Compile Data Set for Download or QSAR

Found 142 hits Enz. Inhib. hit(s) with all data for entry = 7669   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209756 (US9273033, 56) Show SMILES COc1cc(cn(C)c1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1 |r| Show InChI InChI=1S/C25H24N4O3/c1-15-26-12-20(17-11-23(31-3)25(30)29(2)13-17)24(27-15)32-14-18-10-19(18)22-9-8-16-6-4-5-7-21(16)28-22/h4-9,11-13,18-19H,10,14H2,1-3H3/t18-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00400	-65.1	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209736 (US9273033, 34) Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1)-c1ccc(=O)n(C)c1C |r| Show InChI InChI=1S/C25H24N4O2/c1-15-19(9-11-24(30)29(15)3)21-13-26-16(2)27-25(21)31-14-18-12-20(18)23-10-8-17-6-4-5-7-22(17)28-23/h4-11,13,18,20H,12,14H2,1-3H3/t18-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00600	-64.1	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209781 (US9273033, 81) Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1)-c1cc(=O)[nH]cc1C |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0110	-62.5	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209800 (US9273033, 100) Show SMILES COCCn1ccc(cc1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1 |r| Show InChI InChI=1S/C26H26N4O3/c1-17-27-15-22(19-9-10-30(11-12-32-2)25(31)14-19)26(28-17)33-16-20-13-21(20)24-8-7-18-5-3-4-6-23(18)29-24/h3-10,14-15,20-21H,11-13,16H2,1-2H3/t20-,21+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0120	-62.3	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209711 (US9273033, 9) Show SMILES CC(C)n1cc(ccc1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1 |r| Show InChI InChI=1S/C26H26N4O2/c1-16(2)30-14-19(9-11-25(30)31)22-13-27-17(3)28-26(22)32-15-20-12-21(20)24-10-8-18-6-4-5-7-23(18)29-24/h4-11,13-14,16,20-21H,12,15H2,1-3H3/t20-,21+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0140	-62.0	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209796 (US9273033, 96) Show SMILES CCn1ccc(cc1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1 |r| Show InChI InChI=1S/C25H24N4O2/c1-3-29-11-10-18(13-24(29)30)21-14-26-16(2)27-25(21)31-15-19-12-20(19)23-9-8-17-6-4-5-7-22(17)28-23/h4-11,13-14,19-20H,3,12,15H2,1-2H3/t19-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0210	-60.9	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209734 (US9273033, 32) Show SMILES CCn1cc(ccc1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1 |r| Show InChI InChI=1S/C25H24N4O2/c1-3-29-14-18(9-11-24(29)30)21-13-26-16(2)27-25(21)31-15-19-12-20(19)23-10-8-17-6-4-5-7-22(17)28-23/h4-11,13-14,19-20H,3,12,15H2,1-2H3/t19-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0240	-60.6	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209779 (US9273033, 79) Show SMILES Cc1ncc(-c2ccn(C)c(=O)c2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 |r| Show InChI InChI=1S/C24H22N4O2/c1-15-25-13-20(17-9-10-28(2)23(29)12-17)24(26-15)30-14-18-11-19(18)22-8-7-16-5-3-4-6-21(16)27-22/h3-10,12-13,18-19H,11,14H2,1-2H3/t18-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0300	-60.1	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209829 (US9273033, 131) Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3CCCc3n2)n1)-c1cc(=O)n(C)cc1C |r| Show InChI InChI=1S/C24H26N4O2/c1-14-12-28(3)23(29)10-18(14)20-11-25-15(2)26-24(20)30-13-17-9-19(17)22-8-7-16-5-4-6-21(16)27-22/h7-8,10-12,17,19H,4-6,9,13H2,1-3H3/t17-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0330	-59.8	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209776 (US9273033, 76) Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1)-c1cc(=O)n(C)cc1C |r| Show InChI InChI=1S/C25H24N4O2/c1-15-13-29(3)24(30)11-19(15)21-12-26-16(2)27-25(21)31-14-18-10-20(18)23-9-8-17-6-4-5-7-22(17)28-23/h4-9,11-13,18,20H,10,14H2,1-3H3/t18-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0350	-59.7	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209802 (US9273033, 102) Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1)-c1cc(=O)n(C)cc1Cl |r| Show InChI InChI=1S/C24H21ClN4O2/c1-14-26-11-19(18-10-23(30)29(2)12-20(18)25)24(27-14)31-13-16-9-17(16)22-8-7-15-5-3-4-6-21(15)28-22/h3-8,10-12,16-17H,9,13H2,1-2H3/t16-,17+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0400	-59.3	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209797 (US9273033, 97) Show SMILES Cc1ncc(-c2cc(C)n(C)c(=O)c2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 |r| Show InChI InChI=1S/C25H24N4O2/c1-15-10-18(12-24(30)29(15)3)21-13-26-16(2)27-25(21)31-14-19-11-20(19)23-9-8-17-6-4-5-7-22(17)28-23/h4-10,12-13,19-20H,11,14H2,1-3H3/t19-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0410	-59.3	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209728 (US9273033, 26) Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1)-c1cc(F)c(=O)n(C)c1 |r| Show InChI InChI=1S/C24H21FN4O2/c1-14-26-11-19(16-10-20(25)24(30)29(2)12-16)23(27-14)31-13-17-9-18(17)22-8-7-15-5-3-4-6-21(15)28-22/h3-8,10-12,17-18H,9,13H2,1-2H3/t17-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0410	-59.3	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209754 (US9273033, 54) Show SMILES COc1cc(cn(C)c1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2CCCc2n1 |r| Show InChI InChI=1S/C24H26N4O3/c1-14-25-11-19(16-10-22(30-3)24(29)28(2)12-16)23(26-14)31-13-17-9-18(17)21-8-7-15-5-4-6-20(15)27-21/h7-8,10-12,17-18H,4-6,9,13H2,1-3H3/t17-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0450	-59.1	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209738 (US9273033, 36) Show SMILES CCn1c(C)c(ccc1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1 |r| Show InChI InChI=1S/C26H26N4O2/c1-4-30-16(2)20(10-12-25(30)31)22-14-27-17(3)28-26(22)32-15-19-13-21(19)24-11-9-18-7-5-6-8-23(18)29-24/h5-12,14,19,21H,4,13,15H2,1-3H3/t19-,21+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0450	-59.1	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209733 (US9273033, 31) Show SMILES COCCn1c(C)c(ccc1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1 |r| Show InChI InChI=1S/C27H28N4O3/c1-17-21(9-11-26(32)31(17)12-13-33-3)23-15-28-18(2)29-27(23)34-16-20-14-22(20)25-10-8-19-6-4-5-7-24(19)30-25/h4-11,15,20,22H,12-14,16H2,1-3H3/t20-,22+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0450	-59.1	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209713 (US9273033, 11) Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1)-c1ccc(=O)n(c1)C(F)F |r| Show InChI InChI=1S/C24H20F2N4O2/c1-14-27-11-19(16-7-9-22(31)30(12-16)24(25)26)23(28-14)32-13-17-10-18(17)21-8-6-15-4-2-3-5-20(15)29-21/h2-9,11-12,17-18,24H,10,13H2,1H3/t17-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0480	-58.9	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209731 (US9273033, 29) Show SMILES Cc1ncc(-c2ccc(=O)n(C)c2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 |r| Show InChI InChI=1S/C24H22N4O2/c1-15-25-12-20(17-8-10-23(29)28(2)13-17)24(26-15)30-14-18-11-19(18)22-9-7-16-5-3-4-6-21(16)27-22/h3-10,12-13,18-19H,11,14H2,1-2H3/t18-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0520	-58.7	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209714 (US9273033, 12) Show SMILES COn1cc(ccc1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1 |r| Show InChI InChI=1S/C24H22N4O3/c1-15-25-12-20(17-8-10-23(29)28(13-17)30-2)24(26-15)31-14-18-11-19(18)22-9-7-16-5-3-4-6-21(16)27-22/h3-10,12-13,18-19H,11,14H2,1-2H3/t18-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0530	-58.7	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209729 (US9273033, 27) Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(=O)n(C)c1C |r| Show InChI InChI=1S/C22H24N4O3/c1-13-17(6-8-21(27)26(13)3)19-11-23-14(2)25-22(19)29-12-15-9-18(15)20-7-5-16(28-4)10-24-20/h5-8,10-11,15,18H,9,12H2,1-4H3/t15-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.113	