BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 30 hits of ic50 for UniProtKB: P14340   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E]


(Dengue virus 2 (strain TSV01))
BDBM33252
PNG
(phthalazine-based compound, 3)
Show SMILES C1CCC2N=C(NC2C1)c1ccc(Nc2nnc(Nc3ccc(cc3)C3=NC4CCCCC4N3)c3ccccc23)cc1 |c:4,t:28|
Show InChI InChI=1S/C34H36N8/c1-2-8-26-25(7-1)33(35-23-17-13-21(14-18-23)31-37-27-9-3-4-10-28(27)38-31)41-42-34(26)36-24-19-15-22(16-20-24)32-39-29-11-5-6-12-30(29)40-32/h1-2,7-8,13-20,27-30H,3-6,9-12H2,(H,35,41)(H,36,42)(H,37,38)(H,39,40)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+3 7.70E+3n/an/an/a7.537



Novartis Institute for Tropical Diseases



Assay Description
Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....


Anal Biochem 395: 195-204 (2009)


Article DOI: 10.1016/j.ab.2009.08.013
BindingDB Entry DOI: 10.7270/Q2VM49MW
More data for this
Ligand-Target Pair
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E]


(Dengue virus 2 (strain TSV01))
BDBM33256
PNG
(phthalazine-based compound, 7)
Show SMILES COC(=O)c1ccc(cc1)-c1ccc(Nc2nnc(Nc3ccc(cc3)C3=NCCN3)c3ccccc23)cc1 |t:28|
Show InChI InChI=1S/C31H26N6O2/c1-39-31(38)23-8-6-20(7-9-23)21-10-14-24(15-11-21)34-29-26-4-2-3-5-27(26)30(37-36-29)35-25-16-12-22(13-17-25)28-32-18-19-33-28/h2-17H,18-19H2,1H3,(H,32,33)(H,34,36)(H,35,37)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.60E+3n/an/an/an/a7.537



Novartis Institute for Tropical Diseases



Assay Description
Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....


Anal Biochem 395: 195-204 (2009)


Article DOI: 10.1016/j.ab.2009.08.013
BindingDB Entry DOI: 10.7270/Q2VM49MW
More data for this
Ligand-Target Pair
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E]


(Dengue virus 2 (strain TSV01))
BDBM33251
PNG
(phthalazine-based compound, 2)
Show SMILES C1CN=C(N1)c1ccc(Nc2nnc(Nc3ccc(cc3)-c3ccccc3)c3ccccc23)cc1 |c:2|
Show InChI InChI=1S/C29H24N6/c1-2-6-20(7-3-1)21-10-14-23(15-11-21)32-28-25-8-4-5-9-26(25)29(35-34-28)33-24-16-12-22(13-17-24)27-30-18-19-31-27/h1-17H,18-19H2,(H,30,31)(H,32,34)(H,33,35)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.30E+3n/an/an/an/a7.537



Novartis Institute for Tropical Diseases



Assay Description
Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....


Anal Biochem 395: 195-204 (2009)


Article DOI: 10.1016/j.ab.2009.08.013
BindingDB Entry DOI: 10.7270/Q2VM49MW
More data for this
Ligand-Target Pair
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E]


(Dengue virus 2 (strain TSV01))
BDBM33254
PNG
(phthalazine-based compound, 5)
Show SMILES NCc1ccc(Nc2nnc(Nc3ccc(cc3)C3=NCCN3)c3ccccc23)cc1 |t:19|
Show InChI InChI=1S/C24H23N7/c25-15-16-5-9-18(10-6-16)28-23-20-3-1-2-4-21(20)24(31-30-23)29-19-11-7-17(8-12-19)22-26-13-14-27-22/h1-12H,13-15,25H2,(H,26,27)(H,28,30)(H,29,31)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.80E+3 1.86E+4n/an/an/a7.537



Novartis Institute for Tropical Diseases



Assay Description
Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....


