1021/jm058225d BindingDB Entry DOI: 10.7270/Q2SF2WZ9
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM616185 (1-[3-(4-Bromo-2-methyl-2H- pyrazol-3-yl)-4-methoxy...) Show SMILES COc1ccc(NC(=O)Nc2cccc(Cl)c2)cc1-c1c(Br)cnn1C |(5.14,-.34,;6.47,-1.11,;7.8,-.34,;7.8,1.19,;9.14,1.96,;10.47,1.19,;11.8,1.96,;13.14,1.19,;13.14,-.34,;14.47,1.96,;15.8,1.19,;17.14,1.96,;18.47,1.19,;18.47,-.34,;17.14,-1.11,;17.14,-2.65,;15.8,-.34,;10.47,-.34,;9.14,-1.11,;9.14,-2.65,;10.38,-3.56,;11.85,-3.08,;9.91,-5.02,;8.37,-5.02,;7.89,-3.56,;6.43,-3.08,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8CS2
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50306837 (CHEMBL602284 | N-(Cyclohexylmethyl)-N-(3-(4-(4-flu...) Show SMILES Fc1ccc(cc1)N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C30H38FN3O2S/c31-28-12-14-29(15-13-28)33-21-19-32(20-22-33)17-6-18-34(24-25-7-2-1-3-8-25)37(35,36)30-16-11-26-9-4-5-10-27(26)23-30/h4-5,9-16,23,25H,1-3,6-8,17-22,24H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Ewha Womans University Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in avCHO-K1 cells				Bioorg Med Chem 18: 1665-75 (2010) Article DOI: 10.1016/j.bmc.2009.12.067 BindingDB Entry DOI: 10.7270/Q2R78F99
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM119679 (US8680119, 68) Show SMILES COc1cccc(c1)C(=O)Nc1ccc(OCCO)c(c1)-c1c(Cl)cnn1C |(-6.67,1.05,;-6.67,-.49,;-5.33,-1.26,;-5.33,-2.8,;-4,-3.57,;-2.67,-2.8,;-2.67,-1.26,;-4,-.49,;-1.33,-.49,;-1.33,1.05,;,-1.26,;1.33,-.49,;1.33,1.05,;2.67,1.82,;4,1.05,;5.33,1.82,;5.33,3.36,;6.67,4.13,;8,3.36,;4,-.49,;2.67,-1.26,;5.33,-1.26,;5.33,-2.8,;4,-3.57,;6.8,-3.27,;7.7,-2.03,;6.8,-.78,;7.57,.55,)| Show InChI InChI=1S/C20H20ClN3O4/c1-24-19(17(21)12-22-24)16-11-14(6-7-18(16)28-9-8-25)23-20(26)13-4-3-5-15(10-13)27-2/h3-7,10-12,25H,8-9H2,1-2H3,(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.510	n/a	n/a	n/a	n/a	7.4	n/a
Arena Pharmaceuticals, Inc. US Patent					Assay Description Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...				US Patent US8680119 (2014) BindingDB Entry DOI: 10.7270/Q2RV0MB0
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM21395 (3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...) Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 Show InChI InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor in HEK293 cells after 60 mins by scintillation counting				J Med Chem 60: 349-361 (2017) Article DOI: 10.1021/acs.jmedchem.6b01422 BindingDB Entry DOI: 10.7270/Q27M0B6T
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50556204 (ITI 007 | ITI-007 | ITI-722 | ITI007 | Lumateperon...) Show SMILES [H][C@]12CCN(CCCC(=O)c3ccc(F)cc3)C[C@@]1([H])c1cccc3N(C)CCN2c13 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at 5HT2A receptor (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112667 BindingDB Entry DOI: 10.7270/Q2HD80BX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50596723 (CHEMBL5205903 | US20230348421, Compound 59) Show SMILES CN1CCC(CC1)N(Cc1ccc(F)cn1)C(=O)NCc1ccc(OCC(F)(F)F)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50596723 (CHEMBL5205903 | US20230348421, Compound 59) Show SMILES CN1CCC(CC1)N(Cc1ccc(F)cn1)C(=O)NCc1ccc(OCC(F)(F)F)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114246 BindingDB Entry DOI: 10.7270/Q20P142F
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50464898 (CHEMBL4287980) Show SMILES O=C1C2CC=CCC2C(=O)N1CCCCN1CCN(CC1)c1cccc2sccc12 |c:4| Show InChI InChI=1S/C24H29N3O2S/c28-23-18-6-1-2-7-19(18)24(29)27(23)12-4-3-11-25-13-15-26(16-14-25)21-8-5-9-22-20(21)10-17-30-22/h1-2,5,8-10,17-19H,3-4,6-7,11-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica Curated by ChEMBL					Assay Description Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay				Eur J Med Chem 145: 74-85 (2018) Article DOI: 10.1016/j.ejmech.2017.12.099 BindingDB Entry DOI: 10.7270/Q2Z03BVS
