BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 135 hits of ic50 for UniProtKB: P27815   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577094
PNG
((7S)-10-(4-Chlorophenyl)-8-cyclopropyl-7-methyl-7,...)
Show SMILES C[C@H]1Cn2c(c(-c3ccc(Cl)cc3)c3ncccc23)C(=O)N1C1CC1 |r|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<0.300n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577172
PNG
(10-(4-Chloro-3-fluorophenyl)-8-cyclopropyl-3,4,7,8...)
Show SMILES Fc1cc(ccc1Cl)-c1c2OCCCc2n2CCN(C3CC3)C(=O)c12
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<0.310n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577135
PNG
(8-Cyclopropyl-10-(3,4,5-trifluorophenyl)-7,8-dihyd...)
Show SMILES Fc1cc(cc(F)c1F)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<0.410n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577126
PNG
(10-(4-Chloro-3-fluorophenyl)-8-cyclopropyl-7,8-dih...)
Show SMILES Fc1cc(ccc1Cl)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<0.450n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577130
PNG
(10-(3-Chloro-4-fluorophenyl)-8-cyclopropyl-7,8-dih...)
Show SMILES Fc1ccc(cc1Cl)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<0.670n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577128
PNG
(2-Chloro-5-(8-cyclopropyl-9-oxo-6,7,8,9-tetrahydro...)
Show SMILES Clc1ccc(cc1C#N)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.980n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577077
PNG
(10-(4-Chlorophenyl)-8-cyclopropyl-7,8-dihydropyrid...)
Show SMILES Clc1ccc(cc1)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<0.990n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM457828
PNG
(US10738063, Example 58)
Show SMILES Cc1cc(Cl)c(F)cc1-c1c2OCC(F)(F)Cn2nc1C(=O)NC1CC1 |(-2.49,.88,;-1,1.28,;-.6,2.76,;.88,3.16,;1.28,4.65,;1.97,2.07,;3.46,2.47,;1.57,.59,;.09,.19,;-.31,-1.3,;-1.78,-1.78,;-3.11,-1.01,;-4.44,-1.78,;-4.44,-3.32,;-5.78,-4.09,;-4.44,-4.86,;-3.11,-4.09,;-1.78,-3.32,;-.31,-3.79,;.59,-2.55,;2.13,-2.55,;2.9,-1.21,;2.9,-3.88,;4.44,-3.88,;5.78,-4.65,;5.78,-3.11,)|
Show InChI InChI=1S/C17H15ClF3N3O2/c1-8-4-11(18)12(19)5-10(8)13-14(15(25)22-9-2-3-9)23-24-6-17(20,21)7-26-16(13)24/h4-5,9H,2-3,6-7H2,1H3,(H,22,25)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...

US Patent US10738063 (2020)


