Compile Data Set for Download or QSAR

Found 46 hits Enz. Inhib. hit(s) with all data for entry = 275   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261715 (4-((6-Chloropyridin-3-yl)methyl)-1-fluoro-N-((1SR,...) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C23H22ClFN2O2/c24-21-10-9-14(13-26-21)11-15-12-18(22(25)17-6-2-1-5-16(15)17)23(29)27-19-7-3-4-8-20(19)28/h1-2,5-6,9-10,12-13,19-20,28H,3-4,7-8,11H2,(H,27,29)/t19-,20-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	159	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261725 (4-benzyl-1-fluoro-N- ((3RS,4SR)-3- hydroxytetrahyd...) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cc(Cc2ccccc2)c2ccccc2c1F |r| Show InChI InChI=1S/C23H22FNO3/c24-22-18-9-5-4-8-17(18)16(12-15-6-2-1-3-7-15)13-19(22)23(27)25-20-10-11-28-14-21(20)26/h1-9,13,20-21,26H,10-12,14H2,(H,25,27)/t20-,21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	356	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261715 (4-((6-Chloropyridin-3-yl)methyl)-1-fluoro-N-((1SR,...) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C23H22ClFN2O2/c24-21-10-9-14(13-26-21)11-15-12-18(22(25)17-6-2-1-5-16(15)17)23(29)27-19-7-3-4-8-20(19)28/h1-2,5-6,9-10,12-13,19-20,28H,3-4,7-8,11H2,(H,27,29)/t19-,20-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	84	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261718 (4-((6-Chloropyridin-3-yl)methyl)-1-fluoro-N-((3S,4...) Show SMILES O[C@H]1CCOC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C22H20ClFN2O3/c23-20-6-5-13(11-25-20)9-14-10-17(21(24)16-4-2-1-3-15(14)16)22(28)26-18-12-29-8-7-19(18)27/h1-6,10-11,18-19,27H,7-9,12H2,(H,26,28)/t18-,19-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	428	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261719 (4-((6-chloropyridin-3- yl)methyl)-1-fluoro-N- ((1S...) Show SMILES O[C@H]1CCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C22H20ClFN2O2/c23-20-9-8-13(12-25-20)10-14-11-17(21(24)16-5-2-1-4-15(14)16)22(28)26-18-6-3-7-19(18)27/h1-2,4-5,8-9,11-12,18-19,27H,3,6-7,10H2,(H,26,28)/t18-,19-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	363	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261720 (4-((6-chloropydridin-3- yl)methyl)-1-fluoro-N-((1S...) Show SMILES O[C@@H]1CCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C22H20ClFN2O2/c23-20-9-8-13(12-25-20)10-14-11-17(21(24)16-5-2-1-4-15(14)16)22(28)26-18-6-3-7-19(18)27/h1-2,4-5,8-9,11-12,18-19,27H,3,6-7,10H2,(H,26,28)/t18-,19+/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	575	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261721 (4-((6-chloropyridin-3- yl)methyl)-1-fluoro-N- ((1S...) Show SMILES C[C@]1(O)CCCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C24H24ClFN2O2/c1-24(30)11-5-4-8-20(24)28-23(29)19-13-16(12-15-9-10-21(25)27-14-15)17-6-2-3-7-18(17)22(19)26/h2-3,6-7,9-10,13-14,20,30H,4-5,8,11-12H2,1H3,(H,28,29)/t20-,24-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	561	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261722 (4-((6-chloropyridin-3- yl)methyl)-1-fluoro-N- ((1S...) Show SMILES C[C@@]1(O)CCCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C24H24ClFN2O2/c1-24(30)11-5-4-8-20(24)28-23(29)19-13-16(12-15-9-10-21(25)27-14-15)17-6-2-3-7-18(17)22(19)26/h2-3,6-7,9-10,13-14,20,30H,4-5,8,11-12H2,1H3,(H,28,29)/t20-,24+/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	524	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261723 (4-((6-chloropyridin-3- yl)methyl)-1-fluoro-N- ((1S...) Show SMILES O[C@@H]1CCCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C23H22ClFN2O2/c24-21-10-9-14(13-26-21)11-15-12-18(22(25)17-6-2-1-5-16(15)17)23(29)27-19-7-3-4-8-20(19)28/h1-2,5-6,9-10,12-13,19-20,28H,3-4,7-8,11H2,(H,27,29)/t19-,20+/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	539	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261724 (1-Fluoro-N-((3RS,4SR)-3-hydroxytetrahydro-2H-pyran...) Show SMILES Cc1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)cc1 |r| Show InChI InChI=1S/C24H24FNO3/c1-15-6-8-16(9-7-15)12-17-13-20(23(25)19-5-3-2-4-18(17)19)24(28)26-21-10-11-29-14-22(21)27/h2-9,13,21-22,27H,10-12,14H2,1H3,(H,26,28)/t21-,22-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	154	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261725 (4-benzyl-1-fluoro-N- ((3RS,4SR)-3- hydroxytetrahyd...) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cc(Cc2ccccc2)c2ccccc2c1F |r| Show InChI InChI=1S/C23H22FNO3/c24-22-18-9-5-4-8-17(18)16(12-15-6-2-1-3-7-15)13-19(22)23(27)25-20-10-11-28-14-21(20)26/h1-9,13,20-21,26H,10-12,14H2,(H,25,27)/t20-,21-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	197	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261726 (4-(4-chlorobenzyl)- 1-fluoro-N- ((3RS,4SR)-3- hydr...) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)cc2)c2ccccc2c1F |r| Show InChI InChI=1S/C23H21ClFNO3/c24-16-7-5-14(6-8-16)11-15-12-19(22(25)18-4-2-1-3-17(15)18)23(28)26-20-9-10-29-13-21(20)27/h1-8,12,20-21,27H,9-11,13H2,(H,26,28)/t20-,21-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	152	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261727 (4-(4-cyanobenzyl)- 1-fluoro-N- ((3RS,4SR)-3- hydro...) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cc(Cc2ccc(cc2)C#N)c2ccccc2c1F |r| Show InChI InChI=1S/C24H21FN2O3/c25-23-19-4-2-1-3-18(19)17(11-15-5-7-16(13-26)8-6-15)12-20(23)24(29)27-21-9-10-30-14-22(21)28/h1-8,12,21-22,28H,9-11,14H2,(H,27,29)/t21-,22-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	67	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261728 (1-fluoro-4-(2-fluoro- 4-(1-methyl-1H- pyrazol-4- y...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)c(F)c1 |r| Show InChI InChI=1S/C27H25F2N3O3/c1-32-14-19(13-30-32)16-6-7-17(23(28)12-16)10-18-11-22(26(29)21-5-3-2-4-20(18)21)27(34)31-24-8-9-35-15-25(24)33/h2-7,11-14,24-25,33H,8-10,15H2,1H3,(H,31,34)/t24-,25-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261729 (1-fluoro-N- ((3RS,4SR)-3- hydroxytetrahydro- 2H-py...) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cc(Cc2ccc(OC(F)(F)F)cc2)c2ccccc2c1F |r| Show InChI InChI=1S/C24H21F4NO4/c25-22-18-4-2-1-3-17(18)15(11-14-5-7-16(8-6-14)33-24(26,27)28)12-19(22)23(31)29-20-9-10-32-13-21(20)30/h1-8,12,20-21,30H,9-11,13H2,(H,29,31)/t20-,21-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	541	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261730 (1-fluoro-N- ((3RS,4SR)-3- hydroxytetrahydro- 2H-py...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)cc1 |r| Show InChI InChI=1S/C27H26FN3O3/c1-31-15-20(14-29-31)18-8-6-17(7-9-18)12-19-13-23(26(28)22-5-3-2-4-21(19)22)27(33)30-24-10-11-34-16-25(24)32/h2-9,13-15,24-25,32H,10-12,16H2,1H3,(H,30,33)/t24-,25-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261731 (1-Fluoro-N-((1S,2S)-2-hydroxycyclohexyl)-4-((6-(1-...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCCC[C@@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C27H27FN4O2/c1-32-16-19(15-30-32)23-11-10-17(14-29-23)12-18-13-22(26(28)21-7-3-2-6-20(18)21)27(34)31-24-8-4-5-9-25(24)33/h2-3,6-7,10-11,13-16,24-25,33H,4-5,8-9,12H2,1H3,(H,31,34)/t24-,25-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261733 (1-fluoro-N-[(3S,4R)- 3-hydroxytetra- hydropyran-4-...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@@H]3CCOC[C@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C26H25FN4O3/c1-31-14-18(13-29-31)22-7-6-16(12-28-22)10-17-11-21(25(27)20-5-3-2-4-19(17)20)26(33)30-23-8-9-34-15-24(23)32/h2-7,11-14,23-24,32H,8-10,15H2,1H3,(H,30,33)/t23-,24-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	65	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261732 (1-fluoro-N- ((3RS,4SR)-3- hydroxytetrahydro- 2H-py...