-56.8	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209760 (US9273033, 60) Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cc(C#N)c(=O)n(C)c1C |r| Show InChI InChI=1S/C23H23N5O3/c1-13-18(7-15(9-24)23(29)28(13)3)20-11-25-14(2)27-22(20)31-12-16-8-19(16)21-6-5-17(30-4)10-26-21/h5-7,10-11,16,19H,8,12H2,1-4H3/t16-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.117	-56.7	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209719 (US9273033, 17) Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cc(OC)c(=O)n(C)c1 |r| Show InChI InChI=1S/C22H24N4O4/c1-13-23-10-18(14-8-20(29-4)22(27)26(2)11-14)21(25-13)30-12-15-7-17(15)19-6-5-16(28-3)9-24-19/h5-6,8-11,15,17H,7,12H2,1-4H3/t15-,17+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.151	-56.1	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209718 (US9273033, 16) Show SMILES CCc1cc(cn(C)c1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(OC)cn1 |r| Show InChI InChI=1S/C23H26N4O3/c1-5-15-8-16(12-27(3)23(15)28)20-11-24-14(2)26-22(20)30-13-17-9-19(17)21-7-6-18(29-4)10-25-21/h6-8,10-12,17,19H,5,9,13H2,1-4H3/t17-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.185	-55.6	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209712 (US9273033, 10) Show SMILES Cc1ncc(-c2ccc(=O)n(c2)-c2ccccc2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1 |r| Show InChI InChI=1S/C29H24N4O2/c1-19-30-16-25(21-12-14-28(34)33(17-21)23-8-3-2-4-9-23)29(31-19)35-18-22-15-24(22)27-13-11-20-7-5-6-10-26(20)32-27/h2-14,16-17,22,24H,15,18H2,1H3/t22-,24+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.216	-55.2	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209705 (US9273033, 3) Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(=O)n(C)c1C |r| Show InChI InChI=1S/C22H24N4O2/c1-13-5-7-20(24-10-13)18-9-16(18)12-28-22-19(11-23-15(3)25-22)17-6-8-21(27)26(4)14(17)2/h5-8,10-11,16,18H,9,12H2,1-4H3/t16-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.217	-55.2	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209838 (US9273033, 140) Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1)-c1cc(=O)n(C)cn1 |r| Show InChI InChI=1S/C23H21N5O2/c1-14-24-11-18(21-10-22(29)28(2)13-25-21)23(26-14)30-12-16-9-17(16)20-8-7-15-5-3-4-6-19(15)27-20/h3-8,10-11,13,16-17H,9,12H2,1-2H3/t16-,17+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.228	-55.0	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209824 (US9273033, 124) Show SMILES COC(=O)Cn1ccc(cc1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(OC)cn1 |r| Show InChI InChI=1S/C23H24N4O5/c1-14-24-11-19(15-6-7-27(21(28)9-15)12-22(29)31-3)23(26-14)32-13-16-8-18(16)20-5-4-17(30-2)10-25-20/h4-7,9-11,16,18H,8,12-13H2,1-3H3/t16-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.284	-54.5	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209821 (US9273033, 121) Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccn(CC(F)(F)F)c(=O)c1 |r| Show InChI InChI=1S/C22H21F3N4O3/c1-13-26-10-18(14-5-6-29(20(30)8-14)12-22(23,24)25)21(28-13)32-11-15-7-17(15)19-4-3-16(31-2)9-27-19/h3-6,8-10,15,17H,7,11-12H2,1-2H3/t15-,17+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.299	-54.4	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209755 (US9273033, 55) Show SMILES CCc1cc(cn(C)c1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1 |r| Show InChI InChI=1S/C23H26N4O2/c1-5-16-8-17(12-27(4)23(16)28)20-11-24-15(3)26-22(20)29-13-18-9-19(18)21-7-6-14(2)10-25-21/h6-8,10-12,18-19H,5,9,13H2,1-4H3/t18-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.347	-54.0	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209757 (US9273033, 57) Show SMILES COc1cc(cn(C)c1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1 |r| Show InChI InChI=1S/C22H24N4O3/c1-13-5-6-19(24-9-13)17-7-16(17)12-29-21-18(10-23-14(2)25-21)15-8-20(28-4)22(27)26(3)11-15/h5-6,8-11,16-17H,7,12H2,1-4H3/t16-,17+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.349	-54.0	