Found 6 hits Enz. Inhib. hit(s) with all data for entry = 50021050 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50220373
(2-(2,4-DICHLORO-PHENYL)-7-HYDROXY-1H-BENZOIMIDAZOL...)Show SMILES CS(=O)(=O)Nc1ccc(CCNC(=O)c2ccc(O)c3nc([nH]c23)-c2ccc(Cl)cc2Cl)cc1 Show InChI InChI=1S/C23H20Cl2N4O4S/c1-34(32,33)29-15-5-2-13(3-6-15)10-11-26-23(31)17-8-9-19(30)21-20(17)27-22(28-21)16-7-4-14(24)12-18(16)25/h2-9,12,29-30H,10-11H2,1H3,(H,26,31)(H,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
CrystalGenomics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta at 5 uM |
Bioorg Med Chem Lett 17: 5686-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.056 BindingDB Entry DOI: 10.7270/Q2HH6JT3 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50220369
(CHEMBL399140 | N-(4-(methylsulfonamido)phenethyl)-...)Show SMILES CS(=O)(=O)Nc1ccc(CCNC(=O)c2ccc(O)c3nc([nH]c23)-c2ccccc2)cc1 Show InChI InChI=1S/C23H22N4O4S/c1-32(30,31)27-17-9-7-15(8-10-17)13-14-24-23(29)18-11-12-19(28)21-20(18)25-22(26-21)16-5-3-2-4-6-16/h2-12,27-28H,13-14H2,1H3,(H,24,29)(H,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
CrystalGenomics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta at 5 uM |
Bioorg Med Chem Lett 17: 5686-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.056 BindingDB Entry DOI: 10.7270/Q2HH6JT3 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50220370
(3-(1-methylindol-3-yl)-4-[3-(2-aminoethoxy)phenyl]...)Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc(OCCN)c2)c2ccccc12 |t:4| Show InChI InChI=1S/C21H19N3O3/c1-24-12-16(15-7-2-3-8-17(15)24)19-18(20(25)23-21(19)26)13-5-4-6-14(11-13)27-10-9-22/h2-8,11-12H,9-10,22H2,1H3,(H,23,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
CrystalGenomics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta at 5 uM |
Bioorg Med Chem Lett 17: 5686-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.056 BindingDB Entry DOI: 10.7270/Q2HH6JT3 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50220372
(7-hydroxy-N-phenethyl-2-phenyl-1H-benzo[d]imidazol...)Show SMILES Oc1ccc(C(=O)NCCc2ccccc2)c2[nH]c(nc12)-c1ccccc1 Show InChI InChI=1S/C22H19N3O2/c26-18-12-11-17(22(27)23-14-13-15-7-3-1-4-8-15)19-20(18)25-21(24-19)16-9-5-2-6-10-16/h1-12,26H,13-14H2,(H,23,27)(H,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
CrystalGenomics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta at 5 uM |
Bioorg Med Chem Lett 17: 5686-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.056 BindingDB Entry DOI: 10.7270/Q2HH6JT3 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50220374
(CHEMBL250714 | N-benzyl-7-hydroxy-2-phenyl-1H-benz...)Show SMILES Oc1ccc(C(=O)NCc2ccccc2)c2[nH]c(nc12)-c1ccccc1 Show InChI InChI=1S/C21H17N3O2/c25-17-12-11-16(21(26)22-13-14-7-3-1-4-8-14)18-19(17)24-20(23-18)15-9-5-2-6-10-15/h1-12,25H,13H2,(H,22,26)(H,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
CrystalGenomics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta at 5 uM |
Bioorg Med Chem Lett 17: 5686-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.056 BindingDB Entry DOI: 10.7270/Q2HH6JT3 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50220371
(2-(2,4-dichlorophenyl)-7-hydroxy-N-phenethyl-1H-be...)Show SMILES Oc1ccc(C(=O)NCCc2ccccc2)c2[nH]c(nc12)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C22H17Cl2N3O2/c23-14-6-7-15(17(24)12-14)21-26-19-16(8-9-18(28)20(19)27-21)22(29)25-11-10-13-4-2-1-3-5-13/h1-9,12,28H,10-11H2,(H,25,29)(H,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CrystalGenomics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta at 5 uM |
Bioorg Med Chem Lett 17: 5686-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.056 BindingDB Entry DOI: 10.7270/Q2HH6JT3 |
More data for this Ligand-Target Pair | |