Anal Biochem 395: 195-204 (2009)


Article DOI: 10.1016/j.ab.2009.08.013
BindingDB Entry DOI: 10.7270/Q2VM49MW
More data for this
Ligand-Target Pair
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E]


(Dengue virus 2 (strain TSV01))
BDBM33250
PNG
(phthalazine-based compound, 1)
Show SMILES CC1CNC(=N1)c1ccc(Nc2nnc(Nc3ccc(cc3)C3=NC(C)CN3)c3ccccc23)cc1 |c:4,t:24|
Show InChI InChI=1S/C28H28N8/c1-17-15-29-25(31-17)19-7-11-21(12-8-19)33-27-23-5-3-4-6-24(23)28(36-35-27)34-22-13-9-20(10-14-22)26-30-16-18(2)32-26/h3-14,17-18H,15-16H2,1-2H3,(H,29,31)(H,30,32)(H,33,35)(H,34,36)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.00E+3 7.20E+3n/an/an/a7.537



Novartis Institute for Tropical Diseases



Assay Description
Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....


Anal Biochem 395: 195-204 (2009)


Article DOI: 10.1016/j.ab.2009.08.013
BindingDB Entry DOI: 10.7270/Q2VM49MW
More data for this
Ligand-Target Pair
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E]


(Dengue virus 2 (strain TSV01))
BDBM33259
PNG
(Bz-NKRR-H | Bz-Nle-Lys-Arg-Arg-H | CHEMBL256877)
Show SMILES [#6]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6]=O |r|
Show InChI InChI=1S/C31H53N11O5/c1-2-3-14-23(40-26(44)21-11-5-4-6-12-21)28(46)41-24(15-7-8-17-32)29(47)42-25(16-10-19-38-31(35)36)27(45)39-22(20-43)13-9-18-37-30(33)34/h4-6,11-12,20,22-25H,2-3,7-10,13-19,32H2,1H3,(H,39,45)(H,40,44)(H,41,46)(H,42,47)(H4,33,34,37)(H4,35,36,38)/t22-,23-,24-,25-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.90E+3n/an/an/an/a7.537



Novartis Institute for Tropical Diseases



Assay Description
Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....


Anal Biochem 395: 195-204 (2009)


Article DOI: 10.1016/j.ab.2009.08.013
BindingDB Entry DOI: 10.7270/Q2VM49MW
More data for this
Ligand-Target Pair
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E]


(Dengue virus 2 (strain TSV01))
BDBM33257
PNG
(phthalazine-based compound, 8)
Show SMILES C1CN=C(N1)c1ccc(Nc2nnc(Nc3ccc(cc3)C3=NCCN3)c3ccccc23)cc1 |c:2,t:23|
Show InChI InChI=1S/C26H24N8/c1-2-4-22-21(3-1)25(31-19-9-5-17(6-10-19)23-27-13-14-28-23)33-34-26(22)32-20-11-7-18(8-12-20)24-29-15-16-30-24/h1-12H,13-16H2,(H,27,28)(H,29,30)(H,31,33)(H,32,34)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.02E+4 1.63E+4n/an/an/a7.537



Novartis Institute for Tropical Diseases



Assay Description
Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....


Anal Biochem 395: 195-204 (2009)


Article DOI: 10.1016/j.ab.2009.08.013
BindingDB Entry DOI: 10.7270/Q2VM49MW
More data for this
Ligand-Target Pair
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E]


(Dengue virus 2 (strain TSV01))
BDBM33253
PNG
(phthalazine-based compound, 4)
Show SMILES C1CN=C(N1)c1ccc(Nc2nnc(Nc3ccc4CCNCc4c3)c3ccccc23)cc1 |c:2|
Show InChI InChI=1S/C26H25N7/c1-2-4-23-22(3-1)25(30-20-8-6-18(7-9-20)24-28-13-14-29-24)32-33-26(23)31-21-10-5-17-11-12-27-16-19(17)15-21/h1-10,15,27H,11-14,16H2,(H,28,29)(H,30,32)(H,31,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.74E+4 2.29E+4n/an/an/a7.537



Novartis Institute for Tropical Diseases



Assay Description
Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....


