Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6302 (8-cyclopentyl-6-acetyl-5-methyl-2-{[4-(piperazin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6386 (8-Cyclopentyl-5-methyl-7-oxo-2-(4-piperazin-1-yl-p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6301 (6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6383 (8-Cyclopentyl-6-iodo-5-methyl-2-(4-piperazin-1-yl-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6303 (Pyrido-[2,3-d]-pyrimidin-7-one 37 | ethyl 8-cyclop...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6358 (8-Cyclopentyl-2-(4-piperazin-1-yl-phenylamino)-8H-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6276 (8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6355 (8-Cyclopentyl-2-(4-morpholin-4-yl-phenylamino)-8H-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6356 (8-Cyclopentyl-2-(4-piperidin-1-yl-phenylamino)-8H-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6352 (2-Aminoquinazoline 31 | 8-cyclopentyl-5-methyl-2-{...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM6276 (8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6381 (6-Chloro-8-cyclopentyl-5-methyl-2-(4-piperazin-1-y...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6359 (8-Cyclopentyl-5-methyl-2-[4-(4-methyl-piperazin-1-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM6358 (8-Cyclopentyl-2-(4-piperazin-1-yl-phenylamino)-8H-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6379 (8-Cyclopentyl-6-ethyl-5-methyl-2-(4-piperazin-1-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6377 (2-(3-Chloro-4-piperazin-1-yl-phenylamino)-8-cyclop...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM6355 (8-Cyclopentyl-2-(4-morpholin-4-yl-phenylamino)-8H-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6380 (8-Cyclopentyl-6-fluoro-5-methyl-2-(4-piperazin-1-y...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6385 (8-Cyclopentyl-5-methyl-7-oxo-2-(4-piperazin-1-yl-p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6279 (8-Cyclopentyl-2-{4-[4-(3-hydroxypropyl)piperidin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 34 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6374 (8-Cyclopentyl-2-{4-[4-(2-hydroxy-ethyl)-piperazin-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human)) | BDBM6276 (8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6373 (8-Cyclopentyl-2-(4-[1,4]diazepan-1-yl-phenylamino)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6372 (2-[4-(3-Amino-pyrrolidin-1-yl)-phenylamino]-8-cycl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6376 (8-Cyclopentyl-2-[4-(3,3-dimethyl-piperazin-1-yl)-p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human)) | BDBM6358 (8-Cyclopentyl-2-(4-piperazin-1-yl-phenylamino)-8H-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human)) | BDBM6355 (8-Cyclopentyl-2-(4-morpholin-4-yl-phenylamino)-8H-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6369 (2-[4-(4-Acetyl-piperazin-1-yl)-phenylamino]-8-cycl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 103 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6362 (8-Cyclopentyl-2-{4-[4-(3-hydroxy-propyl)-piperidin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 114 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6360 (8-Cyclopentyl-5-methyl-2-(4-morpholin-4-yl-phenyla...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 116 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6368 (4-[4-(8-Cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 161 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6378 (8-Cyclopentyl-5,6-dimethyl-2-(4-piperazin-1-yl-phe...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 165 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6361 (8-Cyclopentyl-5-methyl-2-(4-piperidin-1-yl-phenyla...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM6302 (8-cyclopentyl-6-acetyl-5-methyl-2-{[4-(piperazin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6375 (8-Cyclopentyl-2-[4-(3,5-dimethyl-piperazin-1-yl)-p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human)) | BDBM6356 (8-Cyclopentyl-2-(4-piperidin-1-yl-phenylamino)-8H-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 246 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6371 (8-Cyclopentyl-2-[4-(3-hydroxy-pyrrolidin-1-yl)-phe...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6366 (5-methyl-2-{[4-(piperazin-1-yl)phenyl]amino}-8-(pr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 265 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM6355 (8-Cyclopentyl-2-(4-morpholin-4-yl-phenylamino)-8H-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 275 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human)) | BDBM6383 (8-Cyclopentyl-6-iodo-5-methyl-2-(4-piperazin-1-yl-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 365 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6370 (4-[4-(8-Cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 425 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM6301 (6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 439 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM6383 (8-Cyclopentyl-6-iodo-5-methyl-2-(4-piperazin-1-yl-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 443 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM6356 (8-Cyclopentyl-2-(4-piperidin-1-yl-phenylamino)-8H-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6364 (8-Cyclopentyl-5-ethyl-2-(4-piperazin-1-yl-phenylam...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 655 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM6356 (8-Cyclopentyl-2-(4-piperidin-1-yl-phenylamino)-8H-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human)) | BDBM6301 (6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6367 (5-methyl-8-(3-methylbutyl)-2-{[4-(piperazin-1-yl)p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.08E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM6360 (8-Cyclopentyl-5-methyl-2-(4-morpholin-4-yl-phenyla...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human)) | BDBM6381 (6-Chloro-8-cyclopentyl-5-methyl-2-(4-piperazin-1-y...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 48: 2371-87 (2005) Article DOI: 10.1021/jm049355+ BindingDB Entry DOI: 10.7270/Q2S46Q5B | |||||||||||
More data for this Ligand-Target Pair |
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