BindingDB Entry DOI: 10.7270/Q20Z76BW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577143
PNG
(10-(3-Chlorophenyl)-8-cyclopropyl-7,8-dihydropyrid...)
Show SMILES Clc1cccc(c1)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577123
PNG
(10-(4-Chloro-5-fluoro-2-methylphenyl)-8-cyclopropy...)
Show SMILES Cc1cc(Cl)c(F)cc1-c1c2OCCCc2n2CCN(C3CC3)C(=O)c12 |(-3.15,.66,;-1.65,.98,;-1.17,2.44,;.35,2.81,;.83,4.28,;1.37,1.62,;2.87,1.94,;.89,.15,;-.62,-.17,;-1.09,-1.63,;-2.56,-2.11,;-3.89,-1.34,;-5.22,-2.11,;-5.22,-3.65,;-3.89,-4.42,;-2.56,-3.65,;-1.09,-4.12,;-.47,-5.53,;1.07,-5.69,;1.97,-4.45,;3.5,-4.61,;4.72,-5.55,;4.93,-4.02,;1.34,-3.04,;2.25,-1.79,;-.19,-2.88,)|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577173
PNG
(10-(4-Chloro-2,5-difluorophenyl)-8-cyclopropyl-3,4...)
Show SMILES Fc1cc(-c2c3OCCCc3n3CCN(C4CC4)C(=O)c23)c(F)cc1Cl |(3.02,2.67,;1.51,2.35,;1.04,.89,;-.47,.57,;-.94,-.9,;-2.41,-1.38,;-3.74,-.61,;-5.08,-1.38,;-5.08,-2.92,;-3.74,-3.69,;-2.41,-2.92,;-.94,-3.39,;-.32,-4.8,;1.21,-4.96,;2.12,-3.71,;3.65,-3.87,;4.87,-4.82,;5.08,-3.29,;1.49,-2.31,;2.4,-1.06,;-.04,-2.15,;-1.5,1.71,;-3,1.39,;-1.02,3.17,;.48,3.49,;.96,4.96,)|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577091
PNG
(10-(4-Chloro-3-fluorophenyl)-8-cyclopropyl-7,8-dih...)
Show SMILES Fc1cc(ccc1Cl)-c1c2C(=O)N(CCn2c2nccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.19n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577136
PNG
(8-Cyclopropyl-10-(3-fluorophenyl)-7,8-dihydropyrid...)
Show SMILES Fc1cccc(c1)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.26n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577171
PNG
(10-(4-Chlorophenyl)-8-cyclopropyl-3,4,7,8-tetrahyd...)
Show SMILES Clc1ccc(cc1)-c1c2OCCCc2n2CCN(C3CC3)C(=O)c12
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.26n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577101
PNG
(4-(8-Cyclopropyl-9-oxo-3,4,6,7,8,9-hexahydro-2H-py...)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c2OCCCc2n2CCN(C3CC3)C(=O)c12 |(16.64,-5.82,;18.13,-5.42,;18.53,-3.94,;20.03,-3.48,;20.43,-2,;20.83,-.51,;21.1,-4.63,;22.59,-4.23,;20.7,-6.11,;19.22,-6.51,;18.82,-8,;17.35,-8.48,;16.02,-7.71,;14.69,-8.48,;14.69,-10.02,;16.02,-10.79,;17.35,-10.02,;18.82,-10.49,;19.45,-11.9,;20.98,-12.06,;21.88,-10.81,;23.37,-11.21,;24.46,-12.3,;24.86,-10.81,;21.26,-9.41,;22.03,-8.07,;19.72,-9.25,)|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.57n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577140
PNG
(8-Cyclopropyl-10-(3-fluoro-4-methoxyphenyl)-7,8-di...)
Show SMILES COc1ccc(cc1F)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.59n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577096
PNG
(8-Cyclopropyl-10-(4-methylphenyl)pyrido[2′,3...)
Show SMILES Cc1ccc(cc1)-c1c2ncccc2n2ccn(C3CC3)c(=O)c12
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.86n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM399978
PNG
(US10323042, Example 57 | US10738063, Example 57)
Show SMILES Cc1cc(Cl)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1 |r,wD:14.15,(-2.49,.88,;-1,1.28,;-.6,2.76,;.88,3.16,;1.28,4.65,;1.97,2.07,;3.46,2.47,;1.57,.59,;.09,.19,;-.31,-1.3,;.59,-2.55,;-.31,-3.79,;-1.78,-3.32,;-3.11,-4.09,;-4.44,-3.32,;-5.78,-4.09,;-4.44,-1.78,;-3.11,-1.01,;-1.78,-1.78,;2.13,-2.55,;2.9,-1.21,;2.9,-3.88,;4.44,-3.88,;5.78,-4.65,;5.78,-3.11,)|
Show InChI InChI=1S/C17H16ClF2N3O2/c1-8-4-12(18)13(20)5-11(8)14-15(16(24)21-10-2-3-10)22-23-6-9(19)7-25-17(14)23/h4-5,9-10H,2-3,6-7H2,1H3,(H,21,24)/t9-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.86n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...