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50540327 (CHEMBL4644559) Show SMILES Cl.CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCNCC2)cc1 Show InChI InChI=1S/C24H32FN3O2/c1-18(2)17-30-23-9-5-19(6-10-23)15-27-24(29)28(22-11-13-26-14-12-22)16-20-3-7-21(25)8-4-20/h3-10,18,22,26H,11-17H2,1-2H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Gwangju Institute of Science and Technology Curated by ChEMBL					Assay Description Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium fl...				J Med Chem 63: 4171-4182 (2020) Article DOI: 10.1021/acs.jmedchem.0c00002 BindingDB Entry DOI: 10.7270/Q2CZ3BPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50172414 (2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...) Show SMILES CN(C)CCOc1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1 Show InChI InChI=1S/C22H23Cl2N3O3/c1-14-10-22(29-9-8-27(2)3)26-19-6-5-16(12-17(14)19)25-21(28)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12H,8-9,13H2,1-3H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.610	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Inhibitory concentration against 5-hydroxytryptamine 2A receptor				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM392076 (US10301272, Example 7/9) Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12 |r,wU:27.28,wD:29.33,(8.76,1.15,;7.67,.06,;6.19,.46,;7.28,1.55,;8.07,-1.42,;6.98,-2.51,;6.59,-4,;8.07,-3.6,;5.5,-2.11,;5.1,-.63,;3.61,-.23,;2.52,-1.32,;1.03,-.92,;.56,.55,;-.98,.55,;-1.46,-.92,;-.21,-1.82,;-.21,-3.36,;-1.55,-4.13,;-2.88,-3.36,;-4.21,-4.13,;-4.21,-5.67,;-2.88,-6.44,;-1.55,-5.67,;-2.07,1.64,;-1.67,3.12,;-3.56,1.24,;-4.65,2.33,;-6.19,2.33,;-6.19,3.87,;-4.65,3.87,;-7.28,4.96,;-6.88,6.44,;-8.76,4.56,;2.92,-2.8,;1.83,-3.89,;2.23,-5.38,;3.72,-5.78,;4.81,-4.69,;4.41,-3.2,)| Show InChI InChI=1S/C30H37N3O5S2/c1-30(2,3)33-40(37,38)25-14-13-23(21-11-7-8-12-22(21)25)26-24(15-18-9-5-4-6-10-18)32-28(39-26)27(34)31-20-16-19(17-20)29(35)36/h7-8,11-14,18-20,33H,4-6,9-10,15-17H2,1-3H3,(H,31,34)(H,35,36)/t19-,20-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
Phenex Pharmaceuticals AG Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin human recombinant 5-HT2A receptor after 60 mins by scintillation counting analysis				Bioorg Med Chem Lett 28: 1446-1455 (2018) Article DOI: 10.1016/j.bmcl.2018.03.093 BindingDB Entry DOI: 10.7270/Q27W6FPC
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50306834 (CHEMBL600012 | N-(Cyclohexylmethyl)-N-(3-(4-phenyl...) Show SMILES O=S(=O)(N(CCCN1CCN(CC1)c1ccccc1)CC1CCCCC1)c1ccc2ccccc2c1 Show InChI InChI=1S/C30H39N3O2S/c34-36(35,30-17-16-27-12-7-8-13-28(27)24-30)33(25-26-10-3-1-4-11-26)19-9-18-31-20-22-32(23-21-31)29-14-5-2-6-15-29/h2,5-8,12-17,24,26H,1,3-4,9-11,18-23,25H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Ewha Womans University Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in avCHO-K1 cells				Bioorg Med Chem 18: 1665-75 (2010) Article DOI: 10.1016/j.bmc.2009.12.067 BindingDB Entry DOI: 10.7270/Q2R78F99
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50001885 ((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...) Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12 Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.708	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of Lublin Curated by ChEMBL					Assay Description Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated f...				Eur J Med Chem 180: 673-689 (2019) Article DOI: 10.1016/j.ejmech.2019.07.050 BindingDB Entry DOI: 10.7270/Q2XK8JXM