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209753 (US9273033, 53) Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(=O)n(CC2CC2)c1 |r| Show InChI InChI=1S/C24H26N4O3/c1-15-25-11-21(17-5-8-23(29)28(13-17)12-16-3-4-16)24(27-15)31-14-18-9-20(18)22-7-6-19(30-2)10-26-22/h5-8,10-11,13,16,18,20H,3-4,9,12,14H2,1-2H3/t18-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.377	-53.8	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209814 (US9273033, 114) Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3CCCc3n2)n1)-c1ccn(C)c(=O)c1 |r| Show InChI InChI=1S/C23H24N4O2/c1-14-24-12-19(16-8-9-27(2)22(28)11-16)23(25-14)29-13-17-10-18(17)21-7-6-15-4-3-5-20(15)26-21/h6-9,11-12,17-18H,3-5,10,13H2,1-2H3/t17-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.378	-53.8	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209737 (US9273033, 35) Show SMILES CCn1cc(cc(C)c1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(OC)cn1 |r| Show InChI InChI=1S/C23H26N4O3/c1-5-27-12-16(8-14(2)23(27)28)20-11-24-15(3)26-22(20)30-13-17-9-19(17)21-7-6-18(29-4)10-25-21/h6-8,10-12,17,19H,5,9,13H2,1-4H3/t17-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.381	-53.8	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209828 (US9273033, 130) Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccn(CC(F)F)c(=O)c1 |r| Show InChI InChI=1S/C22H22F2N4O3/c1-13-25-10-18(14-5-6-28(11-20(23)24)21(29)8-14)22(27-13)31-12-15-7-17(15)19-4-3-16(30-2)9-26-19/h3-6,8-10,15,17,20H,7,11-12H2,1-2H3/t15-,17+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.386	-53.7	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209783 (US9273033, 83) Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cc(=O)[nH]cc1Cl |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.390	-53.7	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209827 (US9273033, 129) Show SMILES COC(=O)Cn1ccc(cc1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1 |r| Show InChI InChI=1S/C23H24N4O4/c1-14-4-5-20(25-10-14)18-8-17(18)13-31-23-19(11-24-15(2)26-23)16-6-7-27(21(28)9-16)12-22(29)30-3/h4-7,9-11,17-18H,8,12-13H2,1-3H3/t17-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.394	-53.7	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209785 (US9273033, 101 | US9273033, 85) Show SMILES COCCn1ccc(cc1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1 |r| Show InChI InChI=1S/C23H26N4O3/c1-15-4-5-21(25-12-15)19-10-18(19)14-30-23-20(13-24-16(2)26-23)17-6-7-27(8-9-29-3)22(28)11-17/h4-7,11-13,18-19H,8-10,14H2,1-3H3/t18-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.400	-53.6	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209742 (US9273033, 40) Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cc(C)c(=O)n(C)c1 |r| Show InChI InChI=1S/C22H24N4O2/c1-13-5-6-20(24-9-13)18-8-17(18)12-28-21-19(10-23-15(3)25-21)16-7-14(2)22(27)26(4)11-16/h5-7,9-11,17-18H,8,12H2,1-4H3/t17-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.409	-53.6	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209759 (US9273033, 59) Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cc(C#N)c(=O)n(C)c1C |r| Show InChI InChI=1S/C23H23N5O2/c1-13-5-6-21(26-10-13)19-8-17(19)12-30-22-20(11-25-15(3)27-22)18-7-16(9-24)23(29)28(4)14(18)2/h5-7,10-11,17,19H,8,12H2,1-4H3/t17-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.426	-53.5	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209785 (US9273033, 101 | US9273033, 85) Show SMILES COCCn1ccc(cc1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1 |r| Show InChI InChI=1S/C23H26N4O3/c1-15-4-5-21(25-12-15)19-10-18(19)14-30-23-20(13-24-16(2)26-23)17-6-7-27(8-9-29-3)22(28)11-17/h4-7,11-13,18-19H,8-10,14H2,1-3H3/t18-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.439	-53.4	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209811 (US9273033, 111) Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccn(CC#N)c(=O)c1 |r| Show InChI