US Patent US10738063 (2020)


BindingDB Entry DOI: 10.7270/Q20Z76BW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM399927
PNG
((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Show SMILES F[C@@H]1COc2c(c(nn2C1)C(=O)NC1CC1)-c1cc(F)c(Cl)cc1F |r,wD:1.0,(-5.04,-16.18,;-3.71,-15.41,;-3.71,-13.87,;-2.37,-13.1,;-1.04,-13.87,;.42,-13.4,;1.33,-14.64,;.42,-15.89,;-1.04,-15.41,;-2.37,-16.18,;2.87,-14.64,;3.64,-13.31,;3.64,-15.97,;5.18,-15.97,;6.51,-16.74,;6.51,-15.2,;.82,-11.91,;2.31,-11.51,;2.71,-10.02,;4.2,-9.62,;1.62,-8.93,;2.02,-7.44,;.13,-9.33,;-.27,-10.82,;-1.75,-11.22,)|
Show InChI InChI=1S/C16H13ClF3N3O2/c17-10-4-11(19)9(3-12(10)20)13-14(15(24)21-8-1-2-8)22-23-5-7(18)6-25-16(13)23/h3-4,7-8H,1-2,5-6H2,(H,21,24)/t7-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...

US Patent US10738063 (2020)


BindingDB Entry DOI: 10.7270/Q20Z76BW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577142
PNG
(10-(4-Chloro-2-fluorophenyl)-8-cyclopropyl-7,8-dih...)
Show SMILES Fc1cc(Cl)ccc1-c1c2C(=O)N(CCn2c2cccnc12)C1CC1 |(-3,1.39,;-1.5,1.71,;-1.02,3.17,;.48,3.49,;.96,4.96,;1.51,2.35,;1.04,.89,;-.47,.57,;-.94,-.9,;-.04,-2.15,;1.49,-2.31,;2.4,-1.06,;2.12,-3.71,;1.21,-4.96,;-.32,-4.8,;-.94,-3.39,;-2.41,-2.92,;-3.74,-3.69,;-5.08,-2.92,;-5.08,-1.38,;-3.74,-.61,;-2.41,-1.38,;3.65,-3.87,;4.87,-4.82,;5.08,-3.29,)|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577129
PNG
(8-Cyclopropyl-10-(2,3-dihydro-1-benzofuran-5-yl)-7...)
Show SMILES O=C1N(CCn2c1c(-c1ccc3OCCc3c1)c1ncccc21)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.08n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577121
PNG
(9-(4-Chlorophenyl)-7-cyclopropyl-6,7-dihydro[1,3]t...)
Show SMILES Clc1ccc(cc1)-c1c2C(=O)N(CCn2c2scnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.28n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577141
PNG
(8-Cyclopropyl-10-(2,5-difluorophenyl)-7,8-dihydrop...)
Show SMILES Fc1ccc(F)c(c1)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1 |(3.02,3.4,;1.51,3.08,;.48,4.23,;-1.02,3.91,;-1.5,2.44,;-3,2.12,;-.47,1.3,;1.04,1.62,;-.94,-.17,;-.04,-1.41,;1.49,-1.57,;2.4,-.33,;2.12,-2.98,;1.21,-4.23,;-.32,-4.07,;-.94,-2.66,;-2.41,-2.18,;-3.74,-2.95,;-5.08,-2.18,;-5.08,-.64,;-3.74,.13,;-2.41,-.64,;3.65,-3.14,;4.87,-4.08,;5.08,-2.56,)|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.29n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577107