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50001885 ((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...) Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12 Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.720	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of Lublin Curated by ChEMBL					Assay Description Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated f...				Eur J Med Chem 180: 673-689 (2019) Article DOI: 10.1016/j.ejmech.2019.07.050 BindingDB Entry DOI: 10.7270/Q2XK8JXM
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50194847 (CHEMBL221250 | N-(1-ethylcyclopentyl)-7-(4-fluorop...) Show SMILES CCC1(CCCC1)N=C1CC(=NCCN1)c1ccc(F)cc1 |w:7.7,c:11| Show InChI InChI=1S/C18H24FN3/c1-2-18(9-3-4-10-18)22-17-13-16(20-11-12-21-17)14-5-7-15(19)8-6-14/h5-8H,2-4,9-13H2,1H3,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cells				Bioorg Med Chem Lett 16: 6058-62 (2006) Article DOI: 10.1016/j.bmcl.2006.08.108 BindingDB Entry DOI: 10.7270/Q2D79B26
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50544628 (CHEMBL4638006) Show SMILES COc1cccc(C(=O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC Show InChI InChI=1S/C22H26FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17H,10-15H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.810	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50544628 (CHEMBL4638006) Show SMILES COc1cccc(C(=O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC Show InChI InChI=1S/C22H26FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17H,10-15H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.813	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM21395 (3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...) Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 Show InChI InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a	n/a
National University of Ireland Galway Curated by ChEMBL					Assay Description Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor measured after 60 mins by scintillation counter method				Eur J Med Chem 176: 292-309 (2019) Article DOI: 10.1016/j.ejmech.2019.04.064 BindingDB Entry DOI: 10.7270/Q2NP27V8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50540334 (CHEMBL4647697) Show SMILES CN1CCC(CC1)N(Cc1ccc(F)cc1)C(=O)NCc1ccc(OCC(O)CN2CCN(CC2)c2nsc3ccccc23)cc1 Show InChI InChI=1S/C35H43FN6O3S/c1-39-16-14-29(15-17-39)42(23-27-6-10-28(36)11-7-27)35(44)37-22-26-8-12-31(13-9-26)45-25-30(43)24-40-18-20-41(21-19-40)34-32-4-2-3-5-33(32)46-38-34/h2-13,29-30,43H,14-25H2,1H3,(H,37,44)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.870	n/a	n/a	n/a	n/a	n/a	n/a
Gwangju Institute of Science and Technology Curated by ChEMBL					Assay Description Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium fl...				J Med Chem 63: 4171-4182 (2020) Article DOI: 10.1021/acs.jmedchem.0c00002 BindingDB Entry DOI: 10.7270/Q2CZ3BPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM117018 (US8664258, 197 | US9987252, 197) Show SMILES Cn1ncc(Cl)c1-c1cc(NC(=O)c2ccc(F)c(c2)C(F)(F)F)ccc1OCCN |(7.72,.46,;6.95,-.88,;7.85,-2.12,;6.95,-3.37,;5.48,-2.89,;4.15,-3.66,;5.48,-1.35,;4.15,-.58,;2.82,-1.35,;1.48,-.58,;.15,-1.35,;-1.18,-.58,;-1.18,.96,;-2.52,-1.35,;-2.52,-2.89,;-3.85,-3.66,;-5.19,-2.89,;-6.52,-3.66,;-5.19,-1.35,;-3.85,-.58,;-6.52,-.58,;-7.85,.19,;-5.75,.75,;-7.29,-1.92,;1.48,.96,;2.82,1.73,;4.15,.96,;5.48,1.73,;5.48,3.27,;6.97,3.66,;7.74,2.33,)| Show InChI InChI=1S/C20H17ClF4N4O2/c1-29-18(15(21)10-27-29)13-9-12(3-5-17(13)31-7-6-26)28-19(30)11-2-4-16(22)14(8-11)20(23,24)25/h2-5,8-10H,6-7,26H2,1H3,(H,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