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C26H25FN4O3/c1-31-14-18(13-29-31)22-7-6-16(12-28-22)10-17-11-21(25(27)20-5-3-2-4-19(17)20)26(33)30-23-8-9-34-15-24(23)32/h2-7,11-14,23-24,32H,8-10,15H2,1H3,(H,30,33)/t23-,24-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261735 (1-fluoro-N-((3S,4S)-4- hydroxytetrahydro-2H- pyran...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3COCC[C@@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C26H25FN4O3/c1-31-14-18(13-29-31)22-7-6-16(12-28-22)10-17-11-21(25(27)20-5-3-2-4-19(17)20)26(33)30-23-15-34-9-8-24(23)32/h2-7,11-14,23-24,32H,8-10,15H2,1H3,(H,30,33)/t23-,24-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261736 (1-fluoro-N- ((1SR,2RS)-2- hydroxy-2- methylcyclohe...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCCC[C@@]3(C)O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C28H29FN4O2/c1-28(35)12-6-5-9-25(28)32-27(34)23-14-19(21-7-3-4-8-22(21)26(23)29)13-18-10-11-24(30-15-18)20-16-31-33(2)17-20/h3-4,7-8,10-11,14-17,25,35H,5-6,9,12-13H2,1-2H3,(H,32,34)/t25-,28+/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261737 (1-Fluoro-N-((1SR,2SR)-2-hydroxycyclohexyl)-4-((6-m...) Show SMILES Cc1ccc(Cc2cc(C(=O)N[C@H]3CCCC[C@@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C24H25FN2O2/c1-15-10-11-16(14-26-15)12-17-13-20(23(25)19-7-3-2-6-18(17)19)24(29)27-21-8-4-5-9-22(21)28/h2-3,6-7,10-11,13-14,21-22,28H,4-5,8-9,12H2,1H3,(H,27,29)/t21-,22-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	213	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261738 (4-((6-Cyclopropylpyridin-3-yl)methyl)-1-fluoro-N-(...) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cc(Cc2ccc(nc2)C2CC2)c2ccccc2c1F |r| Show InChI InChI=1S/C26H27FN2O2/c27-25-20-6-2-1-5-19(20)18(13-16-9-12-22(28-15-16)17-10-11-17)14-21(25)26(31)29-23-7-3-4-8-24(23)30/h1-2,5-6,9,12,14-15,17,23-24,30H,3-4,7-8,10-11,13H2,(H,29,31)/t23-,24-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261740 (4-((4-Cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)...) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cc(CN2CCC(CC2)(C#N)c2ccccn2)c2ccccc2c1F |r| Show InChI InChI=1S/C29H31FN4O2/c30-27-22-8-2-1-7-21(22)20(17-23(27)28(36)33-24-9-3-4-10-25(24)35)18-34-15-12-29(19-31,13-16-34)26-11-5-6-14-32-26/h1-2,5-8,11,14,17,24-25,35H,3-4,9-10,12-13,15-16,18H2,(H,33,36)/t24-,25-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	258	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261715 (4-((6-Chloropyridin-3-yl)methyl)-1-fluoro-N-((1SR,...) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C23H22ClFN2O2/c24-21-10-9-14(13-26-21)11-15-12-18(22(25)17-6-2-1-5-16(15)17)23(29)27-19-7-3-4-8-20(19)28/h1-2,5-6,9-10,12-13,19-20,28H,3-4,7-8,11H2,(H,27,29)/t19-,20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	137	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261716 (4-((6-chloropyridin-3- yl)methyl)-1-fluoro-N- ((3R...) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C22H20ClFN2O3/c23-20-6-5-13(11-25-20)9-14-10-17(21(24)16-4-2-1-3-15(14)16)22(28)26-18-7-8-29-12-19(18)27/h1-6,10-11,18-19,27H,7-9,12H2,(H,26,28)/t18-,19-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	118	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261715 (4-((6-Chloropyridin-3-yl)methyl)-1-fluoro-N-((1SR,...) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C23H22ClFN2O2/c24-21-10-9-14(13-26-21)11-15-12-18(22(25)17-6-2-1-5-16(15)17)23(29)27-19-7-3-4-8-20(19)28/h1-2,5-6,9-10,12-13,19-20,28H,3-4,7-8,11H2,(H,27,29)/t19-,20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	101	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261719 (4-((6-chloropyridin-3- yl)methyl)-1-fluoro-N- ((1S...) Show SMILES O[C@H]1CCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C22H20ClFN2O2/c23-20-9-8-13(12-25-20)10-14-11-17(21(24)16-5-2-1-4-15(14)16)22(28)26-18-6-3-7-19(18)27/h1-2,4-5,8-9,11-12,18-19,27H,3,6-7,10H2,(H,26,28)/t18-,19-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	968	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261724 (1-Fluoro-N-((3RS,4SR)-3-hydroxytetrahydro-2H-pyran...) Show SMILES Cc1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)cc1 |r| Show InChI InChI=1S/C24H24FNO3/c1-15-6-8-16(9-7-15)12-17-13-20(23(25)19-5-3-2-4-18(17)19)24(28)26-21-10-11-29-14-22(21)27/h2-9,13,21-22,27H,10-12,14H2,1H3,(H,26,28)/t21-,22-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	221	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261726 (4-(4-chlorobenzyl)- 1-fluoro-N- ((3RS,4SR)-3- hydr...) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)cc2)c2ccccc2c1F |r| Show InChI InChI=1S/C23H21ClFNO3/c24-16-7-5-14(6-8-16)11-15-12-19(22(25)18-4-2-1-3-17(15)18)23(28)26-20-9-10-29-13-21(20)27/h1-8,12,20-21,27H,9-11,13H2,(H,26,28)/t20-,21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	273	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261727 (4-(4-cyanobenzyl)- 1-fluoro-N- ((3RS,4SR)-3- hydro...) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cc(Cc2ccc(cc2)C#N)c2ccccc2c1F |r| Show InChI InChI=1S/C24H21FN2O3/c25-23-19-4-2-1-3-18(19)17(11-15-5-7-16(13-26)8-6-15)12-20(23)24(29)27-21-9-10-30-14-22(21)28/h1-8,12,21-22,28H,9-11,14H2,(H,27,29)/t21-,22-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	71	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261728 (1-fluoro-4-(2-fluoro- 4-(1-methyl-1H- pyrazol-4- y...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)c(F)c1 |r| Show InChI InChI=1S/C27H25F2N3O3/c1-32-14-19(13-30-32)16-6-7-17(23(28)12-16)10-18-11-22(26(29)21-5-3-2-4-20(18)21)27(34)31-24-8-9-35-15-25(24)33/h2-7,11-14,24-25,33H,8-10,15H2,1H3,(H,31,34)/t24-,25-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261730 (1-fluoro-N- ((3RS,4SR)-3- hydroxytetrahydro- 2H-py...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)cc1 |r| Show InChI InChI=1S/C27H26FN3O3/c1-31-15-20(14-29-31)18-8-6-17(7-9-18)12-19-13-23(26(28)22-5-3-2-4-21(19)22)27(33)30-24-10-11-34-16-25(24)32/h2-9,13-15,24-25,32H,10-12,16H2,1H3,(H,30,33)/t24-,25-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261731 (1-Fluoro-N-((1S,2S)-2-hydroxycyclohexyl)-4-((6-(1-...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCCC[C@@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C27H27FN4O2/c1-32-16-19(15-30-32)23-11-10-17(14-29-23)12-18-13-22(26(28)21-7-3-2-6-20(18)21)27(34)31-24-8-4-5-9-25(24)33/h2-3,6-7,10-11,13-16,24-25,33H,4-5,8-9,12H2,1H3,(H,31,34)/t24-,25-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261732 (1-fluoro-N- ((3RS,4SR)-3- hydroxytetrahydro- 2H-py...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C26H25FN4O3/c1-31-14-18(13-29-31)22-7-6-16(12-28-22)10-17-11-21(25(27)20-5-3-2-4-19(17)20)26(33)30-23-8-9-34-15-24(23)32/h2-7,11-14,23-24,32H,8-10,15H2,1H3,(H,30,33)/t23-,24-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261733 (1-fluoro-N-[(3S,4R)- 3-hydroxytetra- hydropyran-4-...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@@H]3CCOC[C@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C26H25FN4O3/c1-31-14-18(13-29-31)22-7-6-16(12-28-22)10-17-11-21(25(27)20-5-3-2-4-19(17)20)26(33)30-23-8-9-34-15-24(23)32/h2-7,11-14,23-24,32H,8-10,15H2,1H3,(H,30,33)/t23-,24-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	97	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261732 (1-fluoro-N- ((3RS,4SR)-3- hydroxytetrahydro- 2H-py...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C26H25FN4O3/c1-31-14-18(13-29-31)22-7-6-16(12-28-22)10-17-11-21(25(27)20-5-3-2-4-19(17)20)26(33)30-23-8-9-34-15-24(23)32/h2-7,11-14,23-24,32H,8-10,15H2,1H3,(H,30,33)/t23-,24-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261735 (1-fluoro-N-((3S,4S)-4- hydroxytetrahydro-2H- pyran...