PNG
(8-Cyclopropyl-10-(4-methylphenyl)-7,8-dihydropyrid...)
Show SMILES Cc1ccc(cc1)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.52n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577182
PNG
(10-Cyclopentyl-8-cyclopropyl-7,8-dihydropyrido[2',...)
Show SMILES O=C1N(CCn2c1c(C1CCCC1)c1ncccc21)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.52n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577131
PNG
(8-Cyclopropyl-10-(4-fluoro-3-methylphenyl)-7,8-dih...)
Show SMILES Cc1cc(ccc1F)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.52n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577144
PNG
(8-Cyclopropyl-10-(4-fluoro-2-methylphenyl)-7,8-dih...)
Show SMILES Cc1cc(F)ccc1-c1c2C(=O)N(CCn2c2cccnc12)C1CC1 |(-3,1.39,;-1.5,1.71,;-1.02,3.17,;.48,3.49,;.96,4.96,;1.51,2.35,;1.04,.89,;-.47,.57,;-.94,-.9,;-.04,-2.15,;1.49,-2.31,;2.4,-1.06,;2.12,-3.71,;1.21,-4.96,;-.32,-4.8,;-.94,-3.39,;-2.41,-2.92,;-3.74,-3.69,;-5.08,-2.92,;-5.08,-1.38,;-3.74,-.61,;-2.41,-1.38,;3.65,-3.87,;4.87,-4.82,;5.08,-3.29,)|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.71n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577166
PNG
(4-(8-Cyclopropyl-9-oxo-8,9-dihydropyrido[2',3':4,5...)
Show SMILES O=c1n(ccn2c3cccnc3c(-c3ccc(cc3)C#N)c12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.80n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577145
PNG
(4-(8-Cyclopropyl-9-oxo-6,7,8,9-tetrahydropyrido[2'...)
Show SMILES Cc1cc(ccc1-c1c2C(=O)N(CCn2c2cccnc12)C1CC1)C#N |(-3,.66,;-1.5,.98,;-1.02,2.44,;.5,2.81,;1.51,1.62,;1.04,.15,;-.47,-.17,;-.94,-1.63,;-.04,-2.88,;1.49,-3.04,;2.4,-1.79,;2.12,-4.45,;1.21,-5.69,;-.32,-5.53,;-.94,-4.12,;-2.41,-3.65,;-3.74,-4.42,;-5.08,-3.65,;-5.08,-2.11,;-3.74,-1.34,;-2.41,-2.11,;3.65,-4.61,;4.87,-5.55,;5.08,-4.02,;.98,4.28,;1.45,5.74,)|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.99n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577152
PNG
(10-(4-Chlorophenyl)-8-(5-methyl-1,2-oxazol-3-yl)-7...)
Show SMILES Cc1cc(no1)N1CCn2c(c(-c3ccc(Cl)cc3)c3ncccc23)C1=O
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.49n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577168
PNG
(4-(7-Cyclopropyl-8-oxo-5,6,7,8-tetrahydro[1,3]thia...)
Show SMILES Fc1cc(ccc1C#N)-c1c2C(=O)N(CCn2c2scnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.53n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577160