University of Virginia at Charlottesville					Assay Description Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...				Chem Biol 14: 1186-97 (2007) BindingDB Entry DOI: 10.7270/Q29K4DKC
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM117018 (US8664258, 197 | US9987252, 197) Show SMILES Cn1ncc(Cl)c1-c1cc(NC(=O)c2ccc(F)c(c2)C(F)(F)F)ccc1OCCN |(7.72,.46,;6.95,-.88,;7.85,-2.12,;6.95,-3.37,;5.48,-2.89,;4.15,-3.66,;5.48,-1.35,;4.15,-.58,;2.82,-1.35,;1.48,-.58,;.15,-1.35,;-1.18,-.58,;-1.18,.96,;-2.52,-1.35,;-2.52,-2.89,;-3.85,-3.66,;-5.19,-2.89,;-6.52,-3.66,;-5.19,-1.35,;-3.85,-.58,;-6.52,-.58,;-7.85,.19,;-5.75,.75,;-7.29,-1.92,;1.48,.96,;2.82,1.73,;4.15,.96,;5.48,1.73,;5.48,3.27,;6.97,3.66,;7.74,2.33,)| Show InChI InChI=1S/C20H17ClF4N4O2/c1-29-18(15(21)10-27-29)13-9-12(3-5-17(13)31-7-6-26)28-19(30)11-2-4-16(22)14(8-11)20(23,24)25/h2-5,8-10H,6-7,26H2,1H3,(H,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	25
Arena Pharmaceuticals, Inc. US Patent					Assay Description Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125]DOI as radioligand. To define nonspecific binding, 10...				US Patent US8664258 (2014) BindingDB Entry DOI: 10.7270/Q2WQ02G1
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM139371 (eplivanserin) Show SMILES [#6]-[#7](-[#6])-[#6]-[#6]-[#8]-[#7]\[#6](=[#6]\[#6]=[#6]-1\[#6]=[#6]-[#6](=O)-[#6]=[#6]-1)-c1ccccc1F |c:11,15| Show InChI InChI=1S/C19H21FN2O2/c1-22(2)13-14-24-21-19(17-5-3-4-6-18(17)20)12-9-15-7-10-16(23)11-8-15/h3-12,21H,13-14H2,1-2H3/b19-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals Inc.					Assay Description R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...				J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50194829 (7-(2,4-difluorophenyl)-N-(1-ethylcyclopentyl)-2,3-...) Show SMILES CCC1(CCCC1)N=C1CC(=NCCN1)c1ccc(F)cc1F |w:7.7,c:11| Show InChI InChI=1S/C18H23F2N3/c1-2-18(7-3-4-8-18)23-17-12-16(21-9-10-22-17)14-6-5-13(19)11-15(14)20/h5-6,11H,2-4,7-10,12H2,1H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cells				Bioorg Med Chem Lett 16: 6058-62 (2006) Article DOI: 10.1016/j.bmcl.2006.08.108 BindingDB Entry DOI: 10.7270/Q2D79B26
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50232153 ((1-(4-fluorophenethyl)piperidin-4-yl)(2,3-dimethox...) Show SMILES COc1cccc(C(O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC Show InChI InChI=1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals Inc.					Assay Description R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...				J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50403974 (CHEMBL84931) Show SMILES CN(C)CC1CC2N(O1)c1cc(F)ccc1Cc1ccccc21 Show InChI InChI=1S/C19H21FN2O/c1-21(2)12-16-11-19-17-6-4-3-5-13(17)9-14-7-8-15(20)10-18(14)22(19)23-16/h3-8,10,16,19H,9,11-12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Binding affinity at human cloned 5-hydroxytryptamine 2A receptor expressed in L929 cells by [125I]R91150 displacement.				Bioorg Med Chem Lett 12: 249-53 (2001) Article DOI: 10.1016/S0960-894X(01)00722-3 BindingDB Entry DOI: 10.7270/Q2ZW1N3V
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM616186 (1-[3-(4-Bromo-2-methyl-2H- pyrazol-3-yl)-4-isoprop...) Show SMILES CC(C)Oc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1c(Br)cnn1C |(9.14,8.12,;9.14,6.58,;10.47,5.81,;7.8,5.81,;6.47,6.58,;6.47,8.12,;5.14,8.89,;3.8,8.12,;2.47,8.89,;2.47,10.43,;1.13,11.2,;3.8,11.2,;3.8,12.74,;2.47,13.51,;2.47,15.05,;3.8,15.82,;3.8,17.36,;5.14,15.05,;5.14,13.51,;3.8,6.58,;5.14,5.81,;5.14,4.27,;6.38,3.37,;7.85,3.85,;5.91,1.9,;4.37,1.9,;3.89,3.37,;2.42,3.85,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8CS2
