Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19130 ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 4 (Homo sapiens (Human)) | BDBM19130 ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Mus musculus) | BDBM19130 ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Histone deacetylase 4 (Homo sapiens (Human)) | BDBM19158 ((3S,9S,14aR)-9-benzyl-3-(7-bromo-6-oxoheptyl)-6,6-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 59.5 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 4 (Homo sapiens (Human)) | BDBM19162 ((3S,9S,14aR)-9-benzyl-3-(7-hydroxy-6-oxoheptyl)-6,...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 60.4 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19158 ((3S,9S,14aR)-9-benzyl-3-(7-bromo-6-oxoheptyl)-6,6-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 61.9 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19162 ((3S,9S,14aR)-9-benzyl-3-(7-hydroxy-6-oxoheptyl)-6,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 223 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 4 (Homo sapiens (Human)) | BDBM19159 ((3S,9S,14aR)-9-benzyl-6,6-dimethyl-3-(6-oxoheptyl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 290 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Mus musculus) | BDBM19158 ((3S,9S,14aR)-9-benzyl-3-(7-bromo-6-oxoheptyl)-6,6-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 621 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Mus musculus) | BDBM19162 ((3S,9S,14aR)-9-benzyl-3-(7-hydroxy-6-oxoheptyl)-6,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 887 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19159 ((3S,9S,14aR)-9-benzyl-6,6-dimethyl-3-(6-oxoheptyl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.08E+3 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 4 (Homo sapiens (Human)) | BDBM19161 (6-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tet...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.29E+3 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Mus musculus) | BDBM19159 ((3S,9S,14aR)-9-benzyl-6,6-dimethyl-3-(6-oxoheptyl)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 4 (Homo sapiens (Human)) | BDBM19157 ((3S,9S,14aR)-9-benzyl-6,6-dimethyl-3-[5-(oxiran-2-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.05E+3 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19161 (6-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tet...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.33E+3 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19157 ((3S,9S,14aR)-9-benzyl-6,6-dimethyl-3-[5-(oxiran-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.69E+3 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Mus musculus) | BDBM19161 (6-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tet...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.41E+4 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Mus musculus) | BDBM19156 ((3S,9S,14aR)-9-benzyl-3-(hept-6-en-1-yl)-6,6-dimet...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Mus musculus) | BDBM19157 ((3S,9S,14aR)-9-benzyl-6,6-dimethyl-3-[5-(oxiran-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 4 (Homo sapiens (Human)) | BDBM19156 ((3S,9S,14aR)-9-benzyl-3-(hept-6-en-1-yl)-6,6-dimet...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19160 ((3S,9S,14aR)-9-benzyl-3-(6,7-dihydroxyheptyl)-6,6-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Mus musculus) | BDBM19160 ((3S,9S,14aR)-9-benzyl-3-(6,7-dihydroxyheptyl)-6,6-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19156 ((3S,9S,14aR)-9-benzyl-3-(hept-6-en-1-yl)-6,6-dimet...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 4 (Homo sapiens (Human)) | BDBM19160 ((3S,9S,14aR)-9-benzyl-3-(6,7-dihydroxyheptyl)-6,6-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Kyushu Institute of Technology | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Bioorg Med Chem 14: 3438-46 (2006) Article DOI: 10.1016/j.bmc.2005.12.063 BindingDB Entry DOI: 10.7270/Q2P55KRB | |||||||||||
More data for this Ligand-Target Pair |