PNG
(8-Cyclopropyl-10-(furo[3,2-b]pyridin-6-yl)-7,8-dih...)
Show SMILES O=C1N(CCn2c1c(-c1cnc3ccoc3c1)c1ncccc21)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.56n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577122
PNG
(4-(7-Cyclopropyl-8-oxo-5,6,7,8-tetrahydro[1,3]thia...)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c2C(=O)N(CCn2c2scnc12)C1CC1 |(-3.15,.66,;-1.65,.98,;-1.17,2.44,;.35,2.81,;.83,4.28,;1.3,5.74,;1.37,1.62,;2.87,1.94,;.89,.15,;-.62,-.17,;-1.09,-1.63,;-.19,-2.88,;1.34,-3.04,;2.25,-1.79,;1.97,-4.45,;1.07,-5.69,;-.47,-5.53,;-1.09,-4.12,;-2.56,-3.65,;-4.02,-4.12,;-4.93,-2.88,;-4.02,-1.63,;-2.56,-2.11,;3.5,-4.61,;4.72,-5.55,;4.93,-4.02,)|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.92n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577103
PNG
(10-(4-Chlorophenyl)-8-cyclopropyl-7,8-dihydropyrro...)
Show SMILES Clc1ccc(cc1)-c1c2C(=O)N(CCn2c2nccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.12n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577115
PNG
(8-Cyclopropyl-10-(3,5-difluoro-4-methoxyphenyl)-7,...)
Show SMILES COc1c(F)cc(cc1F)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.48n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577079
PNG
(4-(8-Cyclopropyl-9-oxo-6,7,8,9-tetrahydropyrido[2&...)
Show SMILES Fc1cc(ccc1C#N)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
US Patent
n/an/a 4.66n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577127
PNG
(8-Cyclopropyl-10-(3,4-dimethylphenyl)-7,8-dihydrop...)
Show SMILES Cc1ccc(cc1C)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.93n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM399928
PNG
(3-(4-Chloro-2-methylphenyl)-N-cyclopropyl-6,6-difl...)
Show SMILES Cc1cc(Cl)ccc1-c1c2OCC(F)(F)Cn2nc1C(=O)NC1CC1 |(1.97,-5.49,;3.45,-5.09,;3.85,-3.6,;5.34,-3.21,;5.74,-1.72,;6.43,-4.29,;6.03,-5.78,;4.54,-6.18,;4.14,-7.67,;2.68,-8.14,;1.35,-7.37,;.01,-8.14,;.01,-9.68,;-.76,-11.02,;-1.53,-9.68,;1.35,-10.45,;2.68,-9.68,;4.14,-10.16,;5.05,-8.91,;6.59,-8.91,;7.36,-7.58,;7.36,-10.25,;8.9,-10.25,;10.23,-11.02,;10.23,-9.48,)|
Show InChI InChI=1S/C17H16ClF2N3O2/c1-9-6-10(18)2-5-12(9)13-14(15(24)21-11-3-4-11)22-23-7-17(19,20)8-25-16(13)23/h2,5-6,11H,3-4,7-8H2,1H3,(H,21,24)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.29n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...