Anal Biochem 395: 195-204 (2009)


Article DOI: 10.1016/j.ab.2009.08.013
BindingDB Entry DOI: 10.7270/Q2VM49MW
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152653
PNG
(4-(1,3-Dioxoisoindolin-2-yl)-N-(4-ethylphenyl)benz...)
Show SMILES CCc1ccc(NS(=O)(=O)c2ccc(cc2)N2C(=O)c3ccccc3C2=O)cc1
Show InChI InChI=1S/C30H20Cl4N4S/c31-17-4-9-26-21(11-17)23(14-35-26)29(24-15-36-27-10-5-18(32)12-22(24)27)16-1-6-20(7-2-16)37-30(39)38-28-13-19(33)3-8-25(28)34/h1-15,29,35-36H,(H2,37,38,39)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.82E+4n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E]


(Dengue virus 2 (strain TSV01))
BDBM33255
PNG
(phthalazine-based compound, 6)
Show SMILES C1CN=C(N1)c1ccc(Nc2nnc(Nc3ccc4CNCCc4c3)c3ccccc23)cc1 |c:2|
Show InChI InChI=1S/C26H25N7/c1-2-4-23-22(3-1)25(30-20-8-5-17(6-9-20)24-28-13-14-29-24)32-33-26(23)31-21-10-7-19-16-27-12-11-18(19)15-21/h1-10,15,27H,11-14,16H2,(H,28,29)(H,30,32)(H,31,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.50E+4 5.40E+4n/an/an/a7.537



Novartis Institute for Tropical Diseases



Assay Description
Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....


Anal Biochem 395: 195-204 (2009)