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50464897 (CHEMBL4291387) Show SMILES O=C1C2CCCC2C(=O)N1CCCCN1CCN(CC1)c1cccc2sccc12 Show InChI InChI=1S/C23H29N3O2S/c27-22-17-5-3-6-18(17)23(28)26(22)11-2-1-10-24-12-14-25(15-13-24)20-7-4-8-21-19(20)9-16-29-21/h4,7-9,16-18H,1-3,5-6,10-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica Curated by ChEMBL					Assay Description Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay				Eur J Med Chem 145: 74-85 (2018) Article DOI: 10.1016/j.ejmech.2017.12.099 BindingDB Entry DOI: 10.7270/Q2Z03BVS
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM463328 ( [3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-(2-pyrrol...) Show SMILES CCC(C)OC(=O)Nc1ccc(OCCN2CCCC2)c(c1)-c1c(Br)cnn1C |(-4,6.93,;-2.67,6.16,;-1.33,6.93,;-1.33,8.47,;,6.16,;,4.62,;-1.33,3.85,;1.33,3.85,;1.33,2.31,;,1.54,;;1.33,-.77,;1.33,-2.31,;0,-3.08,;-1.33,-2.31,;-2.67,-3.08,;-4.07,-2.45,;-5.1,-3.6,;-4.33,-4.93,;-2.83,-4.61,;2.67,,;2.67,1.54,;4,-.77,;5.41,-.14,;5.73,1.36,;6.44,-1.29,;5.67,-2.62,;4.16,-2.3,;3.02,-3.33,)| Show InChI InChI=1S/C21H29BrN4O3/c1-4-15(2)29-21(27)24-16-7-8-19(28-12-11-26-9-5-6-10-26)17(13-16)20-18(22)14-23-25(20)3/h7-8,13-15H,4-6,9-12H2,1-3H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals, Inc. US Patent					Assay Description Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...				US Patent US10781180 (2020) BindingDB Entry DOI: 10.7270/Q2SX6H84
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM631393 (US20230348421, Compound 18) Show SMILES CN1CCC(CC1)N(Cc1ccc(F)cn1)C(=O)NCc1ccc(OC(C)(C)C)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50246480 (1-(4-chloro-2-(p-tolyloxy)phenyl)-N-methylmethanam...) Show SMILES CNCc1ccc(Cl)cc1Oc1ccc(C)cc1 Show InChI InChI=1S/C15H16ClNO/c1-11-3-7-14(8-4-11)18-15-9-13(16)6-5-12(15)10-17-2/h3-9,17H,10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.18	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from 5HT2A receptor (unknown origin)				Bioorg Med Chem Lett 18: 6088-92 (2008) Article DOI: 10.1016/j.bmcl.2008.10.028 BindingDB Entry DOI: 10.7270/Q2RJ4JBK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM578155 (US11478467, Compound (+)-147) Show SMILES COc1cccc(CCc2ccccc2OC[C@@H](O)CN(C)C)c1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Evaluation of the affinity of compounds for the human 5-HT2A receptor in transfected HEK-293 cells determined in a radioligand binding assay. Cell me...				Citation and Details BindingDB Entry DOI: 10.7270/Q2862KPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM117020 (US8664258, 77) Show SMILES Cn1ncc(Cl)c1-c1cc(NC(=O)C(=O)c2cc(Br)cs2)ccc1OCCN |(7.61,.31,;6.84,-1.03,;7.75,-2.27,;6.84,-3.52,;5.38,-3.04,;4.29,-4.13,;5.38,-1.5,;4.05,-.73,;2.71,-1.5,;1.38,-.73,;.05,-1.5,;-1.29,-.73,;-1.29,.81,;-2.62,-1.5,;-2.62,-3.04,;-3.96,-.73,;-3.88,.81,;-5.31,1.36,;-5.71,2.85,;-6.28,.16,;-5.44,-1.13,;1.38,.81,;2.71,1.58,;4.05,.81,;5.38,1.58,;5.38,3.12,;6.87,3.52,;7.96,2.43,)| Show InChI InChI=1S/C18H16BrClN4O3S/c1-24-16(13(20)8-22-24)12-7-11(2-3-14(12)27-5-4-21)23-18(26)17(25)15-6-10(19)9-28-15/h2-3,6-9H,4-5,21H2,1H3,(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.4	25
Arena Pharmaceuticals, Inc. US Patent					Assay Description Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125]DOI as radioligand. To define nonspecific binding, 10...				US Patent US8664258 (2014) BindingDB Entry DOI: 10.7270/Q2WQ02G1