US Patent US10738063 (2020)


BindingDB Entry DOI: 10.7270/Q20Z76BW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM399973
PNG
(US10323042, Example 53A | US10323042, Example 53B ...)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1 |r,wD:15.16,(-2.49,.13,;-1,.53,;-.6,2.02,;.9,2.47,;1.3,3.96,;1.7,5.45,;1.97,1.33,;3.46,1.73,;1.57,-.16,;.09,-.56,;-.31,-2.04,;.59,-3.29,;-.31,-4.54,;-1.78,-4.06,;-3.11,-4.83,;-4.44,-4.06,;-5.78,-4.83,;-4.44,-2.52,;-3.11,-1.75,;-1.78,-2.52,;2.13,-3.29,;2.9,-1.96,;2.9,-4.62,;4.44,-4.62,;5.78,-5.39,;5.78,-3.85,)|
Show InChI InChI=1S/C18H16F2N4O2/c1-9-4-10(6-21)14(20)5-13(9)15-16(17(25)22-12-2-3-12)23-24-7-11(19)8-26-18(15)24/h4-5,11-12H,2-3,7-8H2,1H3,(H,22,25)/t11-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.35n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...

US Patent US10738063 (2020)


BindingDB Entry DOI: 10.7270/Q20Z76BW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577162
PNG
(8-Cyclopropyl-10-(2,4-dimethyl-phenyl)pyrido[2',3'...)
Show SMILES Cc1ccc(-c2c3ncccc3n3ccn(C4CC4)c(=O)c23)c(C)c1 |(.96,4.96,;.48,3.49,;1.51,2.35,;1.04,.89,;-.47,.57,;-.94,-.9,;-2.41,-1.38,;-3.74,-.61,;-5.08,-1.38,;-5.08,-2.92,;-3.74,-3.69,;-2.41,-2.92,;-.94,-3.39,;-.32,-4.8,;1.21,-4.96,;2.12,-3.71,;3.65,-3.87,;4.87,-4.82,;5.08,-3.29,;1.49,-2.31,;2.4,-1.06,;-.04,-2.15,;-1.5,1.71,;-3,1.39,;-1.02,3.17,)|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.42n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577133
PNG
(8-Cyclopropyl-10-(2,4-difluorophenyl)-7,8-dihydrop...)
Show SMILES Fc1ccc(-c2c3C(=O)N(CCn3c3cccnc23)C2CC2)c(F)c1 |(.96,4.96,;.48,3.49,;1.51,2.35,;1.04,.89,;-.47,.57,;-.94,-.9,;-.04,-2.15,;1.49,-2.31,;2.4,-1.06,;2.12,-3.71,;1.21,-4.96,;-.32,-4.8,;-.94,-3.39,;-2.41,-2.92,;-3.74,-3.69,;-5.08,-2.92,;-5.08,-1.38,;-3.74,-.61,;-2.41,-1.38,;3.65,-3.87,;4.87,-4.82,;5.08,-3.29,;-1.5,1.71,;-3,1.39,;-1.02,3.17,)|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.59n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577161
PNG
(8-Cyclopropyl-10-(2,4-dimethylphenyl)-7,8-dihydrop...)
Show SMILES Cc1ccc(-c2c3C(=O)N(CCn3c3cccnc23)C2CC2)c(C)c1 |(.96,4.96,;.48,3.49,;1.51,2.35,;1.04,.89,;-.47,.57,;-.94,-.9,;-.04,-2.15,;1.49,-2.31,;2.4,-1.06,;2.12,-3.71,;1.21,-4.96,;-.32,-4.8,;-.94,-3.39,;-2.41,-2.92,;-3.74,-3.69,;-5.08,-2.92,;-5.08,-1.38,;-3.74,-.61,;-2.41,-1.38,;3.65,-3.87,;4.87,-4.82,;5.08,-3.29,;-1.5,1.71,;-3,1.39,;-1.02,3.17,)|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.65n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM399973
PNG
(US10323042, Example 53A | US10323042, Example 53B ...)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1 |r,wD:15.16,(-2.49,.13,;-1,.53,;-.6,2.02,;.9,2.47,;1.3,3.96,;1.7,5.45,;1.97,1.33,;3.46,1.73,;1.57,-.16,;.09,-.56,;-.31,-2.04,;.59,-3.29,;-.31,-4.54,;-1.78,-4.06,;-3.11,-4.83,;-4.44,-4.06,;-5.78,-4.83,;-4.44,-2.52,;-3.11,-1.75,;-1.78,-2.52,;2.13,-3.29,;2.9,-1.96,;2.9,-4.62,;4.44,-4.62,;5.78,-5.39,;5.78,-3.85,)|
Show InChI InChI=1S/C18H16F2N4O2/c1-9-4-10(6-21)14(20)5-13(9)15-16(17(25)22-12-2-3-12)23-24-7-11(19)8-26-18(15)24/h4-5,11-12H,2-3,7-8H2,1H3,(H,22,25)/t11-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.45n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...

US Patent US10738063 (2020)


