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Compile Data Set for Download or QSAR

Found 414 hits Enz. Inhib. hit(s) with all data for entry = 10004   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50026612
PNG
(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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3.80n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM507109
PNG
(US11046672, Example 58)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN(CCO)CC3)c3ccccc3)c2cc1C
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3.86n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM507056
PNG
((Z)-Methyl 3-(((4-((2-(dimethylamino)ethoxy)carbam...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOCCN(C)C)c(C)c3)c3ccccc3)c2cc1C
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4.57n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507078
PNG
(US11046672, Example 27)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCCN(C)C)c3ccccc3)c2cc1C
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4.77n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507083
PNG
(US11046672, Example 32)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOCCN4CCN(C)CC4)c(F)c3)c3ccccc3)c2cc1C
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4.92n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM507111
PNG
(US11046672, Example 60)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3C4CCC3CNC4)c3ccccc3)c2cc1C |TLB:25:26:28.29:31.33.32|
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5.24n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM507108
PNG
(US11046672, Example 57)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCNCC3)c3ccccc3)c2cc1C
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5.36n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507090
PNG
(US11046672, Example 39)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CCN(CCO)CC3)c3ccccc3)C(=O)Nc2c1
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5.39n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM507110
PNG
(US11046672, Example 59)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3C[C@@H]4C[C@H]3CN4)c3ccccc3)c2cc1C |r|
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5.43n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM507113
PNG
(US11046672, Example 62)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN[C@@H](C)C3)c3ccccc3)c2cc1C |r|
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5.74n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50026612
PNG
(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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5.90n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507116
PNG
(US11046672, Example 66)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CC4CC(C3)N4)c3ccccc3)c2cc1C
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6.30n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507082
PNG
(US11046672, Example 31)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOC4CCN(C)CC4)c(C)c3)c3ccccc3)c2cc1C
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6.58n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507058
PNG
((Z)-Methyl 3-(((4-((2-(4-(2-hydroxyethyl)piperazin...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN3CCN(CCO)CC3)c3ccccc3)c2cc1C
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6.60n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM507090
PNG
(US11046672, Example 39)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CCN(CCO)CC3)c3ccccc3)C(=O)Nc2c1
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6.71n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507056
PNG
((Z)-Methyl 3-(((4-((2-(dimethylamino)ethoxy)carbam...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOCCN(C)C)c(C)c3)c3ccccc3)c2cc1C
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6.78n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507113
PNG
(US11046672, Example 62)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN[C@@H](C)C3)c3ccccc3)c2cc1C |r|
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6.78n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507089
PNG
(US11046672, Example 38)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CC[C@@H](C3)N(C)C)c3ccccc3)C(=O)Nc2c1 |r|
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6.91n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507093
PNG
(US11046672, Example 42)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CCNC(=O)C3)c3ccccc3)C(=O)Nc2c1
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7.06n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507090
PNG
(US11046672, Example 39)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CCN(CCO)CC3)c3ccccc3)C(=O)Nc2c1
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7.06n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507056
PNG
((Z)-Methyl 3-(((4-((2-(dimethylamino)ethoxy)carbam...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOCCN(C)C)c(C)c3)c3ccccc3)c2cc1C
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7.13n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507107
PNG
(US11046672, Example 56)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN(C)CCO)c3ccccc3)c2cc1C
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7.19n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507081
PNG
(US11046672, Example 30)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOC3CCN(C)CC3)c3ccccc3)c2cc1C
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7.32n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507069
PNG
(US11046672, Example 18)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(C(=O)N(C)OCCN4CCN(C)CC4)c(C)c3)c3ccccc3)C(=O)Nc2c1
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7.42n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507080
PNG
(US11046672, Example 29)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOCCCN(C)C)c(C)c3)c3ccccc3)c2cc1C
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7.48n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM507073
PNG
(US11046672, Example 22)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(C(=O)N(C)OCCN(C)C)c(C)c3)c3ccccc3)C(=O)Nc2c1
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7.54n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507091
PNG
(US11046672, Example 40)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CCC(O)CC3)c3ccccc3)C(=O)Nc2c1
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7.66n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507089
PNG
(US11046672, Example 38)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CC[C@@H](C3)N(C)C)c3ccccc3)C(=O)Nc2c1 |r|
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7.68n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507079
PNG
(US11046672, Example 28)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOCCN4CCN(C)CC4)c(C)c3)c3ccccc3)c2cc1C
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7.88n/an/an/an/an/an/an/an/a