Article DOI: 10.1016/j.ab.2009.08.013
BindingDB Entry DOI: 10.7270/Q2VM49MW
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152647
PNG
(4-(1,3-Dioxoisoindolin-2-yl)-N-(4-methoxyphenyl)be...)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(cc2)N2C(=O)c3ccccc3C2=O)cc1
Show InChI InChI=1S/C30H21Br2ClN4S/c31-18-6-10-27-23(12-18)25(15-34-27)29(26-16-35-28-11-7-19(32)13-24(26)28)17-4-8-21(9-5-17)36-30(38)37-22-3-1-2-20(33)14-22/h1-16,29,34-35H,(H2,36,37,38)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152648
PNG
(N-(3-chlorophenyl)-4-(1,3-dioxoisoindolin-2-yl)ben...)
Show SMILES Clc1cccc(NS(=O)(=O)c2ccc(cc2)N2C(=O)c3ccccc3C2=O)c1
Show InChI InChI=1S/C20H13ClN2O4S/c21-13-4-3-5-14(12-13)22-28(26,27)16-10-8-15(9-11-16)23-19(24)17-6-1-2-7-18(17)20(23)25/h1-12,22H
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152649
PNG
(N-(4-chlorophenyl)-4-(1,3-dioxoisoindolin-2-yl)ben...)
Show SMILES Clc1ccc(NS(=O)(=O)c2ccc(cc2)N2C(=O)c3ccccc3C2=O)cc1
Show InChI InChI=1S/C30H20Br2Cl2N4S/c31-17-3-9-26-21(11-17)23(14-35-26)29(24-15-36-27-10-4-18(32)12-22(24)27)16-1-6-20(7-2-16)37-30(39)38-28-13-19(33)5-8-25(28)34/h1-15,29,35-36H,(H2,37,38,39)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152650
PNG
(4-(1,3-Dioxoisoindolin-2-yl)-N-o-tolylbenzenesulph...)
Show SMILES Cc1ccccc1NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C30H21BrCl2N4S/c31-18-2-1-3-22(12-18)37-30(38)36-21-8-4-17(5-9-21)29(25-15-34-27-10-6-19(32)13-23(25)27)26-16-35-28-11-7-20(33)14-24(26)28/h1-16,29,34-35H,(H2,36,37,38)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152651
PNG
(4-(1,3-Dioxoisoindolin-2-yl)-N-m-tolylbenzenesulph...)
Show SMILES Cc1cccc(NS(=O)(=O)c2ccc(cc2)N2C(=O)c3ccccc3C2=O)c1
Show InChI InChI=1S/C30H21Cl2N5O2S/c31-18-3-11-27-23(13-18)25(15-33-27)29(26-16-34-28-12-4-19(32)14-24(26)28)17-1-5-20(6-2-17)35-30(40)36-21-7-9-22(10-8-21)37(38)39/h1-16,29,33-34H,(H2,35,36,40)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152652
PNG
(4-(1,3-Dioxoisoindolin-2-yl)-N-p-tolylbenzenesulph...)
Show SMILES Cc1ccc(NS(=O)(=O)c2ccc(cc2)N2C(=O)c3ccccc3C2=O)cc1
Show InChI InChI=1S/C30H21Cl3N4S/c31-18-2-1-3-22(12-18)37-30(38)36-21-8-4-17(5-9-21)29(25-15-34-27-10-6-19(32)13-23(25)27)26-16-35-28-11-7-20(33)14-24(26)28/h1-16,29,34-35H,(H2,36,37,38)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152654
PNG
(4-(1,3-Dioxoisoindolin-2-yl)-N-(4-nitrophenyl)benz...)
Show SMILES [O-][N+](=O)c1ccc(NS(=O)(=O)c2ccc(cc2)N2C(=O)c3ccccc3C2=O)cc1
Show InChI InChI=1S/C27H22Cl2N4O2S/c1-2-35-27(34)33-26(36)32-18-7-3-15(4-8-18)25(21-13-30-23-9-5-16(28)11-19(21)23)22-14-31-24-10-6-17(29)12-20(22)24/h3-14,25,30-31H,2H2,1H3,(H2,32,33,34,36)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152655
PNG
(4-(4-(1,3-Dioxoisoindolin-2-yl)phenylsulphonamido)...)
Show SMILES OC(=O)c1ccc(NS(=O)(=O)c2ccc(cc2)N2C(=O)c3ccccc3C2=O)cc1
Show InChI InChI=1S/C32H28N4S/c1-20-8-6-12-25-27(18-33-30(20)25)29(28-19-34-31-21(2)9-7-13-26(28)31)22-14-16-24(17-15-22)36-32(37)35-23-10-4-3-5-11-23/h3-19,29,33-34H,1-2H3,(H2,35,36,37)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152646
PNG
(4-(1,3-Dioxoisoindolin-2-yl)-N-(3-methoxyphenyl)be...)
Show SMILES COc1cccc(NS(=O)(=O)c2ccc(cc2)N2C(=O)c3ccccc3C2=O)c1
Show InChI InChI=1S/C30H21Br3N4S/c31-18-2-1-3-22(12-18)37-30(38)36-21-8-4-17(5-9-21)29(25-15-34-27-10-6-19(32)13-23(25)27)26-16-35-28-11-7-20(33)14-24(26)28/h1-16,29,34-35H,(H2,36,37,38)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152645
PNG
(4-(1,3-Dioxoisoindolin-2-yl)-N-(2-hydroxyphenyl)be...)
Show SMILES Oc1ccccc1NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C27H22Br2N4O2S/c1-2-35-27(34)33-26(36)32-18-7-3-15(4-8-18)25(21-13-30-23-9-5-16(28)11-19(21)23)22-14-31-24-10-6-17(29)12-20(22)24/h3-14,25,30-31H,2H2,1H3,(H2,32,33,34,36)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152644
PNG
(4-(1,3-Dioxoisoindolin-2-yl)-N-phenylbenzenesulpho...)
Show SMILES O=C1N(C(=O)c2ccccc12)c1ccc(cc1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C30H22Br2N4S/c31-19-8-12-27-23(14-19)25(16-33-27)29(26-17-34-28-13-9-20(32)15-24(26)28)18-6-10-22(11-7-18)36-30(37)35-21-4-2-1-3-5-21/h1-17,29,33-34H,(H2,35,36,37)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152643
PNG
(2-(4-(4-Methylpiperazin-1-ylsulphonyl)phenyl)isoin...)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C30H23N5O2S/c36-35(37)22-15-13-21(14-16-22)34-30(38)33-20-11-9-19(10-12-20)29(25-17-31-27-7-3-1-5-23(25)27)26-18-32-28-8-4-2-6-24(26)28/h1-18,29,31-32H,(H2,33,34,38)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152657
PNG
(4-(1,3-Dioxoisoindolin-2-yl)-N-phenethylbenzenesul...)
Show SMILES O=C1N(C(=O)c2ccccc12)c1ccc(cc1)S(=O)(=O)NCCc1ccccc1
Show InChI InChI=1S/C32H27BrN4S/c1-19-6-3-10-25-27(17-34-30(19)25)29(28-18-35-31-20(2)7-4-11-26(28)31)21-12-14-23(15-13-21)36-32(38)37-24-9-5-8-22(33)16-24/h3-18,29,34-35H,1-2H3,(H2,36,37,38)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152640
PNG
(4-(1,3-Dioxoisoindolin-2-yl)-N,N-diethyl benzenesu...)
Show SMILES Brc1cccc(NC(=S)Nc2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C30H23BrN4S/c31-20-6-5-7-22(16-20)35-30(36)34-21-14-12-19(13-15-21)29(25-17-32-27-10-3-1-8-23(25)27)26-18-33-28-11-4-2-9-24(26)28/h1-18,29,32-33H,(H2,34,35,36)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152640
PNG
(4-(1,3-Dioxoisoindolin-2-yl)-N,N-diethyl benzenesu...)
Show SMILES Brc1cccc(NC(=S)Nc2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C30H23BrN4S/c31-20-6-5-7-22(16-20)35-30(36)34-21-14-12-19(13-15-21)29(25-17-32-27-10-3-1-8-23(25)27)26-18-33-28-11-4-2-9-24(26)28/h1-18,29,32-33H,(H2,34,35,36)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152639
PNG
(4-(1,3-Dioxoisoindolin-2-yl)-N,N-dimethyl benzenes...)
Show SMILES CN(C)S(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C27H24N4O2S/c1-2-33-27(32)31-26(34)30-18-13-11-17(12-14-18)25(21-15-28-23-9-5-3-7-19(21)23)22-16-29-24-10-6-4-8-20(22)24/h3-16,25,28-29H,2H2,1H3,(H2,30,31,32,34)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152638
PNG
(4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1...)
Show SMILES NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C30H24N4S/c35-30(33-21-8-2-1-3-9-21)34-22-16-14-20(15-17-22)29(25-18-31-27-12-6-4-10-23(25)27)26-19-32-28-13-7-5-11-24(26)28/h1-19,29,31-32H,(H2,33,34,35)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E]