InChI=1S/C22H21N5O3/c1-14-24-12-19(15-5-7-27(8-6-23)21(28)10-15)22(26-14)30-13-16-9-18(16)20-4-3-17(29-2)11-25-20/h3-5,7,10-12,16,18H,8-9,13H2,1-2H3/t16-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.441	-53.4	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209822 (US9273033, 122) Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccn(CC=C)c(=O)c1 |r| Show InChI InChI=1S/C23H24N4O3/c1-4-8-27-9-7-16(11-22(27)28)20-13-24-15(2)26-23(20)30-14-17-10-19(17)21-6-5-18(29-3)12-25-21/h4-7,9,11-13,17,19H,1,8,10,14H2,2-3H3/t17-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.458	-53.3	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209758 (US9273033, 58) Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3CCCc3n2)n1)-c1ccc(=O)n(C)c1C |r| Show InChI InChI=1S/C24H26N4O2/c1-14-18(8-10-23(29)28(14)3)20-12-25-15(2)26-24(20)30-13-17-11-19(17)22-9-7-16-5-4-6-21(16)27-22/h7-10,12,17,19H,4-6,11,13H2,1-3H3/t17-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.481	-53.2	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209782 (US9273033, 82) Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cc(=O)n(C)cc1C |r| Show InChI InChI=1S/C22H24N4O3/c1-13-11-26(3)21(27)8-17(13)19-10-23-14(2)25-22(19)29-12-15-7-18(15)20-6-5-16(28-4)9-24-20/h5-6,8-11,15,18H,7,12H2,1-4H3/t15-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.496	-53.1	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209823 (US9273033, 123) Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccn(CC=C)c(=O)c1 |r| Show InChI InChI=1S/C23H24N4O2/c1-4-8-27-9-7-17(11-22(27)28)20-13-24-16(3)26-23(20)29-14-18-10-19(18)21-6-5-15(2)12-25-21/h4-7,9,11-13,18-19H,1,8,10,14H2,2-3H3/t18-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.508	-53.0	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209725 (US9273033, 23) Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(=O)n(c1)C1CC1 |r| Show InChI InChI=1S/C23H24N4O2/c1-14-3-7-21(25-10-14)19-9-17(19)13-29-23-20(11-24-15(2)26-23)16-4-8-22(28)27(12-16)18-5-6-18/h3-4,7-8,10-12,17-19H,5-6,9,13H2,1-2H3/t17-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.519	-53.0	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209744 (US9273033, 42) Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3CCCc3n2)n1)-c1ccc(=O)n(C)c1 |r| Show InChI InChI=1S/C23H24N4O2/c1-14-24-11-19(16-7-9-22(28)27(2)12-16)23(25-14)29-13-17-10-18(17)21-8-6-15-4-3-5-20(15)26-21/h6-9,11-12,17-18H,3-5,10,13H2,1-2H3/t17-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.531	-52.9	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209743 (US9273033, 41) Show SMILES CCn1cc(cc(C)c1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1 |r| Show InChI InChI=1S/C23H26N4O2/c1-5-27-12-17(8-15(3)23(27)28)20-11-24-16(4)26-22(20)29-13-18-9-19(18)21-7-6-14(2)10-25-21/h6-8,10-12,18-19H,5,9,13H2,1-4H3/t18-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.533	-52.9	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209818 (US9273033, 118) Show SMILES COCCn1ccc(cc1=O)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(OC)cn1 |r| Show InChI InChI=1S/C23H26N4O4/c1-15-24-13-20(16-6-7-27(8-9-29-2)22(28)11-16)23(26-15)31-14-17-10-19(17)21-5-4-18(30-3)12-25-21/h4-7,11-13,17,19H,8-10,14H2,1-3H3/t17-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.553	-52.8	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM209830 (US9273033, 132) Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cc(=O)n(C)cc1C1CC1 |r| Show InChI InChI=1S/C24H26N4O3/c1-14-25-11-20(19-9-23(29)28(2)12-21(19)15-4-5-15)24(27-14)31-13-16-8-18(16)22-7-6-17(30-3)10-26-22/h6-7,9-12,15-16,18H,4-5,8,13H2,1-3H3/t16-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.583	-52.7	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...				US Patent US9273033 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W2R
					More data for this Ligand-Target Pair

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