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3COCC[C@@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C26H25FN4O3/c1-31-14-18(13-29-31)22-7-6-16(12-28-22)10-17-11-21(25(27)20-5-3-2-4-19(17)20)26(33)30-23-15-34-9-8-24(23)32/h2-7,11-14,23-24,32H,8-10,15H2,1H3,(H,30,33)/t23-,24-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261736 (1-fluoro-N- ((1SR,2RS)-2- hydroxy-2- methylcyclohe...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCCC[C@@]3(C)O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C28H29FN4O2/c1-28(35)12-6-5-9-25(28)32-27(34)23-14-19(21-7-3-4-8-22(21)26(23)29)13-18-10-11-24(30-15-18)20-16-31-33(2)17-20/h3-4,7-8,10-11,14-17,25,35H,5-6,9,12-13H2,1-2H3,(H,32,34)/t25-,28+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	41	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261737 (1-Fluoro-N-((1SR,2SR)-2-hydroxycyclohexyl)-4-((6-m...) Show SMILES Cc1ccc(Cc2cc(C(=O)N[C@H]3CCCC[C@@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C24H25FN2O2/c1-15-10-11-16(14-26-15)12-17-13-20(23(25)19-7-3-2-6-18(17)19)24(29)27-21-8-4-5-9-22(21)28/h2-3,6-7,10-11,13-14,21-22,28H,4-5,8-9,12H2,1H3,(H,27,29)/t21-,22-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	490	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261738 (4-((6-Cyclopropylpyridin-3-yl)methyl)-1-fluoro-N-(...) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cc(Cc2ccc(nc2)C2CC2)c2ccccc2c1F |r| Show InChI InChI=1S/C26H27FN2O2/c27-25-20-6-2-1-5-19(20)18(13-16-9-12-22(28-15-16)17-10-11-17)14-21(25)26(31)29-23-7-3-4-8-24(23)30/h1-2,5-6,9,12,14-15,17,23-24,30H,3-4,7-8,10-11,13H2,(H,29,31)/t23-,24-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	347	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261716 (4-((6-chloropyridin-3- yl)methyl)-1-fluoro-N- ((3R...) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C22H20ClFN2O3/c23-20-6-5-13(11-25-20)9-14-10-17(21(24)16-4-2-1-3-15(14)16)22(28)26-18-7-8-29-12-19(18)27/h1-6,10-11,18-19,27H,7-9,12H2,(H,26,28)/t18-,19-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	52	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261740 (4-((4-Cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)...) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cc(CN2CCC(CC2)(C#N)c2ccccn2)c2ccccc2c1F |r| Show InChI InChI=1S/C29H31FN4O2/c30-27-22-8-2-1-7-21(22)20(17-23(27)28(36)33-24-9-3-4-10-25(24)35)18-34-15-12-29(19-31,13-16-34)26-11-5-6-14-32-26/h1-2,5-8,11,14,17,24-25,35H,3-4,9-10,12-13,15-16,18H2,(H,33,36)/t24-,25-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	345	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261732 (1-fluoro-N- ((3RS,4SR)-3- hydroxytetrahydro- 2H-py...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C26H25FN4O3/c1-31-14-18(13-29-31)22-7-6-16(12-28-22)10-17-11-21(25(27)20-5-3-2-4-19(17)20)26(33)30-23-8-9-34-15-24(23)32/h2-7,11-14,23-24,32H,8-10,15H2,1H3,(H,30,33)/t23-,24-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261716 (4-((6-chloropyridin-3- yl)methyl)-1-fluoro-N- ((3R...) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C22H20ClFN2O3/c23-20-6-5-13(11-25-20)9-14-10-17(21(24)16-4-2-1-3-15(14)16)22(28)26-18-7-8-29-12-19(18)27/h1-6,10-11,18-19,27H,7-9,12H2,(H,26,28)/t18-,19-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	27	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM261716 (4-((6-chloropyridin-3- yl)methyl)-1-fluoro-N- ((3R...) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C22H20ClFN2O3/c23-20-6-5-13(11-25-20)9-14-10-17(21(24)16-4-2-1-3-15(14)16)22(28)26-18-7-8-29-12-19(18)27/h1-6,10-11,18-19,27H,7-9,12H2,(H,26,28)/t18-,19-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	53	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair