Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human)) | BDBM244234 (US9428501, 58) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.860 | n/a | n/a | n/a | 37 |
Astellas Pharma Inc. US Patent | Assay Description In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m... | US Patent US9428501 (2016) BindingDB Entry DOI: 10.7270/Q28051JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213199 (US9290517, 129) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213209 (US9290517, 150) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213202 (US9290517, 133) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human)) | BDBM244233 (US9428501, 57) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.80 | n/a | n/a | n/a | 37 |
Astellas Pharma Inc. US Patent | Assay Description In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m... | US Patent US9428501 (2016) BindingDB Entry DOI: 10.7270/Q28051JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human)) | BDBM244236 (US9428501, 69) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.80 | n/a | n/a | n/a | 37 |
Astellas Pharma Inc. US Patent | Assay Description In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m... | US Patent US9428501 (2016) BindingDB Entry DOI: 10.7270/Q28051JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM50195475 (CHEMBL3393127) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos... | J Med Chem 60: 9040-9052 (2017) Article DOI: 10.1021/acs.jmedchem.7b01344 BindingDB Entry DOI: 10.7270/Q2V69N0Q | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213204 (US9290517, 142) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM260447 (US9527839, 45) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2 | n/a | n/a | 7.3 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ... | US Patent US9527839 (2016) BindingDB Entry DOI: 10.7270/Q2N58K9B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213210 (US9290517, 151) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213208 (US9290517, 149) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM260449 (US9527839, 48) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2 | n/a | n/a | 7.3 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ... | US Patent US9527839 (2016) BindingDB Entry DOI: 10.7270/Q2N58K9B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213200 (US9290517, 130) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213198 (US9290517, 128) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213190 (US9290517, 79) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human)) | BDBM244235 (US9428501, 66) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2.80 | n/a | n/a | n/a | 37 |
Astellas Pharma Inc. US Patent | Assay Description In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m... | US Patent US9428501 (2016) BindingDB Entry DOI: 10.7270/Q28051JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213196 (US9290517, 126) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM260439 (US9527839, 35) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3 | n/a | n/a | 7.3 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ... | US Patent US9527839 (2016) BindingDB Entry DOI: 10.7270/Q2N58K9B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM50246158 (CHEMBL3393128) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos... | J Med Chem 60: 9040-9052 (2017) Article DOI: 10.1021/acs.jmedchem.7b01344 BindingDB Entry DOI: 10.7270/Q2V69N0Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213192 (US9290517, 87) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213201 (US9290517, 131) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human)) | BDBM244223 (US9428501, 18) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | 37 |
Astellas Pharma Inc. US Patent | Assay Description In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m... | US Patent US9428501 (2016) BindingDB Entry DOI: 10.7270/Q28051JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM260440 (US9527839, 36) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3 | n/a | n/a | 7.3 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ... | US Patent US9527839 (2016) BindingDB Entry DOI: 10.7270/Q2N58K9B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human)) | BDBM244237 (US9428501, 79) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.30 | n/a | n/a | n/a | 37 |
Astellas Pharma Inc. US Patent | Assay Description In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m... | US Patent US9428501 (2016) BindingDB Entry DOI: 10.7270/Q28051JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human)) | BDBM244226 (US9428501, 35) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.60 | n/a | n/a | n/a | 37 |