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM397088 (4-Bromo-thiophene-2- carboxylic acid [4-(2- amino-...) Show SMILES Cn1ncc(Cl)c1-c1cc(NC(=O)c2cc(Br)cs2)ccc1OCCN |(6.95,.27,;6.18,-1.06,;7.09,-2.31,;6.18,-3.56,;4.72,-3.08,;3.38,-3.85,;4.72,-1.54,;3.38,-.77,;2.05,-1.54,;.72,-.77,;-.62,-1.54,;-1.95,-.77,;-1.95,.77,;-3.28,-1.54,;-4.75,-1.06,;-5.65,-2.31,;-7.14,-1.91,;-4.75,-3.56,;-3.28,-3.08,;.72,.77,;2.05,1.54,;3.38,.77,;4.72,1.54,;4.72,3.08,;6.05,3.85,;7.14,2.76,)| Show InChI InChI=1S/C17H16BrClN4O2S/c1-23-16(13(19)8-21-23)12-7-11(2-3-14(12)25-5-4-20)22-17(24)15-6-10(18)9-26-15/h2-3,6-9H,4-5,20H2,1H3,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Virginia at Charlottesville					Assay Description Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...				Chem Biol 14: 1186-97 (2007) BindingDB Entry DOI: 10.7270/Q29K4DKC
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM319608 (3-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...) Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCN(CC1)c1cccc2sccc12 Show InChI InChI=1S/C23H28N4OS/c1-17-18(23(28)27-10-3-2-7-22(27)24-17)8-11-25-12-14-26(15-13-25)20-5-4-6-21-19(20)9-16-29-21/h4-6,9,16H,2-3,7-8,10-15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Xinjiang Technical Institute of Physics and Chemistry Curated by ChEMBL					Assay Description Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay				Bioorg Med Chem 25: 4904-4916 (2017) Article DOI: 10.1016/j.bmc.2017.07.040 BindingDB Entry DOI: 10.7270/Q2Z3222T
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM578158 (US11478467, Compound (-)-148) Show SMILES COc1cccc(CCc2ccccc2OC[C@H](O)CN(C)C)c1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Evaluation of the affinity of compounds for the human 5-HT2A receptor in transfected HEK-293 cells determined in a radioligand binding assay. Cell me...				Citation and Details BindingDB Entry DOI: 10.7270/Q2862KPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50194836 (CHEMBL436513 | N-(2-cyclobutylpropan-2-yl)-7-(2,4-...) Show SMILES CC(C)(N=C1CC(=NCCN1)c1ccc(F)cc1F)C1CCC1 |w:3.2,c:6| Show InChI InChI=1S/C18H23F2N3/c1-18(2,12-4-3-5-12)23-17-11-16(21-8-9-22-17)14-7-6-13(19)10-15(14)20/h6-7,10,12H,3-5,8-9,11H2,1-2H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cells				Bioorg Med Chem Lett 16: 6058-62 (2006) Article DOI: 10.1016/j.bmcl.2006.08.108 BindingDB Entry DOI: 10.7270/Q2D79B26
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50113332 (3-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-2-t...) Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1 Show InChI InChI=1S/C22H22FN3O2S/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Dominican College Curated by ChEMBL					Assay Description Antagonist activity at recombinant human 5-HT2A expressed in human U2OS cells by pathhunter beta-arrestin assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.127358 BindingDB Entry DOI: 10.7270/Q26113XJ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50194832 (7-(4-fluorophenyl)-N-(3-methylpentan-3-yl)-2,3-dih...) Show SMILES CCC(C)(CC)NC1=NCCN=C(C1)c1ccc(F)cc1 |c:11,t:7| Show InChI InChI=1S/C17H24FN3/c1-4-17(3,5-2)21-16-12-15(19-10-11-20-16)13-6-8-14(18)9-7-13/h6-9H,4-5,10-12H2,1-3H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cells				Bioorg Med Chem Lett 16: 6058-62 (2006) Article DOI: 10.1016/j.bmcl.2006.08.108 BindingDB Entry DOI: 10.7270/Q2D79B26
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50194850 (7-(4-fluorophenyl)-N-(1-methylcyclohexyl)-2,3-dihy...) Show SMILES CC1(CCCCC1)NC1=NCCN=C(C1)c1ccc(F)cc1 |c:13,t:9| Show InChI InChI=1S/C18H24FN3/c1-18(9-3-2-4-10-18)22-17-13-16(20-11-12-21-17)14-5-7-15(19)8-6-14/h5-8H,2-4,9-13H2,1H3,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cells				Bioorg Med Chem Lett 16: 6058-62 (2006) Article DOI: 10.1016/j.bmcl.2006.08.108 BindingDB Entry DOI: 10.7270/Q2D79B26
					More data for this Ligand-Target Pair

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