Compile Data Set for Download or QSAR

Found 98 hits Enz. Inhib. hit(s) with all data for entry = 50009773   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532038 (CHEMBL4463066) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccn2)n(n1)C1CCCCC1 Show InChI InChI=1S/C18H22N8O/c1-13-11-16(26(22-13)14-7-3-2-4-8-14)20-17(27)12-25-23-18(21-24-25)15-9-5-6-10-19-15/h5-6,9-11,14H,2-4,7-8,12H2,1H3,(H,20,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.46E+4	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532049 (CHEMBL4567000) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCC(C)(C)CC1 Show InChI InChI=1S/C21H27N7O/c1-15-13-18(28(24-15)17-9-11-21(2,3)12-10-17)22-19(29)14-27-25-20(23-26-27)16-7-5-4-6-8-16/h4-8,13,17H,9-12,14H2,1-3H3,(H,22,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>221	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532035 (CHEMBL4451422) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCOCC1 Show InChI InChI=1S/C18H21N7O2/c1-13-11-16(25(21-13)15-7-9-27-10-8-15)19-17(26)12-24-22-18(20-23-24)14-5-3-2-4-6-14/h2-6,11,15H,7-10,12H2,1H3,(H,19,26)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.04E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532027 (CHEMBL4529103) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(Cc2ccccc2)n1 Show InChI InChI=1S/C20H19N7O/c1-15-12-18(26(23-15)13-16-8-4-2-5-9-16)21-19(28)14-27-24-20(22-25-27)17-10-6-3-7-11-17/h2-12H,13-14H2,1H3,(H,21,28)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	848	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532002 (CHEMBL4530409) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(C)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H25N7O/c1-14-7-6-8-16(11-14)20-22-25-26(24-20)13-19(28)21-18-12-15(2)23-27(18)17-9-4-3-5-10-17/h6-8,11-12,17H,3-5,9-10,13H2,1-2H3,(H,21,28)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	435	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532044 (CHEMBL4559853) Show SMILES Cc1cc(NC(=O)Cc2nnc(s2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H23N5OS/c1-14-12-17(25(24-14)16-10-6-3-7-11-16)21-18(26)13-19-22-23-20(27-19)15-8-4-2-5-9-15/h2,4-5,8-9,12,16H,3,6-7,10-11,13H2,1H3,(H,21,26)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532040 (CHEMBL4522066) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2F)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H22FN7O/c1-13-11-17(27(23-13)14-7-3-2-4-8-14)21-18(28)12-26-24-19(22-25-26)15-9-5-6-10-16(15)20/h5-6,9-11,14H,2-4,7-8,12H2,1H3,(H,21,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	187	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532041 (CHEMBL4447978) Show SMILES COc1cccc(c1)-c1nnn(CC(=O)Nc2cc(C)nn2C2CCCCC2)n1 Show InChI InChI=1S/C20H25N7O2/c1-14-11-18(27(23-14)16-8-4-3-5-9-16)21-19(28)13-26-24-20(22-25-26)15-7-6-10-17(12-15)29-2/h6-7,10-12,16H,3-5,8-9,13H2,1-2H3,(H,21,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	117	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532042 (CHEMBL4518000) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(c2)C(F)(F)F)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H22F3N7O/c1-13-10-17(30(26-13)16-8-3-2-4-9-16)24-18(31)12-29-27-19(25-28-29)14-6-5-7-15(11-14)20(21,22)23/h5-7,10-11,16H,2-4,8-9,12H2,1H3,(H,24,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	183	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532006 (CHEMBL4593343) Show SMILES Cc1cc(NC(=O)Cc2coc(n2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C21H24N4O2/c1-15-12-19(25(24-15)18-10-6-3-7-11-18)23-20(26)13-17-14-27-21(22-17)16-8-4-2-5-9-16/h2,4-5,8-9,12,14,18H,3,6-7,10-11,13H2,1H3,(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532043 (CHEMBL4476625) Show SMILES Cc1cc(NC(=O)Cc2cccc(c2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C24H27N3O/c1-18-15-23(27(26-18)22-13-6-3-7-14-22)25-24(28)17-19-9-8-12-21(16-19)20-10-4-2-5-11-20/h2,4-5,8-12,15-16,22H,3,6-7,13-14,17H2,1H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	370	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532039 (CHEMBL4538108) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(Cl)c(Cl)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H21Cl2N7O/c1-12-9-17(28(24-12)14-5-3-2-4-6-14)22-18(29)11-27-25-19(23-26-27)13-7-8-15(20)16(21)10-13/h7-10,14H,2-6,11H2,1H3,(H,22,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532010 (CHEMBL4441816) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)-c1ccccc1 Show InChI InChI=1S/C19H17N7O/c1-14-12-17(26(22-14)16-10-6-3-7-11-16)20-18(27)13-25-23-19(21-24-25)15-8-4-2-5-9-15/h2-12H,13H2,1H3,(H,20,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.02E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532050 (CHEMBL4447709) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCS(=O)(=O)CC1 Show InChI InChI=1S/C18H21N7O3S/c1-13-11-16(25(21-13)15-7-9-29(27,28)10-8-15)19-17(26)12-24-22-18(20-23-24)14-5-3-2-4-6-14/h2-6,11,15H,7-10,12H2,1H3,(H,19,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532051 (CHEMBL4536856) Show SMILES CCC(C)n1nc(C)cc1NC(=O)Cn1nnc(n1)-c1ccccc1 Show InChI InChI=1S/C17H21N7O/c1-4-13(3)24-15(10-12(2)20-24)18-16(25)11-23-21-17(19-22-23)14-8-6-5-7-9-14/h5-10,13H,4,11H2,1-3H3,(H,18,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532008 (CHEMBL4453946) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H23N7O/c1-14-12-17(26(22-14)16-10-6-3-7-11-16)20-18(27)13-25-23-19(21-24-25)15-8-4-2-5-9-15/h2,4-5,8-9,12,16H,3,6-7,10-11,13H2,1H3,(H,20,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	96	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532052 (CHEMBL4445429) Show SMILES Cc1cc(NC(=S)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H23N7S/c1-14-12-17(26(22-14)16-10-6-3-7-11-16)20-18(27)13-25-23-19(21-24-25)15-8-4-2-5-9-15/h2,4-5,8-9,12,16H,3,6-7,10-11,13H2,1H3,(H,20,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	623	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532045 (CHEMBL4529550) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(C)cc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H25N7O/c1-14-8-10-16(11-9-14)20-22-25-26(24-20)13-19(28)21-18-12-15(2)23-27(18)17-6-4-3-5-7-17/h8-12,17H,3-7,13H2,1-2H3,(H,21,28)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	408	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532052 (CHEMBL4445429) Show SMILES Cc1cc(NC(=S)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H23N7S/c1-14-12-17(26(22-14)16-10-6-3-7-11-16)20-18(27)13-25-23-19(21-24-25)15-8-4-2-5-9-15/h2,4-5,8-9,12,16H,3,6-7,10-11,13H2,1H3,(H,20,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532051 (CHEMBL4536856) Show SMILES CCC(C)n1nc(C)cc1NC(=O)Cn1nnc(n1)-c1ccccc1 Show InChI InChI=1S/C17H21N7O/c1-4-13(3)24-15(10-12(2)20-24)18-16(25)11-23-21-17(19-22-23)14-8-6-5-7-9-14/h5-10,13H,4,11H2,1-3H3,(H,18,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532030 (CHEMBL4459994) Show SMILES CC1CC1c1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C22H27N7O/c1-15-12-18(15)19-13-20(29(25-19)17-10-6-3-7-11-17)23-21(30)14-28-26-22(24-27-28)16-8-4-2-5-9-16/h2,4-5,8-9,13,15,17-18H,3,6-7,10-12,14H2,1H3,(H,23,30)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532047 (CHEMBL4464987) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccnc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C18H22N8O/c1-13-10-16(26(22-13)15-7-3-2-4-8-15)20-17(27)12-25-23-18(21-24-25)14-6-5-9-19-11-14/h5-6,9-11,15H,2-4,7-8,12H2,1H3,(H,20,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.91E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532025 (CHEMBL4450006) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(F)cc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H22FN7O/c1-13-11-17(27(23-13)16-5-3-2-4-6-16)21-18(28)12-26-24-19(22-25-26)14-7-9-15(20)10-8-14/h7-11,16H,2-6,12H2,1H3,(H,21,28)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	634	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532013 (CHEMBL4549232) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(F)c(F)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H21F2N7O/c1-12-9-17(28(24-12)14-5-3-2-4-6-14)22-18(29)11-27-25-19(23-26-27)13-7-8-15(20)16(21)10-13/h7-10,14H,2-6,11H2,1H3,(H,22,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	392	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532016 (CHEMBL4472955) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)C2CC2)n(n1)C1CCCCC1 Show InChI InChI=1S/C16H23N7O/c1-11-9-14(23(19-11)13-5-3-2-4-6-13)17-15(24)10-22-20-16(18-21-22)12-7-8-12/h9,12-13H,2-8,10H2,1H3,(H,17,24)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532019 (CHEMBL4458146) Show SMILES Cc1cc(NC(=O)Cn2cc(nn2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H24N6O/c1-15-12-19(26(23-15)17-10-6-3-7-11-17)21-20(27)14-25-13-18(22-24-25)16-8-4-2-5-9-16/h2,4-5,8-9,12-13,17H,3,6-7,10-11,14H2,1H3,(H,21,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	412	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532021 (CHEMBL4540010) Show SMILES Cc1cc(NC(=O)Cn2ccc(n2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C21H25N5O/c1-16-14-20(26(23-16)18-10-6-3-7-11-18)22-21(27)15-25-13-12-19(24-25)17-8-4-2-5-9-17/h2,4-5,8-9,12-14,18H,3,6-7,10-11,15H2,1H3,(H,22,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	998	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532004 (CHEMBL4593085) Show SMILES Cc1cc(NC(=O)Cc2ccc(cc2)-c2ccc(Cl)c(Cl)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C24H25Cl2N3O/c1-16-13-23(29(28-16)20-5-3-2-4-6-20)27-24(30)14-17-7-9-18(10-8-17)19-11-12-21(25)22(26)15-19/h7-13,15,20H,2-6,14H2,1H3,(H,27,30)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.35E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532002 (CHEMBL4530409) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(C)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H25N7O/c1-14-7-6-8-16(11-14)20-22-25-26(24-20)13-19(28)21-18-12-15(2)23-27(18)17-9-4-3-5-10-17/h6-8,11-12,17H,3-5,9-10,13H2,1-2H3,(H,21,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	129	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532003 (CHEMBL4475272) Show SMILES Cc1cc(NC(=O)Cc2ncc(o2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C21H24N4O2/c1-15-12-19(25(24-15)17-10-6-3-7-11-17)23-20(26)13-21-22-14-18(27-21)16-8-4-2-5-9-16/h2,4-5,8-9,12,14,17H,3,6-7,10-11,13H2,1H3,(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	631	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532004 (CHEMBL4593085) Show SMILES Cc1cc(NC(=O)Cc2ccc(cc2)-c2ccc(Cl)c(Cl)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C24H25Cl2N3O/c1-16-13-23(29(28-16)20-5-3-2-4-6-20)27-24(30)14-17-7-9-18(10-8-17)19-11-12-21(25)22(26)15-19/h7-13,15,20H,2-6,14H2,1H3,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.47E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532005 (CHEMBL4543208) Show SMILES COc1ccc(cc1)-c1nnn(CC(=O)Nc2cc(C)nn2C2CCCCC2)n1 Show InChI InChI=1S/C20H25N7O2/c1-14-12-18(27(23-14)16-6-4-3-5-7-16)21-19(28)13-26-24-20(22-25-26)15-8-10-17(29-2)11-9-15/h8-12,16H,3-7,13H2,1-2H3,(H,21,28)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	779	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532006 (CHEMBL4593343) Show SMILES Cc1cc(NC(=O)Cc2coc(n2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C21H24N4O2/c1-15-12-19(25(24-15)18-10-6-3-7-11-18)23-20(26)13-17-14-27-21(22-17)16-8-4-2-5-9-16/h2,4-5,8-9,12,14,18H,3,6-7,10-11,13H2,1H3,(H,23,26)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532007 (CHEMBL4473433) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCCC1 Show InChI InChI=1S/C18H21N7O/c1-13-11-16(25(21-13)15-9-5-6-10-15)19-17(26)12-24-22-18(20-23-24)14-7-3-2-4-8-14/h2-4,7-8,11,15H,5-6,9-10,12H2,1H3,(H,19,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	163	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532008 (CHEMBL4453946) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H23N7O/c1-14-12-17(26(22-14)16-10-6-3-7-11-16)20-18(27)13-25-23-19(21-24-25)15-8-4-2-5-9-15/h2,4-5,8-9,12,16H,3,6-7,10-11,13H2,1H3,(H,20,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	259	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532009 (CHEMBL4440217) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CC1 Show InChI InChI=1S/C16H17N7O/c1-11-9-14(23(19-11)13-7-8-13)17-15(24)10-22-20-16(18-21-22)12-5-3-2-4-6-12/h2-6,9,13H,7-8,10H2,1H3,(H,17,24)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532010 (CHEMBL4441816) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)-c1ccccc1 Show InChI InChI=1S/C19H17N7O/c1-14-12-17(26(22-14)16-10-6-3-7-11-16)20-18(27)13-25-23-19(21-24-25)15-8-4-2-5-9-15/h2-12H,13H2,1H3,(H,20,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.09E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM50532011 (CHEMBL4541815) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cc(Cl)cc(Cl)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H21Cl2N7O/c1-12-7-17(28(24-12)16-5-3-2-4-6-16)22-18(29)11-27-25-19(23-26-27)13-8-14(20)10-15(21)9-13/h7-10,16H,2-6,11H2,1H3,(H,22,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.12E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532012 (CHEMBL4461542) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(F)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H22FN7O/c1-13-10-17(27(23-13)16-8-3-2-4-9-16)21-18(28)12-26-24-19(22-25-26)14-6-5-7-15(20)11-14/h5-7,10-11,16H,2-4,8-9,12H2,1H3,(H,21,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	81	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532013 (CHEMBL4549232) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(F)c(F)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H21F2N7O/c1-12-9-17(28(24-12)14-5-3-2-4-6-14)22-18(29)11-27-25-19(23-26-27)13-7-8-15(20)16(21)10-13/h7-10,14H,2-6,11H2,1H3,(H,22,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	116	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532014 (CHEMBL4553987) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccnc(F)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C18H21FN8O/c1-12-9-16(27(23-12)14-5-3-2-4-6-14)21-17(28)11-26-24-18(22-25-26)13-7-8-20-15(19)10-13/h7-10,14H,2-6,11H2,1H3,(H,21,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	441	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532015 (CHEMBL4550753) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(F)n2)n(n1)C1CCCCC1 Show InChI InChI=1S/C18H21FN8O/c1-12-10-16(27(23-12)13-6-3-2-4-7-13)21-17(28)11-26-24-18(22-25-26)14-8-5-9-15(19)20-14/h5,8-10,13H,2-4,6-7,11H2,1H3,(H,21,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532016 (CHEMBL4472955) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)C2CC2)n(n1)C1CCCCC1 Show InChI InChI=1S/C16H23N7O/c1-11-9-14(23(19-11)13-5-3-2-4-6-13)17-15(24)10-22-20-16(18-21-22)12-7-8-12/h9,12-13H,2-8,10H2,1H3,(H,17,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532017 (CHEMBL4529580) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(cc2)C(F)(F)F)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H22F3N7O/c1-13-11-17(30(26-13)16-5-3-2-4-6-16)24-18(31)12-29-27-19(25-28-29)14-7-9-15(10-8-14)20(21,22)23/h7-11,16H,2-6,12H2,1H3,(H,24,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	241	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532018 (CHEMBL4470260) Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(Cl)c(C)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H24ClN7O/c1-13-10-15(8-9-17(13)21)20-23-26-27(25-20)12-19(29)22-18-11-14(2)24-28(18)16-6-4-3-5-7-16/h8-11,16H,3-7,12H2,1-2H3,(H,22,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	712	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532019 (CHEMBL4458146) Show SMILES Cc1cc(NC(=O)Cn2cc(nn2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H24N6O/c1-15-12-19(26(23-15)17-10-6-3-7-11-17)21-20(27)14-25-13-18(22-24-25)16-8-4-2-5-9-16/h2,4-5,8-9,12-13,17H,3,6-7,10-11,14H2,1H3,(H,21,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	116	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532020 (CHEMBL4451814) Show SMILES Cc1cc(NC(=O)Cn2nncc2-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H24N6O/c1-15-12-19(26(23-15)17-10-6-3-7-11-17)22-20(27)14-25-18(13-21-24-25)16-8-4-2-5-9-16/h2,4-5,8-9,12-13,17H,3,6-7,10-11,14H2,1H3,(H,22,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	375	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532021 (CHEMBL4540010) Show SMILES Cc1cc(NC(=O)Cn2ccc(n2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C21H25N5O/c1-16-14-20(26(23-16)18-10-6-3-7-11-18)22-21(27)15-25-13-12-19(24-25)17-8-4-2-5-9-17/h2,4-5,8-9,12-14,18H,3,6-7,10-11,15H2,1H3,(H,22,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	511	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532022 (CHEMBL4540099) Show SMILES Cc1cc(NC(=O)Cc2csc(n2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C21H24N4OS/c1-15-12-19(25(24-15)18-10-6-3-7-11-18)23-20(26)13-17-14-27-21(22-17)16-8-4-2-5-9-16/h2,4-5,8-9,12,14,18H,3,6-7,10-11,13H2,1H3,(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.33E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50532023 (CHEMBL4454445) Show SMILES Cc1cc(NC(=O)Cc2ccc(cc2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C24H27N3O/c1-18-16-23(27(26-18)22-10-6-3-7-11-22)25-24(28)17-19-12-14-21(15-13-19)20-8-4-2-5-9-20/h2,4-5,8-9,12-16,22H,3,6-7,10-11,17H2,1H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay				Bioorg Med Chem Lett 29: 791-796 (2019) Article DOI: 10.1016/j.bmcl.2019.01.027 BindingDB Entry DOI: 10.7270/Q2BV7M47
					More data for this Ligand-Target Pair

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