Compile Data Set for Download or QSAR

Found 48 hits of ec50 for UniProtKB: P05067   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446555 (7-(2-Chloro-4-fluorophenyl)-N2-(3-fluoro-4-(4-meth...) Show SMILES CNc1nc(Nc2ccc(c(F)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)c1ccc(F)cc1Cl Show InChI InChI=1S/C25H24ClF2N7/c1-14-11-34(13-30-14)20-8-6-16(10-18(20)28)31-24-32-22(29-4)21-23(33-24)35(12-25(21,2)3)19-7-5-15(27)9-17(19)26/h5-11,13H,12H2,1-4H3,(H2,29,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446518 (7-(3,4-Difluorophenyl)-N2-(3-methoxy-4-(3-methyl-1...) Show SMILES CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)c1ccc(F)c(F)c1 Show InChI InChI=1S/C25H26F2N8O/c1-14-29-13-35(33-14)19-9-6-15(10-20(19)36-5)30-24-31-22(28-4)21-23(32-24)34(12-25(21,2)3)16-7-8-17(26)18(27)11-16/h6-11,13H,12H2,1-5H3,(H2,28,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM50465355 (CHEMBL4285214 | US10669276, Example 1) Show SMILES CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C25H27FN8O/c1-15-28-14-34(32-15)19-11-8-17(12-20(19)35-5)29-24-30-22(27-4)21-23(31-24)33(13-25(21,2)3)18-9-6-16(26)7-10-18/h6-12,14H,13H2,1-5H3,(H2,27,29,30,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446556 ((S)- or (R)—N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1...) Show SMILES C[C@@H]1CN(c2nc(Nc3ccc(c(F)c3)-n3cnc(C)c3)nc(Cl)c12)c1ccc(F)cc1 |r| Show InChI InChI=1S/C23H19ClF2N6/c1-13-10-32(17-6-3-15(25)4-7-17)22-20(13)21(24)29-23(30-22)28-16-5-8-19(18(26)9-16)31-11-14(2)27-12-31/h3-9,11-13H,10H2,1-2H3,(H,28,29,30)/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446553 (7-(2,3-Difluorophenyl)-N2-(3-fluoro-4-(4-methyl-1H...) Show SMILES CNc1nc(Nc2ccc(c(F)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)c1cccc(F)c1F Show InChI InChI=1S/C25H24F3N7/c1-14-11-34(13-30-14)18-9-8-15(10-17(18)27)31-24-32-22(29-4)20-23(33-24)35(12-25(20,2)3)19-7-5-6-16(26)21(19)28/h5-11,13H,12H2,1-4H3,(H2,29,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446554 (7-(2,3-Difluorophenyl)-N2-(5-methoxy-6-(4-methyl-1...) Show SMILES CNc1nc(Nc2cnc(c(OC)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)c1cccc(F)c1F Show InChI InChI=1S/C25H26F2N8O/c1-14-11-34(13-30-14)22-18(36-5)9-15(10-29-22)31-24-32-21(28-4)19-23(33-24)35(12-25(19,2)3)17-8-6-7-16(26)20(17)27/h6-11,13H,12H2,1-5H3,(H2,28,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446501 (7-(4-Fluorophenyl)-N2-(5-methoxy-6-(4-methyl-1H-im...) Show SMILES CNc1nc(Nc2cnc(c(OC)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C25H27FN8O/c1-15-12-33(14-29-15)22-19(35-5)10-17(11-28-22)30-24-31-21(27-4)20-23(32-24)34(13-25(20,2)3)18-8-6-16(26)7-9-18/h6-12,14H,13H2,1-5H3,(H2,27,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446536 (7-(2,4-Difluorophenyl)-N2-(5-fluoro-6-(4-methyl-1H...) Show SMILES CNc1nc(Nc2cnc(c(F)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)c1ccc(F)cc1F Show InChI InChI=1S/C24H23F3N8/c1-13-10-34(12-30-13)21-17(27)8-15(9-29-21)31-23-32-20(28-4)19-22(33-23)35(11-24(19,2)3)18-6-5-14(25)7-16(18)26/h5-10,12H,11H2,1-4H3,(H2,28,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446539 (2-((7-(4-Fluorophenyl)-2-((5-methoxy-6-(4-methyl-1...) Show SMILES COc1cc(Nc2nc3N(CC(C)(C)c3c(NCCO)n2)c2ccc(F)cc2)cnc1-n1cnc(C)c1 Show InChI InChI=1S/C26H29FN8O2/c1-16-13-34(15-30-16)23-20(37-4)11-18(12-29-23)31-25-32-22(28-9-10-36)21-24(33-25)35(14-26(21,2)3)19-7-5-17(27)6-8-19/h5-8,11-13,15,36H,9-10,14H2,1-4H3,(H2,28,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446543 (7-(4-Fluorophenyl)-N2-(5-methoxy-6-(4-methyl-1H-im...) Show SMILES COc1cc(Nc2nc3N(CCc3c(Cl)n2)c2ccc(F)cc2)cnc1-n1cnc(C)c1 Show InChI InChI=1S/C22H19ClFN7O/c1-13-11-30(12-26-13)21-18(32-2)9-15(10-25-21)27-22-28-19(23)17-7-8-31(20(17)29-22)16-5-3-14(24)4-6-16/h3-6,9-12H,7-8H2,1-2H3,(H,27,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446550 (7-(4-Fluorophenyl)-N2-(5-methoxy-6-(4-methyl-1H-im...) Show SMILES COc1cc(Nc2nc3N(CC(C)c3c(Cl)n2)c2ccc(F)cc2)cnc1-n1cnc(C)c1 Show InChI InChI=1S/C23H21ClFN7O/c1-13-10-32(17-6-4-15(25)5-7-17)22-19(13)20(24)29-23(30-22)28-16-8-18(33-3)21(26-9-16)31-11-14(2)27-12-31/h4-9,11-13H,10H2,1-3H3,(H,28,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446549 (7-(4-Fluorophenyl)-N2-(3-methoxy-4-(3-methyl-1H-1,...) Show SMILES COc1cc(Nc2nc3N(CC(C)c3c(Cl)n2)c2ccc(F)cc2)ccc1-n1cnc(C)n1 Show InChI InChI=1S/C23H21ClFN7O/c1-13-11-31(17-7-4-15(25)5-8-17)22-20(13)21(24)28-23(29-22)27-16-6-9-18(19(10-16)33-3)32-12-26-14(2)30-32/h4-10,12-13H,11H2,1-3H3,(H,27,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446548 (N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-...) Show SMILES Cc1cn(cn1)-c1ccc(Nc2nc3N(CCc3c(Cl)n2)c2ccc(F)cc2)cc1F Show InChI InChI=1S/C22H17ClF2N6/c1-13-11-30(12-26-13)19-7-4-15(10-18(19)25)27-22-28-20(23)17-8-9-31(21(17)29-22)16-5-2-14(24)3-6-16/h2-7,10-12H,8-9H2,1H3,(H,27,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446557 ((R)— or (S)—N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1...) Show SMILES C[C@H]1CN(c2nc(Nc3ccc(c(F)c3)-n3cnc(C)c3)nc(Cl)c12)c1ccc(F)cc1 |r| Show InChI InChI=1S/C23H19ClF2N6/c1-13-10-32(17-6-3-15(25)4-7-17)22-20(13)21(24)29-23(30-22)28-16-5-8-19(18(26)9-16)31-11-14(2)27-12-31/h3-9,11-13H,10H2,1-2H3,(H,28,29,30)/t13-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM50465354 (CHEMBL4293045 | US10669276, Example 4) Show SMILES CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(Cl)c2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C25H25ClFN7O/c1-25(2)13-34(17-8-5-15(27)6-9-17)23-21(25)22(28-3)31-24(32-23)30-16-7-10-18(19(11-16)35-4)33-12-20(26)29-14-33/h5-12,14H,13H2,1-4H3,(H2,28,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446525 (7-(3,4-Difluorophenyl)-N2-(5-methoxy-6-(4-methyl-1...) Show SMILES CNc1nc(Nc2cnc(c(OC)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)c1ccc(F)c(F)c1 Show InChI InChI=1S/C25H26F2N8O/c1-14-11-34(13-30-14)22-19(36-5)8-15(10-29-22)31-24-32-21(28-4)20-23(33-24)35(12-25(20,2)3)16-6-7-17(26)18(27)9-16/h6-11,13H,12H2,1-5H3,(H2,28,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446485 (N2-(3-(Difluoromethoxy)-4-(3-methyl-1H-1,2,4-triaz...) Show SMILES CNc1nc(Nc2ccc(c(OC(F)F)c2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C25H25F3N8O/c1-14-30-13-36(34-14)18-10-7-16(11-19(18)37-23(27)28)31-24-32-21(29-4)20-22(33-24)35(12-25(20,2)3)17-8-5-15(26)6-9-17/h5-11,13,23H,12H2,1-4H3,(H2,29,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446552 (7-(2,3-Difluorophenyl)-N2-(5-fluoro-6-(4-methyl-1H...) Show SMILES CNc1nc(Nc2cnc(c(F)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)c1cccc(F)c1F Show InChI InChI=1S/C24H23F3N8/c1-13-10-34(12-30-13)21-16(26)8-14(9-29-21)31-23-32-20(28-4)18-22(33-23)35(11-24(18,2)3)17-7-5-6-15(25)19(17)27/h5-10,12H,11H2,1-4H3,(H2,28,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446547 (N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-...) Show SMILES CNc1nc(Nc2ccc(c(F)c2)-n2cnc(C)c2)nc2N(CCC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C26H27F2N7/c1-16-14-34(15-30-16)21-10-7-18(13-20(21)28)31-25-32-23(29-4)22-24(33-25)35(12-11-26(22,2)3)19-8-5-17(27)6-9-19/h5-10,13-15H,11-12H2,1-4H3,(H2,29,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446544 (N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-...) Show SMILES CNc1nc(Nc2ccc(c(F)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C25H25F2N7/c1-15-12-33(14-29-15)20-10-7-17(11-19(20)27)30-24-31-22(28-4)21-23(32-24)34(13-25(21,2)3)18-8-5-16(26)6-9-18/h5-12,14H,13H2,1-4H3,(H2,28,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM50465360 (CHEMBL4294948 | US10669276, Example 28) Show SMILES COc1cc(Nc2nc3N(CC(C)(C)c3c(NCCO)n2)c2ccc(F)cc2)ccc1-n1cnc(C)n1 Show InChI InChI=1S/C26H29FN8O2/c1-16-29-15-35(33-16)20-10-7-18(13-21(20)37-4)30-25-31-23(28-11-12-36)22-24(32-25)34(14-26(22,2)3)19-8-5-17(27)6-9-19/h5-10,13,15,36H,11-12,14H2,1-4H3,(H2,28,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM50465357 (CHEMBL4283902 | US10669276, Example 25) Show SMILES CNc1nc(Nc2cnc(c(F)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C24H24F2N8/c1-14-11-33(13-29-14)21-18(26)9-16(10-28-21)30-23-31-20(27-4)19-22(32-23)34(12-24(19,2)3)17-7-5-15(25)6-8-17/h5-11,13H,12H2,1-4H3,(H2,27,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446533 (N2-(6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyridin...) Show SMILES CNc1nc(Nc2cnc(c(OC)c2)-n2cnc(Cl)c2)nc2N(CC(C)(C)c12)c1ccc(F)cc1F Show InChI InChI=1S/C24H23ClF2N8O/c1-24(2)11-35(16-6-5-13(26)7-15(16)27)22-19(24)20(28-3)32-23(33-22)31-14-8-17(36-4)21(29-9-14)34-10-18(25)30-12-34/h5-10,12H,11H2,1-4H3,(H2,28,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446530 (7-(2,4-Difluorophenyl)-N2-(5-methoxy-6-(4-methyl-1...) Show SMILES CNc1nc(Nc2cnc(c(OC)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)c1ccc(F)cc1F Show InChI InChI=1S/C25H26F2N8O/c1-14-11-34(13-30-14)22-19(36-5)9-16(10-29-22)31-24-32-21(28-4)20-23(33-24)35(12-25(20,2)3)18-7-6-15(26)8-17(18)27/h6-11,13H,12H2,1-5H3,(H2,28,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446529 (7-(2,4-Difluorophenyl)-N2-(3-methoxy-4-(3-methyl-1...) Show SMILES CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)c1ccc(F)cc1F