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Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507122
PNG
(US11046672, Example 73)
Show SMILES CNC(=O)CN1CCN(CCONC(=O)c2ccc(N\C(=C3/C(=O)Nc4cc(C(=O)OC)c(C)cc34)c3ccccc3)cc2)CC1
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7.90n/an/an/an/an/an/an/an/a


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Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507122
PNG
(US11046672, Example 73)
Show SMILES CNC(=O)CN1CCN(CCONC(=O)c2ccc(N\C(=C3/C(=O)Nc4cc(C(=O)OC)c(C)cc34)c3ccccc3)cc2)CC1
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Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507115
PNG
(US11046672, Example 65)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN[C@H](C)C3)c3ccccc3)c2cc1C |r|
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7.90n/an/an/an/an/an/an/an/a


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Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50026612
PNG
(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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8n/an/an/an/an/an/an/an/a


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Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507073
PNG
(US11046672, Example 22)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(C(=O)N(C)OCCN(C)C)c(C)c3)c3ccccc3)C(=O)Nc2c1
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8.14n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507057
PNG
((Z)-Methyl 5-methyl-3-(((4-((2-(4-methylpiperazin-...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN3CCN(C)CC3)c3ccccc3)c2cc1C
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8.31n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507054
PNG
((Z)-Methyl 3-(((4-((2-(dimethylamino)ethoxy)carbam...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN(C)C)c3ccccc3)C(=O)Nc2c1
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8.32n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50026612
PNG
(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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8.40n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507087
PNG
(US11046672, Example 36)
Show SMILES CCN1CCN(CCONC(=O)c2ccc(N\C(=C3/C(=O)Nc4cc(C(=O)OC)c(C)cc34)c3ccccc3)cc2)CC1
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8.46n/an/an/an/an/an/an/an/a


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Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507084
PNG
(US11046672, Example 33)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(C(=O)NOCCN4CCN(C)CC4)c(F)c3)c3ccccc3)C(=O)Nc2c1
PDB
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8.47n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507077
PNG
(US11046672, Example 26)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN(C)C)c3ccccc3)c2cc1C
PDB
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8.61n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507054
PNG
((Z)-Methyl 3-(((4-((2-(dimethylamino)ethoxy)carbam...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN(C)C)c3ccccc3)C(=O)Nc2c1
PDB
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8.65n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM507082
PNG
(US11046672, Example 31)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOC4CCN(C)CC4)c(C)c3)c3ccccc3)c2cc1C
PDB

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8.74n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM507058
PNG
((Z)-Methyl 3-(((4-((2-(4-(2-hydroxyethyl)piperazin...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN3CCN(CCO)CC3)c3ccccc3)c2cc1C
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8.80n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM507057
PNG
((Z)-Methyl 5-methyl-3-(((4-((2-(4-methylpiperazin-...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN3CCN(C)CC3)c3ccccc3)c2cc1C
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8.80n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507058
PNG
((Z)-Methyl 3-(((4-((2-(4-(2-hydroxyethyl)piperazin...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN3CCN(CCO)CC3)c3ccccc3)c2cc1C
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8.85n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507109
PNG
(US11046672, Example 58)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN(CCO)CC3)c3ccccc3)c2cc1C
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8.87n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507109
PNG
(US11046672, Example 58)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN(CCO)CC3)c3ccccc3)c2cc1C
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8.96n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM507078
PNG
(US11046672, Example 27)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCCN(C)C)c3ccccc3)c2cc1C
PDB

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9.11n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507110
PNG
(US11046672, Example 59)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3C[C@@H]4C[C@H]3CN4)c3ccccc3)c2cc1C |r|
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9.19n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM507101
PNG
(US11046672, Example 50)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN3CCC(CC3)N(C)C)c3ccccc3)c2cc1C
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9.24n/an/an/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


Citation and Details

BindingDB Entry DOI: 10.7270/Q27084K3
More data for this
Ligand-Target Pair
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