Astellas Pharma Inc. US Patent | Assay Description In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m... | US Patent US9428501 (2016) BindingDB Entry DOI: 10.7270/Q28051JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213206 (US9290517, 146) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213197 (US9290517, 127) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213191 (US9290517, 86) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213189 (US9290517, 73) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213203 (US9290517, 138) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM260445 (US9527839, 43) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4 | n/a | n/a | 7.3 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ... | US Patent US9527839 (2016) BindingDB Entry DOI: 10.7270/Q2N58K9B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213207 (US9290517, 147) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213194 (US9290517, 105) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 5 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213193 (US9290517, 102) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 5 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213193 (US9290517, 102) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Activation of full length human recombinant AMPK alpha2/beta1/gamma1 expressed in baculovirus infected sf21 cells using 5'-FAM-SAMS peptide substrate... | Bioorg Med Chem Lett 26: 5139-5148 (2016) Article DOI: 10.1016/j.bmcl.2016.09.065 BindingDB Entry DOI: 10.7270/Q25M67PH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM260443 (US9527839, 40) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 5 | n/a | n/a | 7.3 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ... | US Patent US9527839 (2016) BindingDB Entry DOI: 10.7270/Q2N58K9B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human)) | BDBM244227 (US9428501, 36) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 5.10 | n/a | n/a | n/a | 37 |
Astellas Pharma Inc. US Patent | Assay Description In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m... | US Patent US9428501 (2016) BindingDB Entry DOI: 10.7270/Q28051JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human)) | BDBM244230 (US9428501, 44) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 5.20 | n/a | n/a | n/a | 37 |
Astellas Pharma Inc. US Patent | Assay Description In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m... | US Patent US9428501 (2016) BindingDB Entry DOI: 10.7270/Q28051JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM50244667 (CHEMBL4105032) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Activation of full-length recombinant N-terminal His-tagged human AMPKalpha2beta1gamma1 expressed in Escherichia coli BL21 cells using Cy-5 SAMS pept... | J Med Chem 61: 7273-7288 (2018) Article DOI: 10.1021/acs.jmedchem.8b00807 BindingDB Entry DOI: 10.7270/Q2Q242WT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM260429 (US9527839, 7) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 6 | n/a | n/a | 7.3 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ... | US Patent US9527839 (2016) BindingDB Entry DOI: 10.7270/Q2N58K9B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213195 (US9290517, 125) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 6 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM213187 (US9290517, 18) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 6 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... | US Patent US9290517 (2016) BindingDB Entry DOI: 10.7270/Q2C24V7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human)) | BDBM244231 (US9428501, 49) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 6.5 | n/a | n/a | n/a | 37 |
Astellas Pharma Inc. US Patent | Assay Description In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m... | US Patent US9428501 (2016) BindingDB Entry DOI: 10.7270/Q28051JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM237920 (US9394285, 1) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 6.80 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Activation of recombinant human AMPK alpha2/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl... | J Med Chem 59: 8068-81 (2016) Article DOI: 10.1021/acs.jmedchem.6b00866 BindingDB Entry DOI: 10.7270/Q2PZ5BRC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM260451 (US9527839, 50) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 7 | n/a | n/a | 7.3 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ... | US Patent US9527839 (2016) BindingDB Entry DOI: 10.7270/Q2N58K9B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM50246156 (CHEMBL4104303) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 7 | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos... | J Med Chem 60: 9040-9052 (2017) Article DOI: 10.1021/acs.jmedchem.7b01344 BindingDB Entry DOI: 10.7270/Q2V69N0Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM260428 (US9527839, 6) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 7 | n/a | n/a | 7.3 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ... | US Patent US9527839 (2016) BindingDB Entry DOI: 10.7270/Q2N58K9B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM260431 (US9527839, 16) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 7 | n/a | n/a | 7.3 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ... | US Patent US9527839 (2016) BindingDB Entry DOI: 10.7270/Q2N58K9B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM260448 (US9527839, 47) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 7 | n/a | n/a | 7.3 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ... | US Patent US9527839 (2016) BindingDB Entry DOI: 10.7270/Q2N58K9B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 (Homo sapiens (Human)) | BDBM50246120 (CHEMBL4082745) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos... | J Med Chem 60: 9040-9052 (2017) Article DOI: 10.1021/acs.jmedchem.7b01344 BindingDB Entry DOI: 10.7270/Q2V69N0Q | |||||||||||
More data for this Ligand-Target Pair |
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