Show InChI InChI=1S/C25H26F2N8O/c1-14-29-13-35(33-14)19-9-7-16(11-20(19)36-5)30-24-31-22(28-4)21-23(32-24)34(12-25(21,2)3)18-8-6-15(26)10-17(18)27/h6-11,13H,12H2,1-5H3,(H2,28,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446551 (7-(2,3-Difluorophenyl)-N2-(3-methoxy-4-(3-methyl-1...) Show SMILES CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)c1cccc(F)c1F Show InChI InChI=1S/C25H26F2N8O/c1-14-29-13-35(33-14)17-10-9-15(11-19(17)36-5)30-24-31-22(28-4)20-23(32-24)34(12-25(20,2)3)18-8-6-7-16(26)21(18)27/h6-11,13H,12H2,1-5H3,(H2,28,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446491 (N2-(6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyridin...) Show SMILES CNc1nc(Nc2cnc(c(OC)c2)-n2cnc(Cl)c2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C24H24ClFN8O/c1-24(2)12-34(16-7-5-14(26)6-8-16)22-19(24)20(27-3)31-23(32-22)30-15-9-17(35-4)21(28-10-15)33-11-18(25)29-13-33/h5-11,13H,12H2,1-4H3,(H2,27,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446542 (7-(4-Fluorophenyl)-N2-(3-methoxy-4-(3-methyl-1H-1,...) Show SMILES COc1cc(Nc2nc3N(CCc3c(Cl)n2)c2ccc(F)cc2)ccc1-n1cnc(C)n1 Show InChI InChI=1S/C22H19ClFN7O/c1-13-25-12-31(29-13)18-8-5-15(11-19(18)32-2)26-22-27-20(23)17-9-10-30(21(17)28-22)16-6-3-14(24)4-7-16/h3-8,11-12H,9-10H2,1-2H3,(H,26,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446524 (N2-(6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyridin...) Show SMILES CNc1nc(Nc2cnc(c(OC)c2)-n2cnc(Cl)c2)nc2N(CC(C)(C)c12)c1ccc(F)c(F)c1 Show InChI InChI=1S/C24H23ClF2N8O/c1-24(2)11-35(14-5-6-15(26)16(27)8-14)22-19(24)20(28-3)32-23(33-22)31-13-7-17(36-4)21(29-9-13)34-10-18(25)30-12-34/h5-10,12H,11H2,1-4H3,(H2,28,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446540 (2-((2-((6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyr...) Show SMILES COc1cc(Nc2nc3N(CC(C)(C)c3c(NCCO)n2)c2ccc(F)cc2)cnc1-n1cnc(Cl)c1 Show InChI InChI=1S/C25H26ClFN8O2/c1-25(2)13-35(17-6-4-15(27)5-7-17)23-20(25)21(28-8-9-36)32-24(33-23)31-16-10-18(37-3)22(29-11-16)34-12-19(26)30-14-34/h4-7,10-12,14,36H,8-9,13H2,1-3H3,(H2,28,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446522 (7-(4-Fluorophenyl)-N4,5,5-trimethyl-N2-(4-(4-methy...) Show SMILES CNc1nc(Nc2ccc(cc2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C25H26FN7/c1-16-13-32(15-28-16)19-11-7-18(8-12-19)29-24-30-22(27-4)21-23(31-24)33(14-25(21,2)3)20-9-5-17(26)6-10-20/h5-13,15H,14H2,1-4H3,(H2,27,29,30,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM50465363 (CHEMBL4278310 | US10669276, Example 35) Show SMILES CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(C)n2)nc2N(CCC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C26H29FN8O/c1-16-29-15-35(33-16)20-11-8-18(14-21(20)36-5)30-25-31-23(28-4)22-24(32-25)34(13-12-26(22,2)3)19-9-6-17(27)7-10-19/h6-11,14-15H,12-13H2,1-5H3,(H2,28,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446528 (7-(3,3-Difluorocyclobutyl)-N2-(5-methoxy-6-(4-meth...) Show SMILES CNc1nc(Nc2cnc(c(OC)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)C1CC(F)(F)C1 Show InChI InChI=1S/C23H28F2N8O/c1-13-10-32(12-28-13)19-16(34-5)6-14(9-27-19)29-21-30-18(26-4)17-20(31-21)33(11-22(17,2)3)15-7-23(24,25)8-15/h6,9-10,12,15H,7-8,11H2,1-5H3,(H2,26,29,30,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446546 (N2-(5-Fluoro-6-(4-methyl-1H-imidazol-1-yl)pyridin-...) Show SMILES CNc1nc(Nc2cnc(c(F)c2)-n2cnc(C)c2)nc2N(CCC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C25H26F2N8/c1-15-13-34(14-30-15)22-19(27)11-17(12-29-22)31-24-32-21(28-4)20-23(33-24)35(10-9-25(20,2)3)18-7-5-16(26)6-8-18/h5-8,11-14H,9-10H2,1-4H3,(H2,28,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM50465358 (CHEMBL4284649 | US10669276, Example 31) Show SMILES Cc1ncn(n1)-c1ccc(Nc2nc3N(CC(C)(C)c3c(NCCO)n2)c2ccc(F)cc2)cc1F Show InChI InChI=1S/C25H26F2N8O/c1-15-29-14-35(33-15)20-9-6-17(12-19(20)27)30-24-31-22(28-10-11-36)21-23(32-24)34(13-25(21,2)3)18-7-4-16(26)5-8-18/h4-9,12,14,36H,10-11,13H2,1-3H3,(H2,28,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446487 (N2-(3-Fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phe...) Show SMILES CNc1nc(Nc2ccc(c(F)c2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C24H24F2N8/c1-14-28-13-34(32-14)19-10-7-16(11-18(19)26)29-23-30-21(27-4)20-22(31-23)33(12-24(20,2)3)17-8-5-15(25)6-9-17/h5-11,13H,12H2,1-4H3,(H2,27,29,30,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446527 (7-(3,3-Difluorocyclobutyl)-N2-(3-methoxy-4-(3-meth...) Show SMILES CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)C1CC(F)(F)C1 Show InChI InChI=1S/C23H28F2N8O/c1-13-27-12-33(31-13)16-7-6-14(8-17(16)34-5)28-21-29-19(26-4)18-20(30-21)32(11-22(18,2)3)15-9-23(24,25)10-15/h6-8,12,15H,9-11H2,1-5H3,(H2,26,28,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446534 (7-(2,4-Difluorophenyl)-N2-(3-fluoro-4-(3-methyl-1H...) Show SMILES CNc1nc(Nc2ccc(c(F)c2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)c1ccc(F)cc1F Show InChI InChI=1S/C24H23F3N8/c1-13-29-12-35(33-13)19-8-6-15(10-17(19)27)30-23-31-21(28-4)20-22(32-23)34(11-24(20,2)3)18-7-5-14(25)9-16(18)26/h5-10,12H,11H2,1-4H3,(H2,28,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446490 (N2-(3-Fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phe...) Show SMILES CNc1nc(Nc2ccc(c(F)c2)-n2ncnc2C)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C24H24F2N8/c1-14-28-13-29-34(14)19-10-7-16(11-18(19)26)30-23-31-21(27-4)20-22(32-23)33(12-24(20,2)3)17-8-5-15(25)6-9-17/h5-11,13H,12H2,1-4H3,(H2,27,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446523 (7-(4-Fluorophenyl)-N4,5,5-trimethyl-N2-(6-(3-methy...) Show SMILES CNc1nc(Nc2ccc(nc2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C23H24FN9/c1-14-27-13-33(31-14)18-10-7-16(11-26-18)28-22-29-20(25-4)19-21(30-22)32(12-23(19,2)3)17-8-5-15(24)6-9-17/h5-11,13H,12H2,1-4H3,(H2,25,28,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446519 (7-(3,4-Difluorophenyl)-N2-(3-fluoro-4-(3-methyl-1H...) Show SMILES CNc1nc(Nc2ccc(c(F)c2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)c1ccc(F)c(F)c1 Show InChI InChI=1S/C24H23F3N8/c1-13-29-12-35(33-13)19-8-5-14(9-18(19)27)30-23-31-21(28-4)20-22(32-23)34(11-24(20,2)3)15-6-7-16(25)17(26)10-15/h5-10,12H,11H2,1-4H3,(H2,28,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	26	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446537 (7-(4-Fluorophenyl)-N2-(3-methoxy-4-(5-methyl-1,3,4...) Show SMILES CNc1nc(Nc2ccc(-c3nnc(C)o3)c(OC)c2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C25H26FN7O2/c1-14-31-32-23(35-14)18-11-8-16(12-19(18)34-5)28-24-29-21(27-4)20-22(30-24)33(13-25(20,2)3)17-9-6-15(26)7-10-17/h6-12H,13H2,1-5H3,(H2,27,28,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446532 (N2-(5-Methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin...) Show SMILES CNc1nc(Nc2cnc(c(OC)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)C12CC(C1)(C2)C(F)(F)F Show InChI InChI=1S/C25H29F3N8O/c1-14-8-35(13-31-14)19-16(37-5)6-15(7-30-19)32-21-33-18(29-4)17-20(34-21)36(12-22(17,2)3)24-9-23(10-24,11-24)25(26,27)28/h6-8,13H,9-12H2,1-5H3,(H2,29,32,33,34)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM50465356 (CHEMBL4289270 | US10669276, Example 16) Show SMILES CNc1nc(Nc2ccc(-c3cnc(C)o3)c(F)c2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C25H24F2N6O/c1-14-29-12-20(34-14)18-10-7-16(11-19(18)27)30-24-31-22(28-4)21-23(32-24)33(13-25(21,2)3)17-8-5-15(26)6-9-17/h5-12H,13H2,1-4H3,(H2,28,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM50465359 (CHEMBL4279052 | US10669276, Example 11) Show SMILES CNc1nc(Nc2ccc(c(F)c2)-n2cc(C)nc2C)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C26H27F2N7/c1-15-13-34(16(2)30-15)21-11-8-18(12-20(21)28)31-25-32-23(29-5)22-24(33-25)35(14-26(22,3)4)19-9-6-17(27)7-10-19/h6-13H,14H2,1-5H3,(H2,29,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446520 (7-(4-Fluorophenyl)-N4,5,5-trimethyl-N2-(4-(3-methy...) Show SMILES CNc1nc(Nc2ccc(cc2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C24H25FN8/c1-15-27-14-33(31-15)19-11-7-17(8-12-19)28-23-29-21(26-4)20-22(30-23)32(13-24(20,2)3)18-9-5-16(25)6-10-18/h5-12,14H,13H2,1-4H3,(H2,26,28,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	51	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446558 (7-(4-Fluorophenyl)-N4,5,5-trimethyl-N2-(4-(5-methy...) Show SMILES CNc1nc(Nc2ccc(cc2)-c2nnc(C)o2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 Show InChI InChI=1S/C24H24FN7O/c1-14-30-31-22(33-14)15-5-9-17(10-6-15)27-23-28-20(26-4)19-21(29-23)32(13-24(19,2)3)18-11-7-16(25)8-12-18/h5-12H,13H2,1-4H3,(H2,26,27,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-713] (Homo sapiens (Human))	BDBM446531 (N2-(3-Methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)ph...) Show SMILES CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)C12CC(C1)(C2)C(F)(F)F Show InChI InChI=1S/C25H29F3N8O/c1-14-30-13-36(34-14)16-7-6-15(8-17(16)37-5)31-21-32-19(29-4)18-20(33-21)35(12-22(18,2)3)24-9-23(10-24,11-24)25(26,27)28/h6-8,13H,9-12H2,1-5H3,(H2,29,31,32,33)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	72	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10669276 (2020) BindingDB Entry DOI: 10.7270/Q2BZ6928
					More data for this Ligand-Target Pair