(Dengue virus 2 (strain TSV01))
BDBM33258
PNG
(phthalazine-based compound, 9)
Show SMILES Nc1ccc2c(Nc3ccc(cc3)C3=NCCN3)nnc(Nc3ccc(cc3)C3=NCCN3)c2c1 |t:14,31|
Show InChI InChI=1S/C26H25N9/c27-18-5-10-21-22(15-18)26(33-20-8-3-17(4-9-20)24-30-13-14-31-24)35-34-25(21)32-19-6-1-16(2-7-19)23-28-11-12-29-23/h1-10,15H,11-14,27H2,(H,28,29)(H,30,31)(H,32,34)(H,33,35)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5 1.00E+5n/an/an/a7.537



Novartis Institute for Tropical Diseases



Assay Description
Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....


Anal Biochem 395: 195-204 (2009)


Article DOI: 10.1016/j.ab.2009.08.013
BindingDB Entry DOI: 10.7270/Q2VM49MW
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152642
PNG
(2-(4-(Piperidin-1-ylsulphonyl)phenyl)isoindoline-1...)
Show SMILES O=C1N(C(=O)c2ccccc12)c1ccc(cc1)S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C30H23ClN4S/c31-20-6-5-7-22(16-20)35-30(36)34-21-14-12-19(13-15-21)29(25-17-32-27-10-3-1-8-23(25)27)26-18-33-28-11-4-2-9-24(26)28/h1-18,29,32-33H,(H2,34,35,36)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2 (Virus))
BDBM152656
PNG
(4-(1,3-Dioxoisoindolin-2-yl)-N-(naphthalen-1-yl)be...)
Show SMILES O=C1N(C(=O)c2ccccc12)c1ccc(cc1)S(=O)(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C32H26Cl2N4S/c1-18-5-3-7-23-25(16-35-30(18)23)29(26-17-36-31-19(2)6-4-8-24(26)31)20-9-12-22(13-10-20)37-32(39)38-28-15-21(33)11-14-27(28)34/h3-17,29,35-36H,1-2H3,(H2,37,38,39)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.22E+5n/an/an/an/a8.5n/a



Birla Institute of Technology



Assay Description
To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...


Bioorg Chem 62: 74-82 (2015)


Article DOI: 10.1016/j.bioorg.2015.07.005
BindingDB Entry DOI: 10.7270/Q2VT1QTG
More data for this
Ligand-Target Pair