BindingDB Entry DOI: 10.7270/Q20Z76BW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577109
PNG
(4-(8-Cyclopropyl-9-oxo-6,7,8,9-tetrahydropyrido[2'...)
Show SMILES Fc1cc(ccc1-c1c2C(=O)N(CCn2c2cccnc12)C1CC1)C#N |(-3,.66,;-1.49,.98,;-1.01,2.44,;.51,2.81,;1.52,1.62,;1.05,.15,;-.46,-.17,;-.93,-1.63,;-.03,-2.88,;1.5,-3.04,;2.41,-1.79,;2.13,-4.45,;1.22,-5.69,;-.31,-5.53,;-.93,-4.12,;-2.4,-3.65,;-3.73,-4.42,;-5.07,-3.65,;-5.07,-2.11,;-3.73,-1.34,;-2.4,-2.11,;3.66,-4.61,;4.91,-5.51,;5.07,-3.98,;.99,4.28,;1.46,5.74,)|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.47n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577169
PNG
(10-(4-Chloro-2-methylphenyl)-8-(pyrimidin-2-yl)-7,...)
Show SMILES Cc1cc(Cl)ccc1-c1c2C(=O)N(CCn2c2cccnc12)c1ncccn1 |(-3.82,3.07,;-2.31,3.39,;-1.84,4.85,;-.33,5.17,;.15,6.64,;.7,4.03,;.22,2.56,;-1.28,2.24,;-1.76,.78,;-.85,-.47,;.68,-.63,;1.58,.62,;1.31,-2.04,;.4,-3.28,;-1.13,-3.12,;-1.76,-1.72,;-3.22,-1.24,;-4.56,-2.01,;-5.89,-1.24,;-5.89,.3,;-4.56,1.07,;-3.22,.3,;2.84,-2.2,;3.42,-3.62,;4.95,-3.83,;5.89,-2.61,;5.31,-1.19,;3.78,-.98,)|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.66n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577120
PNG
(5-(8-Cyclopropyl-9-oxo-6,7,8,9-tetrahydropyrido[2'...)
Show SMILES O=C1N(CCn2c1c(-c1ccc(nc1)C#N)c1ncccc21)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.15n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577108
PNG
(8-Cyclopropyl-10-(2-methylpyrimidin-5-yl)-7,8-dihy...)
Show SMILES Cc1ncc(cn1)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.60n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577163
PNG
(11-(4-Chlorophenyl)-6,6a,7,8-tetrahydro-10H-azeto[...)
Show SMILES Clc1ccc(cc1)-c1c2C(=O)N3CCC3Cn2c2cccnc12
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.87n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM399937
PNG
(US10323042, Example 17 | US10738063, Example 17)
Show SMILES Cc1cc(Cl)c(F)cc1-c1c2OCCCn2nc1C(=O)NC1CC1 |(-3.16,.88,;-1.67,1.28,;-1.27,2.76,;.22,3.16,;.62,4.65,;1.31,2.07,;2.79,2.47,;.91,.59,;-.58,.19,;-.98,-1.3,;-2.44,-1.78,;-3.78,-1.01,;-5.11,-1.78,;-5.11,-3.32,;-3.78,-4.09,;-2.44,-3.32,;-.98,-3.79,;-.07,-2.55,;1.47,-2.55,;2.24,-1.21,;2.24,-3.88,;3.78,-3.88,;5.11,-4.65,;5.11,-3.11,)|
Show InChI InChI=1S/C17H17ClFN3O2/c1-9-7-12(18)13(19)8-11(9)14-15(16(23)20-10-3-4-10)21-22-5-2-6-24-17(14)22/h7-8,10H,2-6H2,1H3,(H,20,23)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...

US Patent US10738063 (2020)


BindingDB Entry DOI: 10.7270/Q20Z76BW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]


(Homo sapiens (Human))		BDBM577155
PNG
(3-(8-Cyclopropyl-9-oxo-6,7,8,9-tetrahydropyrido[2'...)
Show SMILES Cc1ccc(cc1-c1c2C(=O)N(CCn2c2cccnc12)C1CC1)C#N |(-3,2.12,;-1.5,2.44,;-1.02,3.91,;.48,4.23,;1.57,3.09,;1.04,1.62,;-.47,1.3,;-.94,-.17,;-.04,-1.41,;1.49,-1.57,;2.4,-.33,;2.12,-2.98,;1.21,-4.23,;-.32,-4.07,;-.94,-2.66,;-2.41,-2.18,;-3.74,-2.95,;-5.08,-2.18,;-5.08,-.64,;-3.74,.13,;-2.41,-.64,;3.65,-3.14,;4.87,-4.08,;5.08,-2.56,;3.07,3.41,;4.58,3.73,)|
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 11.8n/an/an/an/an/an/a


TBA

Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2XW4P16
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 135 total )  |  Next  |  Last  >>
Jump to: